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  • 1
    Electronic Resource
    Electronic Resource
    A study on the vascular supply of the supraspinatus tendon (1990)
    Springer
    Surgical and radiologic anatomy 12 (1990), S. 161-165 
    Details
    ISSN: 1279-8517
    Keywords: Shoulder joint ; Rotator cuff ; Supraspinatus tendon ; Rupture of the supraspinatus tendon ; Vascular study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La vascularisation de la coiffe des rotateurs a été étudiée sur 22 épaules de sujets adultes après injections vasculaires d'un mélange de gélatine et d'encre de Chine et analyse du réseau vasculaire du tendon du m. supra-épineux au microscope électronique. On a ainsi constaté que les vaisseaux du tendon du m. supra-épineux provenaient essentiellement de l'a. circonflexe antérieure de l'humérus et de l'a. suprascapulaire. Macroscopiquement, on peut voir à la surface de ce tendon une zone avasculaire ou une zone critique dont le bord externe est situé à 7 ou 8 mm en moyenne de l'insertion osseuse de ce tendon. La surface de cette zone avasculaire augmente avec l'âge.
    Notes: Summary The vascular supply of the rotator cuff in 22 adult shoulders was studied by way of mixture infusion of gelatin and India ink and vascular cast, in combination with Scanning Electronic Microscopy of the vascular pattern in the supraspinatus tendon. It was found that the vessels of the supraspinatus tendon mainly derive from the anterior circumflex humeral and suprascapular arteries. Macroscopically, an avascular zone or critical zone could be seen on the surface of supraspinatus, and the mean distance of the external edge from the osteo-tendinous attachment was 7.8 mm. The area of the avascular zone increased with age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01624517
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    6-18F-L-DOPA imaging of the dopamine neostriatal system in normal and clinically normal MPTP-treated rhesus monkeys (1989)
    Springer
    Experimental brain research 78 (1989), S. 69-80 
    Details
    ISSN: 1432-1106
    Keywords: Tomography ; Dopamine ; Striatum ; MPTP ; Monkey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Positron emission tomography following intravenous administration of 6-[18F]-L-fluorodopa was used to investigate the usefulness of PET for the assessment of normal and abnormal dopaminergic function. For this purpose, the incracerebral distribution of 6-[18F]-L-fluorodopa and its metabolites was evaluated in normal control and asymptomatic MPTP-treated rhesus monkeys. MPTP is a neurotoxic compound which destroys selectively the dopaminergic neurons of the nigrostriatal pathways in primates. The 18F accumulation was found to be significantly reduced in the striatum, putamen more than caudate, of the MPTP-treated animals compared to the normal controls. The 18F accumulation in dopamine-poor areas did not differ between the two groups. The ratios of striatum to dopamine-poor brain area were highly correlated to the concentrations of the dopamine metabolite, homovanillic acid, in the cerebrospinal fluid of the same animals. The findings are consistent with the hypothesis that “silent damage” to the dopaminergic nigral neurons may precede the onset of parkinsonism by many years and that PET scanner examination using 6-[18F]-L-fluorodopa may be useful in the detection of subtle dopaminergic dysfunctions as may exist in DA-related motor syndromes and neuropsychiatric disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230688
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  • 3
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    Potassium isotopes as a tracer of hydrothermal alteration in ore systems (2024)
    In:  Geochimica et Cosmochimica Acta
    Details
    Publication Date: 2024-04-22
    Description: Hydrothermal alteration is crucial in the formation of many ore deposits, with potassium (K) mobilization and cycling being prevalent. Potassic metasomatism of wall rocks generally forms K-bearing minerals, such as hydrothermal feldspar and mica. However, determining the source and redistribution of K (and other elements transported by the same fluid) in hydrothermal systems is challenging. K isotopes offer a potential solution to this problem. This study presents new K isotope data from two K-rich alteration assemblages — K-feldspar and sericite-quartz-pyrite — in the Jiaodong gold province of China. The data covers a compositional range from unaltered granites to syn-magmatic potassic alteration (formation of K-feldspar) and post-magmatic syn-mineralization phyllic alteration (formation of sericite). Potassic alteration in granite correlates with significant K addition, whereas phyllic alteration of earlier phases of magmatic and hydrothermal K-feldspar resulted in K loss. K-feldspar altered granites display similar δ41K values (–0.55 to –0.42 ‰ for whole-rocks and –0.56 to –0.48 ‰ for K-feldspar separates) as unaltered granite (–0.52 to –0.47 ‰). The narrow δ41K range suggests that magmatic fluid exsolution and magmatic-hydrothermal alteration have a minor effect on δ41K of the altered rock. Phyllic alteration of K-feldspar altered precursor rock leads to K loss and elevated δ41K values ranging from –0.36 to –0.19 ‰ for whole-rocks and –0.34 to –0.17 ‰ for sericite mineral separates. As sericite preferentially incorporates 41K, sericite will have higher δ41K values than the precursor K-feldspar, whereas the fluids will have lower δ41K values. Our study demonstrates that hydrothermal alteration may affect the K isotope composition of altered rocks in several ways, contingent on the nature of the involved phases, making K isotopes a promising tool for studying hydrothermal alteration and associated mineralization.
