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  • 1
    Electronic Resource
    Electronic Resource
    Human dander in house dust allergy (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 7 (1977), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The possible role of human dander in house dust allergy was investigated. Naturally shed human mite-free skin squames were collected from bedding and used to prepare a human dander extract. When the extract was coupled to cyanogen bromide-activated paper discs, and used in the RAST assay, IgE titres to the skin extract were observed in the sera from several patients with house dust allergy. The sera with IgE to the skin extract also had high IgE titres to either house dust, D. pteronyssinus or cat fur. RAST inhibition studies revealed cross-reaction between the human skin extract and both a D. pteronyssinus extract and a cat fur extract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1977.tb01488.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Occupational allergy due to inhalation of ipecacuanha dust (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A number of workers packing ipecacuanha tablets were complaining of allergic symptoms. Skin-prick tests, RAST and an assessment of clinical history by interview were used to confirm the presence of work-related allergy. Specific IgE antibodies to ipecacuanha were detected and the occurrence of antibodies correlated with the incidence of allergic symptoms. The individuals with positive RAST scores had been employed, on average, longer than those with negative scores. It was found that atopy did not predispose the workers to work-related allergy and that there was no correlation between smoking and respiratory symptoms in this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1984.tb02649.x
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  • 3
    Electronic Resource
    Electronic Resource
    Allergenic activity of fractions of cocksfoot (Dactylis glomerata) pollen (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: With the combined use of skin tests, RAST and isoelectric focusing, a potency profile of a cocksfoot (Dactylis glomerata) pollen extract was prepared. It was found that two fractions with pi 4.5 and 6.0 were the most allergenic, had the highest protein concentration and were also the most easily extracted. The importance of converting mean weal sizes into potency units when comparing the allergenicity of pollen fractions is emphasized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb01595.x
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  • 4
    Electronic Resource
    Electronic Resource
    Activity units for allergen extracts (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 9 (1979), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The two present systems of units for the strength of allergen extracts, Noon and p.n.u. are both unsatisfactory. A new activity unit, based on skin prick in humans, is described, and its relationship to in vitro tests is explored. Potency limits for provocation materials used for skin prick tests are suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1979.tb00484.x
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  • 5
    Electronic Resource
    Electronic Resource
    Prevalence of specific IgE to storage mites (A. siro, L. destructor and T. longior) in an urban population and crossreactivity with the house dust mite (D. pteronyssinus) (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of pyroglyphid mites in house dust allergy is well established and the major allergens from the common house dust mites (Dermatophogoides species) have been characterized. There is, however, relatively little progress in the understanding of the human IgE response to non-pyroglyphid storage mites, allergenic crossreactivity with other mite species and extent of environmental exposure. We studied 196 individuals from an urban environment who were not occupationally exposed to storage mites and found a 24% prevalence of specific IgE antibody to Dermatophagoides pteronyssinus and a 14% prevalence of RAST positivity to at least one of three storage mites, Acarus siro, Lepidoglyphus destructor and Tyrophagus longior. All individuals with a positive RAST to storage mites had specific IgE to D.pteronyssinus. RAST inhibition studies with the eight sera with greater than 2% RAST binding to both families of mites showed considerable crossreactivity between D. pteronyssinus and the storage mites A.siro and T. longior and limited crossreactivity between D. pteronyssinus and L. destructor. This suggests that at least some of the response to storage mites observed by direct RAST is a consequence of crossreactivity with the more abundant D. pteronyssinus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02801.x
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  • 6
    Electronic Resource
    Electronic Resource
    Allergenic activity of fractions of cocksfoot (Dactylis glomerata) pollen (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A cocksfoot (Dactylis glomerata) pollen extract has been fractionated by isoelectric focusing in polyacrylamide gel, the separated components extracted from the gel and assayed by three methods: prick tests in human skin, RAST and PCA tests in monkey skin.Prick testing in human skin showed that subjects responded differently to the separated components, indicating the presence of more than one antigenic determinant, and a prolile of antibody activity against each fraction could be constructed.In general, good agreement was observed between RAST profiles and skin test profiles, although some patients who gave positive skin tests lacked circulating IgE and consequently did not give a RAST profile or a monkey PCA.These studies emphasize the current difficulty in attempting to isolate a single pure allergen from cocksfoot which can be used either diagnostically for the detection of pollen allergy, or for the standardization of diagnostic extracts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb00445.x
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  • 7
    Electronic Resource
    Electronic Resource
    Barn allergy among Scottish farmers (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have shown that allergy to storage mites is a significant contributor to allergic disease among an isolated farming community in the Orkneys. The present study was undertaken to determine the prevalence of disease due to storage mites among farmers on the mainland of Scotland. Of the 290 subjects employed on 102 randomly selected farms studied, eighty-seven (30%) reported allergic symptoms on entering barns or byres, and prick tests to storage mites were positive in 62 (21%). Rhinitis and conjunctivitis together were the more frequently reported symptoms, with less than half the subjects recording respitatory symptoms. Specific IgE antibody to storage mites was detected in 43% of subjects reporting allergic symptoms associated with hay dust. Specific IgE to storage mites was strongly associated with atopy in those subjects who reported allergic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1984.tb02653.x
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  • 8
    Electronic Resource
    Electronic Resource
    Castor Bean Allergy Among Workers in the Felt Industry (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 37 (1982), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe occupational allergy to castor bean in workers in a felt manufacturing plant. Twenty-six (37%) of the workers complained they were affected by the felt and were examined by us. Of these, 12 were considered to have occupational allergy. These 12 subjects had raised specific IgE levels to both felt and castor bean extracts. In addition, three subjects without occupational allergy had raised specific IgE. The presence of castor bean allergens in the felt was suggested by the correlation between the RAST scores to the felt and castor bean and confirmed by RAST inhibition experiments. The RAST results correlated well with the results of skin prick tests to felt and castor bean extracts. In addition it was found that atopy did not predispose the workers to castor bean allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1982.tb02347.x
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