GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Sprache und Sprachen in Den Wissenschaften : Geschichte und Gegenwart. Festschrift Für Walter de Gruyter and Co. Anläßlich Einer 250jährigen Verlagstradition. (1999)
    Berlin/Boston :Walter de Gruyter GmbH,
    Details
    Keywords: Science -- Language. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (756 pages)
    Edition: 1st ed.
    ISBN: 9783110801323
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=929084
    Language: German
    Note: Intro -- Vorwort -- Kapitel I -- Die Sprachmäßigkeit des Körpers -- Überlegungen zwischen Psychologie und Logik -- Überlegungen zur Genese von Sprachkompetenz -- Kommunikation und Rationalität -- Sprache und Wirklichkeit in der Quantenphysik -- Sprache und Anschauung in der modernen Physik -- Morphologische Irritationen -- Die Konstitution des Gegenstandes der linguistischen Morphologie im Wege der terminologischen Setzung -- Wissenschaftstheorie der Wissenschaftssprache oder: Wie beeinflußt die Sprache die Wissenschaft? -- Inwiefern wissenschaftliche Gegenstände sprachlich konstituiert sind (und inwiefern nicht) -- Kapitel II -- Theoretisches und Empirisches zur Typographie der parole über language(s) und langage in Grammatiken des 16. bis 19. Jahrhunderts -- Linguistics and Philosophy -- Von der Fachsprache zum Modell -- Das funktionalistische Paradox -- Zum Problem funktionaler Erklärungen in der Linguistik -- Linguistische und neurobiologische Struktur der Sprachbeherrschung -- Gibt es eine Sprache hinter dem Sprechen? -- Mit Wittgenstein über die Wortbedeutung nachdenken Gebrauch? Regel des Gebrauchs? Ein Etwas im Kopf? -- Sprachvertrauen. Die notwendige Illusion der „richtigen Bezeichnung" in der Wissenschaftssprache -- Language and Institutions -- Wie bestimmen Sprachformen den Horizont einer Wissenschaft? -- Bemerkungen zur Vagheit und zur Norm der Exaktheit -- Kapitel III -- „Wissenschaftssprachen" - heilige Kühe oder Unumgänglichkeiten? -- Wissenschaftssprache und Sprache in dichterischen Texten -- Sprachwissenschaft und Wissenschaftssprache -- Mit den gemeinen Leuten - der Aufbruch der Royal Society zu einer neuen Wissenschaftssprache -- Brauchen wir eine vergleichende europäische Sprachgeschichte? -- Latein als Hintergrund und Untergrund unserer Wissenschaftssprache. , Deutsch als Wissenschaftssprache: die Entwicklung im 20. Jahrhundert und die Zukunftsperspektive -- Afrikaans as a language of science -- La lingua di questa Scienza: Alte Sprache - Neue Wissenschaft.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    Glial fibrillary acidic protein and RNA expression in adult rat hippocampus following low-level lead exposure during development (1996)
    Springer
    Histochemistry and cell biology 105 (1996), S. 431-442 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The astroglial cytoskeletal element, glial fibrillary acidie protein (GFAP), is a generally accepted sensitive indicator for neurotoxic effects in the mature brain. We used GFAP as a marker for structural changes in rat hippocampus related to chronic low level lead exposure during different developmental periods. Four groups of rats were investigated: a control group, a perinatal group, which was exposed during brain development (EO-P16), a permanent group, exposed during and after brain development (E0-P100), and a postweaning group, exposed after brain development (P16–P100). Sections were processed for light microscopy (hematoxylin-eosin, Nissl, periodic acid Schiff (PAS) and GFAP-specific immunohistology), for electron microscopy, and for in-situ hybridization (GFAP). Sections were prepared from animals tested for active avoidance learning (AAL) and long-term potentiation (LTP). Chronic lead exposure did not affect glial and neuronal functions, as assessed by LTP and AAL, when lead exposure started after brain development (postweaning group). In this group, astrocytes displayed increased GFAP and GFAP gene transcript levels. However, lead exposure affected neuronal and glial function when the intoxication fell into the developmental period of the brain (perinatal and permanent groups). In these groups, LTP and AAL were impaired, and astrocytes failed to react to the toxic exposure with an adequate increase of GFAP and GFAP gene transcripts. Although GFAP is an accepted marker for neurotoxicity, our data suggest the marker function of GFAP to be restricted to postnatal toxic insult.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01457656
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Neurophysiological and psychophysical measurements reveal effects of acute low-level organic solvent exposure in humans (1990)
    Springer
    International archives of occupational and environmental health 62 (1990), S. 493-499 
