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  • 1
    Electronic Resource
    Electronic Resource
    Age distribution of human gene families shows significant roles of both large- and small-scale duplications in vertebrate evolution (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 31 (2002), S. 205-209 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The classical (two-round) hypothesis of vertebrate genome duplication proposes two successive whole-genome duplication(s) (polyploidizations) predating the origin of fishes, a view now being seriously challenged. As the debate largely concerns the relative merits of the 'big-bang mode' theory ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng902
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Evolutionary Patterns of Gene Families Generated in the Early Stage of Vertebrates (2000)
    Springer
    Journal of molecular evolution 51 (2000), S. 88-96 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Gene (genome) duplication — Vertebrate evolution — Gene family — Duplication time dating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. In this paper we have analyzed 49 vertebrate gene families that were generated in the early stage of vertebrates and/or shortly before the origin of vertebrates, each of which consists of three or four member genes. We have dated the first (T1) and second (T2) gene duplications of 26 gene families with 3 member genes. The means of T1 (594 mya) and T2 (488 mya) are largely consistent to a well-cited version of two-round (2R) genome duplication theory. Moreover, in most cases, the time interval between two successive gene duplications is large enough that the fate of duplicate genes generated by the first gene duplication was likely to be determined before the second one took place. However, the phylogenetic pattern of 23 gene families with 4 members is complicated; only 5 of them are predicted by 2R model, but 11 families require an additional gene (or genome) duplication. For the rest (7 families), at least one gene duplication event had occurred before the divergence between vertebrate and Drosophila, indicating a possible misleading of the 4:1 rule (member gene ratio between vertebrates and invertebrates). Our results show that Ohno's 2R conjecture is valid as a working hypothesis for providing a most parsimonious explanation. Although for some gene families, additional gene duplication is needed, the credibility of the third genome duplication (3R) remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002390010069
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Water column raw data (Kongsberg EM 122 entire dataset) of RV SONNE during cruise SO269 (2023)
    PANGAEA
    Details
    Publication Date: 2024-05-08
    Description: Water column raw data using the ship's own Kongsberg EM 122 multibeam echosounder was recorded on 20 days between 2019-08-06 and 2019-09-03 RV SONNE cruise SO269 in the South China Sea. The data are archived at the Federal Maritime and Hydrographic Agency of Germany (Bundesamt für Seeschifffahrt und Hydrographie, BSH) and provided to PANGAEA database for data curation and publication. Ancillary sound velocity profiles (SVP) files from the cruise are archived at the BSH and added to the corresponding multibeam raw dataset https://doi.org/10.1594/PANGAEA.945591 This publication is conducted within the efforts of the German Marine Research Alliance in the core area 'Data management and Digitalization' (Deutsche Allianz Meeresforschung, DAM).
    Keywords: Bathymetry; Binary Object; Comment; DAM_Underway; DAM Underway Research Data; Data file recording distance; Data file recording duration; DATE/TIME; ELEVATION; Event label; File content; Kongsberg datagram raw file name; LATITUDE; LONGITUDE; Multibeam Echosounder; Number of pings; Ship speed; SO269; SO269_0_Underway-3; Sonne_2; Start of data file, depth; Start of data file, heading; Start of data file recording, date/time; Start of data file recording, latitude; Start of data file recording, longitude; Stop of data file, depth; Stop of data file, heading; Stop of data file recording, date/time; Stop of data file recording, latitude; Stop of data file recording, longitude; Swath-mapping system Simrad EM122 (Kongsberg Maritime AS)
    Type: Dataset
    Format: text/tab-separated-values, 2574 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 4
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    Multibeam bathymetry raw data (Kongsberg EM 122 entire dataset) of RV SONNE during cruise SO269 (2023)
    PANGAEA
    Details
    Publication Date: 2024-05-08
    Description: Multibeam bathymetry raw data using the ship's own Kongsberg EM 122 multibeam echosounder was not continuously recorded during RV SONNE cruise SO269. Data was recorded on 13 days between 2019-08-05 and 2019-08-28. This dataset contains a survey in the South China Sea. The approximate average depth of the entire dataset is around 2300m. The data are archived at the Federal Maritime and Hydrographic Agency of Germany (Bundesamt für Seeschifffahrt und Hydrographie, BSH) and provided to PANGAEA database for data curation and publication. Ancillary sound velocity profiles (SVP) files from the cruise are archived at the BSH, thus SVP files are added to this dataset. However, also data analysis of the multibeam raw data revealed that SVP has been changed during the survey. This publication is conducted within the efforts of the German Marine Research Alliance in the core area 'Data management and Digitalization' (Deutsche Allianz Meeresforschung, DAM). Data are unprocessed and therefore contains incorrect depth measurements (artifacts) without further processing. Note that refraction errors can be expected due to the lack of proper SVP. Overall, it appears that the data quality is rather good since the gridded hillshade data showed relatively few obstacles. Data can be processed e.g. with the open source software package MB-System (Caress, D. W., and D. N. Chayes, MB-System: Mapping the Seafloor, http://www.mbari.org/products/research-software/mb-system/, 2022).
