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  • 1
    Electronic Resource
    Electronic Resource
    On the Role of Calcium Ions in the Regulation of Glycogenolysis in Mouse Brain Cortical Slices (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 38 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Using mouse brain cortical slices, we investigated the relative roles of cyclic AMP and of calcium ions as the intracellular messengers for the activation of glycogen phosphorylase (EC 2.4.1.1; α-1,4-glucan:orthophosphate glucosyltransferase) induced by noradrenaline and by depolarization. Activation of phosphorylase by 100 μM noradrenaline is mediated by β-adrenergic receptors and does not require the copresence of adenosine. The role of the concomitant small increase in cyclic AMP is questioned. Short-term treatment with EGTA or LaCl3 abolishes the noradrenaline activation of phosphorylase, pointing to a critical role of extracellular calcium. Depolarization by 25 mM K+ or 100 μM veratridine produces a rapid and large (fourfold) activation of phosphorylase. Only veratridine increases the cyclic AMP levels; exogenous adenosine deaminase essentially blocks this cyclic AMP accumulation but not the phosphorylase activation. A halfmaximal activation of phosphorylase occurs at about 12 mM K+. Addition of EGTA or LaCl3, reduces the effect of both depolarizations to a slight and transient activation of phosphorylase. These results indicate that activation of glycogen phosphorylase by K+ or veratridine occurs by a cyclic AMP-independent and calcium-dependent mechanism. The calcium dependency of brain phosphorylase kinase renders this kinase the prime target enzyme for regulation of glycogenolysis by calcium ions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb07903.x
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  • 2
    Electronic Resource
    Electronic Resource
    MR Imaging of Lhermitte-Duclos disease: report of two cases (1992)
    Springer
    European radiology 2 (1992), S. 269-2721 
    Details
    ISSN: 1432-1084
    Keywords: Brain neoplasm ; MR studies ; Magnetic resonance imaging ; Brain diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two cases of Lhermitte-Duclos of the cerebellum are presented. MRI was essential in the radiological diagnosis of both lesions by the demonstration, both on T1- and T2 weighted images of thickened cerebellar folia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00595844
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tissue distribution of human interferons after exogenous administration in rabbits, monkeys, and mice (1981)
    Springer
    Archives of virology 68 (1981), S. 19-25 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Preparations of human leukocyte (α) and fibroblast (β) interferon were given intramuscularly to rabbits and monkeys, and circulating interferon was measured. In rabbits, but not in monkeys, a marked difference between the two interferons was noted in that higher titers of circulating antiviral activity were obtained with leukocyte than with fibroblast interferon. In mice, injected interperitoneally, a similar difference could be noted. However, levels of antiviral activity in homogenates of spleens and lungs did not differ between mice injected with either interferon. Fibroblast interferon that was injected intrathecally in monkeys was found to diffuse throughout the cerebrospinal canal and to reach the serum compartment. Some interferon could also be recovered from the pia mater surrounding the brain hemispheres, but none was found in the deeper layers of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315163
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