In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 102, No. 9 ( 2005-03), p. 3513-3518
Kurzfassung:
Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine β-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol- O -methyltransferase), or Th -/- , Dbh Th/+ (tyrosine hydroxylase), and in rats born by Cesarean-section. The functional state of D2, or the high-affinity state for dopamine (D2 High ), was measured in these supersensitive animal brain striata. Increased levels and higher proportions (40-900%) for D2 High were found in all these tissues. If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2 High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted.
Materialart:
Online-Ressource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.0409766102
Sprache:
Englisch
Verlag:
Proceedings of the National Academy of Sciences
Publikationsdatum:
2005
ZDB Id:
209104-5
ZDB Id:
1461794-8
SSG:
11
SSG:
12
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