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  • 1
    Keywords: Data mining. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (570 pages)
    Edition: 1st ed.
    ISBN: 9783031059360
    Series Statement: Lecture Notes in Computer Science Series ; v.13281
    DDC: 006.3
    Language: English
    Note: Intro -- General Chairs' Preface -- PC Chairs' Preface -- Organization Committee -- Contents - Part II -- Foundations -- Text2Chart: A Multi-staged Chart Generator from Natural Language Text -- 1 Introduction -- 2 Related Work -- 3 Proposed Method -- 3.1 Stage 1: x-Axis and y-Axis Label Entity Recognition -- 3.2 Stage 2: Mapping of x and y Label Entities -- 3.3 Stage 3: Chart Type Prediction -- 4 Experimental Analysis -- 4.1 Dataset Construction -- 4.2 Performance Evaluation -- 4.3 Axis Label Recognition Task -- 4.4 Mapping Task -- 4.5 Chart Type Prediction Task -- 4.6 Overall Performance -- 5 Conclusion -- A Network Architectures -- References -- ENDASh: Embedding Neighbourhood Dissimilarity with Attribute Shuffling for Graph Anomaly Detection -- 1 Introduction -- 2 Related Work -- 3 Preliminaries -- 3.1 Problem Formulation -- 3.2 Representation Learning via GraphSAGE -- 4 Proposed Methods -- 4.1 Embedding Neighbourhood Dissimilarity -- 4.2 Augmenting Training via Attribute Shuffling -- 4.3 Two Stage Training -- 4.4 Runtime and Scalability -- 5 Experiments -- 5.1 Empirical Performance -- 5.2 Ablation Study -- 5.3 Parameter Analysis -- 6 Conclusion -- References -- Convergence and Applications of ADMM on the Multi-convex Problems -- 1 Introduction -- 2 Related Work -- 3 ADMM on the Multi-convex Problems -- 3.1 Preliminaries -- 3.2 The ADMM Algorithm -- 3.3 Convergence Analysis -- 4 Applications -- 4.1 Weakly-Constrained Multi-task Learning -- 4.2 Learning with Signed-Network Constraints -- 5 Experiments -- 5.1 Experiment I: Weak-Constrained Multi-task Learning -- 5.2 Experiment II: Event Forecasting with Multi-lingual Indicators -- 6 Conclusions -- References -- Prototypical Classifier for Robust Class-Imbalanced Learning -- 1 Introduction -- 2 Related Work -- 3 Prototypical Classifier with Dynamic Threshold -- 3.1 Motivation. , 3.2 Dynamic Thresholding for Label Noise Detection -- 3.3 Example Reweighting -- 4 Experiments -- 4.1 Results on Simulated Datasets -- 4.2 Results on Real-World Dataset -- 4.3 Ablation Studies -- 5 Conclusion -- A Ablations on Dynamic Threshold -- B Results on Clean Datasets -- References -- Quantum Entanglement Inspired Correlation Learning for Classification -- 1 Introduction -- 2 Theoretical Analysis and Verification by Bell Inequality -- 2.1 The Measurement on Density Matrix -- 2.2 Verification by Bell Inequality -- 2.3 Analysis -- 3 Implement Classification Algorithm by the Framework -- 3.1 Calculate Joint Probability Between Features and Categories -- 3.2 Constructing QECA by Quantum Joint Probability -- 3.3 Parameter Learning -- 4 Experiments -- 4.1 Datasets and Evaluation Metrics -- 4.2 Compared with Classical Classification Algorithms -- 4.3 Comparison with the Training Process of Standard MLP -- 5 Conclusion and Future Work -- References -- Self-paced Safe Co-training for Regression -- 1 Introduction -- 2 Related Work -- 3 The Proposed Algorithm -- 3.1 The Model -- 3.2 The Safe Technique -- 3.3 The Instances Selection Strategy -- 3.4 Algorithm Description -- 4 Experiments -- 4.1 Experiment Settings -- 4.2 The Effectiveness of the Safe Strategy -- 4.3 Comparison with Semi-supervised Methods -- 5 Conclusion and Future Work -- References -- Uniform Evaluation of Properties in Activity Recognition -- 1 Introduction -- 2 Preliminaries and Related Work -- 3 Proposed Metric -- 4 Experimental Results -- 5 Conclusions -- References -- Effect of Different Encodings and Distance Functions on Quantum Instance-Based Classifiers -- 1 Introduction -- 2 Related Works -- 3 Setting the Stage -- 4 Quantum KNN Algorithms -- 5 Experiments -- 6 Conclusion -- References -- Attention-to-Embedding Framework for Multi-instance Learning -- 1 Introduction. , 2 Related Work -- 2.1 MIL Attention Neural Networks -- 2.2 MIL Embedding Methods -- 3 Methodology -- 3.1 The Attention-Net -- 3.2 The Bag-Level Embedding -- 3.3 Scheme Analysis -- 4 Experiments -- 4.1 Data Sets -- 4.2 Comparative Algorithms -- 4.3 Experimental Results -- 5 Conclusion and Further Work -- References -- Multi-instance Embedding Learning Through High-level Instance Selection -- 1 Introduction -- 2 Related Work -- 3 The Proposed Algorithm -- 3.1 Algorithm Description -- 3.2 The Fast Bag-Inside Instance Selection Technique -- 3.3 High-level Instance Selection Technique -- 3.4 Embedding Technique via HI -- 4 Experiments -- 4.1 Comparison Algorithms -- 4.2 Experimental Data Sets -- 4.3 Performance Comparison -- 4.4 Parameter Analysis -- 4.5 Efficiency Comparison -- 5 Conclusion -- References -- High Average-Utility Itemset Sampling Under Length Constraints -- 1 Introduction -- 2 Related Works -- 3 Preliminaries