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  • 1
    Electronic Resource
    Electronic Resource
    Tumour induction in the rodent Mastomys natalensis by activation of endogenous papilloma virus genomes (1984)
    [s.l.] : Nature Publishing Group
    Nature 308 (1984), S. 291-292 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. l Detection of MnPV-specific DNA sequences in normal tissues of Mastomys natalensis. The DNA preparations in lanes 1-5 were uncleaved; those in lanes 6, 8 and 10 were cleaved with HpaII, and those in lanes 7, 9 and 11 were cleaved with HhaI. The DNA samples were isolated from: lane 1, skin; ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/308291a0
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  • 2
    Electronic Resource
    Electronic Resource
    Wirkung von Lithium- und Rhodanidionen auf die Nukleinsäure- und Protein-Synthese beiTetrahymena pyriformis GL (1970)
    Springer
    Development genes and evolution 165 (1970), S. 125-131 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Logarithmisch wachsendeTetrahymena pyriformis reagieren auf Lithiumionen mit Hemmung, auf Rhodanidionen mit Steigerung der DNS- und RNS-Synthese. Der Angriffspunkt dieser Ionen wird bei der Reduplikation der DNS und der Transcription gesucht.
    Notes: Summary A 0.01 M solution of lithium chloride inhibits whereas an equivalent solution of sodium thiocyanate increases the synthesis of DNA and RNA inTetrahymena pyriformis In our opinion the ions act during the replication of DNA and during transcription.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00650141
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  • 3
    Electronic Resource
    Electronic Resource
    Initial and early effects of adriamycin in murine sarcoma 180 cannot be restored in a resistant subline by increasing the uptake and external concentration of the drug (1989)
    Springer
    Cancer chemotherapy and pharmacology 24 (1989), S. 33-40 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We demonstrate the early effects (1 day) of Adriamycin (ADM) on proliferation-stimulated and quiescent sensitive, and ADM-resistant cells of the murine tumor sarcoma 180 (S 180). By investigating cell-cycle distribution and thymidine labeling, it can be shown that sensitive cells are strongly affected by the drug, even in a proliferationarrested state. A remarkable but slow DNA synthesis is the prominent effect of this drug treatment on sensitive cells, even under nonstimulating conditions. In resistant cells, neither an increase in concentration nor a variation in drug uptake can induce effects that could be compared with those observed in the sensitive line. From these results we conclude that the early effects of ADM are not modulated by drug uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254102
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  • 4
    Electronic Resource
    Electronic Resource
    Induced multidrug resistance in murine leukemia L1210 and associated changes in a surface-membrane glycoprotein (1989)
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 17-24 
    Details
    ISSN: 1432-1335
    Keywords: Multidrug resistance ; Leukemia L1210 ; Membrane glycoprotein ; Rhodamine-123 ; Monoclonal antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to find out whether only resistant cells of the “multidrug-resistant” phenotype show the described changes of plasma membrane glycoprotein (170 kDa) or whether resistant cells that do not express this phenotype reveal corresponding results. Doxorubicin-resistant (L1210dox) and daunorubicin-resistant L1210 ascites tumor cells (L1210dur) (multidrug-resistant tumor cells) were therefore compared with cytosine-arabinoside-resistant (L1210AraC) and cyclophosphamide-resistant L1210 ascites tumor cells (L1210ctx) (not multidrug-resistant tumor cells). The resistant cell lines were generated in vivo in tumor-bearing mice and the resistance to cytostatic agents was evaluated in vivo and in vitro. Using the accumulation assay with rhodamine-123, the multidrug resistance can be detected. In order to determine alterations in the plasma membranes we used the monoclonal antibodies 265/F4 and C219, which were prepared against the membrane glycoprotein P170 (170 kDa) in colchicin-resistant Chinese hamster ovary cells. The results demonstrate that L1210dox and L1210dnr tumor cells show an intense immunostaining by the streptavidin/biotinylated-peroxidase-complex method and by the streptavidin/biotin/phycoerythrin immunofluorescence method. In contrast no specific immunostaining was observed in parental (sensitive) and L1210AraC or L1210etx tumor lines. The results were confirmed by immunoblotting. To determine whether multidrug-resistant DNA sequences were expressed in the multidrug-resistant tumor cells, Northern blots with RNA od sensitive and resistant cells were performed using the clone pcDR1.5. Elevated RNA levels were detected only in resistant cells with the multidrug-resistant phenotype. Thus, the results of this study demonstrate that only resistant cells with the multidrug-resistant phenotype show an increased expression of the membrane 170-kDa glycoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391594
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  • 5
    Electronic Resource
    Electronic Resource
    Modulation of doxorubicin-toxicity by tamoxifen in multidrug-resistant tumor cells in vitro and in vivo (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 422-426 
    Details
    ISSN: 1432-1335
    Keywords: Multidrug-resistance ; Circumvention of resistance ; Solid tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Modulation of the resistance of tumors offers new strategies to improve the therapeutical treatment of cancer. In this report, the anti-oestrogen tamoxifen was investigated in multidrug-resistant tumor cells in vitro and in vivo. The doxorubicin-resistance of L 1210/DOX-tumor cells, which express the multidrug-resistance phenotype, could be completely circumvented by addition of 1 μg/ml tamoxifen. In contrast, no increased effect could be observed in the parental L 1210 tumor cells or in cytosine arabinoside-resistant L 1210 cells not expressing the multidrug-resistance phenotype. Thus, the enhancing effect of tamoxifen was restricted only to the multidrug-resistant L 1210/DOX tumor cells. Similar to the in vitro experiments, a significant reduction in the growth in solid tumors of mice by the combined treatment of doxorubicin and tamoxifen was again observed only in the multidrug-resistant L 1210/DOX tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240142
