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  • 1
    Online Resource
    Online Resource
    Singapore : Springer Nature Singapore | Singapore : Imprint: Springer
    Keywords: Environment. ; Climatology. ; Environmental protection. ; Civil engineering. ; Water. ; Hydrology.
    Description / Table of Contents: Sustainable Water Management in Developing Countries -- Progress, Challenges and Prospects for Sustainable Water Resources Management and Development in Zimbabwe -- Sustainable Water Treatment and Management Approaches in the Urban Environments of Developing Countries -- Modern Water Treatment Methods: Exploring Public Acceptance and Socio- economic Factors influencing their Implementation -- Ensuring Sustainability of Groundwater Resources: A Review of Challenges and Initiatives by Southern African Arid and Semi-arid Countries -- Micro plastics Contamination in Urban Water System: A Risk Assessment and Mitigation -- Discovery of Novel Butyrylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease caused due to the Presence of Aluminium in Drinking Water -- Combating Plastic Contamination: Strategies for Removing Micro plastic from Water Resources -- Low-cost Sustainable Nanotechnology Approaches for Water Quality Monitoring in Developing Countries -- Sustainable Treatment of Contaminants of Emerging Concerns in Water and Wastewater -- An Evaluation of the Potential Use of Environmental Coagulants to Decontaminate Leachates -- Significance of Renewable Energy in Water Management and Irrigation -- Securing and Preserving the Support of the Community for the Implementation of the Continuous Water Supply System in India -- Exploring Ethical Impacts of Nanomaterials for Wastewater Remediation -- Using Applied Theatre in Communicating Water Management Challenges and Solutions in African Communities -- Using Desalination to Supplement the Groundwater Supply to Arid and Semi- arid Environments -- Contextual Engendering of Water and Climate Adaptations in Developing Countries -- Water and Sanitation: A Global Priority -- Regional Water Harvesting Structures in Kerala: A Gender Perspective -- Using Geochemical Assessments for Basin-wide Monitoring of Groundwater Quality and Quantity: Case of Omaruru-Swakop Basin -- Water and Sanitation Management in Urban Slum of Bandung City, Indonesia: Assessing the Potential Acceptance and Impact of Composting Toilet Technology in Urban Slum Areas -- The Impact of Municipal Waste on Groundwater Quality: Case of Omaruru Municipal Dumpsite -- Security of Food and Water: For a Sustainable Future -- Future Perception and Opportunities for Sustainable Water Management in Developing Countries.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource(XV, 480 p. 147 illus., 113 illus. in color.)
    Edition: 1st ed. 2024.
    ISBN: 9789819986392
    Series Statement: Water Resources Development and Management
    Language: English
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  • 2
    Publication Date: 2016-02-16
    Description: Hereditary sensory and autonomic neuropathy type 1 (HSAN1) is a rare autosomal dominant inherited peripheral neuropathy caused by mutations in the SPTLC1 and SPTLC2 subunits of serine palmitoyltransferase (SPT). The mutations induce a permanent shift in the substrate preference from l -serine to l -alanine, which results in the pathological formation of atypical and neurotoxic 1-deoxy-sphingolipids (1-deoxySL). Here we compared the enzymatic properties of 11 SPTLC1 and six SPTLC2 mutants using a uniform isotope labelling approach. In total, eight SPT mutants (STPLC1p.C133W, p.C133Y, p.S331F, p.S331Y and SPTLC2p.A182P, p.G382V, p.S384F, p.I504F) were associated with increased 1-deoxySL synthesis. Despite earlier reports, canonical activity with l -serine was not reduced in any of the investigated SPT mutants. Three variants (SPTLC1p.S331F/Y and SPTLC2p.I505Y) showed an increased canonical activity and increased formation of C 20 sphingoid bases. These three mutations are associated with an exceptionally severe HSAN1 phenotype, and increased C 20 sphingosine levels were also confirmed in plasma of patients. A principal component analysis of the analysed sphingoid bases clustered the mutations into three separate entities. Each cluster was related to a distinct clinical outcome (no, mild and severe HSAN1 phenotype). A homology model based on the protein structure of the prokaryotic SPT recapitulated the same grouping on a structural level. Mutations associated with the mild form clustered around the active site, whereas mutations associated with the severe form were located on the surface of the protein. In conclusion, we showed that HSAN1 mutations in SPT have distinct biochemical properties, which allowed for the prediction of the clinical symptoms on the basis of the plasma sphingoid base profile.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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