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  • 1
    Online Resource
    Online Resource
    Messung der stratosphärischen H2O- und CH4-Konzentrationen mit Hilfe von NIR-Diodenlasern : Abschlussbericht (2001)
    Heidelberg
    Details Availability
    Keywords: Forschungsbericht
    Description / Table of Contents: Diode laser, NIR-TDL, absorption, spectrometer, stratosphere, methane, water vapour, balloon, small and lightweight, in situ instrument
    Type of Medium: Online Resource
    Pages: Online-Ressource (49 p., 1,64 Mb.) , ill., graphs
    Edition: [Elektronische Ressource]
    URL: https://edocs.tib.eu/files/e01fb02/346523796.pdf
    URL: https://edocs.tib.eu/files/e01fb02/346523796l.pdf
    Language: German
    Note: Contract BMBF 01 LA 9816. - Differences between the printed and electronic version of the document are possible. - nIndex p. 47 - 49. - Engl. title: Measurement of the stratospheric H2O and CH4 concentrations using NIR diode lasers , Also available as printed version , Systemvoraussetzungen: Acrobat Reader.
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  • 2
    Electronic Resource
    Electronic Resource
    Stable photobleaching of P840 in Chlorobium reaction center preparations: Presence of the 42-kDa bacteriochlorophyll a protein and a 17-kDa polypeptide (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 9617-9624 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00029a039
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    l-Arginine: Effect on Reperfusion Injury after Heart Transplantation (1998)
    Springer
    World journal of surgery 22 (1998), S. 791-798 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Global myocardial ischemia and reperfusion injury play a major role in early postoperative myocardial graft dysfunction. The aim of the present study was to investigate the effects of the nitric oxide (NO) precursor l-arginine on myocardial and endothelial function after hypothermic ischemia and reperfusion in a heterotopic rat heart transplantation model. After 1 hour ischemic preservation, reperfusion was started after application of placebo (control, n = 12) or l-arginine (l-Arg 40 mg/kg, n = 12), a substrate of NO synthesis. Myocardial blood flow (MBF) was assessed by the hydrogen clearance method. An implanted balloon was used to obtain pressure–volume relations of the transplanted heart. Left ventricular developed pressure (LVDP), rate of pressure development (dP/dt), end-diastolic pressure (LVEDP), isovolumic relaxation constant (T E ), and MBF were measured after 60 minutes and 24 hours of reperfusion. Endothelium-dependent vasodilatation in response to acetylcholine (ACh) and endothelium-independent vasodilatation in response to sodium nitroprusside (SNP) were also determined. After 1 hour the MBF was significantly higher in the l-Arg group (3.6 ± 0.6 vs. 1.9 ± 0.2 ml/min/g, p 〈 0.05). The l-Arg group showed better recovery of systolic function and myocardial relaxation (LVDP 106 ± 6 vs. 70 ± 7 mmHg, p 〈 0.05; maximal dP/dt 5145 ± 498 vs. 3410 ± 257 mmHg/s, p 〈 0.05; T E 12.1 ± 0.9 vs. 16.1 ± 1.5 ms, p 〈 0.05, at an intraventricular volume of 80 μl). LVEDP was similar in the two groups. After 24 hours no difference was found between the groups for basal MBF, LVP, dP/dt, T E , LVEDP, or the response of MBF to SNP. However, ACh led to a significantly higher increase in MBF in the l-Arg group (52 ± 8% vs. 29 ± 7%, p 〈 0.05). These results indicate that (1) NO donation improves myocardial and endothelial functional recovery during early reperfusion after heart transplantation; and (2) initial treatment with l-Arg has a persisting beneficial effect against reperfusion-induced graft coronary endothelial dysfunction during late reperfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002689900471
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  • 4
    Electronic Resource
    Electronic Resource
    Irreversible shock of rats after acute renal vein thrombosis (1979)
    Springer
    Virchows Archiv 384 (1979), S. 65-84 
    Details
    ISSN: 1432-2307
    Keywords: Rat kidney ; Renal vein occlusion ; Prostaglandins ; Kallikreins ; Renal microcirculation ; Renal lymphflow ; Lactate acidosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After occlusion of the renal veins rats die quickly in progressive shock (within 4.5 h), but after ligating the renal hilum of both Kidneys they survive 27 h. To learn why renal vein occlusion is so rapidly lethal, and what substances are given off and by what method from the hemorrhagically infarcted kidneys, we studied eight groups of rats, each containing at least seven animals. The groups differed in the combination of hilar structures (renal veins, ureters, lymphatics) ligated. We compared: survival times, changes in blood