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  • 1
    Online Resource
    Online Resource
    Infectious Diseases of the Central Nervous System. (2012)
    Dordrecht :Springer Netherlands,
    Details
    Keywords: Human beings-Central nervous system-Communicable diseases. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (261 pages)
    Edition: 1st ed.
    ISBN: 9789401163323
    Series Statement: Neurologic Illness Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6558293
    DDC: 612.82
    Language: English
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    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    Complement changes during exercise-induced asthma (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two groups of asthmatic children, one with and one without a history of post-exercise wheezing, and one non-asthmatic adult, were exercised on a treadmill, and their complement levels were measured before and after exercise.The first group of patients had the most obvious fall in FEV1 and all showed a slight rise in haemolytic complement following exercise. Two of the patients of the second group also had a rise in haemolytic complement.The C4 litre did not change in any of the asthmatic children who did not wheeze after exercise, but there were changes, albeit inconsistent, in the litres of C4 in four of the six patients who exhibiled post exercise wheezing. C3 breakdown products were not detected in any of the sera, following exercise.The role of complement in exercise-induced bronchospasm is not clear, but there does appear lo be a greater liability of the complement system in patients who are susceptible lo this form of provocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb01500.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Polymorph function in asthma (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In vitro polymorph movement, phagocytosis and bactericidal activity were compared in asthmatics, patients with bacterial infection and control subjects. No gross defects were observed, but statistical analysis indicated that asthmatics have depressed polymorph movement (P〉0.05) and lower augmentation of an intracellular enzyme activity (NBT reduction), associated with bactericidal function (P〉0–01). As expected, polymorphs from patients with bacterial infection are capable of increased NBT reduction (P〉0.001).Correlations between a wide range of clinical and laboratory data were also performed by computer analysis. Among significant findings were indications that atopic extrinsic asthmatics, in comparison with intrinsic asthmatics, have raised unstimulated NBT activity (P〉0.05) and lower augmentation in response to endotoxin (P〈0.05), as well as increased IgE and cosinophil counts (P〈 0.002). These findings suggest that in extrinsic asthmatics there may be some impairment of polymorph function which would account for an increased tendency to respiratory infections or to a prolonged recovery from such infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb01632.x
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Distinct genes for fibroblast and serum C1q (1981)
    [s.l.] : Nature Publishing Group
    Nature 292 (1981), S. 549-551 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Family tree showing the inheritance of the gene responsible for the production of the non-functional serum Clq. This condition appears to behave as an autosomal recessive in which both affected siblings, II 1 and II 2, are homozygous for the defective gene, and both parents and sibling II4 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/292549a0
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Lambda-gamma determinant of human IgG (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 98-99 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenjassung Die Antigendeterminanten der IgG wurden mit Hilfe des Myelomproteins charakterisiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01913277
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Secretory Piece linked to IgM in Individuals deficient in IgA (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 946-948 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Reaction with isolated colostral IgA (C) of the piece specific antiserum (aP), absorbed with normal human serum (S). A reaction of identity is given with the antibodies to piece determinants in an anti-secretory IgA antiserum (UN), provided by Dr R. W. Newcomb of Denver, Colorado. A ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226946a0
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    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Hypersonic airfoils of maximum lift-to-drag ratio (1970)
    Springer
    Journal of optimization theory and applications 5 (1970), S. 432-448 
    Details
    ISSN: 1573-2878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of determining the slender, hypersonic airfoil shape which produces the maximum lift-to-drag ratio for a given profile area, chord, and free-stream conditions is considered. For the estimation of the lift and the drag, the pressure distribution on a surface which sees the flow is approximated by the tangent-wedge relation. On the other hand, for surfaces which do not see the flow, the Prandtl-Meyer relation is used. Finally, base drag is neglected, while the skin-friction coefficient is assumed to be a constant, average value. The method used to determine the optimum upper and lower surfaces is the calculus of variations. Depending on the value of the governing parameter, the optimum airfoil shapes are found to be of three types. For low values of the governing parameter, the optimum shape is a flat plate at an angle of attack followed by slightly concave upper and lower surfaces. The next type of solution has a finite thickness over the entire chord with the upper surface inclined so that the flow is an expansion. Finally, for the last type of solution, the upper surface begins with a portion which sees the flow and is followed by an inclined portion similar to that above. For all of these solutions, the lower surface sees the flow. Results are presented for the optimum dimensionless airfoil shape, its dimensions, and the maximum lift-to-drag ratio. To calculate an actual airfoil shape requires an iteration procedure due to the assumption on the skin-friction coefficient. However, simple results can be obtained by assuming an approximate value for the skin-friction coefficient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927442
