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  • 1
    Electronic Resource
    Electronic Resource
    Design and validation of guarded hot plate instruments for measuring heat flow between evacuated plane-parallel glass surfaces (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 2939-2947 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This article discusses the design and construction of guarded hot plate instruments for measuring the heat flow through an evacuated space between plane-parallel glass surfaces. In this structure, the insulating region is surrounded by two pieces of relatively highly conducting material. High resolution measurements of heat flow using these instruments therefore requires the detection of quite small temperature differences (10−4 K) between the metering piece and the guard. The instruments are calibrated, and the linearity evaluated, by measuring radiative heat transfer through the evacuated space between uncoated soda lime glass sheets; this is because this heat flow can be calculated to high accuracy from the infrared optical properties of the glass. The level of parasitic heat flow in the instruments is estimated by measuring radiative heat flow between glass surfaces coated with very low emittance layers, such as evaporated gold. These instruments operate over a range of temperatures from 0 to about 70 °C. It is shown that the heat flow between evacuated glass surfaces can be measured with these instruments to high resolution (∼10 μW) and high accuracy (∼1%) over an area of ∼1 cm2. The departures from linearity, and the level of parasitic heat flow, are within the measurement resolution. For a temperature difference across the sample of 20 K, the measurement resolution corresponds to an uncertainty in the thermal conductance of the sample of ∼0.005 W m−2 K−1. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149038
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dynamic strain measurement by optical speckle correlation method using LCTV panels
    Amsterdam : Elsevier
    Optics Communications 101 (1993), S. 133-138 
    Details
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0030-4018(93)90354-8
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Germanium implanted with high dose oxygen and its optical properties
    Amsterdam : Elsevier
    Nuclear Inst. and Methods in Physics Research, B 47 (1990), S. 257-262 
    Details
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-583X(90)90755-J
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Multiple dynamic speckle correlation method with a LCTV panel
    Amsterdam : Elsevier
    Optics Communications 96 (1993), S. 195-201 
    Details
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0030-4018(93)90259-8
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  • 5
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    Rapid evolutionary turnover underlies conserved lncRNA-genome interactions [Research Papers] (2016)
    Cold Spring Harbor Laboratory Press
    Details
    Publication Date: 2016-01-16
    Description: Many long noncoding RNAs (lncRNAs) can regulate chromatin states, but the evolutionary origin and dynamics driving lncRNA–genome interactions are unclear. We adapted an integrative strategy that identifies lncRNA orthologs in different species despite limited sequence similarity, which is applicable to mammalian and insect lncRNAs. Analysis of the roX lncRNAs, which are essential for dosage compensation of the single X chromosome in Drosophila males, revealed 47 new roX orthologs in diverse Drosophilid species across ~40 million years of evolution. Genetic rescue by roX orthologs and engineered synthetic lncRNAs showed that altering the number of focal, repetitive RNA structures determines roX ortholog function. Genomic occupancy maps of roX RNAs in four species revealed conserved targeting of X chromosome neighborhoods but rapid turnover of individual binding sites. Many new roX-binding sites evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensation to transcribed genes. Thus, dynamic change in lncRNAs and their genomic targets underlies conserved and essential lncRNA–genome interactions.
    Print ISSN: 0890-9369
    Topics: Biology
    Published by Cold Spring Harbor Laboratory Press
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  • 6
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    High Specificity of a Quantitative PCR Assay Targeting a Saxitoxin Gene for Monitoring Toxic Algae Associated with Paralytic Shellfish Toxins in the Yellow Sea [Environmental Microbiology] (2015)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2015-09-23
    Description: The identification of core genes involved in the biosynthesis of saxitoxin (STX) offers a great opportunity to detect toxic algae associated with paralytic shellfish toxins (PST). In the Yellow Sea (YS) in China, both toxic and nontoxic Alexandrium species are present, which makes it a difficult issue to specifically monitor PST-producing toxic algae. In this study, a quantitative PCR (qPCR) assay targeting sxtA4 , a domain in the sxt gene cluster that encodes a unique enzyme involved in STX biosynthesis, was applied to analyze samples collected from the YS in spring of 2012. The abundance of two toxic species within the Alexandrium tamarense species complex, i.e., A. fundyense and A. pacificum , was also determined with TaqMan-based qPCR assays, and PSTs in net-concentrated phytoplankton samples were analyzed with high-performance liquid chromatography coupled with a fluorescence detector. It was found that the distribution of the sxtA4 gene in the YS was consistent with the toxic algae and PSTs, and the quantitation results of sxtA4 correlated well with the abundance of the two toxic species ( r = 0.857). These results suggested that the two toxic species were major PST producers during the sampling season and that sxtA -based qPCR is a promising method to detect toxic algae associated with PSTs in the YS. The correlation between PST levels and sxtA -based qPCR results, however, was less significant ( r = 0.552), implying that sxtA -based qPCR is not accurate enough to reflect the toxicity of PST-producing toxic algae. The combination of an sxtA -based qPCR assay and chemical means might be a promising method for monitoring toxic algal blooms.
