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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the temporal development of the ovaries in Gadus morhua from the Sound and Kattegat, North Sea (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The gonadal development of cod Gadus morhua in the Sound and Kattegat, North Sea, was studied by investigating their histological structure on a temporal scale by intense sampling from September 2002 to May 2003. Different age classes were followed and the proportion mature in each age class within each area was analysed. Based on existing maturity criteria, a modified system, based on histological features, was developed in order to emphasize the crucial step in the developmental process, i.e. the passage from endogenous to exogenous vitellogenesis. Only fish that had attained exogenous vitellogenesis could be considered as being reproductively active in the forthcoming breeding season (Kjesbu et al., 2003). The histological based maturity scale will greatly improve the capability of separating mature from immature individuals in the studied areas, that is fundamental for an accurate and unambiguous estimate of the spawning stock biomass. Furthermore, the results showed a larger proportion of mature individuals per age class in the Kattegat stock compared to the Sound stock, which implied an earlier maturity for this stock. This difference in maturation pattern might have been related to a relaxation of competition, i.e. enhanced growth rate, as an effect of different levels of exploitation and technical fishing regulations between the two adjacent areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2005.00767.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum rantes levels in HIV-positive individuals and in HIV-negative exposed health-care workers (1997)
    Springer
    Infection 25 (1997), S. 381-382 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740826
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Transerythrocytic concentrations of urea and creatinine in normals and in azotemic patients (1977)
    Springer
    International urology and nephrology 9 (1977), S. 169-176 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preliminary studies in our laboratory suggested alterations in the distribution of urea and creatinine between red cells and plasma in azotemic patients, as compared to normal controls. The present studies compare plasma erythrocyte concentrations of urea and creatinine in azotemic patients and in control subjects. Effects of adding exogenous urea and creatinine to the blood of control subjects were also studied. The findings suggest alterations of solute distribution patterns in azotemic blood. Specifically, the proportions of the solutes in cells appear reduced in azotemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02082020
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Soluble tumor necrosis factor α receptors (sTNF-Rs) in HIV-1-infected intravenous drug users: Change in circulating sTNF-R type II level and survival for AIDS patients (2000)
    Springer
    European journal of epidemiology 16 (2000), S. 209-216 
    Details
    ISSN: 1573-7284
    Keywords: AIDS ; HIV-1 Infection ; Intravenous drug users ; Soluble tumor necrosis factor α receptors ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study in intravenous drug users (IVDUs) investigated differences in serum soluble tumor necrosis factor types I and II (sTNFR-I and II) concentrations in HIV-1-infected IVDUs and controls. This study also investigated whether changes of sTNFRs concentration affect the risk of death among patients with AIDS. A cross-sectional study of 54 subjects with AIDS, 47 HIV-seropositive IVDUs, 47 HIV-seronegative IVDUs, and 21 healthy subjects showed that sTNFRs concentration increases from healthy controls to AIDS patients through HIV-seronegative and HIV-seropositive subjects (p 〈 0.01). sTNFR-I concentration, however, was shown to be similar in HIV-seronegative IVDUs and healthy controls. In the longitudinal study, serum concentration of sTNFRs was determined near AIDS diagnosis in 21 IVDUs and 1 year later (start for the survival study). Cox proportional hazards regression was performed to assess the prognostic value of percent change of sTNFR level alone and in combination with T lymphocyte subsets, HIV-p24 antigenemia and opportunistic infections for death within 240 days. Uni- and multivariate Cox modelling for dichotomised variables according to its median showed an increase of sTNFR-II by at least 30% to be single significant predictor of death: crude relative risk 3.69, p = 0.03; adjusted relative risk 5.67, p = 0.02. Mean survival was 126 days in 11 patients whose sTNFR-II level increased by at least 30%, and 176 days in 10 patients with less change in sTNFR-II (p = 0.02). Conclusions: sTNFRs concentration is higher in IVDUs than in healthy controls and is highest in AIDS patients. Survival of patients with AIDS is associated with variation in the concentration of sTNFR-II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007632617516
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  • 5
    Electronic Resource
    Electronic Resource
    Aids in sicily: Prevalence of antibodies to human immunodeficiency virus (HIV) in low and high risk groups (1987)
    Springer
    European journal of epidemiology 3 (1987), S. 278-283 
    Details
    ISSN: 1573-7284