    Details
    ISSN: 1432-1246
    Keywords: VEP ; BAEP ; Contrast sensitivity ; Tetrachloroethylene ; Neurotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The organic solvent tetrachloroethylene (Per) is proposed to be a human neurotoxicant. In order to evaluate whether the sensory system is affected by Per at low concentrations, two groups of male volunteers were exposed in an inhalation chamber to 10 and 50 ppm Per, respectively. During the inhalation exposure, which lasted for 4 h per day on four consecutive days, visually evoked potentials (VEPs) and brainstem auditory evoked potentials (BAEPs) were measured. In addition, in some of these volunteers, the visual contrast sensitivity was determined psychophysically. In the group exposed to 50 ppm Per, the VEP peak latencies N75, P100 and N150 increased in the course of the inhalation period. A comparison of the two groups revealed statistically significant differences of these latency changes during Per exposure. In contrast, the BAEPs of the two groups did not differ significantly during the whole exposure period. The contrast sensitivity functions showed a tendency of increased threshold contrasts at low and intermediate spatial frequencies during exposure to 50 ppm Per. The results indicate visual system dysfunctions in terms of delayed neuronal processing time and altered contrast perception due to acute Per exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381179
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The action of thallium acetate on phasic transmitter release in the mouse neuromuscular junction (1986)
    Springer
    Archives of toxicology 58 (1986), S. 265-270 
    Details
    ISSN: 1432-0738
    Keywords: Thallium ; Phasic transmitter release ; Spontaneous transmitter release ; 4-Aminopyridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endplate potentials (EPP's) and miniature endplate potentials (MEPP's) were recorded from neuromuscular junctions of the mouse phrenic nerve-diaphragm preparation, blocked by high Mg++ (12×10−3 mol/l)-Ringer. Superfusion of the preparations with Mg++-Ringer solutions containing thallium acetate (5×10−4 mol/l Tlac) decreased phasic transmitter release as judged by EPP amplitudes as well as average quantal content, until total synaptic blockade (within about 300 min) occurred. Simultaneously MEPP amplitudes remained unchanged, whereas the frequency of MEPP's increased. When EPP amplitudes and/or quantal content were reduced by 50% (usually within about 180 min), superfusion with Mg++-Ringer solution without Tlac did not restore phasic transmitter release. However, the increase in spontaneous transmitter release was reversible, as MEPP frequencies returned to normal values. 4-Aminopyridine (5×10−4 mol/l 4-AP) as added to the bath solution in the state of 50%-reduced phasic release temporarily restored EPP amplitudes and average quantal content, whereas MEPP amplitudes remained unchanged. It is concluded that thallium irreversibly blocks phasic transmitter release, whereas spontaneous transmitter release is reversibly enhanced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297118
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Reduced probability of orthodromically evoked action potential firing in CA1 pyramidal cellof guinea pig hippocampal slices after acute thallium exposure (1996)
    Springer
    Archives of toxicology 70 (1996), S. 430-439 
    Details
    ISSN: 1432-0738
    Keywords: Key words Hippocampus ; Guinea pig ; Field potentials ; Acute thallium exposure ; Thallium neurotoxicity ; Paired-pulse stimulation ; Cell metabolism ; Matched-pair experiments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We investigated the effect of thallium ions on extracellular field potentials in the CA1 region of guinea pig hippocampal slices in a matched-pair experimental setup. Somatic and dendritic responses evoked by paired-pulse stimulation of the Schaffer collateral-commissural pathway were recorded before, during and after acute thallium exposure and compared to field potentials from nontreated control slices recorded simultaneously. Thallium reduced the orthodromically evoked population spike reversibly in a clear concentration-effect relationship. In contrast, the field excitatory postsynaptic potential fEPSP, as well as the presynaptic fiber volley of the afferent pathway, were not affected by thallium. Furthermore, the paired-pulse facilitation was reversibly reduced during thallium exposure. Input-output relations clearly demonstrated that thallium did not interfere with the presynaptic transmitter release mechanisms or the postsynaptic transmitter receptor sensitivity, but had a predominant postsynaptic target site. Additionally, any influence of thallium ions on the somatic and/or axonal membrane excitability could be excluded, as the antidromically evoked responses after alvear stimulation were not diminished by thallium. Therefore, the main effect of thallium was a decoupling of the somatic from the dendritic activity at the CA1 pyramidal cells. We conclude that the toxic influence of thallium ions in the guinea pig hippocampus must be confined to intracellular somatic mechanisms. Interactions with intracellular organelles and an impairment of their calcium storage capacity are supposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050295
