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  • 1
    Electronic Resource
    Electronic Resource
    A novel inhibitor of advanced glycation end-product formation inhibits mesenteric vascular hypertrophy in experimental diabetes (1999)
    Springer
    Diabetologia 42 (1999), S. 472-479 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Mesenteric arteries ; aminoguanidine ; advanced glycation end-products ; experimental diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Previous studies in our laboratory have shown that the vascular changes in diabetes include hypertrophy of the mesenteric vasculature and that this process can be attenuated by the inhibition of advanced glycation with aminoguanidine. Since aminoguanidine can also act as an inhibitor of nitric oxide synthase, the effect of a novel inhibitor of advanced glycation end-products, formation that does not inhibit nitric oxide synthase, known as 2,3 diaminophenazine (2,3 DAP) was evaluated. Methods. Initially, in vitro assessment of the ability of 2,3 diaminophenazine to inhibit formation of advanced glycation products was performed. Subsequently, in vivo studies evaluating 2,3 diaminophenazine and aminoguanidine were carried out. Animals were followed for 3 weeks after induction of diabetes and randomised to no treatment, aminoguanidine or 2,3 diaminophenazine. Mesenteric vessels were weighed and advanced glycation end-products were measured by radioimmunoassay in vessel and kidney homogenates. In addition, these products were assessed in mesenteric vessels by immunohistochemistry. Results. When compared with control animals, diabetes was associated with an increase in mesenteric vascular weight. Treatment of diabetic rats with aminoguanidine or 2,3 diaminophenazine resulted in attenuation of vascular hypertrophy. Both aminoguanidine and 2,3 diaminophenazine reduced the formation of advanced glycation end-products as measured by radioimmunoassay and as assessed immunohistochemically in these vessels. This reduction was also observed in the kidney. Conclusion/interpretation. These data support the concept that the effects of aminoguanidine in reducing diabetes associated vascular hypertrophy are via inhibition of advanced glycation end-products dependent pathways. [Diabetologia (1999) 42: 472–479]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051181
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The DiGeorge syndrome (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 496-502 
    Details
    ISSN: 1432-1076
    Keywords: DiGeorge syndrome ; Thymus ; Thymic aplasia ; Immunoglobulins ; Cellular immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study describes clinical signs and symptoms in 16 patients with the DiGeorge syndrome (DGS). Diagnosed on the basis of typical facial stigmata, a broad spectrum of severity is seen with respect to congenital heart disease, hypoparathyroidism and immunologic parameters. A simple index of severity is introduced that clearly differentiates complete forms of the syndrome (cDGS) with poor prognosis from partial forms of the syndrome (pDGS). Of 13 pDGS patients, 12 are still living; 8 underwent corrective heart surgery without infectious complications. Moderate to severe mental retardation is seen in all pDGS patients. Due to the lack of thymus function, immunodeficiency is a result of cDGS, whereas immunoregulatory disturbances (hypergammaglobulinaemia, high titres of specific antibody production) prevail in pDGS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441974
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Porewater chemistry of inorganic nitrogen compounds in the eastern Skagerrak (NE North Sea) (1990)
    Springer
    Hydrobiologia 207 (1990), S. 179-186 
    Details
    ISSN: 1573-5117
    Keywords: Skagerrak ; postindustrial sediments ; porewater chemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Porosity, Eh and interstitital nitrogen compounds profiles are given for four locations in the eastern Skagerrak. Sediments down to 30 cm depth, i.e. postindustrial in age, were analysed. The results together with a detailed age determination (210Pb) suggest a high degree of both lateral and vertical variability as a result of local bottom topography and currents as well as event-controlled sedimentation processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00041455
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    Paper (German National Licenses)
    Fulltext
  • 4
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    Sediment transport on the inner shelf off Khao Lak (Andaman Sea, Thailand) during the 2004 Indian Ocean tsunami and former storm events: evidence from foraminiferal transfer functions (2013)
    Copernicus Publications
    In:  Natural Hazards and Earth System Sciences, 13 (12). pp. 3113-3128.
