Publication Date:
2013-05-16
Description:
The EMBO Journal 32, 1425 (2013). doi:10.1038/emboj.2013.88 Authors: Weiqiang Lin, Shilpa Sampathi, Huifang Dai, Changwei Liu, Mian Zhou, Jenny Hu, Qin Huang, Judith Campbell, Kazuo Shin-Ya, Li Zheng, Weihang Chai & Binghui Shen Efficient and faithful replication of telomeric DNA is critical for maintaining genome integrity. The G-quadruplex (G4) structure arising in the repetitive TTAGGG sequence is thought to stall replication forks, impairing efficient telomere replication and leading to telomere instabilities. However, pathways modulating telomeric G4 are poorly
Keywords:
aneuploidycancerDNA2 nucleaseG4telomere
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
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