and Problem Formulation -- 4 Two-Phase Sampling of High Average-Utility Itemsets -- 4.1 Basics of Our Sampling Method -- 4.2 HAISampler: High Average-utility Itemset Sampler Algorithm -- 5 Theoretical Analysis of the Method -- 6 Experiments -- 7 Conclusion -- A Appendix (Proof of Theoretical Results) -- References -- Divide and Imitate: Multi-cluster Identification and Mitigation of Selection Bias -- 1 Introduction -- 2 Problem Statement -- 3 Related Work -- 4 Proposed Method -- 5 Experiments and Discussion -- 6 Conclusion -- References -- Hypersphere Neighborhood Rough Set for Rapid Attribute Reduction -- 1 Introduction -- 2 Preliminaries -- 2.1 Neighborhood Rough Set -- 2.2 Hypersphere -- 3 Hypersphere Neighborhood Rough Set -- 3.1 Theory and Mathematical Models -- 3.2 Algorithm Design -- 4 Experiments -- 4.1 Experimental Setup -- 4.2 Effectiveness -- 4.3 Efficiency -- 5 Conclusion -- References. , A Novel Clustering Algorithm with Dynamic Boundary Extraction Strategy Based on Local Gravitation -- 1 Introduction -- 2 Natural Neighbor -- 3 Methodology -- 3.1 Dynamic Boundary Extraction -- 3.2 Association Strategy -- 3.3 Core Group Clustering -- 3.4 The Complexity Analysis -- 4 Experimental Evaluation -- 4.1 Experiment on Synthetic Datasets -- 4.2 Experiment on Real-World Datasets -- 5 Conclusions -- References -- Modelling Zeros in Blockmodelling -- 1 Introduction -- 2 Blockmodelling with a Chosen Block Metric -- 2.1 Blockmodelling Metric -- 2.2 Candidate Block Metrics -- 2.3 Effect of Blockmodelling Metric on Real Data -- 3 Simulated Data with Hamming and Jaccard Noise -- 3.1 Simulated Block Structures -- 3.2 Generating Noise -- 3.3 Analysis of Simulated Data -- 4 Discussion -- 5 Conclusion -- References -- Towards Better Generalization for Neural Network-Based SAT Solvers -- 1 Introduction -- 2 Background and Related Works -- 2.1 SAT Problem -- 2.2 Neural Network Based SAT Solvers -- 2.3 SAT Applications -- 3 Method -- 4 Experiments -- 4.1 Setting -- 4.2 Results -- 4.3 Influence of Temperature Scaling Factor -- 5 Case Study-Circuit Design Evaluation -- 6 Conclusion and Discussion -- References -- Robust and Provable Guarantees for Sparse Random Embeddings -- 1 Introduction -- 1.1 Background: Random Embeddings -- 1.2 Contributions -- 1.3 Related Work -- 2 Robust Guarantees for Sparse Random Projections -- 2.1 Preliminaries and Notation -- 2.2 Construction of the Embeddings -- 2.3 Key Techniques for the Analysis -- 2.4 Bounds Based on Error Moments -- 2.5 Discussion -- 3 Empirical Evaluation -- 3.1 Synthetic Benchmark -- 3.2 Real-World Datasets -- 4 Conclusions -- References -- Transferable Interpolated Adversarial Attack with Random-Layer Mixup -- 1 Introduction -- 2 Related Work -- 2.1 Mixup -- 2.2 Adversarial Attack Methods -- 3 Methodology. , 3.1 Random-Layer Mixup Attack Method Without Momentum -- 3.2 Random-Layer Mixup Attack Method -- 4 Experiments -- 4.1 Experiment Setup -- 4.2 Attacking Performance -- 4.3 Analysis of Random-Layer Mixup -- 4.4 Single Iterations vs. Inner-outer Iterations -- 5 Conclusion -- References -- Deep Depression Prediction on Longitudinal Data via Joint Anomaly Ranking and Classification -- 1 Introduction -- 2 Related Work -- 3 Multi-task Recurrent Neural Networks -- 3.1 The Proposed Framework -- 3.2 Primary Task: Depression Classification -- 3.3 Auxiliary Tasks -- 3.4 Data Augmentation -- 3.5 The Algorithm of MTNet -- 4 Experiments -- 4.1 Datasets -- 4.2 Experimental Setup -- 4.3 Implementation Details -- 4.4 Performance Evaluation Measures -- 4.5 Empirical Results -- 5 Conclusions and Future Work -- References -- DeepPAMM: Deep Piecewise Exponential Additive Mixed Models for Complex Hazard Structures in Survival Analysis -- 1 Introduction -- 2 Related Literature -- 2.1 Piecewise Exponential Additive Models and Cox Proportional Hazard Models -- 2.2 Machine Learning Approaches -- 2.3 Deep Learning Approaches -- 3 Piecewise Exponential Additive Models -- 3.1 Data Transformation -- 3.2 Model Estimation -- 4 Deep Piecewise Exponential Additive Mixed Models -- 5 Numerical Experiments -- 5.1 Simulation and Ablation Study -- 5.2 Benchmark Analysis -- 5.3 Extended Case Study -- 6 Concluding Remarks -- References -- Assessing Classifier Fairness with Collider Bias -- 1 Introduction -- 2 Background -- 3 Problem Definition -- 4 Estimating CDE -- 5 Implementing Unbiased Situation Test -- 6 Experiments -- 6.1 Correcting Collider Biases -- 6.2 Simulating an Audit Process Using Adult Data Set -- 6.3 Comparing the Audit Performance of NST and UST -- 6.4 Data Based Audit May Be Biased -- 6.5 Rank Models Based on Fairness -- 7 Related Works -- 8 Conclusions. , A Additional Definition and Theorem.
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  • 2
    Online Resource
    Online Resource
    San Diego :Elsevier,
    Keywords: Surface plasmon resonance. ; Analytical biochemistry. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (426 pages)
    Edition: 1st ed.
