GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Expression of insulin-like growth factor-binding protein 2 in melanocytic lesions (2003)
    Oxford, UK : Munksgaard International Publishers
    Journal of cutaneous pathology 30 (2003), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Insulin-like growth factor-1 (IGF-1) is one of the most critical proteins required for the survival, migration, and growth of melanoma cells. IGF-binding protein 2 (IGFBP2), which binds and regulates the function of IGF-1, is upregulated in a dose-dependent manner in melanoma cells treated with IGF-1, suggesting a possible role of IGFBP2 in the pathogenesis of melanoma.Methods:  Tissue microarrays were constructed using formalin-fixed, paraffin-embedded archival tissue blocks from 94 melanocytic lesions: 20 benign nevi, 20 dysplastic nevi, 23 primary melanomas, and 31 metastatic melanomas. IGFBP2 expression was evaluated immunohistochemically using a polyclonal antibody against the C-terminus of IGFBP2. The number of cells and labeling intensity were assessed semiquantitatively.Results:  Positive IGFBP2 labeling was observed in 5.0% of benign nevi, which was significantly lower than in dysplastic nevi (35.0%), primary melanomas (52.2%), or metastatic melanomas (54.8%) (p 〈 0.05). Among the IGFBP2-positive cases, moderate-to-strong immunostaining was observed in 64.7% of metastatic melanomas and 33.3% of primary melanomas. But none of the dysplastic nevi had moderate-to-strong immunostaining (p 〈 0.05).Conclusions:  Our study shows that IGFBP2 expression increases from benign and dysplastic nevi to primary and metastatic melanomas and suggests that it may play a role in melanoma progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2003.00120.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones (2000)
    Springer
    Molecular and cellular biochemistry 213 (2000), S. 127-135 
    Details
    ISSN: 1573-4919
    Keywords: cytochrome P450 3A9 ; steroid hormones ; progesterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The catalytic requirements and the role of P450 3A9, a female-specific isoform of CYP3A from rat brain, in the metabolism of several steroid hormones were studied using recombinant P450 3A9 protein. The optimal steroid hormone hydroxylase activities of P450 3A9 required cholate but not cytochrome b5. P450 3A9 was active in the hydroxylation reactions of testosterone, androstenedione, progesterone and dehydroepiandrosterone (DHEA). No activity of P450 3A9 toward cortisol was detectable under our reconstitution conditions. Among all the steroid hormones examined, female-specific P450 3A9 seemed to catalyze most efficiently the metabolism of progesterone, one of the major female hormones, to form three mono-hydroxylated products, 6β-, 16α-, and 21-hydroxyprogesterone. Our data also showed that P450 3A9 can catalyze the formation of a dihydroxy product, 4-pregnen-6β, 21-diol-3, 20-dione, from progesterone with a turnover number, 1.3 nmol/min/nmol P450. Based on the Vmax/Km values for P450 3A9 using either 21-hydroxprogesterone or 6β-hydroxyprogesterone as a substrate, 4-pregnen-6β, 21-diol-3, 20-dione may be formed either by 6β-hydroxylation of 21-hydroxprogesterone or 21-hydroxylation of 6β-hydroxyprogesterone. As a major isoform of CYP3A expressed in rat brain, the activities of P450 3A9 toward two major neurosteroids, progesterone and DHEA suggested a possible role for P450 3A9 in the metabolism of neurosteroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007124417566
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Renal sodium transport in healthy elderly and elderly with systolic hypertension (1996)
    Springer
    Geriatric nephrology and urology 6 (1996), S. 13-19 
    Details
    ISSN: 1573-7306
    Keywords: lithium clearance ; sodium transfer ; proximal nephron ; elderly ; hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is accepted that lithium clearance expresses the delivery of sodium and water. This study was designed to investigate renal sodium transport in healthy and hypertensive elderly using lithium clearance (Cli) and fractional lithium clearance (FEli). The clearance studies were performed and analyzed in young healthy volunteers (n = 29, 26.2 ± 3.7 years), elderly with normal blood pressure (n = 49, 67.8 ± 6.1 years) and elderly with systolic hypertension (n = 37, 68.5 ± 7.2 years, blood pressure ≥ 160/95 mmHg). FENa of healthy elderly group was greater than that of young group (1.36 ± 0.49% vs. 1.06 ± 0.54%, P 〈 0.05), but there was no difference between the healthy elderly group and hypertensive elderly group. In the healthy elderly with normal GFR (subgroup 1, n = 27), FELi was still significantly higher than that of young group (26.1 ± 10.0 vs. 18.6 ± 4.0%, P 〈 0.001). The absolute proximal reabsorption of sodium (APRNa) and the fractional proximal reabsorption of sodium (FDRNa) in subgroup 1 were obviously lower than that of the young group (11.9 ± 1.8 vs. 13.3 ± 3.1 mmol/min, P 〈 0.05 and 76.5 ±6.4% vs. 81.5 ± 4.0%, P 〈 0.005). On the other hand, no significant difference was found in absolute or fractional distal reabsorption of sodium (ADRNa or FDRNa) between subgroup 1 and the young group. ADRNa/filtered sodium load (FLNa) in subgroup 1 was significantly higher than that of the young group (22.6 ± 6.8% vs. 17.6 ± 3.9%, P 〈 0.05), whereas there were no differences in CLi, FELi, APRNa, ADRNa, FDRNa or ADRNa/FLNa between the healthy elderly group and the aged systolic hypertensive group. It is concluded that in ageing, sodium reabsorption in the proximal nephron is reduced alone with a relative enhancement of sodium reabsorption in distal nephron, which might be a compensation in sodium balance of old persons. Abnormalities of sodium reabsorption were unlikely to be responsible for systolic hypertension in the elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451972
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    facet.materialart.
