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  • 1
    Electronic Resource
    Electronic Resource
    99mTc(V)-dimercaptosuccinic acid scintigraphy for medullary thyroid carcinoma (1986)
    Springer
    World journal of surgery 10 (1986), S. 640-645 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dix malades présentant un cancer médullaire thyroïdien et 2 malades un cancer papillaire ont été soumis à une scintigraphie employant un nouveau radioisotope le99mTc(V)-DMS. Au cours de l'intervention une dose traçante de ce nouvel agent fut injectée par voie intraveineuse pour permettre l'étude de sa répartition au niveau de la pièce opératiore. Parmi les malades atteints de cancer médullaire 7 sur 10 ont présenté des images scintigraphiques patentes, 2 des images estompées cependant qu'un malade qui était porteur d'une récidive au niveau d'un ganglion lymphatique ne présentait pas d'image significative. Chez 3 malades une diffusion médiastinale fut clairement démontrée et la dissection médiastinale vint confirmer les constatations scintigraphiques. En revanche aucune image ne fut observée chez les malades atteints de cancer papillaire. Les études de la distribution tissulaire du99mTC(V)-DMS démontrent une imprégnation spécifique importante du néoplasme médullaire par rapport aux autres tissus. Ce nouvel agent scintigraphique de dépistage du cancer médullaire thyroïdien est d'une grande valeur pour déterminer la conduite opératoire et pour suivre le malade après l'intervention.
    Abstract: Resumen Diez pacientes con carcinoma medular de tiroides (CMT) y 2 pacientes con carcinoma papilar fueron investigados mediante centelleografía utilizando99mTc(V)-ácido dimercaptosuccínico, un nuevo agente radiofarmacéutico para imágenes de CMT. En el curso de la cirugía se administró una dosis trazadora del agente por vía intravenosa, y su distribución fue estudiada en los tejidos de la resección quirúrgica. Entre los pacientes con CMT, 7 presentaron imágenes claras de centelleografía del tumor, 2 presentaron imágenes débiles, y 1 paciente con tumor recurrente en un ganglio linfático no exhibió imagen de significación. En 3 pacientes la invasión mediastinal pudo ser claramente demostrada, y la disección mediastinal confirmó los hallazgos de la centelleografía. No se obtuvieron imágenes significativas en los pacientes con carcinoma papilar. Los estudios de distribución tisular del99mTc(V)-ADMS revelaron acumulación específica del agente en tejido de CMT y baja captación por otros tejidos. Este nuevo método de centelleografía para CMT es de gran valor para decidir sobre el aproche quirúrgico y para el seguimiento.
    Notes: Abstract Ten patients with medullary thyroid carcinoma (MTC) and 2 patients with papillary carcinoma of the thyroid were investigated by scintigraphy using99mTc(V)-dimercaptosuccinic acid [99mTc(V)-DMS], a new radiopharmaceutical agent for imaging MTC. At surgery, a tracer dose of the agent was administered intravenously, and the distribution of the agent was studied in the surgically removed tissues. Among the patients with MTC, 7 had clear scintigraphic images of tumors, 2 had faint images, and 1 patient with a recurrent tumor in a lymph node had no significant image. In 3 patients, mediastinal involvements were clearly demonstrated, and mediastinal dissection confirmed the scintigraphic findings. No significant images were obtained in the patients with papillary carcinoma. The tissue distribution studies of99mTc(V)-DMS revealed specific accumulation of the agent in MTC tissue and low uptake in other tissues. This new scintigraphy for MTC is of great value in deciding the surgical approach and follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01655544
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  • 2
    Electronic Resource
    Electronic Resource
    Reactive endosteal bone formation (1987)
    Springer
    Skeletal radiology 16 (1987), S. 545-551 
    Details
    ISSN: 1432-2161
    Keywords: Bone diseases ; Radiography ; Osteoblasts ; Endosteum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The microstructure of reactive endosteal new bone was examined using undecalcified ground sections in five pathologic conditions (bone metastasis from prostate cancer in seven cases, intervertebral osteochondrosis in five, Paget disease in four, chronic suppurative osteomyelitis in two, and fracture healing in one). To determine a basic form of rapid intramembranous bone formation, fetal rat calvaria and primitive bones made in clonal osteogenic cell culture were also observed. In slow bone-forming conditions, lamellar new bone was deposited on pre-existing trabecular surface and caused trabecular thickening on radiographs. In contrast, in rapid bone-forming conditions, woven bone was deposited as spicules extending from trabecular surface so as to form new networks in intertrabecular space. This causes obscurity of trabecular margins radiographically. Reactive endosteal bone formation may be nonspecific and have a significance for assessing the virulence of underlying pathologic conditions like periosteal reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351269
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  • 3
    Electronic Resource
    Electronic Resource
    Case report 429 (1987)
    Springer
    Skeletal radiology 16 (1987), S. 412-415 
    Details
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00350970
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  • 4
    Electronic Resource
    Electronic Resource
    Scintigraphic diagnosis of primary and metastatic bone tumour by technetium-99m diphosphonate (1978)
    Springer
    International orthopaedics 2 (1978), S. 199-206 
    Details
    ISSN: 1432-5195
    Keywords: Tumour ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le diagnostic par scintigraphie a été effectué sur 134 patients atteints de tumeurs osseuses, en utilisant les isotopes radioactifs: 99m Tc-EHDP, 99m Tc-Bléo et 67 Ga. La scintigraphie au 99m Tc-EHDP s'est révélée être une méthode de dépistage efficace chez les patients présentant des métastases osseuses de tumeurs malignes. Les tumeurs malignes des os fixent de façon particulièrement marquée ces trois radioisotopes. Par contre, les tumeurs osseuses bénignes ne montrent aucune accumulation anormale de ces produits. Les exceptions sont le myélome, qui présente une fixation diminuée au niveau de la lésion par rapport à la radioactivité de fond, et les tumeurs à cellules géantes qui manifestent une accumulation anormale des trois isotopes radioactifs. La scintigraphie au 99m Tc-EDHP, en association avec le 99m T-Bléo et le 67 Ga, est une méthode sûre, simple et sensible pour la détection et le diagnostic des tumeurs osseuses. Cependant, il faut souligner qu'il existe plusieurs pièges dans l'interprétation de la scintigraphie, notamment les fractures sur tumeurs osseuses bénignes et l'ostéomyélite chronique.
