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  • 1
    ISSN: 1573-2800
    Keywords: transsexual ; hormone ; estrogen ; testosterone ; breast ; clitoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The optimal hormonal therapy for transsexual patients is not known. The physical and hormonal characteristics of 38 noncastrate male-to-female transsexuals and 14 noncastrate female-to-male transsexuals have been measured before and/or during therapy with various forms and dosages of hormonal therapy. All patients were hormonally and physically normal prior to therapy. Ethinyl estradiol was superior to conjugated estrogen in suppression of testosterone and gonadotropins but equal in effecting breast growth. The changes in physical and hormonal characteristics were the same for 0.1 mg/d and 0.5 mg/d of ethinyl estradiol. The female-to-male transsexuals were well managed with a dose of intramuscular testosterone cypionate of 400 mg/month, usually given 200 mg every two weeks. The maximal clitoral length reached was usually 4 cm. Higher doses of testosterone did not further increase clitoral length or suppression of gonadotropins; lower doses did not suppress the gonadotropins. Based on the information found in this study, we recommend 0.1 mg/d of ethinyl estradiol for the noncastrate male-to-female transsexual and 200 mg of intramuscular testosterone cypionate every two weeks for the noncastrate female-to-male transsexual.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2800
    Keywords: transsexual ; hormone ; estrogen ; testosterone ; breast ; clitoris ; testes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The physical and hormonal characteristics of 60 male-to-female transsexuals and 30 female-to-male transsexuals were measured before or during treatment with commonly used forms and dosages of hormones. Only two patients (both female-to-male) had either a congenital defect in hormonal production or abnormal genital development. Patients were seen at 3- to 6-month intervals for an average of 18 months. The response to therapy was examined over time; physical parameters, hormonal concentrations, liver function tests, lipids, and glucose were measured. Three patients were changed from ethinyl estradiol to conjugated estrogen because of liver enzyme elevations. Ethinyl estradiol (0.1–0.5 mg/day) was equal to conjugated estrogen (7.5–10 mg/day) in its ability to suppress testosterone and gonadotropins and to promote breast growth. Maximum breast growth required 2 years of therapy. During treatment with testosterone, female-to-male transsexuals had a significant mild elevation of cholesterol and triglyceride. The female-to-male transsexuals receiving testosterone cypionate, 200 mg every 2 weeks, ceased to have menstrual periods and became progressively masculinized. A mean maximal clitoral length of 4.6 cm which achieved by 1 year of therapy. Based on the data generated by this study, we recommend as hormonal therapy 0.1–0.5 mg/day of ethinyl estradiol or 7.5–10 mg/day of conjugated estrogen for male-to-female transsexuals, and intramuscular testosterone cypionate, 200 mg every 2 weeks, for female-to-male transsexuals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of sexual behavior 4 (1975), S. 309-311 
    ISSN: 1573-2800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of sexual behavior 1 (1971), S. 45-60 
    ISSN: 1573-2800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Fifteen females with a history of idiopathic sexual precocity were selected without known sampling bias. They had been followed for as long as 18 years. They showed various behavioral characteristics as a group, but were also individually unique. If the IQ permitted, they benefited socially from school acceleration. Left to their own devices, the majority preferred friends nearer to them in physique age rather than chronologic age. Play interests, though influenced by the age of playmates, showed no features unique to the precocious onset of hormonal puberty. About half of the girls had occasional moody or depressed spells and wanted to be left alone. Maternalistic interests were strongly represented; only one girl was a tomboy. Masturbation and sexual play in childhood were rarely confirmed, and in no instances were totally contrary to family or community mores. No consistent progression of erotic dream content was discerned. Dreams of having a baby were rare, but antedated intercourse dreams, which were also rarely reported and did not include sensations of climax. Whereas the youngest age of having a serious boyfriend was 8 years, and the youngest age of intercourse, 11, the majority of girls did not report romantic and sexual involvements before the middle teenage years or later. In the three instances of marriage, the youngest was at age 21. Motherhood has so far been achieved by only one patient. She delivered her first child at age 11. The visible appearance of early sexual development and early advanced statural growth created a problem in childhood human relationships for most of the girls, regardless of what they said, and regardless of their skill or ineptitude in handling it. They all benefited even from minimal counseling, as did their parents. Early appearance of physical sexual development does not automatically lead to premature engagement in erotic activity or promiscuous sexual behavior. Such activity and behavior require appropriate experience and facilitating knowledge of erotic opportunities.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2017-04-08
    Description: The increase in contributions from non base load renewables, such as wind and solar, can have adverse effects on the stability of an electrical grid. In this study, the possibility of rapidly loading a Francis turbine from a tail water depression (TWD) mode for providing additional system frequency control is investigated. Based on the analysis of full-scale TWD test results and key findings from the transient testing of a micro-hydro scale turbine unit, a detailed description of the TWD transition process is given. The formulation of an improved turbine model for use in one-dimensional hydro-electric plant models is presented with simulation results compared to full-scale data. The analytical model, which calculates output power according to the conservation of angular momentum and identified sources of loss, is used in parallel with full-scale and model scale test observations to elucidate the events and mechanisms occurring during this proposed transition. The output response, in terms of active power, was found to be highly dependent on guide vane opening rate in both full-scale and model tests. For an approximate doubling in opening rate, the duration of the reverse power flow was reduced by 38% and 21%, for full-scale and model units, while the low pressure transient increased by 16% and 8%, respectively. The analytical model was shown to capture the general response characteristic in all cases tested; however, output power response was over predicted due to two identified model assumptions made, while, for the more rapid opening, the penstock pressure was under predicted by approximately 15%.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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