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  • 1
    Electronic Resource
    Electronic Resource
    A clinical evaluation of the maximal histalog test (1967)
    Springer
    Digestive diseases and sciences 12 (1967), S. 468-474 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary and conclusions A maximal dose of Histalog (2.0 mg./kg.) was evaluated as a stimulant for clinical testing of gastric secretion in 131 patients. The tube must be positioned fluoroscopically in the gastric antrum prior to testing—failure to do so results in a significantly reduced recovery of secretion. It is also recommended that continued antral position of the tube be checked fluoroscopicaly toward the end of the test. The highest hourly output of gastric secretion was found to occur between 30 and 90 min. after Histalog administration in patients with duodenal ulcer and between 60 and 120 min. in control subjects. However, the highest discriminating difference in secretion between ulcer and nonulcer subjects occurs within the first hour (p=〈1%), whereas the difference between 60 and 120 min. is negligible. In the detection and secretory evaluation of duodenal ulcer patients, therefore, it would seem most practical and sufficient to run the test for 90 min. after Histalog administration. Serious side reactions to these large doses of Histalog may occur. Severe vasomotor collapse was observed in 3 patients (2%) and occurred despite the prior administration of Benadryl in 2. Significant bleeding from the stomach was noted in 14 patients (10%). These reactions limit the usefulness of the procedure and underscore the necessity for caution in its application as a routine diagnostic aid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233179
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Delayed hypersensitivity reactions in the gastrointestinal tract (1969)
    Springer
    Digestive diseases and sciences 14 (1969), S. 853-863 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen niniature swine were skin-sensitized to 2–4 dinitrochlorobenzene (DNCB) and had a colostomy in the midtransverse colon. All were given DNCB in adhesive paste 3 times weekly for 6 months, through the colostomy. In addition 6 animals received Freund's complete adjuvant, 6 were given E. coli endotoxin, and 4 were given neostigmine 2 times weekly for 6 months. The morphological changes produced in all animals were those of microscopic ulceration and partial glandular destruction. The lamina propria showed a chronic inflammatory infiltrate. The vessels showed perivascular congestion. The adjuvant group seemed to have a more grossly intense lesion. In the neostigmine group, crypt abscesses were found in all pigs, the first production of such lesions in an experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02233206
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    Paper (German National Licenses)
    Fulltext
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