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    The action of thallium acetate on neuromuscular transmission in the rat phrenic nerve-diaphragm preparation (1984)
    Springer
    Archives of toxicology 55 (1984), S. 55-58 
    Details
    ISSN: 1432-0738
    Keywords: Thallium acetate ; Neuromuscular transmission ; 4-amino-pyridine ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the isolated phrenic nerve-hemidiaphragm preparation from the rat, thallium acetate induced a dose-dependent irreversible paralysis. There was a major time lag between the onset of the exposure and the decline in the indirectly elicited muscle twitches. The slope of the decline was in proportion to the applied concentration, which ranged from 1×10−3 to 5×10−6 mol/l. The paralysis was definitively manifest after approximately 40 min of incubation. In the phase of paralysis, both electrical stimulation of the muscle and chemical stimulation by addition of K+ were fully effective. However, addition of 4-aminopyridine and/or guanidine restored the indirect muscle twitches, indicating a previous reduction of synaptic activity by thallium. Lowering the Ca2+-concentration resulted in a reduced paralysis time. From these results it is suggested that thallium interferes with synaptic transmission by presynaptically antagonizing Ca2+-dependent processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316586
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Effects of inorganic mercury (Hg2+) on calcium channel currents and catecholamine release from bovine chromaffin cells (1995)
    Springer
    Archives of toxicology 69 (1995), S. 191-196 
    Details
    ISSN: 1432-0738
    Keywords: Key words Inorganic mercury ; Bovine chromaffin cells ; Calcium channels ; Catecholamine release ; Cadmium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The effects of inorganic mercury (Hg2+) on calcium channel currents and the potassium-evoked catecholamine release of bovine chromaffin cells in culture were examined. The effects of cadmium (Cd2+), known to block calcium channels and reduce catecholamine release of chromaffin cells, were studied for comparison. Calcium channel currents were recorded in the whole-cell configuration of the patch-clamp technique. Hg2+ is a potent calcium channel blocker in bovine chromaffin cells. The IC50 value is about 3 μM, the Hill slope 1.46. In a concentration of 100 μM, Hg2+ blocked the currents completely; 100 μM Cd2+ had the same effect. Potassium-evoked catecholamine release from chromaffin cells was measured at different timepoints with high-performance-liquid-chromatography (HPLC) under control conditions and in the presence of different Hg2+ concentrations. Low Hg2+ concentrations (0.1 and 1 μM) did not affect the amount of the catecholamines epinephrine (E) and norepinephrine (NE) which was released. Under identical conditions 1 μM Cd2+ also had no effect on release. With 10 μM Hg2+ there was a time-dependent increase in the potassium-evoked catecholamine release (by 27% after 8 min). The E/NE ratio was not altered, suggesting that the release of both hormones was increased similarly. In contrast to this, the release was slightly reduced with 10 μM Cd2+. In the presence of 100 μM Hg2+, there was a reduction of the release during an early phase, followed by an increase. The reduction is most probably due to the fast and effective calcium channel block by Hg2+ in this high concentration. The calcium channel block by 100 μM Cd2+ also reduced the release significantly. Catecholamine release of bovine chromaffin cells is driven into two opposite directions by Hg2+. On the one hand, a calcium channel block reduces the release, while on the other hand effects occur which can increase the release. Both tendencies occur simultaneously, but have different concentration- and time- dependencies; therefore one can overcome the other under specific conditions. The catecholamine output at a given timepoint reflects the “sum” of these different effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050157