    Keywords: Bathymetry; Binary Object; Binary Object (File Size); Binary Object (Media Type); Comment; DAM_Underway; DAM Underway Research Data; Data file recording distance; Data file recording duration; DATE/TIME; ELEVATION; Event label; File content; Kongsberg datagram raw file name; LATITUDE; LONGITUDE; Multibeam Echosounder; Number of pings; Ship speed; SO269; SO269_0_Underway-3; Sonne_2; Start of data file, depth; Start of data file, heading; Start of data file recording, date/time; Start of data file recording, latitude; Start of data file recording, longitude; Stop of data file, depth; Stop of data file, heading; Stop of data file recording, date/time; Stop of data file recording, latitude; Stop of data file recording, longitude; Swath-mapping system Simrad EM122 (Kongsberg Maritime AS)
    Type: Dataset
    Format: text/tab-separated-values, 2576 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 5
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    Unknown
    Multibeam bathymetry raw data (Kongsberg EM710 entire dataset) of RV SONNE during cruise SO269 (2023)
    PANGAEA
    Details
    Publication Date: 2024-05-08
    Description: Multibeam bathymetry raw data using the ship's own Kongsberg EM 710 multibeam echosounder was not continuously recorded during RV SONNE cruise SO269. Data was recorded on 20 days between 2019-08-06 and 2019-09-03. This dataset contains a survey in the South China Sea. The approximate average depth of the entire dataset is around 300m. The data are archived at the Federal Maritime and Hydrographic Agency of Germany (Bundesamt für Seeschifffahrt und Hydrographie, BSH) and provided to PANGAEA database for data curation and publication. Ancillary sound velocity profiles (SVP) files from the cruise are archived at the BSH, thus SVP files are added to this dataset. However, also data analysis of the multibeam raw data revealed that SVP has been changed during the survey. This publication is conducted within the efforts of the German Marine Research Alliance in the core area 'Data management and Digitalization' (Deutsche Allianz Meeresforschung, DAM). Data are unprocessed and therefore contains incorrect depth measurements (artifacts) without further processing. Note that refraction errors can be expected due to the lack of proper SVP. Overall, it appears that the data quality is rather good since the gridded hillshade data showed relatively few obstacles. Data can be processed e.g. with the open source software package MB-System (Caress, D. W., and D. N. Chayes, MB-System: Mapping the Seafloor, http://www.mbari.org/products/research-software/mb-system/, 2022).
    Keywords: Bathymetry; Binary Object; Binary Object (File Size); Binary Object (Media Type); Comment; DAM_Underway; DAM Underway Research Data; DATE/TIME; ELEVATION; Event label; File content; Kongsberg datagram raw file name; LATITUDE; LONGITUDE; Multibeam Echosounder; Number of pings; Ship speed; SO269; SO269_0_Underway-4; Sonne_2; Start of data file, depth; Start of data file, heading; Start of data file recording, date/time; Start of data file recording, latitude; Stop of data file, depth; Stop of data file, heading; Stop of data file recording, date/time; Stop of data file recording, latitude; Swath-mapping system Simrad EM710 (Kongsberg Maritime AS)
    Type: Dataset
    Format: text/tab-separated-values, 3684 data points
    Location Call Number Limitation Availability
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    DATA PANGAEA
  • 6
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    New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-10-23
    Description: New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins Scientific Reports, Published online: 22 October 2015; doi:10.1038/srep15660
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 7
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    Experimental Study on Mercury Oxidation in a Fluidized Bed under O2/CO2 and O2/N2 Atmospheres (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-05-19
    Description: Energy & Fuels DOI: 10.1021/acs.energyfuels.6b00457
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 8
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    Prediction of Synergic Effects of H2O, SO2, and HCl on Mercury and Arsenic Transformation under Oxy-Fuel Combustion Conditions (2016)
    American Chemical Society (ACS)
    Details
    Publication Date: 2016-09-29
    Description: Energy & Fuels DOI: 10.1021/acs.energyfuels.6b01109
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 9
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    Influence of gender and age on the survival of patients with nasopharyngeal carcinoma (2013)
