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  • 1
    ISSN: 1434-3932
    Keywords: Schlüsselwörter  Apoplexie ; Karotis-TEA ; Karotisstenting ; Neuromonitoring ; Embolie ; Transkranielle Dopplersonographie ; Key words Stroke ; Carotid TEA ; Carotid stenting ; Neuromonitoring ; Emboli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract  In a retrospective study we examined whether it is possible to achieve better results in carotid artery surgery with a new operative technique called ”no-touch-isolation technique” in combination with intraoperative angiography than with conventional operative techniques. Patients and methods: In 1997 and 1998, 80 patients who were operated on using this new operative technique were compared with a group of 144 patients who had undergone conventional carotid endarterectomy. The new aspect of the no-touch-isolation technique is that the whole operation strategy aims to avoid possible intraoperative and postoperative embolism. At first, the internal carotid artery is exposed and clamped distally to the stenotic plaque very atraumatically. The operation was then continued without an intraluminal shunt. At the end of the operation the result was checked by means of an intraoperative angiography. If any suggestion of a possible embolism, such as tears of the intima, were seen, an intraoperative revision was carried out until all thrombembolic material was removed. Results: The two groups were not different regarding age, sex, symptoms, degree of stenosis and risk factors nor did any significant differences exist in the operative technique used for endarterectomy (with or without patch, eversions-TEA, etc.). The group operated on with the no-touch-isolation technique had significantly longer operation- times (110 min vs 90 min) and also significantly longer clamping times (38.7 min vs 28.2 min) than the group operated on using conventional technique. The postoperative results, however, were still better. There were significantly fewer neurological deficits (4.1% vs 9.3%). Conclusion: The no-touch-isolation technique in combination with intraoperative angiography is a very safe method of treatment in patients with symptomatic stenosis of the internal carotid artery with a more than 70% degree of stenosis.
    Notes: Zusammenfassung  In einer retro-spektiven Studie wurde untersucht, inwieweit sich mit einer Optimierung der Operationstechnik an der A. carotis, der sog. No-touch-isolation-Technik, bessere Ergebnisse erzielen lassen. 80 Patienten, die 1997 und 1998 in der neuen Technik operiert worden waren, wurden mit einer Gruppe von 144 Patienten, die zuvor in herkömmlicher Technik operiert worden waren, verglichen. Das Neue der No-touch-isolation-Technik bestand darin, dass die ganze Operationstaktik darauf abzielte, mögliche intraoperative und postoperative Embolien zu vermeiden. Zu diesem Zweck wurde als Erstes die A. carotis interna ganz atraumatisch freigelegt und distal des stenosierenden Plaques abge-klemmt. Anschließend erfolgte die weitere Operation ohne Einlage eines intraluminären Shunts. Am Ende der Operation wurde das Ope-rationsergebnis mittels einer intra-operativen Angiographie kontrol- liert. Wenn sich dabei mögliche übriggebliebene Embolisationsquellen, wie Intimalefzen zeigten, erfolgte eine intraoperative Revision, bis alle Embolisationsquellen besei-tigt waren. Die beiden verglichenen Gruppen unterschieden sich nicht bezüglich Alter, Geschlecht, Sympto-matik, Stenosegrad und Risikofaktoren. Auch bezüglich der angewandten