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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosing infection of extracardiac conduit in children (1995)
    Springer
    Heart and vessels 10 (1995), S. 214-217 
    Details
    ISSN: 1615-2573
    Keywords: Extracardiac conduit operation ; Conduit infection ; Blood cultures ; Echocardiography ; 67Ga imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between August 1985 and July 1992, at our center, 142 Japanese children had an extracardiac conduit operation to reconstruct the right ventricular outflow tract. The study group consisted of 22 of these 142 children who had a persistent fever and whose serum was positive for acute-phase reactants after the operation. We present the diagnostic findings for 10 children with infection of an extracardiac conduit that had been placed to restore the continuity of the right ventricle-pulmonary artery. They were part of the group of 22 children who were followed over the past 7 years with blood cultures, echocardiography, and67Ga imaging. All 10 developed a persistent fever and were seropositive for acute-phase reactants. Conduit infection was diagnosed in only 2 patients by the detection of vegetation on echocardiography and was diagnosed in 9 of the 10 patients by an abnormal67Ga uptake in the area of the artificial vessels used to reconstruct the pulmonary artery. The present study compared the use of blood cultures, echocardiography, and67Ga imaging in diagnosing an infection of the extracardiac conduit. The sensitivity of blood cultures in diagnosing an extracardiac conduit infection was 70% (7/10), and the specificity was 92% (1/12).67Ga imaging showed a higher sensitivity than echocardiography in diagnosing infection of an extracardiac conduit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01744989
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Significant regional heterogeneity of coronary flow reserve in paediatric hypertrophic cardiomyopathy (2000)
    Springer
    European journal of nuclear medicine 27 (2000), S. 1340-1348 
    Details
    ISSN: 1619-7089
    Keywords: Myocardial blood flow Cardiomyopathy Coronary flow reserve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Previous studies have indicated that cardiac events in young patients with hypertrophic cardiomyopathy (HCM) are related to ischaemia rather than to arrhythmia. We measured coronary flow reserve in paediatric HCM and compared the values with those in adult HCM. We studied 12 patients with HCM including six paediatric (〈20 years old; mean 13 years) and six adult patients (〉20 years old: mean 62 years), and six healthy young adults (mean 29 years) as controls. Every patient underwent magnetic resonance imaging (MRI) for anatomical assessment. Myocardial blood flow at rest and after dipyridamole infusion was measured with dynamic nitrogen-13 ammonia positron emission tomography (PET). Partial volume effect was corrected for using the anatomical data obtained with MRI. In adult patients with HCM, coronary flow reserve in the hypertrophied septal region was not significantly different from that in the non-hypertrophied lateral wall (1.38±0.29 vs 1.77±0.39, respectively). In the paediatric patients, coronary flow reserve in the hypertrophied septal region was significantly lower than in the non-hypertrophied lateral wall (0.84±0.33 vs 2.74±0.90, respectively, P〈0.01). In addition, coronary flow reserve in adult patients was lower than in control subjects both in the septal wall (1.38±0.29 vs 2.94±0.35, respectively, P〈0.0001) and in the lateral wall (1.77±0.39 vs 2.85±0.69, respectively, P〈0.05). In contrast, coronary flow reserve in paediatric patients was not significantly different from that in control subjects in the lateral wall (2.74±0.90 vs 2.85±0.69, respectively), while absolute reduction of myocardial blood flow was noted after pharmacological vasodilatation in the hypertrophied septal region. In conclusion, significant regional differences of coronary flow reserve were present in the paediatric patients with HCM. These results suggest that paediatric patients with HCM intrinsically have the potential to experience significant regional ischaemia even in the absence of coronary stenosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002590000300
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    Paper (German National Licenses)
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