    ISBN: 9780323853101
    Series Statement: Issn Series
    DDC: 530.416
    Language: English
    Note: Intro -- Surface Plasmon Resonance in Bioanalysis -- Copyright -- Contents -- Contributors to Volume 95 -- Preface -- Series editor´s preface -- Chapter One: Surface plasmon resonance sensing in cell biology and drug discovery -- 1. Introduction -- 2. Typical SPR sensing techniques in bioanalysis -- 3. Application of SPR sensing techniques in cell biology and drug discovery -- 3.1. Application of cSPR in cell biology and drug discovery -- 3.1.1. Viral and bacterial detection -- 3.1.2. Stem cells research -- 3.1.3. Cancer research -- 3.1.4. T cell based therapy and diagnosis -- 3.1.5. Drug screening and efficacy evaluation -- 3.1.6. Distribution and interaction kinetics of drug targets -- 3.1.7. Herbal medicine research -- 3.2. Application of SPRi in cell biology and drug discovery -- 3.2.1. Cell morphology study -- 3.2.2. Cell-extracellular matrix (ECM) interactions -- 3.2.3. Cellular mass density measurements -- 3.2.4. Extracellular vesicles detection -- 3.2.5. Stem cells research -- 3.2.6. Cancer research -- 3.2.7. Blood group detection -- 3.2.8. Allergic disease diagnosis -- 3.2.9. Distribution and interaction kinetics of drug targets -- 3.2.10. Drug delivery -- 3.2.11. Other applications -- 3.3. Application of SPRM in cell biology and drug discovery -- 3.3.1. Cell morphology study -- 3.3.2. Cell-ECM interactions -- 3.3.3. Cellular mass density measurements -- 3.3.4. Cell-substrate distance measurement -- 3.3.5. Subcellular activities -- 3.3.6. DNA molecular imaging -- 3.3.7. Binding kinetics detection -- 3.3.8. Extracellular vesicles detection -- 3.3.9. Viral and bacterial detection -- 3.3.10. Drug screening and efficacy evaluation -- 3.4. Other SPR devices and their applications in cell biology and drug discovery -- 3.4.1. Plasmonic scattering microscopy (PSM) -- 3.4.2. Plasmonic-based electrochemical impedance imaging technique (P-EIM). , 3.4.3. Interferometric plasmonic microscopy (iPM) -- 3.4.4. Spatially switched SPM (ssSPM) -- 3.4.5. Wavelength-scanning surface plasmon resonance microscope (WS-SPRM) -- 3.4.6. Surface plasmon resonance with arrays of nanostructures -- 4. Outlook -- References -- Chapter Two: Phase-sensitive surface plasmon resonance sensors for highly sensitive bioanalysis -- 1. Introduction -- 2. Principle of phase-sensitive SPR biosensors -- 2.1. Schematic of the model -- 2.2. Simulation analysis -- 2.2.1. Comparison between amplitude-sensitive and phase-sensitive SPR sensors -- 2.2.2. Effect of model parameters on SPR sensors -- 2.2.3. Sample system analysis -- 2.2.4. Resolution calculation -- 3. Phase interrogation methods for SPR biosensors -- 3.1. Heterodyne detection -- 3.1.1. Optical configurations -- 3.1.2. Bioanalysis applications -- 3.2. Ellipsometry -- 3.2.1. Optical configurations -- 3.2.2. Bioanalysis applications -- 3.3. Interferometry -- 3.3.1. Shear interferometry -- 3.3.2. Spatial phase modulation interferometry -- 3.3.3. Temporal phase modulation interferometry -- 4. Prospects -- 4.1. Sensitivity enhancement -- 4.2. Dynamic range expansion -- 4.3. Spatial resolution improvement -- 4.4. Portable and miniaturized design -- 5. Conclusion -- References -- Chapter Three: Surface plasmon resonance coupled to mass spectrometry in bioanalysis -- 1. Introduction -- 2. Different approaches for coupling SPR to MS -- 2.1. Off-line coupling approaches -- 2.2. On-line coupling approaches -- 3. Applications of SPR-MS for biomolecular interactions analysis -- 3.1. Protein-protein interactions -- 3.2. Enzyme-substrates/inhibitors interactions -- 3.3. Protein-small molecule interactions -- 3.4. Nucleic acids-protein/nucleic acids interactions -- 4. Perspectives -- Acknowledgement -- References -- Chapter Four: Single-cell plasmonic imaging for activity analysis. , 1. Introduction -- 2. Principles of plasmonic imaging -- 2.1. Surface plasmon resonance -- 2.2. Instrumentations for plasmonic imaging -- 2.2.1. Prism-based SPR imaging -- 2.2.2. Surface plasmon resonance microscopy -- 2.2.3. Scanning localized surface plasmon microscopy -- 2.2.4. Plasmonic-based electrochemical impedance microscopy -- 3. Applications of single-cell plasmonic imaging -- 3.1. Plasmonic imaging of single mammalian cells -- 3.1.1. Detection of biomolecular binding -- 3.1.2. Probing cell signalling process -- 3.1.3. Visualization of cellular electrical activity -- 3.1.4. Analysis of cell-substrate interactions -- 3.1.5. Monitoring complex cellular process -- 3.2. Plasmonic imaging of single bacterial cells -- 3.2.1. Quantification of biomolecular binding -- 3.2.2. Vibration-based analysis of bacterial viability -- 3.2.3. Measurement of bacterial adhesion strength -- 4. Conclusions and outlook -- References -- Chapter Five: SPR for water pollutant detection and water process analysis -- 1. Introduction -- 1.1. SPR -- 1.1.1. SPR principle -- 1.1.2. Localized SPR (LSPR) and long-range SPR (LRSPR) -- 1.2. Ligand immobilization -- 1.2.1. Physical adsorption -- 1.2.2. Thiol binding -- 1.2.3. Covalent immobilization -- 1.2.4. Capture method -- 1.2.5. Polymer film deposition -- 2. Pollutant determination -- 2.1. SPR assay formats -- 2.2. Heavy metals determination -- 2.2.1. Alkanethiol SAM-modified chips -- 2.2.2. Biomacromolecule-modified chip -- 2.2.3. Nanomaterial-enhanced chip -- 2.3. Decetion of organic toxic pollutants -- 2.3.1. Pesticides -- 2.3.2. Antibiotics -- 2.3.3. Endocrine disrupting chemicals (EDCs) -- 2.3.4. Polycyclic aromatic hydrocarbons (PAHs) -- 2.4. Counting pathogens -- 2.4.1. Viruses -- 2.4.2. Bacteria -- 3. Monitoring microbial attachment and biofilm development -- 4. Probing of antifouling. , 4.1. Inhibiting macromolecules