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  • 1
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 98 (1990), S. 40-61 
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 258 (1980), S. 993-993 
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 13 (1934), S. 780-782 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 80 (1991), S. 179-186 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract The Miocene Farellones Formation in central Chile (32°-35°S) is one of several up to 3000 mthick Tertiary volcanic sequences in the Central Andes with ash flows and intercalations of lacustrine sediments in their lower part, and intermediate to basic lavas and rhyolitic domes in their upper part. The Farellones rocks were probably deposited in a volcano-tectonic graben formed through a series of caldera collapses. This is suggested by (a) the fact that the formation frequently is delimited by normal faults towards which the subhorizontal strata pinch out and become upraised, indicating deposition during subsidence, (b) the huge volume of erupted acid magma and (c) a high paleothermal gradient of geothermal field type. Similar Tertiary volcanic sequences in northern Chile and central Peru probably also formed by eruptions in a caldera-graben setting. This setting and the geothermal field type of alteration make these sequences good prospecting targets for epithermal preciousmetal deposits.
    Abstract: Resumen La Formación Farellones de Chile central (32°–35°S), deedadmiocena, es una de las muchas secuencias terciarias de más de 3000 m de espesor que existen en la alta cordillera de los Andes Centrales que contiene depósitos de flujos piroclásticos e intercalaciones de sedimentos lacustres en su parte inferior, y lavas intermedias a básicas y domos riolíticos en su parte superior. Las rocas de la Formación Farellones se depositaron, probablemente, en un graben volcano-tectónico formado a través de una serie de colapsos de calderas. Esta interpretación se basa en: (a) la frecuente delimitación de la formación por fallas normales contra las cuales los estratos subhorizontales se adelgazany se levantan, indicando depositación durante subsidencia, (b) el gran volumen de magma ácido extruido y (c) un gradiente paleotermal alto de tipo campo geotérmico. En el norte de Chile y en Perú central existen secuencias terciarias similares depositadas probablemente también en depresiones volcano — tectónicas tipo caldera — graben. Este marco tectónico y la alteración de tipo campo geotérmico, hace que éstas secuencias sean buenos blancos de prospección para depósitos epitermales de metales preciosos.
    Notes: Zusammenfassung Die miozäne Farellones-Formation im zentralen Chile (32°–35°S) ist eine von mehreren bis zu 3000 m mächtigen, tertiären vulkanischen Abfolgen der zentralen Anden, mit Ignimbriten und Zwischenlagerungen von lakustrinen Sedimenten im unteren, und mit intermediären bis basischen Laven und rhyolitischen Staukuppen im oberen Teil der Abfolgen. Die Gesteine der Farellones-Formation wurden wahrscheinlich in einem vulkano-tektonischen, durch eine Reihe von Caldera-Absenkungen entstandenen Graben abgelagert. Für diese Tatsache sprechen (a) häufige Begrenzung der Formation durch Normalverwerfungen gegen welche die subhorizontalen Schichten ausdünnen und aufgebogen werden, was Ablagerung während der Absenkung andeutet, (b) das große Volumen der sauren Vulkanite und (c) der hohe paläothermale Gradient von geothermalem Charakter. Ähnlich ausgebildete, tertiäre vulkanische Abfolgen im nördlichen Chile und zentralen Peru sind vermutlich ebenfalls durch Eruptionen in Caldera-Gräben gebildet worden. Aufgrund der tektonischen Ausbildung und des geothermalen Umwandlungstyp dürften diese Abfolgen für die Prospektion nach epithermalen Vorkommen von Edelmetallen von besonderem Interesse sein.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty patients with advanced renal cell carcinoma (RCC), 23 of whom had distant metastases in at least one organ, were entered after nephrectomy into a protocol involving vaccination with Newcastle disease virus (NDV)-modified autologous tumour material, with a subsequent induction week and repetitive bi-weekly cycles of interleukin-2 (rIL-2) and interferon α2b/rIFN-α2b at a lower s. c. dose (1.5 million Cetus units m−2 day−1 every 12 h on 2 days and 3 million IU/m2 once a day on days 1, 3 and 5). The inpatient treatment was followed by a maintenance phase during which 0.3 million Cetus units/m2 rIL-2 was given s. c. every 12 h on days 1–5 and 3 million IU m−2 day−1 rIFN-α2b was administered on days 1, 3, and 5 on an outpatient basis. All but 3 patients completed the induction week and 6 weeks of outpatient therapy. No grade 3 or 4 toxicities occurred during the therapy. Therapy was discontinued for 3 patients because of rapid tumour progression. Of the 23 evaluable RCC patients, 3 exhibited a complete response and 4 displayed partial remission, 7 showed stable disease during 1–18 months (median = 5 months) of therapy, and progression was seen in 9. We conclude that vaccination with autologous tumour material combined with s. c. rIL-2 and rIFN-α2b administration can induce regressions in patients with advanced RCC and that even in non-responding patients a more favourable course of the disease can be achieved.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 86 (1918), S. 263-276 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 46 (1904), S. 394-406 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-2277
