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  • 1
    Digitale Medien
    Digitale Medien
    Inactivation of Visna Virus and Other Enveloped Viruses by Free Fatty Acids and Monoglycerides (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb38948.x
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  • 2
    Digitale Medien
    Digitale Medien
    The Use of Lipid Antiviral Compounds in Lentivirus Infections: Summary (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb38950.x
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  • 3
    Digitale Medien
    Digitale Medien
    Inactivation of Enveloped Viruses in Human Bodily Fluids by Purified Lipids (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb38947.x
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  • 4
    Digitale Medien
    Digitale Medien
    Absence of M protein in a cell-associated subacute sclerosing panencephalitis virus (1980)
    [s.l.] : Nature Publishing Group
    Nature 285 (1980), S. 490-492 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Figure 1 shows the protein patterns in Vero cells infected with wt Edmonston virus and 3 cell-associated SSPE viruses, Biken, IP-3 and D.R. Uninfected Vero cells and purified Edmonston viriaons are also included. A protein of molecular weight 60,000 designated6 NP was detected in all the infected ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/285490a0
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  • 5
    Digitale Medien
    Digitale Medien
    Cultivation of visna virus in tissue culture (1960)
    Springer
    Archives of virology 10 (1960), S. 368-381 
    Details
    ISSN: 1432-8798
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The virus of Visna, a slow, demyelinating leucoencephalitis of sheep, has been cultivated in tissue culture. The cells employed are derived from the chorioid plexus of sheep. The virus causes characteristic cytopathic changes in the culture, so that the method may be used to detect virus activity and measure the activity of virus containing material. Virus which had undergone 3, 11, and 12 passages in TC was injected intracerebrally into sheep and found to produce typical Visna lesions. Neutralizing antibody has been detected in sera from a certain proportion of sheep affected with Visna. The rate of virus multiplication in tissue culture after inocula of varying size has been studied. Small inocula tend to give rise to a mild infection which persists in the culture for long periods of time without destroying more than a certain proportion of the cells. The possible relationship between this relatively stable balance between virus and cells and the extraordinarily slow progress of Visna in the CNS of sheep is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01250682
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  • 6
    Digitale Medien
    Digitale Medien
    Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 215-217 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Herpes simplex virus ; Visna virus ; Demyelination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled “bystander effect” of a cell-mediated immune response (bystander demyelination).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690522
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  • 7
    Digitale Medien
    Digitale Medien
    Immunolabeling of SSPE and wild-type measles viruses in ferret brain cell culture (1980)
    Springer
    Acta neuropathologica 50 (1980), S. 181-186 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Subacute sclerosing panencephalitis ; Measies ; Immunoperoxidase ; Ferret brain cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Immunocytochemical studies using horseradish peroxidase labeled antibody were undertaken in an attempt to determine whether there are detectable antigenic differences which correlate with the biological properties of different strains of SSPE and wild-type measles virus grown in ferret brain cell cultures. The rabbit anti-measles hyperimmune serum used in this experiment contained antibodies to all the measles virus proteins when tested by immunoprecipitation. When cells infected with the wild-type measles or productive SSPE virus strains were treated with this serum, heavy deposits of reaction product were seen on the cell membrane and virion envelope. When SSPE serum which contained relatively little antibody to the M protein was applied, a clear unlabeled area was evident just beneath the surface label. Cells infected with the non-productive SSPE strains were labeled by both sera in a spotty or discontinuous pattern on the outer surface of the cell membrane. The differences in membrane labeling seem to reflect differences in the expression of viral membrane proteins by the various SSPE and measles virus strains.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688751
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  • 8
    Digitale Medien
    Digitale Medien
    Immunoperoxidase staining of simple nuclear bodies in subacute sclerosing panencephalitis (SSPE) by antiserum to measles nucleocapsids (1976)
    Springer
    Acta neuropathologica 36 (1976), S. 259-267 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Subacute sclerosing panencephalitis ; Nuclear bodies ; Nucleocapsids ; Immunoperoxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Nuclear bodies have been found with great consistency in brain tissue from patients with subacute sclerosing panencephalitis (SSPE). There has been controversy as to the significance of these structures and their relationship, if any, to the disease. In this study, a non-productive, cell-associated strain of SSPE measles virus grown in tissue culture on Vero cells showed the continued presence of nuclear bodies, frequently in close association with the SSPE measles virus nucleocapsids. Immunoperoxidase (I-P) staining with specific antiserum against measles virus nucleocapsids was done. The resultant positive labeling of the nuclear bodies demonstrates that they contain measles virus antigen and suggests that the nuclear bodies play a role in the development of the measles virus nucleocapsids of SSPE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00685370
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  • 9
    Digitale Medien
    Digitale Medien
    Antibody in SSPE serum and brain IgG against measles virus smooth nucleocapsids detected by immunoelectron microscopy (1977)
    Springer
    Acta neuropathologica 40 (1977), S. 183-188 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Subacute sclerosing panencephalitis ; Measles ; Nucleocapsids ; Immunoperoxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary SSPE patients characteristically have high complement-fixing (CF) and neutralizing (N) antibody titers against measles virus in their sera, CSF, and brain. However, using SSPE patients' sera, the immunoperoxidase (IP) labeling of smooth nucleocapsids in SSPE or measles virus infected Vero cells or measles virions has not been achieved using conventional EM fixatives. Using the periodate-lysine-paraformaldehyde (PLP) fixative developed by McLean and Nakane (1974), and the indirect IP technique, antibodies against smooth nucleocapsids in SSPE and measles virus infected Vero cell cultures have been detected in serum from SSPE patients and normal individuals with high measles antibody titers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00688709
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  • 10
    Digitale Medien
    Digitale Medien
    A non-productive subacute sclerosing panencephalitis (SSPE) virus of human and ferret (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 339-351 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Subacute sclerosing panencephalitis ; Measles virus ; Nucleocapsids ; Immunoperoxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A non-productive syncytiogenic measles virus isolated from the brain of an SSPE patients was grown on Vero cells. The ultrastructure of the infected syncytia was studied by electron microscopic and immunoperoxidase techniques. It was compared with the isolate of the virus after passage in ferrets, the Edmonston strain of wild measles virus and the Halle productive strain of SSPE, all on Vero cells. The immunoperoxidase labeling of the cell membranes of the Edmonston measles virus infected cells was very heavy and uniform. In contrast, the labeling of the non-productive SSPE infected cells was clearly discontinuous. In the latter, there was a preponderance of intranuclear over cytoplasmic nucleocapsid formation, whereas cytoplasmic nucleocapsids were prevalent in the virion-producing strains. Many similarities between Vero cells infected with the wild measles virus and the Halle strain of SSPE were observed, although differences between this SSPE strain and strains reported by others were noted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00696563
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