adsorption -- 4.2. Restraining microbial cell attachment and biofilm growth -- 4.3. Inducing biofilm dispersal -- 5. Exploration of the interaction of microorganisms with toxic substances -- 6. Future work needs -- 6.1. Characterizing pollutant removal -- 6.1.1. Biosorbents development -- 6.1.2. Biosorption and metabolism -- 6.2. SPR imaging -- 6.2.1. Observation of microbial motion -- 6.2.2. High-throughput detection of pollutant -- 6.3. SPR combination with other techniques -- 6.3.1. Improving detection level -- 6.3.2. Investigating composition and morphology changes -- 6.3.3. Extending sensing depth -- 7. Conclusions -- References -- Chapter Six: SPR imaging for cellular analysis and detection -- 1. Introduction -- 2. Mammalian cell analysis -- 2.1. Monitoring of cell behaviours -- 2.1.1. Dynamic interactions of cells on substratum -- 2.1.2. Cellular secretion of molecules -- 2.2. Monitoring of intracellular processes -- 2.2.1. Monitoring of intracellular signal transduction -- 2.2.2. Tracking of single organelle transportation in cells -- 2.3. Detection of allergenic response -- 2.4. Cell surface protein expression and binding kinetics analysis -- 2.4.1. Analysis of cell surface antigens expression -- 2.4.2. Quantification of receptor expression level and receptor-induced response in single living cells -- 2.4.3. Measuring binding kinetics of membrane proteins of single cells -- 2.4.4. Quantitative analysis of drug binding in single cells -- 2.4.5. Measuring binding kinetics of nanoconjugates with intact cells -- 2.5. Direct detection and quantification of cells -- 2.6. Monitoring capture and release of cells -- 2.7. Monitoring, characterization, and analysis of exosomes -- 2.8. Rapid ABO blood typing -- 2.9. Multi-parametric analysis of living cell -- 3. Bacterial cell analysis. , 3.1. Detection and/or identification of bacteria and virus -- 3.1.1. Acidovorax avenae detection in plant samples -- 3.1.2. Detection of Candida albicans from mixed microbes -- 3.1.3. New probes for the identification of closely related bacteria strains -- 3.1.4. On-chip culture for specific detection of low-level bacteria -- 3.1.5. Early detection of Listeria monocytogenes and Listeria innocua based on event counting -- 3.1.6. Detection of Salmonella enteritidis growth under AgNPs -- 3.1.7. Detection of stressed E. coli in food matrices -- 3.1.8. Detection of Cronobacter and Salmonella in powdered infant formula -- 3.1.9. Detection of single viruses -- 3.1.10. Detection of E. coli O157:H7 by a hybrid SPR and molecular imaging device -- 3.1.11. Detection of Legionella pneumophila -- 3.2. Evaluation of biofilm growth and adhesion -- 3.2.1. Imaging of biofilm formation and removal -- 3.2.2. Multiplexed evaluation of bacterial adhesion onto surface coatings -- 3.2.3. Study of Lubricin as a coating to decrease bacterial adhesion and proliferation -- 3.3. Studies of single bacterial cells -- 3.3.1. Imaging of protein interactions with single bacterial cells -- 3.3.2. Antimicrobial susceptibility test and tracking of single bacterial motions -- 3.3.3. Rapid assessment of water toxicity by direct readout of single bacterial activity -- 3.4. Characterization of nanocompartments of bacteria -- 4. Summary -- References -- Chapter Seven: Progress in the applications of surface plasmon resonance for food safety -- 1. Introduction -- 2. SPR for the detection of food allergen -- 2.1. Applications of SPR on detecting food allergen -- 2.1.1. Seafood allergens -- 2.1.2. Peanut allergens -- 2.1.3. Milk allergens -- 2.1.3.1. Detection of casein -- 2.1.3.2. Detection of α-Lac -- 2.1.3.3. Detection of β-lac -- 2.1.3.4. Detection of BSA. , 2.1.3.5. Detection of multiple milk allergens simultaneously.
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  • 3
    Keywords: Artificial intelligence. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (396 pages)
    Edition: 1st ed.
    ISBN: 9783031059810
    Series Statement: Lecture Notes in Computer Science Series ; v.13282
    DDC: 006.3
    Language: English
    Note: Intro -- General Chairs' Preface -- PC Chairs' Preface -- Organization Committee -- Contents - Part III -- Applications -- NewsKVQA: Knowledge-Aware News Video Question Answering -- 1 Introduction -- 2 Related Work -- 3 NewsKVQA Dataset Curation -- 3.1 Initial Data Collection -- 3.2 Question Generation -- 3.3 Option Generation -- 3.4 Dataset Analysis -- 4 Knowledge-Aware Video QA Methodology -- 5 Experiments and Results -- 6 Conclusions and Future Work -- References -- Multicommunity Graph Convolution Networks with Decision Fusion for Personalized Recommendation -- 1 Introduction -- 2 Related Work -- 3 The MultiGCN Model -- 3.1 Community Exploration -- 3.2 Local Recommendation -- 3.3 Decision Fusion -- 3.4 Optimization -- 4 Experiments -- 4.1 Experiment Datasets -- 4.2 Experimental Settings -- 4.3 Experiment Results -- 5 Conclusion -- References -- Deep Learning for Prawn Farming -- 1 Introduction -- 2 Related Work -- 3 System Architecture and Overview -- 4 Methods -- 4.1 Forecasting -- 4.2 Anomaly Detection -- 5 Dataset, Preprocessing, and Evaluation -- 6 Forecasting Results -- 7 Anomaly Detection Case Studies -- 7.1 DO Crash Case Study -- 7.2 Sensor Biofouling Case Study -- 8 Summary and Conclusion -- References -- Input Enhanced Logarithmic Factorization Network for CTR Prediction -- 1 Introduction -- 2 Related Work -- 3 Our Approach -- 3.1 Input and Embedding Layer -- 3.2 Input Enhanced Component -- 3.3 Hidden Layers -- 3.4 Prediction Score and Learning -- 3.5 Relationship with FM and HOFM -- 4 Experiments -- 4.1 Experimental Settings -- 4.2 Performance Comparison -- 4.3 Hyper-parameter Study -- 4.4 Ablation Study -- 4.5 Component Comparison -- 5 Conclusion -- References -- A Novel Bayesian Deep Learning Approach to the Downscaling of Wind Speed with Uncertainty Quantification -- 1 Introduction -- 2 Problem Formulation and Data Selection. , 2.1 Problem Formulation -- 2.2 Local Wind Data -- 2.3 Reanalysis Data -- 3 Method -- 3.1 Attention-Based Input Grouping -- 3.2 Transformer -- 3.3 Uncertainty Quantification -- 4 Experiments and Results -- 4.1 Experiment Setup -- 4.2 Ablation Studies -- 4.3 Comparative Results -- 5 Conclusions -- References -- Bribery in Rating Systems: A Game-Theoretic Perspective -- 1 Introduction -- 2 Profit Modeling on Data Observation -- 3 Static Game -- 3.1 Best Response -- 4 Conclusion -- References -- IDSGAN: Generative Adversarial Networks for Attack Generation Against Intrusion Detection -- 1 Introduction -- 2 Related Work -- 3 Methodology -- 3.1 Dataset: NSL-KDD Dataset Description -- 3.2 Data Preprocessing -- 3.3 Structure of IDSGAN -- 4 Empirical Evaluation -- 4.1 Experimental Setup -- 4.2 Effectiveness in Different Attack Categories -- 4.3 Robustness with Different Numbers of Modified Features -- 4.4 Baseline Comparisons -- 5 Conclusion and Future Work -- References -- Recommending Personalized Interventions to Increase Employability of Disabled Jobseekers -- 1 Introduction -- 2 Problem Setup -- 2.1 Preliminaries -- 2.2 Problem Statement -- 3 Method -- 3.1 Overview of the Proposed Method (PIR) -- 3.2 Building a Population Causal Graph -- 3.3 Reverse Engineering Using Linear Interpolation -- 3.4 Building the Prediction Model -- 4 Setup for Empirical Evaluation -- 5 Australian Disability Employment Case Study -- 6 Experiments with Public Datasets -- 7 Practical Implication -- 8 Related Work -- 9 Conclusion and Future Work -- References -- Estimating Skill Proficiency from Resumes -- 1 Introduction -- 2 Related Work -- 3 Problem Definition -- 3.1 Resume Information Model -- 3.2 Skill Proficiency Function -- 4 Skill Proficiency Estimation Techniques -- 4.1 B1: Ordinal Regression Clustering -- 4.2 B2: Supervised Linear Model. , 4.3 M1: Supervised Model with Constraints -- 4.4 M2: Weak Supervision Using Clustering -- 4.5 Handling New Skills -- 5 Resume Information Extraction -- 6 Experimental Analysis -- 6.1 Dataset -- 6.2 Evaluation Metrics and Results -- 7 Conclusions and Further Work -- References -- Causal Enhanced Uplift Model -- 1 Introduction -- 2 Related Work -- 3 Preliminaries -- 4 Proposed Method -- 5 Experiment -- 5.1 Datasets -- 5.2 Experiment Settings -- 5.3 Experimental Result Analysis -- 6 Conclusion -- References -- An Incentive Dispatch Algorithm for Utilization-Perfect EV Charging Management -- 1 Introduction -- 2 Problem Definition -- 3 The POSIT Framework -- 3.1 Optimal Charging Capacity Estimation -- 3.2 Online Charging Scheduling -- 3.3 Interactive Arrangement Recommendation -- 4 Experiments -- 4.1 Experimental Setup -- 4.2 Experimental Results -- 5 Related Works -- 6 Conclusions -- References -- A Two-Stage Self-adaptive Model for Passenger Flow Prediction on Schedule-Based Railway System -- 1 Introduction -- 2 Preliminaries -- 3 Stage 1: Next-Day Passenger Flow Prediction Model -- 3.1 Model Inputs Decomposing Component (DC1) -- 3.2 Self-attention-Based Prediction Component -- 3.3 Passenger Flow Reallocation Decomposing Component (DC2) -- 4 Stage 2: Real-Time Fine-Tuning Model -- 4.1 Fast Short-Term Fine-Tuning -- 4.2 Real-Time Adjustment for Interchange and Crowdedness -- 5 Experiments -- 5.1 Experimental Dataset and Setting -- 5.2 Benchmark Methods -- 5.3 The Evaluation of Next-Day Passenger Flow Prediction -- 5.4 The Evaluation of Real-Time Fine-Tuning -- 6 Conclusion -- References -- ToothCR: A Two-Stage Completion and Reconstruction Approach on 3D Dental Model -- 1 Introduction -- 2 Related Work -- 3 Our Approach -- 3.1 Incomplete Dental Model Completion -- 3.2 Surface Reconstruction -- 4 Experiments. , 4.1 Incomplete Dental Model Completion Results -- 4.2 Surface Reconstruction Results -- 5 Conclusion -- References -- BaDumTss: Multi-task Learning for Beatbox Transcription -- 1 Introduction -- 2 Related Work -- 2.1 Automatic Music Transcription -- 2.2 Input Audio Representation -- 2.3 Datasets for AMT -- 3 Proposed Dataset -- 3.1 Beatbox Sample Collection -- 3.2 Data Augmentation -- 3.3 Audio Sequence Generation -- 3.4 User Study on the Generated Audio Sequences -- 4 Proposed Methodology -- 4.1 Pretraining Unit -- 4.2 Bottled Sequence Traversal Unit -- 4.3 Multi-task Autoencoder Unit -- 4.4 Inference-Time MIDI Generation -- 5 Experimental Results -- 6 Error Analysis: BaDumTss vs. BaDumTss-NM -- 7 Conclusion -- References -- Detail Perception Network for Semantic Segmentation in Water Scenes -- 1 Introduction -- 2 Related Work -- 3 Distance Field Loss for Imbalance Problem -- 4 Detail Perception Network -- 4.1 Model Structure -- 4.2 Category Edge Perception Attention Module -- 4.3 Total Loss of DPNet -- 5 Experiments -- 5.1 Datasets -- 5.2 Ablation Study -- 5.3 Comparison with State-of-the-Arts -- 6 Conclusion -- References -- Learning Discriminative Representation Base on Attention for Uplift -- 1 Introduction -- 2 Related Work -- 3 Preliminaries -- 4 Proposed Method -- 4.1 Input Representation -- 4.2 Attention Network -- 4.3 Outcome Prediction Network -- 5 Experiments -- 5.1 Experimental Data -- 5.2 Implementation Details -- 5.3 Comparison Methods -- 5.4 Experimental Results -- 5.5 Effect of Attention Mechanism -- 6 Conclusion -- References -- Mental Health Treatments Using an Explainable Adaptive Clustering Model -- 1 Introduction -- 2 Related Work -- 3 Deep Adaptive Clustering Based on an Explainable Attention Network (EAN) -- 3.1 Psychometric Questionnaires (PQ) -- 3.2 Emotional Lexicon Used to Embed Words in Sentences -- 3.3 Dataset. , 3.4 