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  • 1
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood mononuclear cells (PBMC) were taken by leukapheresis from a patient with melanoma skin metastases and stimulated in vitro using 1000 IU recombinant interleukin 2 (IL-2)/ml to generate lymphokine-activated killer cells (LAK cells). Two-colour immunofluorescence analysis demonstrated an IL-2-induced up-regulation of CD25 on natural killer cells (CD56+) as well as on T lymphocytes (CD3+). After radiolabelling with indium-111, the cells were reinfuse. Gamma-camera imaging revealed an enrichment at the tumour sites. Immunostaining of tumour tissue taken before and after scintigraphy demonstrated CD25+ Tlymphocytes (CD2+, CD3+), but no natural killer cells (CD16+, CD56+) infiltrating the metastases.LAK cell enrichment at melanoma metastases in vivo did not involve natural killer cells, but was characterized by increased numbers of activated T lymphocytes in this patient.
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics of the Earth and Planetary Interiors 77 (1993), S. 109-125 
    ISSN: 0031-9201
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 38 (1960), S. 21-25 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei 200 Männern wurde das Plasmavolumen mit Hilfe von 8–10µC J131-Serumalbumin bestimmt und das Blutvolumen mittels des venösen Hämatokrits errechnet. Diese Werte wurden in Beziehung zum relativen Gewicht (tatsächliches Gewicht, ausgedrückt in Prozent des jeweiligen Sollgewichtes) der Untersuchten gesetzt. Zwischen Plasma- und Blutvolumen pro Gewichtseinheit einerseits und relativem Gewicht der Probanden andererseits konnte eine deutliche Korrelation gefunden werden. Im Durchschnitt entsprach einem höheren relativen Gewicht (d. h. einem größeren Fettanteil) ein kleineres Blut- und Plasmavolumen und umgekehrt. Demnach ist bei einem höheren Fettanteil des Körpers von einem niedrigeren Sollwert für das Blutvolumen pro Kilogramm Körpergewicht auszugehen. Da sich der venöse Hämatokrit jedoch gegensinnig verhält (d. h. mit zunehmendem Fettanteil des Körpers ansteigt), ist das Erythrocytenvolumen von dieser Abnahme weniger als das Plasmavolumen betroffen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 7 (1975), S. 295-301 
    ISSN: 1432-0630
    Keywords: Reflection and refraction of beam waves ; Angular beam shift ; Cauchy beam profile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract New phenomena have been reported recently in connection with Gaussian beam interaction with a plane dielectric interface, namely, the deterioration of the reflected and refracted beams from shapes predicted by geometric optics, and the generation of higherorder components that cause angular beam deflection. Any bounded, symmetric beam, which is not necessarily Gaussian, can be comprised in terms of an angular spectrum of plane waves. Utilizing such a modal expansion, a model of the interaction process that seems to point out the generality of the phenomena involved for bounded symmetrical beams with any cross-section is presented. The procedure is applied to a Cauchy profile, and analytical results are given. Comparison with previous results obtained for the Gaussian beam and careful examination of the respective spectral functions demonstrate close correspondence between the results. This adds credence to the general approach presented here which can be applied to bounded symmetrical beams of general shape.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 141-148 
    ISSN: 1432-1440
    Keywords: Crohn's disease ; 111In-oxine-labelled white blood cells ; Localization ; Disease activity ; Follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prospectively, 43 patients with Crohn's disease (41 clinically active, 2 clinically inactive) and 7 patients with irritable bowel syndrome were examined by111In-oxine-labelled leukocytes (‘mixed’ leukocyte preparations,n=8; ‘pure’ granulocyte preparations,n=42). The number of scintigraphically diagnosed inflamed bowel segments correlated significantly (r=0,95,p〈0.001) with the number of radiologically and endoscopically diagnosed segments. The exact localization of the diseased ileum may be difficult by scintigraphy. One complicating abscess and two fistulas were correctly diagnosed. The percentage of fecal excretion of radiolabelled leukocytes is highly specific for intestinal inflammations. It correlates significantly with the erythrocyte sedimentation rate (r=+0.69,p〈0.001), serum albumin (r=−0.54,p〈0.001), orosomucoid (r=+0.65,p〈0.001), and with the A.I. (van Hees) (r=+0.67,p〈0.001). In the follow-up of 9 patients, the percentage of fecal excretion decreased or increased more rapidly, but in correlation with the CDAI, A.I., or ESR. The authors conclude that this method is an alternative to common methods and that it is superior in primary diagnosis in patients with severe disease, bowel stenosis, abscesses, and after surgery. After clinical and biopsy-proven diagnosis of Crohn's disease, the special value of the leukocyte scan lies in the noninvasive follow-up of patients and its potential of localizing inflamed bowel segments and assessing disease activity.
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Wave Motion 3 (1981), S. 311-333 
    ISSN: 0165-2125
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 13 (1977), S. 71-79 
    ISSN: 1432-0630
    Keywords: 42.30
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The holographic method disclosed in this paper allows holographic recording with a very high reference-to-object wave energy ratio without attenuating the rays diffracted by the object. In those holographic methods permitting local generation of the reference beam, which have been proposed so far, the reference beams are obtained by either wavefront or amplitude division of the wave of coherent radiation impinging onto the optical apparatus. It is readily seen that most of the incident energy is used to process the reference beam reducing drastically the energy of the object bearing wave. In the novel method proposed here the reference wave is obtained by separation of the low spatial frequency components from the high-order spatial frequency components which bear the object information. As a result of the removal of the low frequency components, a dark-field image is recorded and later reconstructed by the holographic plate. Even though the configuration is of the off-axis type, proper design may reduce the coherence requirements of the source of radiation to those for in-line holography. The paper discusses the basic properties of the method and experimental results are presented.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 445-446 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Lung 84 (1934), S. 411-415 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 40 (1962), S. 1162-1167 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über eine Patientin mit einem Cushingschen Syndrom berichtet, die therapeutisch mittels einer auf stereotaktischem Wege vorgenommenen Hypophysenimplantation von Yttrium90 sehr gut beeinflußt wurde. Innerhalb von 4–5 Monaten nach der Implantation von zwei Yttrium-Stäbchen mit einer Gesamtaktivität von 3,4 mC bildeten sich alle Symptome des Cushingschen Syndroms zurück. Eine Beeinträchtigung der Funktion der übrigen, von der Hypophyse abhängigen endokrinen Drüsen erfolgte nicht. Es kam lediglich zum Auftreten einer leichten sekundären Nebennierenrindeninsuffizienz, die keine Substitutionstherapie erforderlich machte. Verschiedene endokrinologische Untersuchungen, wie die Vornahme des Metopiron-Testes und des ACTH-Testes, gewährten einen Einblick in die Veränderungen der Hypophysen-Nebennierenrinden-Funktion im Anschluß an die Implantation. Im Vergleich zu anderen bei der Behandlung des Cushingschen Syndroms gebräuchlichen Verfahren stellt die Implantation von Yttrium90 einen verhältnismäßig schonenden, aber therapeutisch wirksamen Eingriff dar.
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