    Unknown
    Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-01-29
    Description: Two-dimensional culture of human pancreatic adenocarcinoma cells results in an irreversible transition from epithelial to mesenchymal phenotype Laboratory Investigation 95, 207 (February 2015). doi:10.1038/labinvest.2014.143 Authors: Ya'an Kang, Ran Zhang, Rei Suzuki, Shao-qiang Li, David Roife, Mark J Truty, Deyali Chatterjee, Ryan M Thomas, James Cardwell, Yu Wang, Huamin Wang, Matthew H Katz & Jason B Fleming
    Print ISSN: 0023-6837
    Electronic ISSN: 1530-0307
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-07-18
    Description: Article The transcription factor c-Myc is a master regulator of cellular metabolism and has an important role in tumorigenesis. Phan et al . show that 14-3-3σ, an inhibitor of cell cycle progression, also suppresses tumour-promoting metabolic programmes by promoting the degradation of c-Myc. Nature Communications doi: 10.1038/ncomms8530 Authors: Liem Phan, Ping-Chieh Chou, Guermarie Velazquez-Torres, Ismael Samudio, Kenneth Parreno, Yaling Huang, Chieh Tseng, Thuy Vu, Chris Gully, Chun-Hui Su, Edward Wang, Jian Chen, Hyun-Ho Choi, Enrique Fuentes-Mattei, Ji-Hyun Shin, Christine Shiang, Brian Grabiner, Marzenna Blonska, Stephen Skerl, Yiping Shao, Dianna Cody, Jorge Delacerda, Charles Kingsley, Douglas Webb, Colin Carlock, Zhongguo Zhou, Yun-Chih Hsieh, Jaehyuk Lee, Andrew Elliott, Marc Ramirez, Jim Bankson, John Hazle, Yongxing Wang, Lei Li, Shaofan Weng, Nibal Rizk, Yu Ye Wen, Xin Lin, Hua Wang, Huamin Wang, Aijun Zhang, Xuefeng Xia, Yun Wu, Mouhammed Habra, Wei Yang, Lajos Pusztai, Sai-Ching Yeung, Mong-Hong Lee
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Energies, Vol. 11, Pages 428: Experimental Enrichment of Low-Concentration Ventilation Air Methane in Free Diffusion Conditions (2018)
    MDPI Publishing
    In: Energies
    Details
    Publication Date: 2018-02-14
    Description: Energies, Vol. 11, Pages 428: Experimental Enrichment of Low-Concentration Ventilation Air Methane in Free Diffusion Conditions Energies doi: 10.3390/en11020428 Authors: Wen Wang Heng Wang Huamin Li Dongyin Li Huaibin Li Zhenhua Li The massive emission of low concentrations (≤0.5%) of methane (CH4) from ventilation roadways results in resource waste and environmental pollution. To mitigate these emissions, an enrichment tower for low-concentration methane is designed, and segregation and non-segregation experiments are conducted. The results reveal that stable concentrations of methane under segregation and non-segregation states in the enrichment tower gradually increase with height, with a maximum methane concentration of 0.64% and 0.54%, respectively. This shows that the methane enrichment effect in free diffusion conditions is more significant under the segregation state than under the non-segregation state. The stable concentration of methane in the middle and upper sections of the enrichment tower shows an increasing trend. However, the stable concentration of methane in the lower section of the enrichment tower has an increasing trend (less than 0.50%). According to the methane molecule Boltzmann distribution law, methane concentration enrichment decreases with height, and the conversion of the methane from the segregated to non-segregated is irreversible. Consequently, industrial applications of methane enrichment from buoyant forces are not feasible for low concentrations of methane.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Energies, Vol. 11, Pages 428: Experimental Enrichment of Low-Concentration Ventilation Air Methane in Free Diffusion Conditions (2018)
    MDPI Publishing
    In: Energies
    Details
    Publication Date: 2018-02-14
    Description: Energies, Vol. 11, Pages 428: Experimental Enrichment of Low-Concentration Ventilation Air Methane in Free Diffusion Conditions Energies doi: 10.3390/en11020428 Authors: Wen Wang Heng Wang Huamin Li Dongyin Li Huaibin Li Zhenhua Li The massive emission of low concentrations (≤0.5%) of methane (CH4) from ventilation roadways results in resource waste and environmental pollution. To mitigate these emissions, an enrichment tower for low-concentration methane is designed, and segregation and non-segregation experiments are conducted. The results reveal that stable concentrations of methane under segregation and non-segregation states in the enrichment tower gradually increase with height, with a maximum methane concentration of 0.64% and 0.54%, respectively. This shows that the methane enrichment effect in free diffusion conditions is more significant under the segregation state than under the non-segregation state. The stable concentration of methane in the middle and upper sections of the enrichment tower shows an increasing trend. However, the stable concentration of methane in the lower section of the enrichment tower has an increasing trend (less than 0.50%). According to the methane molecule Boltzmann distribution law, methane concentration enrichment decreases with height, and the conversion of the methane from the segregated to non-segregated is irreversible. Consequently, industrial applications of methane enrichment from buoyant forces are not feasible for low concentrations of methane.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...