Developed EANDC Model -- 4 Experimental Analytics -- 5 Conclusion -- References -- S2QL: Retrieval Augmented Zero-Shot Question Answering over Knowledge Graph -- 1 Introduction -- 2 Preliminaries -- 3 Method -- 3.1 The General Pipeline of the KGQA Model -- 3.2 S2QL -- 4 Experiments and Results -- 4.1 Setup -- 4.2 Results -- 4.3 Ablation Study -- 4.4 Case Study -- 5 Related Work -- 6 Conclusions and Future Works -- References -- Improve Chinese Spelling Check by Reevaluation -- 1 Introduction -- 2 Related Work -- 3 The Proposed Approach -- 3.1 Problem -- 3.2 The Pinyin Enhanced BERT -- 3.3 The Reevaluation Strategy -- 3.4 The Filter Guided by the Extended Confusion Set -- 4 Experiments -- 4.1 Datasets -- 4.2 Implementation Details -- 4.3 Baselines -- 4.4 Main Results -- 5 Ablation Study -- 6 Case Study -- 7 Conclusion -- References -- Extreme Multi-label Classification with Hierarchical Multi-task for Product Attribute Identification -- 1 Introduction -- 2 Related Works -- 2.1 Multi-task Learning -- 2.2 Extreme Multi-label Classification -- 3 Problem Formulation -- 4 The Proposed Model -- 4.1 Contextualized Term Representation -- 4.2 Coarse-Grained Product Classification -- 4.3 Fine-Grained Product Classification -- 4.4 Brand Classification -- 4.5 Loss Function -- 4.6 Online Inference -- 5 Experiments -- 5.1 Dateset -- 5.2 Evaluation Metrics -- 5.3 Main Results -- 5.4 Online A/B Tests -- 5.5 Ablation Studies -- 5.6 Visualization -- 6 Conclusion -- References -- Exploiting Spatial Attention and Contextual Information for Document Image Segmentation -- 1 Introduction -- 2 Related Works -- 3 New Framework for Document Image Segmentation -- 3.1 Feature Extraction Network -- 3.2 Pixel-wise Spatial Attention Module -- 3.3 Contextual Information Integration -- 4 Experimental Results -- 4.1 Implementation Details -- 4.2 Ablation Study. , 4.3 Comparisons Against State-of-the Art Methods.
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  • 4
    Keywords: Big data. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (150 pages)
    Edition: 1st ed.
    ISBN: 9789811983313
    Series Statement: Communications in Computer and Information Science Series ; v.1709
    DDC: 005.7
    Language: English
    Note: Intro -- Preface -- Organization -- Contents -- Searching Similar Trajectories Based on Shape -- 1 Introduction -- 2 Preliminaries -- 3 Align-Based Trajectory Match -- 3.1 Trajectory Preprocessing -- 3.2 Align-Based Trajectory Match -- 3.3 Distance Calculation -- 4 Symbolic Trajectory Match -- 4.1 Symbolic Representation for Trajectory -- 4.2 Symbol Distance Calculation -- 4.3 Multiple Balanced Symbol Trajectory -- 4.4 Query Processing -- 5 Experimental Study -- 5.1 Experiment Setup -- 5.2 Experiment Results -- 6 Related Work -- 6.1 Trajectory Similarity Measurement -- 6.2 Symbolic Representation -- 7 Conclusion -- References -- Unsupervised Discovery of Disentangled Interpretable Directions for Layer-Wise GAN -- 1 Introduction -- 2 Related Works -- 2.1 Generative Adversarial Networks -- 2.2 Semantic Discovery for GANs -- 2.3 Disentanglement Learning with Orthogonal Regularization -- 3 Methods -- 3.1 Overview -- 3.2 Layer-Wise Semantic Discovering Model -- 3.3 Orthogonal Jacobian Regularization -- 4 Experiments -- 4.1 Experiment Settings -- 4.2 Non-trivial Visual Effects -- 4.3 Comparison -- 4.4 Ablation Studies -- 5 Conclusion -- References -- ASNN: Accelerated Searching for Natural Neighbors -- 1 Introduction -- 2 Related Work -- 2.1 K-Nearest Neighbor -- 2.2 Reverse k-Nearest Neighbor -- 2.3 Natural Neighbor -- 3 Proposed Method -- 3.1 Motivation and Theory -- 3.2 Accelerated Search of Natural Neighbors Algorithm -- 3.3 Complexity Analysis -- 4 Experimental Evaluation -- 4.1 Results on Synthetic Datasets -- 4.2 Results on Real-World Datasets -- 5 Conclusions -- References -- A Recommendation Algorithm for Auto Parts Based on Knowledge Graph and Convolutional Neural Network -- 1 Introduction -- 2 Related Work -- 3 Proposed Method -- 3.1 Knowledge Graph -- 3.2 KGCNUI Layer -- 3.3 Learning Algorithm -- 4 Experiment -- 4.1 Datasets. , 4.2 Baselines -- 4.3 Experiments Setup -- 4.4 Results -- 5 Conclusion -- References -- Identifying Urban Functional Regions by LDA Topic Model with POI Data -- 1 Introduction -- 2 Related Works -- 3 Region Functions Based on LDA Topic Model -- 3.1 Problem Statement -- 3.2 Embedded Representation of Blocks -- 3.3 Functional Region Identification -- 4 Experiment -- 4.1 Experimental Settings -- 4.2 Experimental Results and Analysis -- 5 Conclusion -- References -- A Data-to-Text Generation Model with Deduplicated Content Planning -- 1 Introduction -- 2 Related Work -- 3 Proposed Model -- 3.1 Word Embedding -- 3.2 Content Planning -- 3.3 Text Generation -- 3.4 Training and Inference -- 4 Experiment -- 4.1 Dataset -- 4.2 Training Configuration -- 5 Conclusion -- References -- Clustering-Enhanced Knowledge Graph Embedding -- 1 Introduction -- 2 Related Work -- 3 Problem Description -- 4 Methodology -- 4.1 KGE Models with Shared Cluster Embeddings -- 4.2 Loss Function -- 5 Experiment -- 5.1 Data Sets -- 5.2 Baseline -- 5.3 Link Prediction -- 5.4 Triplet Classification -- 6 Conclusion -- Appendix A Model parameters -- References -- FCI: Feature Cross and User Interest Network -- 1 Introduction -- 2 Related Work -- 2.1 Feature Cross Mining -- 2.2 User Behavior Sequence Mining -- 3 Our Approach -- 3.1 Problem Statement -- 3.2 Input and Output -- 3.3 Model Structure -- 3.4 Output Layer -- 3.5 Complexity Analysis -- 4 Experiment -- 4.1 Data Set -- 4.2 Evaluation Metrics -- 4.3 Model Training Details -- 4.4 Hyperparameter Settings -- 4.5 Experimental Comparison -- 4.6 Ablation Experiment -- 5 Conclusion -- References -- Author Index.