    BioMed Central
    Details
    Publication Date: 2013-05-05
    Description: Background: The prognostic value of gender and age in the survival of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT) is unclear. Several studies have suggested a female advantage in the prognosis of solid tumors. We investigated the relationship between gender differences and disease outcome in NPC patients treated with IMRT in South China. Methods: A total of 299 patients with non-disseminated NPC were analyzed retrospectively. IMRT was delivered with a simultaneous modulated, accelerated radiotherapy boost technique at prescribed doses of 70 Gy/30 fractions/6 weeks to the primary tumor (GTVp) and positive neck nodes (GTVn), 60Gy (2.0 Gy/day) to the clinical target volume (CTV) and upper neck region and 54 Gy (1.8 Gy/day) to the clinically negative low neck. A median boost dose of 9.2 Gy (4--20 Gy) was administered to patients with persistent disease at the primary site. Results: With a median follow-up of 52 months, the male patients had a significantly unfavorable 5-year OS (70.7% compared to 94.1%, P 〈 0.001), DPFS (71.5% compared to 87.3%, P = 0.029) and DMFS (77.2% compared to 89.7%, P = 0.036) than the female patients. In patients younger than 45, the male patients had a poorer 5-year OS (66.8% compared to 91.2%, P = 0.008), DPFS (59.9% compared to 91.2%, P = 0.005) and DMFS (66.4% compared to 94.0%, P = 0.004) than the female patients. For patients older than 45, only the 5-year OS (72.2% compared to 96.0%, P = 0.001) was significantly different. Conclusions: Gender and age are strong independent prognostic factors for NPC in this study. We are the first to report that younger male patients were more likely to have distant metastases and exhibited inferior overall survival and disease progression-free survival rates compared to other patients.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 10
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    Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates (2013)
    BioMed Central
    Details
    Publication Date: 2013-05-01
    Description: Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is largely responsible for heavy economic losses in the swine industry worldwide because of its high mutation rate and subsequent emergence of virulent strains. However, the immunological and pathological responses of pigs to PRRSV strains with different virulence have not been completely elucidated. Methods: Twenty-four piglets were divided into 4 groups (n = 6 each) and inoculated with highly pathogenic PRRSV isolate BB0907 (HP), low pathogenic PRRSV NT0801 (LP), LP derivative strain NT0801-F70 (LP-der), and DMEM medium (control), respectively. The changes in TLR2, 3, 7, and 8 gene expression and TNF-alpha, IL-1beta, IL-6, IFN-gamma, and IL-10 secretion were evaluated using real-time PCR and ELISA at 6, 9, and 15 days post inoculation (d.p.i.). The cytokine levels were evaluated in the supernatants of porcine alveolar macrophages (PAMs) and peripheral blood mononuclear cells (PBMCs) following stimulation with LTA, poly(I:C), CL097, and PRRSV individually. Results: HP caused more severe clinical signs and pathological lesions in swine than LP and LP-der had almost no virulence compared with LP. The serum levels of IL-1beta, IL-6, TNF-alpha, and IFN-gamma were increased in HP-infected piglets, which were greater than in those infected with LP or LP-der. The mRNA levels of TLR3, 7, and 8 were significantly up-regulated in PAMs in HP-infected pigs compared to those in groups LP and LP-der. Furthermore, TNF-alpha and IL-1beta secretion in PAMs from group LP was statistically greater than those from the control group after stimulation with either poly(I:C) or CL097. Meanwhile, TNF-alpha, IL-1beta, and IL-6 levels in CL097-stimulated PBMCs from HP-infected pigs were markedly higher than those from the LP- and LP-der-infected groups. Conclusions: We found that HP was a stronger inducer of TLR 3, 7, and 8 expression and IL-1beta, IL-6, TNF-alpha, and IFN-gamma production compared to LP and LP-der. HP enhanced production of TNF-alpha, IL-1beta, and IL-6 in PBMCs following CL097-stimulation more than LP and LP-der, whereas LP enhanced the secretion of TNF-alpha and IL-1beta in poly(I:C)- and CL097-stimulated PAMs. Our data regarding cellular reactivity to different isolates should be useful in the development of more efficacious vaccines.
    Electronic ISSN: 1743-422X
    Topics: Medicine
    Published by BioMed Central
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