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  • 1
    Electronic Resource
    Electronic Resource
    Isolation and Characterization of a Rat Brain Triakontatetraneuropeptide, a Posttranslational Product of Diazepam Binding Inhibitor: Specific Action at the Ro 5-4864 Recognition Site (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 53 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: This report describes the purification and characterization from rat brain of triakontatetraneuropeptide (TTN, DBI 17-50), a major biologically active processing product of diazepam binding inhibitor (DBI). Brain TTN was purified by immunoaffinity chromatography with polyclonal octa-decaneuropeptide, DBI 33-50) antibodies coupled to CNBr-Sepharose 4B followed by two reverse-phase HPLC steps. The amino acid sequence of the purified peptide is: Thr-Gln-Pro-Thr-Asp-Glu-Glu-Met-Leu-Phe-Ile-Tyr-Ser-His-Phe-Lys-Gln-Ala-Thr-Val-Gly-Asp-Val-Asn-Thr-Asp-Arg-Pro-Gly-Leu-Leu-Asp-Leu-Lys. Synthetic TTN injected intra-cerebroventricularly into rats induces a proconflict activity (IC50 0.8 nmol/rat) that is prevented by the specific “peripheral” benzodiazepine (BZ) receptor antagonist isoquinoline carboxamide, PK 11195, but not by the “central” BZ receptor antagonist imidazobenzodiazepine, flumazenil. TTN displaces [3H]Ro 5-4864 from synaptic membranes of olfactory bulb with a Ki of approximately 5 μM. TTN also enhances picrotoxinin inhibition of γ-aminobutyric acid (GABA)-stimulated [3H]flunitrazepam binding. These data suggest that TTN, a natural DBI processing product acting at “Ro 5-4864 preferring” BZ binding site subtypes, might function as a putative neuromodulator of specific GABAA receptor-mediated effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1989.tb07425.x
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  • 2
    Electronic Resource
    Electronic Resource
    INFLUENCE OF FLA-63 ON PENTOBARBITONE SLEEP IN CHICKS AND RATS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The influence of FLA-63 on pentobarbitone-induced sleep was studied in young chicks and adult rats.2. FLA-63 produced a time-dependent biphasic effect on the gross behaviour of chicks and rats; an initial sedation followed by behavioural excitation.3. The behavioural effects of FLA-63 were associated with an initial EEG synchronization prior to an increased activity of the EMG of the neck muscle and desynchronization of the EEG of the hyperstriatum, optic tectum and pontine reticular formation of the chick. Similarly, in rats, the EEG of the frontal cortex, optic lobe and pontine reticular formation was desynchronized while the EMG activity of the neck muscle was enhanced by FLA-63.4. FLA-63 delayed the onset and shortened the duration of pentobarbitone sleep.5. Pentobarbitone-induced EEG synchronization and decreased EMG activity in chicks was antagonized by FLA-63.6. Dopamine-induced antagonism of pentobarbitone sleep was potentiated by FLA-63 in chicks.7. Levodopa antagonized pentobarbitone-induced sleep in rats and this effect was potentiated by FLA-63.8. FLA-63 potentiated levodopa-induced desynchronization of the EEG of the frontal cortex, optic lobe and pontine reticular formation of the rat.9. Haloperidol antagonized the effect of FLA-63 on pentobarbitone-induced sleep in both rats and chicks.10. Noradrenaline induced behavioural sleep in young chicks dose-dependently; this effect was antagonized by phentolamine. In the rat, phentolamine shortened pentobarbitone sleeping time but did not significantly influence the effects of FLA-63 on pentobarbitone sleep.11. Those results suggest that an increased dopamine neurotransmission may be associated with the mechanism of wakefulness in chicks and rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1983.tb00224.x
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  • 3
    Electronic Resource
    Electronic Resource