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  • 5
    Keywords: Artificial intelligence. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (677 pages)
    Edition: 1st ed.
    ISBN: 9783031059339
    Series Statement: Lecture Notes in Computer Science Series ; v.13280
    DDC: 006.3
    Language: English
    Note: Intro -- General Chairs' Preface -- PC Chairs' Preface -- Organization Committee -- Contents - Part I -- Contents - Part II -- Contents - Part III -- Data Science -- PGADA: Perturbation-Guided Adversarial Alignment for Few-Shot Learning Under the Support-Query Shift -- 1 Introduction -- 2 Preliminary -- 2.1 Few-shot Learning -- 2.2 The Support-Query Shift and Optimal Transportation -- 3 Methodology -- 3.1 Motivation -- 3.2 Perturbation-Guided Adversarial Alignment (PGADA) -- 3.3 Regularized Optimal Transportation -- 4 Experiment -- 4.1 Experiment Setup -- 4.2 Quantitative Analysis -- 4.3 Ablation Studies -- 5 Related Work -- 6 Conclusion -- References -- Auxiliary Local Variables for Improving Regularization/Prior Approach in Continual Learning -- 1 Introduction -- 2 Related Work and Backgrounds -- 2.1 Related Work -- 2.2 Background -- 3 Improving Regularization/Prior-Based Methods with Auxiliary Local Variables in Continual Learning -- 3.1 Auxiliary Local Variables in Each Neural Network Layer -- 3.2 ALV for Regularization/Prior-Based Methods -- 3.3 Theoretical Analyses -- 4 Experiments -- 4.1 Effectiveness of ALV on Split and Permuted MNIST Datasets -- 4.2 Effectiveness of ALV on Split CIFAR-100 and Split CIFAR-10/100 -- 5 Conclusion -- References -- Emerging Scientific Topic Discovery by Finding Infrequent Synonymous Biterms -- 1 Introduction -- 2 Problem Statement -- 3 Related Work -- 4 The Proposed Method -- 4.1 Document-Level Clustering -- 4.2 Corpus-Level Clustering -- 4.3 The Search Expression Extraction -- 5 Experiments -- 6 Conclusions -- References -- Predicting Abnormal Events in Urban Rail Transit Systems with Multivariate Point Process -- 1 Introduction -- 2 Related Work -- 3 Preliminaries -- 4 Methodology -- 4.1 Problem Definition -- 4.2 Categorization of Event Pairs -- 4.3 Multivariate Hawkes Process -- 5 Experiments. , 5.1 Experimental Setup -- 5.2 Experimental Results -- 6 Conclusion -- References -- Are Edge Weights in Summary Graphs Useful? - A Comparative Study -- 1 Introduction and Related Works -- 2 Graph Summarization Models -- 2.1 Weighted Graph Summarization Model -- 2.2 Unweighted Graph Summarization Model -- 3 Problem Formulation and Algorithms -- 3.1 Optimization Problem Formulation -- 3.2 Weighted Graph Summarization Algorithms -- 3.3 Unweighted Graph Summarization Algorithms -- 4 Experiments -- 4.1 Experimental Settings -- 4.2 Results -- 5 Discussion: Why Can Edge Weights Be Harmful? -- 6 Conclusion and Future Directions -- A Appendix: Graph Algorithms on Summary Graphs -- References -- Mu2ReST: Multi-resolution Recursive Spatio-Temporal Transformer for Long-Term Prediction -- 1 Introduction -- 2 Related Works -- 3 The Proposed Method -- 3.1 Multi-resolution Recursive Prediction -- 3.2 Spatio-Temporal Transformer -- 4 Experiments -- 4.1 Results and Analysis -- 4.2 Ablation Study -- 4.3 Further Discussions -- 5 Conclusion -- References -- LCAN: Light Cross-Attention Network for Collaborative Filtering Recommendation -- 1 Introduction -- 2 Related Work -- 2.1 Collaborative Filtering -- 2.2 Graph Neural Networks -- 3 Approach -- 3.1 Embedding Layer -- 3.2 Cross-Attention Layer -- 3.3 Preference Extractor -- 3.4 Fusion Layer -- 3.5 Prediction Layer -- 4 Experiments -- 4.1 Performance Comparison -- 4.2 Ablation Experiments -- 4.3 Hyper-Parameter Studies -- 5 Conclusion -- References -- Coded Hate Speech Detection via Contextual Information -- 1 Introduction -- 2 Related Work -- 3 Method -- 3.1 Coded Word Representation -- 3.2 Transformation Layers -- 3.3 Coded Hate Speech Detection -- 4 Experiments -- 4.1 Experimental Setup -- 4.2 Experimental Results -- 5 Conclusion -- References. , Reducing Catastrophic Forgetting in Neural Networks via Gaussian Mixture Approximation -- 1 Introduction -- 2 Backgrounds -- 2.1 Bayesian Inference -- 2.2 Bayesian Approach in Continual Learning -- 2.3 Gumbel Softmax and Categorical Reparameterization -- 3 Gaussian Mixture Approximation in Bayesian Inference for Continual Learning -- 3.1 Proposed Method -- 3.2 Dimension Reduction via Neural Matrix Factorization -- 4 Experiments -- 4.1 Task-Incremental with Multi-head Architecture -- 4.2 Task-Incremental with Single-Head Architecture -- 4.3 Task-Incremental with Data Overlapping -- 4.4 Additional Experiments About Dimension Reduction -- 5 Conclusion and Future Work -- References -- A Novel Semi-supervised Neural Network for Recognizing Parkinson's Disease -- 1 Introduction -- 2 Related Work -- 3 Methods -- 3.1 The Addition of