    Keywords: HIV infection ; Acquired immunodeficiency syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A seroepidemiological survey, carried out to evaluate the prevalence of antibodies to HIV in patients with ARC and in healthy individuals at risk for AIDS, showed the infection to be widespread in the groups at risk, namely in drug abusers and hemophiliacs. However, remarkable difference existed between the prevalence of antibodies to HIV in drug abusers of the city of Palermo and those of other Sicilian provinces. Spread of the virus among Sicilian thalassemics, however, was very low and quite similar in all geographic areas. Antibodies were found very rarely (0.06)% in unpaid voluntary blood donors. The spread of the virus is still confined in high risk groups, and the major part of the seropositive blood donors were identified a posteriori as drug abusers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149736
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  • 6
    Electronic Resource
    Electronic Resource
    Selective culture of rat CNS neurons in a synthetic medium (1983)
    Springer
    Neurological sciences 4 (1983), S. 323-326 
    Details
    ISSN: 1590-3478
    Keywords: cell culture ; neurons ; glial cells ; chemically defined medium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene descritto un terreno chimicamente definito che facilita la sopravvivenza di neuroni di cervello di feto di ratto in coltura primaria. Più del 90% delle cellule in coltura vengono identificate come neuroni mediante immunofluorescenza con anticorpi antineurofilamenti. Il terreno, arricchito con siero, invece, stimolando la proliferazione delle cellule nonneuronali, ostacola la sopravvivenza dei neuroni.
    Notes: Abstract A Chemically Defined Medium is described which facilitates the survival of neurons in primary cultures of rat cerebral hemispheres. More than 90% of all cells were identified as neurons using neurofilament as a marker in an immunocytochemical assay. In contrast, serumsupplemented medium, by stimulating nonneuronal cell proliferation, hinders the survival of neurons in culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043486
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  • 7
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    Effect of fish length and nutritional condition on the fecundity of distressed Atlantic cod Gadus morhua from the Baltic Sea (2018)
    Wiley-Blackwell / The Fisheries Society of the British Isles
    In:  Journal of Fish Biology, 92 (4). pp. 1016-1034.
    Details
    Publication Date: 2021-02-08
    Description: The disappearance of larger individuals and the decrease in individual body condition suffered by Atlantic cod Gadus morhua in the eastern Baltic during the past two decades can be expected to affect the stock reproductive output. To investigate this, female G. morhua were collected during the spawning and pre-spawning period in 2015-2016. The current individual potential fecundity (FP) of eastern Baltic G. morhua was estimated and analysed in relation to total length (LT) and indices of nutritional status such as body condition (K) and hepato-somatic index (IH) using generalized linear models. In addition, the current prevalence of atresia and its potential relation to K were investigated. Moreover, a calibration curve to estimate FP from oocyte diameter, based on the autodiametric oocyte counting method, was established for the first time for eastern Baltic G. morhua and can be used for future fecundity studies on this stock. The results showed that FP was mainly positively related to fish length, but K and IH also contributed significantly to the variation in FP. The model predicted that fish with K=1·2 have a FP 51% higher than fish of the same LT with K=0·8. The prevalence of fecundity regulation by atresia was 5·8%, but it was found only in fish in the pre-spawning maturity stage and with low K. Temporal changes in biological features such as the length composition and individual body condition of eastern Baltic G. morhua, should be accounted for when estimating stock reproductive potential.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1111/jfb.13563
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 8
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    MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy (2018)
    Hindawi
    Details
    Publication Date: 2018-03-06
    Description: The aim of this study was to assess with MRI morphometric ultrastructural changes in nerves affected by diabetic peripheral neuropathy (DPN). We used an MR micro-neurography imaging protocol and a semiautomated technique of tissue segmentation to visualize and measure the volume of internal nerve components, such as the epineurium and nerve fascicles. The tibial nerves of 16 patients affected by DPN and of 15 healthy volunteers were imaged. Nerves volume (NV), fascicles volume (FV), fascicles to nerve ratio (FNR), and nerves cross-sectional areas (CSA) were obtained. In patients with DPN the NV was increased and the FNR was decreased, as a result of an increase of the epineurium (FNR in diabetic neuropathy 0,665; in controls 0,699, ). CSA was increased in subjects with DPN (12,84 mm2 versus 10,22 mm2, ). The FV was increased in patients with moderate to severe DPN. We have demonstrated structural changes occurring in nerves affected by DPN, which otherwise are assessable only with an invasive biopsy. MR micro-neurography appears to be suitable for the study of microscopic changes in tibial nerves of diabetic patients.
