In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 31, No. 4_suppl ( 2013-02-01), p. 561-561
Abstract:
561 Background: Liver resection remains the only potentially curative option for a subset of patients with metastatic colorectal cancer (CRC) to liver. Preoperative imaging used to determine resectability includes contrast enhanced computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET). The objective of this study was to determine the utility of PET scanning for potentially resectable metastatic CRC to liver. Methods: We retrospectively reviewed a prospectively maintained database for all patients considered for liver resection of metastatic CRC from July 2010 to July 2012 in a specialist colorectal/hepatobiliary cancer centre. We extracted and analysed data with respect to preoperative staging imaging and definitive treatment performed on completion of staging. Results: We identified 50 patients who underwent preoperative staging investigations for potentially resectable metastatic CRC to liver. The imaging techniques performed included: CT (n=50, 100%), MRI liver (n=45, 90%), PET (n= 47, 94%). In 9 (9/47, 19%) patients PET scanning added to the preoperative cross sectional staging information, identifying local recurrence (n=1, 2%), confirming liver metastases following an inconclusive CT/MRI (n=1, 2%), and identifying extrahepatic sites suspicious for disease (n=7, 15%). The extrahepatic sites included either lung (n=4) or bone (n=1) or lymph nodes (n=2). One patient with FDG-avid mediastinal lymph nodes had no cancer on endobronchial biopsy. PET scanning definitively changed the therapeutic strategy in 6 patients (6/47, 12.8%): precluding liver resection in 2 patients (2/47, 4.3%), leading to resection of extrahepatic disease in 3 patients (3/47, 6.4%) and resection of hepatic metastases in one patient (1/47, 2.1%). Conclusions: In this small retrospective cohort the addition of metabolic imaging changed the management in 12.8% of patients with potentially resectable liver confined metastatic CRC. We plan to include data from other cancer centres in Ireland to confirm our findings.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2013.31.4_suppl.561
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2005181-5
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