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  • 1
    Electronic Resource
    Electronic Resource
    A comparison of the acute effects of a tricyclic and a MAOI antidepressant on septal driving of hippocampal rhythmical slow activity (1994)
    Springer
    Psychopharmacology 114 (1994), S. 337-344 
    Details
    ISSN: 1432-2072
    Keywords: Tricyclic antidepressants ; Monoamine oxidase inhibitors ; Hippocampus ; Rhythmic slow activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In free-moving male rats, the function relating frequency to the threshold current required to drive hippocampal rhythmical slow activity (RSA) with septal stimulation has a minimum at 130 ms. Both classical anxiolytics (e.g. benzodiazepines) and the novel anxiolytic buspirone show similar effects on septal driving of RSA. The tricyclic antidepressant imipramine may be as effective as anxiolytic drugs in treatment of generalized anxiety disorder. The antidepressant monoamine oxidase inhibitor phenelzine has also been reported to be effective in treating anxiety, but this may reflect an action on “atypical depression” rather than “anxiety”. The present study therefore compared the effects of acute administration of imipramine and phenelzine on septal driving of RSA to determine whether either would mimic anxiolytics in this test. Rats were chronically implanted with septal stimulating electrodes and subicular recording electrodes. Three groups of rats received IP injection of either imipramine (5.9–13.3 mg/kg or 13.3–30 mg/kg) or phenelzine (0.2–5.4 mg/kg). The effects produced by imipramine were very similar to the effects produced by anxiolytic drugs. In contrast, the effects produced by phenelzine were essentially opposite to those of both anxiolytic drugs and imipramine. The present experiment suggests that imipramine may act as a true anxiolytic, in addition to its conventional antidepressant properties. In contrast, phenelzine may be effective in cases where the etiology is essentially that of depression even when the symptomatology appears to be that of anxiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of long-term administration of imipramine on reticular-elicited hippocampal rhythmical slow activity (1991)
    Springer
    Psychopharmacology 105 (1991), S. 433-438 
    Details
    ISSN: 1432-2072
    Keywords: Imipramine ; Rat ; Reticular-elicited hippocampal rhythmical slow activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract All anxiolytics so far tested show a common reduction in the frequency of reticular-elicited hippocampal rhythmical slow activity (RSA). The present experiments tested whether imipramine, an antidepressant drug which has also been used to treat generalized anxiety disorders, shares the common characteristics of anxiolytics on hippocampal RSA. Rats implanted with reticular stimulating electrodes and subicular recording electrodes received both acute and chronic injection of different doses of imipramine. Only relatively high doses (20 and 30 mg/kg, IP) of imipramine produced a reduction in RSA frequency after a single administration. Long-term administration of 20 mg/kg (but not 10 mg/kg, IP) imipramine induced anincrease in baseline RSA frequency but there was no change in the acute frequency-reducing effect of the drug. These results suggest that changes in hippocampal RSA reflect different mechanisms of action for chronic versus acute treatment with antidepressant. It is possible that, at high doses, apparently anxiolytic effects of imipramine may be mediated by similar mechanisms to conventional anxiolytic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244441
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    Paper (German National Licenses)
    Fulltext
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