    Print ISSN: 0099-2240
    Electronic ISSN: 1098-5336
    Topics: Biology
    Published by The American Society for Microbiology (ASM)
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  • 7
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    PrePPI: a structure-informed database of protein-protein interactions (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-20
    Description: PrePPI ( http://bhapp.c2b2.columbia.edu/PrePPI ) is a database that combines predicted and experimentally determined protein–protein interactions (PPIs) using a Bayesian framework. Predicted interactions are assigned probabilities of being correct, which are derived from calculated likelihood ratios (LRs) by combining structural, functional, evolutionary and expression information, with the most important contribution coming from structure. Experimentally determined interactions are compiled from a set of public databases that manually collect PPIs from the literature and are also assigned LRs. A final probability is then assigned to every interaction by combining the LRs for both predicted and experimentally determined interactions. The current version of PrePPI contains ~2 million PPIs that have a probability more than ~0.1 of which ~60 000 PPIs for yeast and ~370 000 PPIs for human are considered high confidence (probability 〉 0.5). The PrePPI database constitutes an integrated resource that enables users to examine aggregate information on PPIs, including both known and potentially novel interactions, and that provides structural models for many of the PPIs.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 8
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    Effect of supersonic molecular beam injection deposition on edge localized mode mitigation in the HL-2A H-mode plasmas (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-01-30
    Description: The ELM (edge localized mode) mitigation by SMBI (supersonic molecular beam injection) has been studied in the HL-2A H-mode plasmas. The ELM mitigation effect and its relationship with the deposition position of SMBI in the H-mode pedestal are reported for the first time experimentally. We found that when the deposition of SMBI is about 20% into the pedestal, the best ELM mitigation effect is achieved, which is identified by a significant increase of the ELM frequency and also a decrease of the ELM amplitude. The theoretical inference that no deep injection is needed is confirmed. The sand-pile model is used to simulate the ELM burst and explain the mitigation effect for different SMBI deposited positions. It is found that the gradient threshold is a key parameter in the process of the ELM mitigation, and there should be a local gradient threshold in the middle of the pedestal. When the deposition of SMBI is close to the edge of this region, the best ELM mitigation effect can be observed.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
    Published by American Institute of Physics (AIP)
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  • 9
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    Impact of dexmedetomidine infusion during general anaesthesia on incidence of postoperative delirium in elderly patients after major non-cardiac surgery: study protocol of a randomised, double-blinded and placebo-controlled trial (2018)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2018-04-22
    Description: Introduction Delirium is a common complication in the elderly after surgery and is associated with worse outcomes. Multiple risk factors are related with postoperative delirium, such as exposure to general anaesthetics, pain and postoperative inflammatory response. Preclinical and clinical studies have shown that dexmedetomidine attenuated neurotoxicity induced by general anaesthetics, improved postoperative analgesia and inhibited inflammatory response after surgery. Several studies found that intraoperative use of dexmedetomidine can prevent postoperative delirium, but data were inconsistent. This study was designed to investigate the impact of dexmedetomidine administered during general anaesthesia in preventing delirium in the elderly after major non-cardiac surgery. Methods and analysis This is a randomised, double-blinded and placebo-controlled trial. 620 elderly patients (age ≥60 years) who are scheduled to undertake elective major non-cardiac surgery (with an expected duration ≥2 hours) are randomly divided into two groups. For patients in the dexmedetomidine group, a loading dose dexmedetomidine (0.6 µg/kg) will be administered 10 min before anaesthesia induction, followed by a continuous infusion at a rate of 0.5 µg/kg/hour until 1 hour before the end of surgery. For patients in the control group, normal saline will be administered with an identical rate as in the dexmedetomidine group. The primary endpoint is the incidence of delirium during the first five postoperative days. The secondary endpoints include pain intensity, cumulative opioid consumption and subjective sleep quality during the first three postoperative days, as well as the incidence of non-delirium complications and all-cause mortality within 30 days after surgery. Ethics and dissemination The study protocol was approved by the Clinical Research Ethics Committee of Peking University First Hospital (2015–987) and registered at Chinese Clinical Trial Registry ( http://www.chictr.org.cn ) with identifier ChiCTR-IPR-15007654. The results of the study will be presented at academic conferences and submitted to peer-reviewed journals. Trial registration number ChiCRR-IPR-15007654; Pre-results.
    Keywords: Open access, Anaesthesia
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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