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  • 1
    ISSN: 1432-1076
    Keywords: Phenylketonuria ; Adolescents ; Magnetic resonance imaging ; Myelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cranial magnetic resonance imaging (MRI) was performed in nine treated adolescents with hyperphenylalaninaemia (HPA) in order to analyse possible changes in myelination. Three patients suffered from type I HPA, four from type II and two from type III (persistent HPA). Images were obtained with a 1.5T unit using spin-echo-sequences. In all patients with type I or type II HPA, abnormal findings in the cerebral white matter were demonstrated including band-like and/or confluent patchy areas of high signal intensity predominantly in the peritrigonal region, with anterior and posterior periventricular extension and/or involvement of the subcortical white matter. The extent of MRI changes did not correlate with the initiation, duration or quality of dietary treatment. There was also no consistent relationship between electrophysiological changes and white matter abnormalities on MRI. Our findings suggest a disturbance of myelination in patients with treated HPA. These results correspond well with earlier neuropathological and biochemical studies in untreated patients.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2016-01-08
    Description: WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1 Oncogene 35, 12 (07 January 2016). doi:10.1038/onc.2015.61 Authors: I Vassallo, P Zinn, M Lai, P Rajakannu, M-F Hamou & M E Hegi
    Print ISSN: 0950-9232
    Topics: Medicine
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  • 3
    Publication Date: 2014-03-28
    Description: Epidemiological and experimental studies indicate that early vascular dysfunction occurs in low-birth-weight subjects, especially preterm (PT) infants. We recently reported impaired angiogenic activity of endothelial colony-forming cells (ECFCs) in this condition. We hypothesized that ECFC dysfunction in PT might result from premature senescence and investigated the underlying mechanisms. Compared with ECFCs from term neonates (n = 18), ECFCs isolated from PT (n = 29) display an accelerated senescence sustained by growth arrest and increased senescence-associated β-galactosidase activity. Increased p16 INK4a expression, in the absence of telomere shortening, indicates that premature PT-ECFC aging results from stress-induced senescence. SIRT1 level, a nicotinamide adenine dinucleotide-dependent deacetylase with anti-aging activities, is dramatically decreased in PT-ECFCs and correlated with gestational age. SIRT1 deficiency is subsequent to epigenetic silencing of its promoter. Transient SIRT1 overexpression or chemical induction by resveratrol treatment reverses senescence phenotype, and rescues in vitro PT-ECFC angiogenic defect in a SIRT1-dependent manner. SIRT1 overexpression also restores PT-ECFC capacity for neovessel formation in vivo. We thus demonstrate that decreased expression of SIRT1 drives accelerated senescence of PT-ECFCs, and acts as a critical determinant of the PT-ECFC angiogenic defect. These findings lay new grounds for understanding the increased cardiovascular risk in individuals born prematurely and open perspectives for therapeutic strategy.
    Keywords: Pediatric Hematology, Vascular Biology
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 4
    Publication Date: 2022-02-18
    Description: The Ligurian Sea is a deep basin in the northernmost sector of the western Mediterranean which shows peculiar hydrodynamic and meteo-oceanographic features. The coasts of the Ligurian Sea are among the most urbanised and industrialised along the Italian coastline: the main causes of disturbance being littoral urban development and harbour activities, the building of littoral rail- and highways, and the presence of several polluted discharges. This review, by evaluating the huge scientific output published in the last three decades, describes and discusses the most important geological, hydrological and biological characteristics of the Ligurian Sea.We show that this regional sea has largely been investigated in terms of its geological and structural evolution, as well as in terms of the sedimentation dynamics of the littoral and deep bottoms, with particular attention to the sedimentation balance of the beaches and their erosive processes.We report that the prevalent hydrodynamic and meteo-oceanographic conditions favour a continuous exchange of coastal water masses, and that the seasonal and interannual dynamics of water masses can effects the local climate, with direct and indirect consequences on fish and benthic communities documented in the last decade. We stress that although recent studies offer good knowledge of the distribution of coastal benthic communities, only scant information is available for the whole continental shelf, the submarine canyons and the rocky bathyal bottoms. Our meta-analysis reveals that significant fishing activities are monitored, but also that certain sectors of the biological resource are suffering, and suggests the set up of appropriate management measures. The Ligurian Sea hosts a number of Marine Protected Areas (MPAs) of high relevance, while the institution of the Whale Sanctuary completes the protection policy of the Regione Liguria. Our meta-analysis points out the need for long-term studies, based primarily on the analysis of those areas of the Ligurian Sea that have been little investigated to date. Finally, only properly addressed studies, using experimental approaches and along appropriate spatial and temporal scales, might allow us to understand the functioning of the Ligurian marine ecosystems, evaluate their health conditions and the dynamics of the main variables that affect the distribution of the single species (including species of high economic value) and benthic communities.
    Description: Published
    Description: 319-340
    Description: 3.7. Dinamica del clima e dell'oceano
    Description: JCR Journal
    Description: restricted
    Keywords: Mediterranean Sea ; Ligurian Sea ; geomorphology ; hydrology ; plankton ; benthos ; necton ; fisheries ; biodiversity ; introduced species ; Marine Protected Areas ; environmental policy ; 03. Hydrosphere::03.01. General::03.01.07. Physical and biogeochemical interactions
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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