    Language: English
    Type: info:eu-repo/semantics/article
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  • 4
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    Sex Difference in Urocortin Production Is Contributory to the Gender Disparity in a Rat Model of Vasculitis Induced by Sodium Laurate (2013)
    Oxford University Press
    Details
    Publication Date: 2013-11-24
    Description: Cardiovascular diseases, the most common leading death diseases, occur more in men than women of the same ages. Increasing evidence shows that urocortin (Ucn1), an autocrine or paracrine pro-inflammatory factor, can be regulated by sex hormones. The purpose of the study is to investigate the role of Ucn1 in gender disparity in a sodium laurate–induced vasculitis model. Rats exhibited visible signs of vasculitis on the 14th day after sodium laurate injection. Inflammatory states of the rat femoral artery were observed by histological examination. Significant gender disparity, with the symptoms much grosser in males than females, was seen. In males, the serum levels of Ucn1, prostaglandin estradiol, and soluble intercellular adhesion molecule-1 and the expressions of Ucn1, cyclooxygenase-2, and intercellular adhesion molecule-1 in femoral artery were higher than those in females. Orchidectomy significantly ameliorated the symptoms of vasculitis accompanied with a decrease in the plasma Ucn1 level. However, estradiol supplement after orchidectomy failed to improve the inflammatory states further. In females, ovariectomy and/or dihydrotestosterone supplement significantly increased Ucn1 level and exacerbated symptoms of vasculitis. Furthermore, ip administration of rabbit antiserum to Ucn1 almost abolished the gender differences in vasculitis. These results demonstrated that vasculitis of this model is androgen-responsive and hormonal manipulation by surgical orchidectomy could substantially attenuate the symptoms of vasculitis. Moreover, Ucn1 is a contributory factor to the gender disparity in vasculitis and dihydrotestosterone-promoted Ucn1 secretion exacerbated the development of vasculitis.
    Print ISSN: 0013-7227
    Topics: Medicine
    Published by Oxford University Press on behalf of The Endocrine Society.
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  • 5
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    3Cpro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation [Virus-Cell Interactions] (2014)
    The American Society for Microbiology (ASM)
    Details
    Publication Date: 2014-04-05
    Description: Foot-and-mouth disease virus (FMDV) causes a highly contagious, debilitating disease in cloven-hoofed animals with devastating economic consequences. To survive in the host, FMDV has evolved to antagonize the host type I interferon (IFN) response. Previous studies have reported that the leader proteinase (L pro ) and 3C pro of FMDV are involved in the inhibition of type I IFN production. However, whether the proteins of FMDV can inhibit type I IFN signaling is less well understood. In this study, we first found that 3C pro of FMDV functioned to interfere with the JAK-STAT signaling pathway. Expression of 3C pro significantly reduced the transcript levels of IFN-stimulated genes (ISGs) and IFN-stimulated response element (ISRE) promoter activity. The protein level, tyrosine phosphorylation of STAT1 and STAT2, and their heterodimerization were not affected. However, the nuclear translocation of STAT1/STAT2 was blocked by the 3C pro protein. Further mechanistic studies demonstrated that 3C pro induced proteasome- and caspase-independent protein degradation of karyopherin α1 (KPNA1), the nuclear localization signal receptor for tyrosine-phosphorylated STAT1, but not karyopherin α2, α3, or α4. Finally, we showed that the protease activity of 3C pro contributed to the degradation of KPNA1 and thus blocked STAT1/STAT2 nuclear translocation. Taken together, results of our experiments describe for the first time a novel mechanism by which FMDV evolves to inhibit IFN signaling and counteract host innate antiviral responses. IMPORTANCE We show that 3C pro of FMDV antagonizes the JAK-STAT signaling pathway by blocking STAT1/STAT2 nuclear translocation. Furthermore, 3C pro induces KPNA1 degradation, which is independent of proteasome and caspase pathways. The protease activity of 3C pro contributes to the degradation of KPNA1 and governs the ability of 3C pro to inhibit the JAK-STAT signaling pathway. This study uncovers a novel mechanism evolved by FMDV to antagonize host innate immune responses.
    Print ISSN: 0022-538X
    Electronic ISSN: 1098-5514
    Topics: Medicine
    Published by The American Society for Microbiology (ASM)
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  • 6
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    Effect of crop residue returns on N2O emissions from red soil in China (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-10-20
    Description: For a long time, farmers in the red soil region of southern China have returned crop residues to the soil, but how various crop residues influence nitrous oxide (N 2 O) emissions is not well understood. We compared the influence of returning different crop residues [rapeseed cake (RC), maize straw, rice straw and wheat straw (WS)] in combination with different levels of nitrogen (N) fertilizer (nil, low and high) on red soil N 2 O emissions. Results confirmed the inverse relationship between cumulative N 2 O emissions and residue C:N ratio in red soil under different levels of N fertilizer. However, N-fertilizer application did not significantly influence N 2 O emissions in the WS (which had the highest C:N ratio) and corresponding control treatments, while it enhanced N 2 O emissions in the RC (which had the lowest C:N ratio) treatment and displayed significantly higher cumulative N 2 O emissions with low N fertilizer application. This phenomenon may be attributed to the poor nutrient content in red soil, which leads to ‘Liebig's Law of the Minimum’ on available C. N fertilizer application provided sufficient available N, while the readily available C, which was mainly dependent on the degradability of the residue, became the crucial factor influencing N 2 O emissions. Additional experiments, which showed that the addition of glucose and sucrose could increase N 2 O emissions when N ( ) was sufficient, confirmed this hypothesis. Thus, to reduce N 2 O emissions when returning residues to red soil, we suggest that both the residue C:N ratio and the quality should be considered when deciding whether to apply N fertilizer.