pressure, blood volume, levels of plasma kinins, adenosine, and lactate, changes of blood pH, responses to Indomethacin, Trasylol®, and plasma expanders, tubular and capillary flow rates, histopathological changes in organs and cerebral blood flow and changes in the blood coagulation system. Our results suggest that the venous stasis, anoxia, and hemorrhagic necrosis caused by bilateral venous occlusion release into renal lymphatics toxic substances which reach the systemic circulation and induce irreversible shock. We have excluded prostaglandins and adenosine as the toxic substances inducing shock but could not rule out an action of the kallikrein-kinin-system. We postulate that the striking degenerative changes occurring in the arterioles of the brain after bilateral venous occlusion may mean these vessels are especially susceptible to high levels of lactic acid and that this may explain why these animals die so quickly. Our conclusions should help not only in understanding why high levels of lactate in shock portend a poor prognosis but also help in formulating appropriate therapy for circulatory failure of renal origin and for protracted hypotension after extensive tissue injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427152
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart (1997)
    Springer
    Pflügers Archiv 433 (1997), S. 563-570 
    Details
    ISSN: 1432-2013
    Keywords: Key words Myocardial stunning ; Myocardial infarction ; Myocardial blood flow ; Regional myocardial function ; Myeloperoxidase ; Elastase ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We investigated the potential of inhibition of elastase, a granulocyte-derived proteolytic enzyme, in ameliorating the effects of myocardial stunning caused by repetitive ischaemia (RI) and myocardial infarction (MI) for the first time in an in situ, perfused, rat heart model. The effects of the elastase-inhibitors Elafin (EL, 10 mg/kg/h) and ICI 200,880 (ICI,5 mg/kg/h) on myocardial blood flow (MBF, H2 clearance), regional myocardial function (FT, pulsed doppler) and neutrophil extravasation (myocardial myeloperoxidase activity, MPO) were investigated in RI (5×10 min ligature of the anterior descending ramus (LAD), 5×20 min reperfusion) and MI (50 min LAD ligature, 60 min reperfusion). Under control conditions, MBF and FT were significantly reduced and MPO was significantly increased after RI (n=8) and MI (n=8) in the ischaemic area compared with baseline. Pretreatment with EL (n=7) or ICI (n=7) did not improve MBF significantly and did not influence the successive attenuation of peak values of reactive hyperaemia. However, both EL and ICI significantly improved FT and significantly reduced MPO after RI and MI compared with control conditions. Additionally, both the area at risk and MI size were reduced significantly by both inhibitors. These results demonstrate that elastase inhibitors significantly improve the reduction of FT both in myocardial stunning and in myocardial infarction in the rat without significant improvement of MBF. It is concluded that elastase inhibitors exert a cardioprotective effect against reperfusion injury, probably by inhibition of leukocyte extravasation as indicated by the decrease in MPO activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050315
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  • 6
    Electronic Resource
    Electronic Resource
    Processing of 201Tl serial images for the assessment of myocardial clearance and redistribution (1982)
    Springer
    European journal of nuclear medicine 7 (1982), S. 248-253 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Regional activity changes over the myocardium after IV injection of 201Tl were assessed in 90 patients by applying a superposition algorithm for paired images. The kinetics were expressed as quotients C 1/C 2 of the initial divided by the delayed count rate within any myocardial segment. Regarding the total left ventricular myocardium, normal subjects showed count rate ratios (C 30 min/C 4 h) of 1.75±0.075 (SD, n=19) when the nuclide was injected under submaximal (80% of maximum) exercise. In patients with triple-vessel disease (n=21) the corresponding values were 1.46±0.05, in single-vessel (n=14) disease the quotients averaged 1.62±0.12. Average quotients in poststenotic myocardial segments increased from 1.46 before to 1.73 following bypass surgery in cases of graft patency (n=8), while a decrease was observed in a patient with occlusion of the bypass graft. In small-vessel disease and in congestive cardiomyopathy, global values of 1.50±0.07 (n=7) and 1.53±0.12 (n=19) were obtained. The display of C1/C2 matrices provided typical patterns in uptake defects caused by ischemic heart disease and by congestive cardiomyopathy. The procedure described may provide diagnostic information in addition to conventional myocardial scintigraphy in triplevessel disease, in patients with angina who fail to demonstrate hemodynamically significant coronary artery stenoses, and in patients with inhomogeneous Tl-scintigrams.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251475