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    The action of thallium acetate on spontaneous transmitter release in the rat neuromuscular junction (1984)
    Springer
    Archives of toxicology 55 (1984), S. 253-257 
    Details
    ISSN: 1432-0738
    Keywords: Thallium ; Spontaneous transmitter release ; MEPP's
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Frequencies and amplitudes of miniature endplate potentials (MEPP's) were recorded from neuromuscular junctions of the rat phrenic nerve-diaphragm preparation in vitro. Superfusion of the preparations with Ringer solution containing thallium acetate (Tlac) gradually increased the frequency of MEPP's by a factor of 10 within 30 min (1×10−3 mol/l Tlac) and 180 min (5×10−4 mol/l Tlac), whereas the amplitude of MEPP's remained unchanged. Frequency of MEPP's fitted a Poisson-distribution which persisted during superfusion with Tl+-Ringer. Sub-MEPP amplitudes remained unaffected by the action of thallium. It is concluded that thallium interferes presynaptically with spontaneous transmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341021
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effects of deltamethrin on catecholamine secretion of bovine chromaffin cells (1994)
    Springer
    Archives of toxicology 68 (1994), S. 532-534 
    Details
    ISSN: 1432-0738
    Keywords: Key words: Pyrethroids – Deltamethrin – Bovine chromaffin cells – HPLC
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effects of the pyrethroid deltamethrin (D) on catecholamine secretion of cultured bovine chromaffin cells were investigated in vitro using high performance liquid chromatography (HPLC). Spontaneous release of catecholamines was increased by 10 μM and 100 μM D. This increase could partially be prevented by the simultaneous use of 2 μM tetrodotoxin (TTX), which reduced the increase by 10 μM D of catecholamine secretion by 90% and that of 100 μM D by 50%. TTX 2 μM alone did not alter the spontaneous release in comparison to controls. Medullary chromaffin cells consist of two cell groups, one secreting mainly epinephrine (E), the other norepinephrine (NE). The ratio between the spontaneously secreted catecholamines E and NE was increased after treatment with D, indicating a dominant effect on E secreting cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050109
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Congener specific effects by polychlorinated biphenyls on catecholamine content and release in chromaffin cells (1997)
    Springer
    Archives of toxicology 71 (1997), S. 416-421 
    Details
    ISSN: 1432-0738
    Keywords: Key words Polychlorinated biphenyls  ;  Neurotoxicity  ;  Catecholamine release  ;  In vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the non-planar polychlorinated biphenyl (PCB) congener 2,2′,4,4′-tetrachlorobiphenyl (2,4-TCB) and of the coplanar PCB congener 3,3′,4,4′-tetrachlorobiphenyl (3,4-TCB) were investigated on the catecholamine content and release from bovine adrenal chromaffin cells in culture. Each congener was tested at three concentrations (20, 50 and 100 μM) and two exposure periods (24 h and 5 days). Catecholamine release induced by K+-stimulation as well as catecholamine content of Triton X-100 treated cell cultures were examined using high-performance liquid chromatography (HPLC). 2,4-TCB showed dose- and time-dependent effects. 2,4-TCB at 100 μM reduced the K+-stimulated catecholamine release after 24 h of exposure. After 5 days of exposure, 2,4 TCB at 50 and 100 μM drastically reduced the K+-stimulated catecholamine release. 3,4-TCB even at a concentration of 100 μM over exposure of either 24 h or 5 days had no effects on the K+-stimulated secretion. When chromaffin cells, exposed to 2,4-TCB, were lysed with 0.5% Triton X-100, a dose- and time-dependent reduction of the catecholamine content appeared. The 3,4-TCB did not reduce the catecholamine content. Conversely there seemed to be a trend towards an increase in catecholamine content. Spontaneous release of catecholamines was strongly increased by the non-planar 2,4 TCB, while the coplanar 3,4 TCB showed no effects on this parameter. Furthermore, the effects of 2,4 TCB appeared to be reversible after replacing the highest concentration (100 μM) of the TCB-solution with culture-medium at the end of the 24-h exposure. Thus, K+-stimulated catecholamine release and the catecholamine content of bovine adrenal chromaffin cells was effectively reduced by the non-planar PCB congener whereas spontaneous catecholamine release was strongly increased. The coplanar PCB congener was ineffective at the same conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050405
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...