    Print ISSN: 2090-1941
    Electronic ISSN: 2090-195X
    Topics: Medicine
    Published by Hindawi
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    PAPER CURRENT
  • 9
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    Funnel plots and choropleth maps in cancer risk communication: a comparison of tools for disseminating population-based incidence data to stakeholders (2017)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2017-04-01
    Description: Background Population-based cancer registries provide epidemiological cancer information, but the indicators are often too complex to be interpreted by local authorities and communities, due to numeracy and literacy limitations. The aim of this paper is to compare the commonly used visual formats to funnel plots to enable local public health authorities and communities to access valid and understandable cancer incidence data obtained at the municipal level. Methods A funnel plot representation of standardised incidence ratio (SIR) was generated for the 82 municipalities of the Palermo Province with the 2003–2011 data from the Palermo Province Cancer Registry (Sicily, Italy). The properties of the funnel plot and choropleth map methodologies were compared within the context of disseminating epidemiological data to stakeholders. Results The SIRs of all the municipalities remained within the control limits, except for Palermo city area (SIR=1.12), which was sited outside the upper control limit line of 99.8%. The Palermo Province SIRs funnel plot representation was congruent with the choropleth map generated from the same data, but the former resulted more informative as shown by the comparisons of the weaknesses and strengths of the 2 visual formats. Conclusions Funnel plot should be used as a complementary valuable tool to communicate epidemiological data of cancer registries to communities and local authorities, visually conveying an efficient and simple way to interpret cancer incidence data.
    Keywords: Open access, Communication, Epidemiology, Oncology, Public health
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 10
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    Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-control Study (2016)
    Oxford University Press
    Details
    Publication Date: 2016-01-08
    Description: Background.  Kaposi sarcoma (KS) is a complication of KS-associated herpesvirus (KSHV) infection. Other oncogenic viral infections and malignancies are associated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor ( KIR ) ligands. We tested whether HLA - KIR influences the risk of KSHV infection or KS. Methods.  In population-based case-control studies, we compared HLA class I and KIR gene frequencies in 250 classic (non-AIDS) KS cases, 280 KSHV-seropositive controls, and 576 KSHV-seronegative controls composing discovery and validation cohorts. Logistic regression was used to calculate sex- and age-adjusted odds ratios (ORs) and 95% confidence intervals. Results.  In both the discovery and validation cohorts, KS was associated with HLA-A*11:01 (adjusted OR for the combined cohorts, 0.4; P = .002) and HLA-C*07:01 (adjusted OR, 1.6; P = .002). Consistent associations across cohorts were also observed with activating KIR3DS1 plus HLA-B Bw4-80I and homozygosity for HLA-C group 1. With KIR3DS1 plus HLA-B Bw4-80I , the KSHV seroprevalence was 40% lower (adjusted OR for the combined cohorts, 0.6; P = .01), but the KS risk was 2-fold higher (adjusted OR, 2.1; P = .002). Similarly, the KSHV seroprevalence was 40% lower (adjusted OR, 0.6; P = .01) but the KS risk 80% higher with HLA-C group 1 homozygosity (adjusted OR, 1.8; P = .005). Conclusions.   KIR -mediated NK cell activation may decrease then risk of KSHV infection but enhance KSHV dissemination and progression to KS if infection occurs.
    Print ISSN: 0022-1899
    Electronic ISSN: 1537-6613
    Topics: Medicine
    Published by Oxford University Press on behalf of The Infectious Diseases Society of America (IDSA).
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