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  • 7
    Electronic Resource
    Electronic Resource
    Myocardial scintigraphy with iodine-123 phenylpentadecanoic acid and thallium-201 in patients with coronary artery disease: a comparative dual-isotope study (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 364-366 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169818
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  • 8
    Electronic Resource
    Electronic Resource
    Myocardial scintigraphy with iodine-123 phenylpentadecanoic acid and thallium-201 in patients with coronary artery disease: a comparative dual-isotope study (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 946-954 
    Details
    ISSN: 1619-7089
    Keywords: Iodine-123 phenylpentadecanoic acid ; Thallium-201 ; Myocardial scintigraphy ; Coronary artery disease ; Myocardial fatty acid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To characterise the clinical usefulness of serial myocardial scintigraphy with iodine-123 phenylpentadecanoic acid (IPPA) in comparison with thallium-201, dual-isotope investigations were performed in 41 patients with angiographically documented coronary artery disease. Both tracers were administered simultaneously during symptom-limited ergometry. Planar scintigrams were acquired immediately after stress, and delayed imaging was performed after 1 h for IPPA and 4 h for 201Tl. Scintigrams were evaluated both qualitatively and quantitatively using a newly developed algorithm for automated image superposition. Initial myocardial uptake of both tracers was closely correlated (r=0.75, p〈0.001). Both tracers also revealed a similar sensitivity for the identification of individual coronary artery stenoses ≥ 75% (IPPA: 70.0%, 201Tl: 66.3%, P=NS) with identical specificity (69.8%). The number of persistent defects, however, was significantly higher with IPPA (P=0.021), suggesting that visual analysis of serial IPPA scintigrams may over-estimate the presence of myocardial scar tissue. On the other hand, previous Q wave myocardial infarction was associated with a decreased regional IPPA clearance (29% ± 11% vs 44%±11% in normal myocardium, P〈0.05). The data indicate that serial myocardial scintigraphy with IPPA is essentially as sensitive as scintigraphy with 201Tl for the detection of stress-induced perfusion abnormalities. Quantitative analysis of myocardial IPPA kinetics, however, is required for the evaluation of tissue viability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175860
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  • 9
    Electronic Resource
    Electronic Resource
    The Lepton Brusselator: Creation of structure in the early universe (1982)
    Springer
    General relativity and gravitation 14 (1982), S. 1051-1060 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The creation of structure in the Lepton Era of the early universe is discussed in terms of a suitably chosen dynamical system of Brusselator type. A bifurcation analysis is performed and a criterion is extracted for the onset of instabilities in the system which in turn lead to self-organizing processes in the associated conglomerate of elementary particles which may be visualized as an imperfect fluid in the hydrodynamic approximation chosen here. This may be interpreted as a symmetry-breaking mechanism which might be responsible for the creation of protostructures on space-time due to density fluctuations, the latter being thought of as controlling the further agglomeration of matter once matter and radiation have decoupled at a temperature level of some 4000 K. This may eventually lead to the formation of galaxies as are observed in the present stage of the universe. The influence of curvature is discussed in considering a metric background of Bianchi type I with respect to the onset of instability. The notion of a local concept on space-time is reviewed from an interactive point of view.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00756287
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  • 10
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    Targeting Histidine Side Chains in Molecular Design through Nitrogen–Halogen Bonds (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-11-26
    Description: Journal of Chemical Information and Modeling DOI: 10.1021/ci4004305
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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