    Keywords: Key words Interleukin-1 receptor antagonist ; heart transplantation ; allograft rejection ; Heart transplantation ; interleukin-1 receptor antagonist ; Allograft rejection ; interleukin-1 receptor antagonist ; heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a pilot study we determined the serum levels of circulating interleukin-1 receptor antagonist (IL-1ra) in patients undergoing orthotopic heart transplantation and in control patients scheduled for open heart surgery without allograft transplantation. Blood samples were obtained from 12 transplant recipients and 7 controls prior to the operative procedures to determine baseline values. Serum levels of IL-1ra were measured within 12 h of decrossclamping of the aorta and every 24 h for the following 14 days. Endomyocardial biopsies were obtained weekly for the 1st month after transplantation. Compared to baseline values, IL-1ra serum levels 12 h after decrossclamping of the aorta were significantly higher both in the control group (507 ± 165 vs 3980 ± 452 pg/ml, P 〈 0.01) and among the transplant recipients (413 ± 180 vs 4117 ± 459 pg/ml, P 〈 0.01) IL-1ra levels remained significantly elevated for 2 and 5 days, respectively. There were no significant differences in the IL-1ra serum levels between the two groups throughout the observation period. Endomyocardial biopsies of two patients showed acute allograft rejection, Billingham grade III a and III b, respectively. In both cases, the rejection episodes were accompanied by a renewed and more pronounced elevation in the IL-1ra serum levels beyond 4000 pg/ml for at least 2 days. These preliminary results indicate that IL-1ra may be a nonspecific immune marker during the first few days after orthotopic heart transplantation and cardiopulmonary bypass. Moreover, renewed, prolonged increases in IL-1ra appear to be associated with rejection. Further studies are needed to confirm the predictive value of IL-1ra in the detection of acute allograft rejection.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1420
    Keywords: Key words Exogenic indications ; Schlüsselwörter Exogene Intoxikationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Beobachtungszeitraum von Mai 1993 bis Mai 1995 wurden 2 202 Patienten im Funktionsbereich Internistische Intensivtherapie der Klinik für Innere Medizin behandelt, darunter waren 247 Patienten (11,2%) mit exogenen Intoxikationen. Von diesen Patienten verstarben 3% (n = 7). In einem zweijährigen Vergleichszeitraum (1984–1985) wurden 2 121 Patienten betreut, davon 16% mit exogenen Intoxikationen; die Mortalität lag bei 2%. Unter den verwendeten Noxen dominierte Alkohol allein (22%) oder in Kombination (27%). Bei den verbleibenden Fällen lagen Benzo-diazepine an erster Stelle, gefolgt von Hypnotika und Sedativa, Kardiaka, Pilzen und Gasen. Auch 1984–1985 war die Reihenfolge ähnlich (Sedativa und Hypnotika 32,2%, Transquilizer 24,8%, Analgetika 10,5%, Neuroleptika 6%). Stadtgasintoxikationen entfielen gänzlich. Die Situation hat sich bezüglich der Antidotgaben (z.B. Anticholium und Anexate) gebessert, so daß die Verläufe mit den Intoxikationen durch Anticholinergika und Benzodiazepine nicht mehr so schwer sind.
    Notes: Analysis of the collection of clinical cases with acute exogenic intoxications over a period of two years Summary 2,202 patients were treated during the treatment period from May 1993 to May 1995 in the functional area medical intensive treatment in the Clinic for Internal Medicine, among them 247 patients (11.2%) with exogenic indications. 3% (n = 7) of these patients died. Within a comparative period (1984–1985), 2,121 were treated, among them 16% with exogenic indications; the mortality was 2%. Among the noxa employed, alcohol dominated alone (22%) or in combination with other substances (27%). Benzodiazepines were used primarily in the remaining cases, followed by hypnotics and sedatives, cardiacs, mushrooms and gases. The sequence was also similar during 1984–1985 (sedatives and hypnotics 32.2%, tranquilizers 24.8%, analgetics 10.5%, neuroleptics 6%). Intoxications with carbon gas were not observed at all. The situation relating to the administration of antidotes (e.g. anticholium and anexates) has improved so that the courses with intoxications with anticholinergics and benzodiazepines are not as severe as previously.
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