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  • 1
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    Elsevier
    In:  Deep-Sea Research Part II-Topical Studies in Oceanography, 44 (1/2). pp. 23-50.
    Publication Date: 2016-10-10
    Description: Small-scale features of the Antarctic Circumpolar Current (ACC) along a meridional section at 6°W between the Polar Front and the ACC-Weddell Gyre Boundary Front are discussed using data collected during the austral spring cruise ANT X/6 of R. V. Polarstern organized within the framework of the European IGBP-JGOFS (Southern Ocean). The section covered three distinct fronts, namely the Polar Front, the Southern Polar Front (also Southern ACC Front), and the ACC-Weddell Gyre Boundary Front. Physical measurements during repeated transects over a period of 6 weeks in October/November revealed a large variability in the Polar Frontal region, indicating meandering and eddy shedding. The positions of the Southern Polar Front and the ACC-Weddell Gyre Boundary Front were observed to be far more stable than that of the Polar Front. A possible reconstruction of the meandering flow field near the Polar Front, based upon the physical observations, is presented. Details in the flow field coincide with the spatial distribution of a number of biological parameters such as phytoplankton biomass and species, and photosynthetic pigments. Although a causal relationship between them is likely, biomass enhancement cannot be understood simply in terms of macronutrients from deeper layers entering the euphotic zone, as substantiated for other oceanic frontal regions, because macronutrients do not limit phytoplankton blooms. This process, however, can be important for the micronutrient iron. Evidence is presented that the Antarctic Zone of the ACC can be subdivided into a number of spheres of influence related to the fronts. Interleaving of water is apparent between positions within such a region, but not between the regions.
    Type: Article , PeerReviewed
    Format: text
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  • 2
    Publication Date: 2015-01-06
    Description: Genome-wide association studies (GWAS) identify regions of the genome correlated with disease risk but are restricted in their ability to identify the underlying causative mechanism(s). Thus, GWAS are useful "roadmaps" that require functional analysis to establish the genetic and mechanistic structure of a particular locus. Unfortunately, direct functional testing in humans is limited, demonstrating the need for complementary approaches. Here we used an integrated approach combining zebrafish, rat, and human data to interrogate the function of an established GWAS locus ( SHROOM3 ) lacking prior functional support for chronic kidney disease (CKD). Congenic mapping and sequence analysis in rats suggested Shroom3 was a strong positional candidate gene. Transferring a 6.1-Mb region containing the wild-type Shroom3 gene significantly improved the kidney glomerular function in FHH (fawn-hooded hypertensive) rat. The wild-type Shroom3 allele, but not the FHH Shroom3 allele, rescued glomerular defects induced by knockdown of endogenous shroom3 in zebrafish, suggesting that the FHH Shroom3 allele is defective and likely contributes to renal injury in the FHH rat. We also show for the first time that variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effacement and impairment of the glomerular filtration barrier.
    Electronic ISSN: 1549-5469
    Topics: Biology , Medicine
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