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  • 6
    Electronic Resource
    Electronic Resource
    Prognostic significance of the expression of c-fos, c-jun and c-erbB-1 oncogene products in human squamous cell lung carcinomas (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 507-510 
    Details
    ISSN: 1432-1335
    Keywords: Immunohistochemistry ; Oncoproteins ; Squamous cell lung carcinoma ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of the oncogenes c-fos, c-jun, c-myc, c-erbB-1 and c-erbB-2 at the protein level was analyzed in squamous cell lung carcinomas of 121 patients by means of immunohistochemistry. Patients with overexpression of proteins encoded by the oncogenes c-fos, c-jun and c-erbB-1 had significantly shorter survival times than these without overexpression of these oncogene products (c-fos:p=0.009; c-jun:p=0.029; c-erbB-1:p=0.018). No significant correlations were found between the expression of c-myc and c-erbB-2 products and the survival of the patients. In addition to the univariate analyses (Kaplan-Meier-estimates) multivariate analyses (Cox-regression-model) revealed that protein expression of the oncogenes c-fos, c-jun and c-erbB1 are significant prognostic factors in addition to staging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01686458
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  • 7
    Electronic Resource
    Electronic Resource
    Die Tagesperiodik der Zellteilung von Paramecium bursaria (1964)
    Springer
    Journal of comparative physiology 48 (1964), S. 157-180 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 1. Bei zwei Stämmen von Paramecium bursaria (T5 und 25B), die eine verschiedene Teilungsfrequenz besitzen, konnte eine deutliche Tagesrhythmik der Teilung festgestellt werden. Die Teilungsmaxima liegen dabei in der Dunkelphase. 2. Menge und Zeitpunkt der Fütterung sowie Umsetzung der Tiere in neues Nährmedium haben keinen Einfluß auf die Teilungsperiodik. 3. Durch Verschiebung von Licht-Dunkel-Perioden gelingt in wenigen Tagen sowohl eine 6stündige Phasenverschiebung wie auch vollständige Inversion. 4. Beide Stämme können sich einem 10∶10stündigen und 14∶14-stündigen Licht-Dunkel-Wechsel anpassen. Der Stamm mit der höheren Teilungsfrequenz (25B) kann auch noch einem 9∶9-Std und 6∶6-Std Licht-Dunkel-Wechsel folgen. Der Stamm mit der geringeren Teilungsrate (T5) zeigt bei diesen beiden letzten Licht-Dunkel-Perioden seine Eigenfrequenz von 24 Std. Einem 24∶24stündigen Licht-Dunkel-Wechsel können beide Stämme nicht mehr folgen. 5. Paramecium bursaria besitzt eine endogene Tagesrhythmik der Teilung, deren Periodenlänge etwa 24 Std beträgt. In konstanten Bedingungen dauert die Teilungsrhythmik ungefähr 8 Tage an. 6. Einmalige 12-, 8- und 3stündige Dunkelphasen in Dauerlicht lösen eine neue Teilungsperiodik aus. 7. Die Teilungsperiodik ist im Bereich zwischen 18 und 30° C temperaturunabhängig. 8. Bei niedriger Temperatur (10° C) hören die Teilungen auf. Der Wiederanstieg der Temperatur auf 25° C wirkt als erneuter Anstoß der Periodik und legt zugleich die Phasenlage fest. 9. Einmalige 24-, 12- und 6stündige Kältephasen, die in konstante Temperatur und Dauerlicht eingeschoben werden, lösen eine neue Periodik aus. 10. Licht-Dunkel-Wechsel sind stärkere Zeitgeber als periodische Temperaturschwankungen von 5–6° C. 11. Zoochlorellenfreie Tiere zeigen keine Unterschiede gegenüber Tieren mit Zoochlorellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297857
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  • 8
    Electronic Resource
    Electronic Resource
    Enhancement of incorporation of 131Iododeoxyuridine into tumors after application of Clostridium oncolyticum s. butyricum (M 55) (1977)
    Springer
    European journal of nuclear medicine 2 (1977), S. 117-120 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The application of spores of the bacterium Clostridium oncolyticum s. butyricum (M 55) results in an increased incorporation of 131Iododeoxyuridine in tumors (amelanotic melanoma Fortner III of the golden hamster and Brown-Pearce carcinoma of the rabbit). This leads to an improved scintigraphic demonstration of the tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253684
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  • 9
    Electronic Resource
    Electronic Resource
    Role of oxygenation and vascularization in drug resistance (1998)
    Springer
    Cytotechnology 27 (1998), S. 249-256 
    Details
    ISSN: 1573-0778
    Keywords: drug resistance ; oxygenation ; tumors ; vascularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Oxygenation status and tumor vascularization seem to be important factors in determining therapeutic effectiveness and patient prognosis. An abundance of data on tumor oxygenation and vascularization is available and it clearly shows that most human solid tumors are heterogeneously oxygenated and vascularized. They contain hypoxic regions. Such regions and areas of reduced vascularization can affect the response to a variety of drugs. Direct measurements of pO2 and the vascular density in various types of tumors have, upon correlation of the data to therapeutic outcome, shown that low pO2 values and low vascular density are associated with a decreased response to therapy. Therefore, oxygenation status and the extent of tumor vascularization may well be important factors contributing to the difficulty of successful therapy in certain types of tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008033326059
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  • 10
    Electronic Resource
    Electronic Resource
    Predicting chemosensitivity of tumors (1986)
    Springer
    Breast cancer research and treatment 8 (1986), S. 157-159 
    Details
    ISSN: 1573-7217
    Keywords: chemosensitivity testing ; clonogenic assay ; DNA flow cytometry ; proliferative index ; receptor assays ; thymidine kinase ; thymidine labelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01807704
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