Operationsverfahren (TEA mit oder ohne Patch, Eversions-TEA etc.) bestanden keine signifikanten Unterschiede. Die in No-touch-isolation-Technik operierte Gruppe hatte signifikant längere Operationszeiten (110 vs. 90 min) und auch signifikant längere Abklemmzeiten (38,7 vs. 28,2 min) als die in der herkömmlichen Technik operierte Gruppe. Die perioperativen Ergeb-nisse waren jedoch besser. So traten signifikant weniger neurologische Defizite auf (4,1 vs. 9,3%). Die No-touch-isolation-Technik in Verbindung mit einer intraoperativen Angiographie ist eine Methode mit einer sehr geringen Insultrate bei Patienten mit symptomatischen 〉70%igen Karotisstenosen.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2011-01-11
    Description: Author(s): E. Behnke, J. Behnke, S. J. Brice, D. Broemmelsiek, J. I. Collar, P. S. Cooper, M. Crisler, C. E. Dahl, D. Fustin, J. Hall, J. H. Hinnefeld, M. Hu, I. Levine, E. Ramberg, T. Shepherd, A. Sonnenschein, and M. Szydagis (COUPP Collaboration) Data from the operation of a bubble chamber filled with 3.5 kg of CF_{3} I in a shallow underground site are reported. An analysis of ultrasound signals accompanying bubble nucleations confirms that alpha decays generate a significantly louder acoustic emission than single nuclear recoils, leading ... [Phys. Rev. Lett. 106, 021303] Published Mon Jan 10, 2011
    Keywords: Gravitation and Astrophysics
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
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  • 3
    Publication Date: 2013-01-15
    Description: Aims Experimental autoimmune myocarditis (EAM) model mirrors important mechanisms of inflammatory dilated cardiomyopathy (iDCM). In EAM, inflammatory CD133 + progenitors are a major cellular source of cardiac myofibroblasts in the post-inflammatory myocardium. We hypothesized that exogenous delivery of macrophage-colony-stimulating factor (M-CSF) can stimulate macrophage lineage differentiation of inflammatory progenitors and, therefore, prevent their naturally occurring myofibroblast fate in EAM. Methods and results EAM was induced in wild-type (BALB/c) and nitric oxide synthase 2-deficient ( Nos2 –/– ) mice and CD133 + progenitors were isolated from inflamed hearts. In vitro, M-CSF converted inflammatory CD133 + progenitors into nitric oxide-producing F4/80 + macrophages and prevented transforming growth factor-β-mediated myofibroblast differentiation. Importantly, only a subset of heart-infiltrating CD133 + progenitors expresses macrophage-specific antigen F4/80 in EAM. These CD133 + /F4/80 hi cells show impaired myofibrogenic potential compared with CD133 + /F4/80 – cells. M-CSF treatment of wild-type mice with EAM at the peak of disease markedly increased CD133 + /F4/80 hi cells in the myocardium, and CD133 + progenitors isolated from M-CSF-treated mice failed to differentiate into myofibroblasts. In contrast, M-CSF was not effective in converting CD133 + progenitors from inflamed hearts of Nos2 –/– mice into macrophages, and M-CSF treatment did not result in increased CD133 + /F4/80 hi cell population in hearts of Nos2 –/– mice. Accordingly, M-CSF prevented post-inflammatory fibrosis and left ventricular dysfunction in wild-type but not in Nos2 –/– mice. Conclusion Active and NOS2-dependent induction of macrophage lineage differentiation abrogates the myofibrogenic potential of heart-infiltrating CD133 + progenitors. Modulating the in vivo differentiation fate of specific progenitors might become a novel approach for the treatment of inflammatory heart diseases.