    Print ISSN: 0266-0032
    Electronic ISSN: 1475-2743
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley-Blackwell
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  • 7
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    High-Fidelity Universal Gate Set for ^{9} Be^{+} Ion Qubits (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-08-05
    Description: Author(s): J. P. Gaebler, T. R. Tan, Y. Lin, Y. Wan, R. Bowler, A. C. Keith, S. Glancy, K. Coakley, E. Knill, D. Leibfried, and D. J. Wineland The highest two-qubit gate fidelities have been demonstrated in two experiments that use scalable trapped ion platforms. [Phys. Rev. Lett. 117, 060505] Published Thu Aug 04, 2016
    Keywords: General Physics: Statistical and Quantum Mechanics, Quantum Information, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Relation of Body Mass Index With Adverse Outcomes Among Patients With Atrial Fibrillation: A Meta-Analysis and Systematic Review [Arrhythmia and Electrophysiology] (2016)
    American Heart Association (AHA)
    Details
    Publication Date: 2016-10-08
    Description: Background Several studies have investigated the impact of body mass index (BMI) on the prognosis of atrial fibrillation, but the results remain controversial. We sought to estimate the association of BMI with atrial fibrillation–related outcomes. Methods and Results We systematically searched the Cochrane Library, PubMed, and Elsevier databases for all studies reporting associations between BMI and atrial fibrillation–related outcomes. Relative risks (RRs) and 95% CIs were extracted and pooled. Nine studies with 49 364 participants were included. Underweight BMI was associated with an increased risk of stroke or systemic embolism (RR 1.67, 95% CI 1.12–2.49), all-cause mortaliity (RR 2.61, 95% CI 2.21–3.09), and cardiovascular death (RR 2.49, 95% CI 1.38–4.50). Nevertheless, the pooled RRs of overweight and obese patients were lower than those of normal-weight patients for stroke or systemic embolism (overweight: RR 0.91, 95% CI 0.80–1.04; obese: RR 0.84, 95% CI 0.72–0.98; grade 1 obesity: RR 0.89, 95% CI 0.71–1.11; grade 2 obesity: RR 0.64, 95% CI 0.45–0.91; grade 3 obesity: RR 0.82, 95% CI 0.54–1.25), all-cause death (overweight: RR 0.78, 95% CI 0.62–0.96; obese: RR 0.84, 95% CI 0.64–1.10; grade 1 obesity: RR 0.64, 95% CI 0.57–0.73; grade 2 obesity: RR 0.70, 95% CI 0.47–1.03; grade 3 obesity: RR 0.72, 95% CI 0.59–0.88), and cardiovascular death (overweight: RR 0.79, 95% CI 0.58–1.08; obese: RR 0.99, 95% CI 0.79–1.24). Conclusions Underweight BMI is associated with an increased risk of stroke or systemic embolism, cardiovascular death, and all-cause death in Asian patients with atrial fibrillation, whereas in all atrial fibrillation patients, overweight and obese BMI was not associated with increased risks of these outcomes.
    Keywords: Arrhythmias, Atrial Fibrillation, Obesity, Risk Factors
    Electronic ISSN: 2047-9980
    Topics: Medicine
    Published by American Heart Association (AHA)
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  • 9
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    Optimization of Catalyst Loading for Porous Copper Fiber Sintered Felts Used in Methanol Steam Reforming Microreactors (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-01-09
    Description: A novel porous copper fiber sintered felt (PCFSF) has been used as catalyst support to construct a methanol steam reforming microreactor for hydrogen production. The Cu/Zn/Al/Zr catalyst was loaded on the PCFSF by means of a two-layer impregnation method. The ultrasonic water bath vibration method was employed to investigate the effect of porosity, catalyst loading, and sintering temperature on the loading performance of PCFSFs. The effective catalyst loading, being limited by porosity and pore size, was 〉 92 % in the lower porosity range of 70–80 %, but significantly reduced in higher porosity ranges 〉80 %. An innovative porous copper fiber sintered felt (PCFSF) has been applied as catalyst support to construct a methanol steam reforming microreactor. The effects of varying porosities, catalyst loadings, and sintering temperatures were evaluated by ultrasonic water bath vibration, leading to optimized conditions for the catalyst.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell
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  • 10
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    A key component of gene expression, revealed (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-11-23
    Keywords: Cell Biology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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