    Notes: Summary Diagnosis by serial bone scan was performed on 134 patients with bone tumours using the radioactive isotopes 99m TcEHDP, 99m TcBleo and 67 Ga. 99m TcEHDP bone scan was found to be a highly sensitive screening test in patients with skeletal metastases from malignant bone tumours. Malignant bone tumours demonstrated a marked uptake of all three radiopharmaceuticals. Benign bone tumours did not reveal any abnormal accumulation. The exceptions however were myeloma which showed a decreased uptake in the lesion compared to the background radioactivity and also giant cell tumours which showed an abnormal uptake of all three bone-seeking radiopharmaceuticals. Bone scanning using 99m TcEHDP combined with 99m TcBleo and 67 Ga is a safe, simple and sensitive method for the detection and evaluation of bone tumours. It should, however, be emphasised that there are several pitfalls in the interpretation of bone scans. These include fractures in benign bone tumours and chronic osteomyelitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266078
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  • 5
    Electronic Resource
    Electronic Resource
    A new approach toward a pancreas-seeking zinc radiopharmaceutical (1986)
    Springer
    European journal of nuclear medicine 11 (1986), S. 484-487 
    Details
    ISSN: 1619-7089
    Keywords: Zinc Zn62 ; Zinc Zn65 ; Zn-EDDA ; Zn-NTA ; Pancreas ; Zn radiopharmaceuticals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There have been many attempts to develop zinccontaining radiopharmaceuticals for use as pancreas-seeking agents, but little consideration has been given to Zn-complex structure as being a factor that contributes to Zn utilization by the pancreas. In the present study, various ligands having N-O donor groups (amino acids and amino-polycarboxylic acids) with variable numbers of coordination sites (2–6) were investigated with regard to the coordination of the radiometal Zn. As an experimental model, freshly prepared slices of rat pancreas were studied, and Sephadex-column chromatography analysis was also performed. The structure and stability of Zn complexes were found to affect the accumulation of Zn in pancreas slices. In particular, the administration of tetradentate ligand complexes of 65Zn-ethylenediamine-N,N′-diacetic acid (EDDA) and 65Zn-nitrilotriacetic acid (NTA) resulted in high Zn utilization in the pancreas. Also, Zn complexes of intermediate stability (as demonstrated by elution behavior at Sephadex-column chromatography) produced the best results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252794
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of metastatic medullary thyroid cancer with 131I-MIBG scans in Sipple's syndrome (1986)
    Springer
    European journal of nuclear medicine 11 (1986), S. 502-504 
    Details
    ISSN: 1619-7089
    Keywords: 131I-MIGBG scans ; Sipple's syndrome ; MEA IIa ; Pheochromocytoma ; Medullary thyroid cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract While 131I-meta-iodobenzyl guanidine (131I-MIBG) scanning has made possible the scintigraphic visualization of pheochromocytoma and neuroblastoma, an accumulation of this agent has recently been reported in medullary thyroid cancer. We present the case of a patient with Sipple's syndrome (multiple endocrine neoplasia type IIa), in whom we were able to identify distant metastases and local invasion of medullary thyroid cancer as well as primary thyroid tumour and right adrenal pheochromocytoma, using 131I-MIBG scans. This case highlights the usefulness of 131I-MIBG in the detection of metastatic medullary thyroid cancer and suggests that this agent may also be of therapeutic use in the treatment of tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252798
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  • 7
    Electronic Resource
    Electronic Resource
    Myocardial positron computed tomography with 13N-ammonia at rest and during exercise (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 246-251 
    Details
    ISSN: 1619-7089
    Keywords: Positron computed tomography ; 13N-Ammonia ; Ischemia ; Coronary-artery disease ; Myocardial-perfusion imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the value of myocardial-perfusion positron computed tomography (PCT) for the evaluation of coronary artery disease (CAD), 13N-ammonia PCT using a whole-body multislice PCT device was performed at rest and during exercise in 6 normal subjects and 19 patients with angiographically documented CAD. The 13N-ammonia distribution in the myocardium was assessed both qualitatively and quantitatively. At rest and during exercise, the tracer distribution was homogeneous in the 6 normal cases. In the 19 patients with CAD, regional hypoperfusion was observed in 14 cases (74%) at rest and in 18 cases (95%) during exercise. Additional perfusion abnormalities were detecting during exercise in 12 cases. Segmental analysis of the myocardial perfusion identified 30 out of 34 stenosed vessels (88%) during exercise, with only one false-positive finding of diseased vessels (specificity, 98%). For the quantitative analysis of myocardial perfusion by PCT, the percentage of change in the tracer concentration in the same region between the rest and stress images was calculated. The concentration was slightly increased in normal myocardial segments (14.4%±5.8%; P〈0.001), whereas in CAD, it was significantly decreased in segments with stenosed vesels (-18.0%±18.3%; P〈0.02). We conclude that 13N-ammonia PCT at rest and during exercise provides highquality images, and is a sensitive and effective technique for detecting CAD and identifying individual stenosed vessels. Furthermore, this technique makes possible quantitative assessment of the coronary reserve function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279078