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    Paper (German National Licenses)
    Fulltext
  • 8
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    Spin differences in the ^{90} Zr compound nucleus induced by (p,p^{′} ), (p,d), and (p,t) surrogate reactions (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-11-06
    Description: Author(s): S. Ota, J. T. Burke, R. J. Casperson, J. E. Escher, R. O. Hughes, J. J. Ressler, N. D. Scielzo, I. J. Thompson, R. A. E. Austin, B. Abromeit, N. J. Foley, E. McCleskey, M. McCleskey, H. I. Park, A. Saastamoinen, and T. J. Ross The effect of the production mechanism on the decay of a compound nucleus is investigated. The nucleus Zr 90 was produced by three different reactions, namely Zr 90 ( p , p ′ ) Zr 90 , Zr 91 ( p , d ) Zr 90 , and Zr 92 ( p , t ) Zr 90 , which served as surrogate reactions for Zr 89 ( n , γ ) . The spin-parity ( J π ) distributions of the… [Phys. Rev. C 92, 054603] Published Wed Nov 04, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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    PAPER CURRENT
  • 9
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    Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data [Articles] (2016)
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Details
    Publication Date: 2016-04-15
    Description: As part of the drug discovery and development process, it is important to understand the human metabolism of a candidate drug prior to clinical studies. Preclinical in vitro and in vivo experiments across species are conducted to build knowledge concerning human circulating metabolites in preparation for clinical studies; therefore, the quality of these experiments is critical. Within AstraZeneca, all metabolite identification (Met-ID) information is stored in a global database using ACDLabs software. In this study, the Met-ID information derived from in vitro and in vivo studies for 27 AstraZeneca drug candidates that underwent human absorption, distribution, metabolism, and excretion studies was extracted from the database. The retrospective analysis showed that 81% of human circulating metabolites were previously observed in preclinical in vitro and/or in vivo experiments. A detailed analysis was carried out to understand which human circulating metabolites were not captured in the preclinical experiments. Metabolites observed in human hepatocytes and rat plasma but not seen in circulation in humans (extraneous metabolites) were also investigated. The majority of human specific circulating metabolites derive from multistep biotransformation reactions that may not be observed in in vitro studies within the limited time frame in which cryopreserved hepatocytes are active. Factors leading to the formation of extraneous metabolites in preclinical studies seemed to be related to species differences with respect to transporter activity, secondary metabolism, and enzyme kinetics. This retrospective analysis assesses the predictive value of Met-ID experiments and improves our ability to discriminate between metabolites expected to circulate in humans and irrelevant metabolites seen in preclinical studies.
    Print ISSN: 0090-9556
    Electronic ISSN: 1521-009X
    Topics: Chemistry and Pharmacology , Medicine
    Published by The American Society for Pharmacology and Experimental Therapeutics (ASPET)
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  • 10
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    Multiple Compound-Related Adverse Properties Contribute to Liver Injury Caused by Endothelin Receptor Antagonists [Toxicology] (2014)
    The American Society for Pharmacology and Experimental Therapeutics
    Details
    Publication Date: 2014-12-21
    Description: Drug-induced liver injury has been observed in patients treated with the endothelin receptor antagonists sitaxentan and bosentan, but not following treatment with ambrisentan. The aim of our studies was to assess the possible role of multiple contributory mechanisms in this clinically relevant toxicity. Inhibition of the bile salt export pump (BSEP) and multidrug resistance-associated protein 2 was quantified using membrane vesicle assays. Inhibition of mitochondrial respiration in human liver–derived HuH-7 cells was determined using a Seahorse XF e96 analyzer. Cytochrome P450 (P450)–independent and P450-mediated cell toxicity was assessed using transfected SV40-T-antigen–immortalized human liver epithelial (THLE) cell lines. Exposure-adjusted assay ratios were calculated by dividing the maximum human drug plasma concentrations by the IC 50 or EC 50 values obtained in vitro. Covalent binding (CVB) of radiolabeled drugs to human hepatocytes was quantified, and CVB body burdens were calculated by adjusting CVB values for fractional drug turnover in vitro and daily therapeutic dose. Sitaxentan exhibited positive exposure-adjusted signals in all five in vitro assays and a high CVB body burden. Bosentan exhibited a positive exposure-adjusted signal in one assay (BSEP inhibition) and a moderate CVB body burden. Ambrisentan exhibited no positive exposure-adjusted assay signals and a low CVB body burden. These data indicate that multiple mechanisms contribute to the rare, but potentially severe liver injury caused by sitaxentan in humans; provide a plausible rationale for the markedly lower propensity of bosentan to cause liver injury; and highlight the relative safety of ambrisentan.
    Print ISSN: 0022-3565
    Electronic ISSN: 1521-0103
    Topics: Medicine
    Published by The American Society for Pharmacology and Experimental Therapeutics
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