    Print ISSN: 0008-6363
    Electronic ISSN: 1755-3245
    Topics: Medicine
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  • 4
    Publication Date: 2012-09-06
    Description: Author(s): E. Behnke, J. Behnke, S. J. Brice, D. Broemmelsiek, J. I. Collar, A. Conner, P. S. Cooper, M. Crisler, C. E. Dahl, D. Fustin, E. Grace, J. Hall, M. Hu, I. Levine, W. H. Lippincott, T. Moan, T. Nania, E. Ramberg, A. E. Robinson, A. Sonnenschein, M. Szydagis, and E. Vázquez-Jáuregui (COUPP Collaboration) New data are reported from the operation of a 4.0-kg CF 3 I bubble chamber in the 6800-foot-deep SNOLAB underground laboratory. The effectiveness of ultrasound analysis in discriminating alpha-decay background events from single nuclear recoils has been confirmed, with a lower bound of 〉99.3% rejec... [Phys. Rev. D 86, 052001] Published Wed Sep 05, 2012
    Keywords: Experiment
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 5
    Publication Date: 2013-06-11
    Description: Background— Activation of innate pattern-recognition receptors promotes CD4 + T-cell–mediated autoimmune myocarditis and subsequent inflammatory cardiomyopathy. Mechanisms that counterregulate exaggerated heart-specific autoimmunity are poorly understood. Methods and Results— Experimental autoimmune myocarditis was induced in BALB/c mice by immunization with α-myosin heavy chain peptide and complete Freund’s adjuvant. Together with interferon-, heat-killed Mycobacterium tuberculosis , an essential component of complete Freund’s adjuvant, converted CD11b hi CD11c – monocytes into tumor necrosis factor-α– and nitric oxide synthase 2–producing dendritic cells (TipDCs). Heat-killed M. tuberculosis stimulated production of nitric oxide synthase 2 via Toll-like receptor 2–mediated nuclear factor-B activation. TipDCs limited antigen-specific T-cell expansion through nitric oxide synthase 2–dependent nitric oxide production. Moreover, they promoted nitric oxide synthase 2 production in hematopoietic and stromal cells in a paracrine manner. Consequently, nitric oxide synthase 2 production by both radiosensitive hematopoietic and radioresistant stromal cells prevented exacerbation of autoimmune myocarditis in vivo. Conclusions— Innate Toll-like receptor 2 stimulation promotes formation of regulatory TipDCs, which confine autoreactive T-cell responses in experimental autoimmune myocarditis via nitric oxide. Therefore, activation of innate pattern-recognition receptors is critical not only for disease induction but also for counterregulatory mechanisms, protecting the heart from exaggerated autoimmunity.
    Keywords: Other heart failure
    Electronic ISSN: 1524-4539
    Topics: Medicine
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  • 6
    Publication Date: 2014-10-11
    Description: Author(s): E. Behnke, J. Behnke, S. J. Brice, D. Broemmelsiek, J. I. Collar, A. Conner, P. S. Cooper, M. Crisler, C. E. Dahl, D. Fustin, E. Grace, J. Hall, M. Hu, I. Levine, W. H. Lippincott, T. Moan, T. Nania, E. Ramberg, A. E. Robinson, A. Sonnenschein, M. Szydagis, and E. Vázquez-Jáuregui (COUPP Collaboration) [Phys. Rev. D 90, 079902] Published Fri Oct 10, 2014
    Keywords: Errata
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
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  • 7
    Publication Date: 2016-02-26
    Description: Weather and climate affect many ecological processes, making spatially continuous yet fine-resolution weather data desirable for ecological research and predictions. Numerous downscaled weather data sets exist, but little attempt has been made to evaluate them systematically. Here we address this shortcoming by focusing on four major questions: (1) How accurate are downscaled, gridded climate data sets in terms of temperature and precipitation estimates?, (2) Are there significant regional differences in accuracy among data sets?, (3) How accurate are their mean values compared with extremes?, and (4) Does their accuracy depend on spatial resolution? We compared eight widely used downscaled data sets that provide gridded daily weather data for recent decades across the United States. We found considerable differences among data sets and between downscaled and weather station data. Temperature is represented more accurately than precipitation, and climate averages are more accurate than weather extremes. The data set exhibiting the best agreement with station data varies among ecoregions. Surprisingly, the accuracy of the data sets does not depend on spatial resolution. Although some inherent differences among data sets and weather station data are to be expected, our findings highlight how much different interpolation methods affect downscaled weather data, even for local comparisons with nearby weather stations located inside a grid cell. More broadly, our results highlight the need for careful consideration among different available data sets in terms of which variables they describe best, where they perform best, and their resolution, when selecting a downscaled weather data set for a given ecological application. This article is protected by copyright. All rights reserved.
    Print ISSN: 1051-0761
    Electronic ISSN: 1939-5582
    Topics: Biology
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