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  • 8
    Electronic Resource
    Electronic Resource
    [125I] Radioiodinated metaraminol: a new platelet-specific labeling agent (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 269-275 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In our search for a platelet-specific labeling agent, metaraminol (MA), a low-toxic pharmaceutical for the treatment of hypotension and cardiogenic shock, attracted our attention. Its active incorporation and accumulation by platelets have been recognized. At first, the preparation of 125I radioiodinated metaraminol (125I-MA) was carried out using the chloramine-T method. Then, upon the harvest of platelets as platelet-rich plasma (PRP), their labeling with this new radiopharmaceutical was easily performed by incubation for 10 min at 37° C. The cell-labeling efficiency was dependent on cell density, reaching 63.0%±3.1% at 2.4x109 cells/ml. The specific incorporation of 125I-MA by an active transport system similar to that of 5-hydroxytryptamine (5-HT) as well as by passive diffusion was demonstrated. In in vitro studies, the unaltered state of 125I-MA-labeled platelets with their cellular functions fully retained was estimated. In vivo studies carried out in rabbits with induced thrombi in the femoral artery showed a rather rapid disappearance of the radioactivity from circulating blood, reaching a high thrombus-to-blood activity ratio of 19.8±4.3 within 30 min of the administration of 125I-MA-labeled autologous platelets. Thus, with the potential availability of 123I, 123I-MA-labeled platelets appear to be a promising agent for thrombus imaging using single-emission computed tomography (CT) studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254473
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  • 9
    Electronic Resource
    Electronic Resource
    Analysis of 99mTc-pyridoxylidene-glutamate complex formation and its preparation with tin-adsorbed-resin: Sn-resin kit method (1981)
    Springer
    European journal of nuclear medicine 6 (1981), S. 567-572 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc-Pyridoxylidene-glutamate (Pc-PG) was introduced in 1975 by Baker et al. as a cholescintigraphic agent. Nevertheless its routine use has been limited due to the autoclaving process involved. To shorten the labeling procedure, an analysis of Tc-PG complex formation using the stannous chloride method was carried out. Sn-Resin (stannous ion adsorbed onto cation exchange resin) was used for labeling a stable Tc-PG with high efficiency. A preautoclaved complex of pyridoxal and glutamate was required but the labeling procedure took only 10–15 min after the elution of 99m-TcO 4 - from the generator. Formation of a complex other than a 99mTc-complex of the Schiff-base ligand pyridoxylidene-glutamate is discussed. The new formulation of a Tc-PG kit (Sn-Resin) simplified the labeling method and reproducible data to that already reported by Baker was obtained in chromatographic studies. Its suitability in hospital departments has already been shown in clinical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252671
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical evaluation of 99mTc-pyrophosphate myocardial emission computed tomography: Comparison with planar imaging (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 106-111 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To depict the three-dimensional distribution of 99mTc-pyrophosphate in the heart, emission computed tomography (ECT) was performed, following the conventional planar imaging, in 32 cases with suspected acute myocardial infarction (AMI). There were 23 cases with evidence of AMI, 7 with unstable angina (UA), and 2 with dilated cardiomyopathy (DCM). While the planar images showed discrete cardiac activity in only 11 of the 23 cases (48%) with AMI, the ECT images delineated focal myocardial uptake clearly in 20 of them (87%). On the other hand, the ECT images revealed cardiac blood-pool activity without significant myocardial uptake in all cases with UA and DCM in which the planar images showed diffuse activity. Thus, the ECT imaging of 99mTc-pyrophosphate seems to be a valuable technique for assessing the presence and localization of myocardial necrosis, especially in cases showing diffuse cardiac activity in the planar imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253510
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