    The Influence of Intraperitoneally Injected 6-Hydroxydopamine on Electroshock Seizure in Chicks and Rats (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 6 (1979), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. 6-Hydroxydopamine, injected intraperitoneally in rats and chicks, did not induce spontaneous seizures but produced significant alterations in the threshold to electroshock seizure in chicks; the particular effects were dose-dependent and time-dependent.2. Administration of 6-hydroxydopamine to 3 day old chicks and rats in the first and third days after birth resulted in an increase in the proportion exhibiting tonic seizure with electroshock when tested after 10–12 weeks.3. When 6-hydroxydopamine was injected intraperitoneally into adult rats and cocks, there was no significant alteration in seizure threshold.4. The results suggest that 6-hydroxydopamine penetrates the central nervous system of young chicks and rats and that adrenergic mechanisms are probably involved in modulating seizure mechanisms in both the chick and rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1979.tb00023.x
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  • 4
    Electronic Resource
    Electronic Resource
    ANTAGONISM OF PENTOBARBITONE SLEEP BY DOPAMINE, LEVODOPA AND APOMORPHINE IN CHICKS (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The influence of dopamine, levodopa and apomorphine on sleep produced by pentobarbitone was studied in 1-14 day old chicks.2. Pentobarbitone-induced sleep was associated with synchronization of the electroencephalogram (EEG) of the hyperstriatum, optic tectum and pontine reticular formation.3. Dopamine desynchronized the EEG and antagonized pentobarbitone-induced EEG synchronization.4. High doses of dopamine produced a delayed sleep which was potentiated by pimozide and antagonized by adrenoreceptor blocking agents.5. Dopamine, levodopa and apomorphine delayed the onset and shortened the duration of pentobarbitone-induced sleep; apomorphine was the most potent.6. Pimozide prolonged the duration of pentobarbitone-induced sleep, but had less effect when dopamine was also given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1980.tb00068.x
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  • 5
    Electronic Resource
    Electronic Resource
    Simultaneous determination of monoamines and their principal metabolites in brain tissue of the young chick by reversed-phase ion-pair high-performance liquid chromatography
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 7 (1989), S. 899-905 
    Details
    ISSN: 0731-7085
    Keywords: High-performance liquid chromatography ; brain tissue ; chicks. ; ion-pair ; monoamines and their principal metabolites ; reversed-phase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0731-7085(89)80012-3
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  • 6
    Electronic Resource
    Electronic Resource
    Alteration of 5-hydroxytryptophan-induced hypothermia by serotonergic agents in the adult domestic fowl (Gallus domesticus)
    Amsterdam : Elsevier
    Journal of Thermal Biology 11 (1986), S. 53-57 
    Details
    ISSN: 0306-4565
    Keywords: 5-HTP ; adult fowls ; rectal temperature ; serotonergic agents
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4565(86)90018-5
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  • 7
    Electronic Resource
    Electronic Resource
    Studies on the pharmacology of d-amphetamine on maximal electroconvulsive seizure in young chicks (1983)
    Springer
    Psychopharmacology 81 (1983), S. 119-121 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Dopamine ; Electroconvulsive seizure ; Chick
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract d-Amphetamine protected young chicks against electroconvulsive seizure (ECS) in a dose-dependent manner in the dose range of 1–10 mg/kg. Reserpine pretreatment reduced ECS threshold and decreased the anticonvulsant effect of d-amphetamine in chicks. FLA-63 protected chicks against ECS and potentiated the anticonvulsant effect of d-amphetamine, whereas the dopamine antagonist pimozide antagonised the protective effect of d-amphetamine against ECS. Both the alpha-adrenoceptor antagonist phentolamine, and the serotonin antagonist cyproheptadine, had no significant influence on the anticonvulsant effect of d-amphetamine. d-Amphetamine significantly increased the levels of 5-hydroxytryptamine, noradrenaline and dopamine in the hyperstriatum, brain stem and optic tectum of the chick respectively. The present data suggests that brain dopamine may be the principal monoamine involved in the protective influence of d-amphetamine against ECS in young chicks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429004
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