ISSN:
1432-1041
Keywords:
Caffeine
;
metabolites
;
urine
;
age dependant changes
;
drug interactions
;
enzyme induction
;
cirrhosis
;
smoking
;
phenytoin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In an exploratory study the 24-h urinary excretion pattern of caffeine and 14 of its major metabolites was studied in 32 volunteers (adults, adolescents and children), 14 patients either with end stage renal disease or liver cirrhosis, 7 heavy smokers and 27 patients on therapy with cimetidine, allopurinol, theophylline or phenytoin. Caffeine and its metabolites were quantified by UV-absorption after liquid/liquid-extraction and HPLC-separation, which ensured proper analysis of 1-methyluric acid. In adults the renal excretion of caffeine derivatives corresponded to an intake of 509 mg caffeine/day, with 1-methyluric acid as the predominant metabolite. About 69% of caffeine was degraded by the paraxanthine pathway, and theobromine- (19%) and the theophylline pathway (14%) were less important. The ratio of paraxanthine formation to urinary caffeine concentration ( = clearance equivalent) was about 2.2 ml·min−1·kg−1 in adults, and the corresponding ratios for theophylline and theobromine were 0.43 ml·min−1·kg−1 and 0.59 ml·min−1·kg−1, respectively. As expected, caffeine degradation was impaired in patients with cirrhosis and was increased in persons who smoked heavily or who were on phenytoin therapy. The results document the possibility of noninvasively investigating gross differences in caffeine disposition by analysis of the urinary pattern of its metabolites.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01740665
Permalink