    Details
    Publication Date: 2017-02-27
    Description: We have investigated the benthic foraminiferal fauna from sediment event layers associated with the 2004 Indian Ocean tsunami and former storms that have been retrieved in short sediment cores from offshore environments of the Andaman Sea, off Khao Lak, western Thailand. Species composition and test preservation of the benthic foraminiferal faunas exhibit pronounced changes across the studied sections and provide information on the depositional history of the tsunami layer, particularly on the source water depth of the displaced foraminiferal tests. In order to obtain accurate bathymetric information on sediment provenance, we have mapped the distribution of modern faunas in non-tsunamigenic surface sediments and created a calibration data set for the development of a transfer function. Our quantitative reconstructions revealed that the resuspension of sediment particles by the tsunami wave was restricted to a maximum water depth of approximately 20 m. Similar values were obtained for former storm events, thus impeding an easy distinction of different high-energy events.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.5194/nhess-13-3113-2013
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 5
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    A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation [RESEARCH ARTICLES] (2015)
    The Company of Biologists
    Details
    Publication Date: 2015-01-21
    Description: Yumi Ueki, Matthew S. Wilken, Kristen E. Cox, Laura B. Chipman, Olivia Bermingham-McDonogh, and Thomas A. Reh The primary glial cells in the retina, the Müller glia, differentiate from retinal progenitors in the first postnatal week. CNTF/LIF/STAT3 signaling has been shown to promote their differentiation; however, another key glial differentiation signal, BMP, has not been examined during this period of Müller glial differentiation. In the course of our analysis of the BMP signaling pathway, we observed a transient wave of Smad1/5/8 signaling in the inner nuclear layer at the end of the first postnatal week, from postnatal day (P) 5 to P9, after the end of neurogenesis. To determine the function of this transient wave, we blocked BMP signaling during this period in vitro or in vivo , using either a BMP receptor antagonist or noggin (Nog). Either treatment leads to a reduction in expression of the Müller glia-specific genes Rlbp1 and Glul , and the failure of many of the Müller glia to repress the bipolar/photoreceptor gene Otx2 . These changes in normal Müller glial differentiation result in permanent disruption of the retina, including defects in the outer limiting membrane, rosette formation and a reduction in functional acuity. Our results thus show that Müller glia require a transient BMP signal at the end of neurogenesis to fully repress the neural gene expression program and to promote glial gene expression.
    Print ISSN: 0950-1991
    Electronic ISSN: 1477-9129
    Topics: Biology
    Published by The Company of Biologists
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    PAPER CURRENT
  • 6
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    Mouse retinal regeneration [Neuroscience] (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-11-04
    Description: Müller glial cells are the source of retinal regeneration in fish and birds; although this process is efficient in fish, it is less so in birds and very limited in mammals. It has been proposed that factors necessary for providing neurogenic competence to Müller glia in fish and birds after...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Saprophytic and pathogenic fungi in the Ceratocystidaceae differ in their ability to metabolize plant-derived sucrose (2015)
    BioMed Central
    Details
    Publication Date: 2015-12-09
    Description: Background: Proteins in the Glycoside Hydrolase family 32 (GH32) are carbohydrate-active enzymes known as invertases that hydrolyse the glycosidic bonds of complex saccharides. Fungi rely on these enzymes to gain access to and utilize plant-derived sucrose. In fungi, GH32 invertase genes are found in higher copy numbers in the genomes of pathogens when compared to closely related saprophytes, suggesting an association between invertases and ecological strategy. The aim of this study was to investigate the distribution and evolution of GH32 invertases in the Ceratocystidaceae using a comparative genomics approach. This fungal family provides an interesting model to study the evolution of these genes, because it includes economically important pathogenic species such as Ceratocystis fimbriata, C. manginecans and C. albifundus, as well as saprophytic species such as Huntiella moniliformis, H. omanensis and H. savannae. Results: The publicly available Ceratocystidaceae genome sequences, as well as the H. savannae genome sequenced here, allowed for the identification of novel GH32-like sequences. The de novo assembly of the H. savannae draft genome consisted of 28.54 megabases that coded for 7 687 putative genes of which one represented a GH32 family member. The number of GH32 gene family members appeared to be related to the ecological adaptations of these fungi. The pathogenic Ceratocystis species all contained two GH32 family genes (a putative cell wall and a putative vacuolar invertase), while the saprophytic Huntiella species had only one of these genes (a putative cell wall invertase). Further analysis showed that the evolution of the GH32 gene family in the Ceratocystidaceae involved transposable element-based retro-transposition and translocation. As an example, the activity of a Fot5-like element likely facilitated the assembly of the genomic regions harbouring the GH32 family genes in Ceratocystis. Conclusions: This study provides insight into the evolutionary history of the GH32 gene family in Ceratocystidaceae. Our findings suggest that transposable elements shaped the evolution of the GH32 gene family, which in turn determines the sucrolytic activities and related ecological strategies of the Ceratocystidaceae species that harbour them. The study also provides insights into the role of carbohydrate-active enzymes in plant-fungal interactions and adds to our understanding of the evolution of these enzymes and their role in the life style of these fungi.
    Electronic ISSN: 1471-2148
    Topics: Biology
    Published by BioMed Central
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