Classifier -- 3.2 Progressive Network -- 3.3 Manifold Regularization and Use of Generated Samples -- 4 Experiments and Results -- 4.1 Dataset -- 4.2 Experimental Settings -- 4.3 Comparison Methods -- 4.4 Experimental Results and Analysis -- 4.5 Parameters Sensitivity Analysis -- 5 Conclusion and Future Work -- References -- ADAM: An Attentional Data Augmentation Method for Extreme Multi-label Text Classification -- 1 Introduction -- 2 Related Work -- 2.1 Extreme Multi-label Text Classification -- 2.2 Data Augmentation in NLP -- 3 Method -- 3.1 Notations -- 3.2 Relevance Learning -- 3.3 Segments Memory Construction -- 3.4 Segments Replacement -- 4 Experiment -- 4.1 Datasets -- 4.2 Evaluation Measures -- 4.3 Baseline -- 4.4 Experiment Details -- 4.5 Comparison Results and Discussion -- 4.6 Analysis of Different Segment Numbers -- 4.7 Analysis of Maximum Number of Replacements -- 4.8 Analysis of Long Tail Labels -- 4.9 Effectiveness of Data Augmentaion -- 5 Conclusion -- References. , AutoTransformer: Automatic Transformer Architecture Design for Time Series Classification -- 1 Introduction -- 2 Relate Work -- 3 Methodology -- 3.1 Time Series Classification Search Space -- 3.2 Optimization Procedure -- 4 Experiments -- 4.1 Experiment Setup and Details -- 4.2 Overall Results -- 4.3 Case Study -- 4.4 Ablation Studies -- 5 Conclusion -- References -- Aspect-Based Sentiment Analysis Through EDU-Level Attentions -- 1 Introduction -- 2 Related Work -- 3 The Proposed Model: EDU-Attention -- 3.1 Model Overview -- 3.2 EDU Representation -- 3.3 Sentence Representation and Learning Objective -- 4 Experiments -- 4.1 Datasets and Baselines -- 4.2 Implementation and Parameter Setting -- 4.3 Comparison with Baselines -- 4.4 Ablation Study -- 4.5 Analysis of Sparse Attention -- 4.6 Model Size and Inference Time -- 5 Conclusion -- References -- Interconnected Neural Linear Contextual Bandits with UCB Exploration -- 1 Introduction -- 2 Related Work -- 3 Problem Formulation and Background -- 4 The Interconnected Neural-Linear UCB Framework -- 5 Regret Analysis -- 6 Experiments -- 6.1 Experimental Setting -- 6.2 Results -- 7 Conclusion -- References -- Node Information Awareness Pooling for Graph Representation Learning -- 1 Introduction -- 2 Preliminaries -- 2.1 Notations and Problem Formulation -- 2.2 Graph Convolutional Neural Network -- 2.3 Self-attention Mechanism -- 3 NIAPool (Proposed Method) -- 3.1 Local Node Information Enhancement -- 3.2 Global Node Scoring Using NFAConv -- 3.3 Graph Coarsening -- 3.4 Model Architecture -- 4 Experiments -- 4.1 Experimental Setting -- 4.2 Q1: Comparison with Baseline Models -- 4.3 Q2: Effectiveness of D2T Attention -- 4.4 Q3: Effectiveness of NFAConv -- 5 Conclusion -- References -- dK-Personalization: Publishing Network Statistics with Personalized Differential Privacy -- 1 Introduction -- 2 Related Work. , 3 Problem Formulation -- 4 Sensitivity Analysis -- 5 Proposed Approaches -- 5.1 Local Least Based Personalized Perturbation -- 5.2 Threshold Projection Based Personalized Perturbation -- 5.3 Sampling Based Personalized Perturbation -- 5.4 Aggregation Based Personalized Perturbation -- 6 Experiments -- 6.1 Experimental Setup -- 6.2 Results and Discussion -- 7 Conclusions and Future Work -- References -- Residual Vector Product Quantization for Approximate Nearest Neighbor Search -- 1 Introduction -- 2 Related Work -- 3 Residual Vector Product Quantization -- 3.1 Learning for Residual Hierarchy Structure -- 3.2 Encoding Algorithm -- 3.3 Learning for Transformation Matrix R -- 4 Experiment Results and Analysis -- 4.1 Parameters Setting for RVPQ -- 4.2 Comparison of Encoding Algorithms -- 4.3 Exhaustive ANN Search -- 4.4 Non Exhaustive Search Based on Inverted Multi-index -- 5 Conclusion -- References -- Data Removal from an AUC Optimization Model -- 1 Introduction -- 2 Preliminaries -- 3 Data Removal for AUC Optimization -- 3.1 Deal with High Dimension -- 4 Theoretical Results -- 5 Experiment -- 5.1 Benchmark Results -- 5.2 High-Dimensional Results -- 6 Conclusion -- A Analysis of DRAUC with High-Dimensional Data -- References -- Distributed Differentially Private Ranking Aggregation -- 1 Introduction -- 2 Preliminaries -- 2.1 Ranking Aggregation -- 2.2 Differential Privacy -- 2.3 Shuffle Model -- 3 Ranking Aggregation Algorithm Under DDP -- 3.1 Ranking Preference Collection -- 3.2 Shuffling -- 3.3 Ranking Aggregation -- 3.4 Privacy Guarantee -- 4 Experiments -- 4.1 Experiment Settings -- 4.2 Performance of DDP-Helnaksort -- 5 Conclusions -- References -- Semantics-Guided Disentangled Learning for Recommendation -- 1 Introduction -- 2 Preliminary and Related Work -- 3 Methodology -- 3.1 Graph Disentangling for Users Intents. , 3.2 Semantic-Aware Intent Representation Learning.
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  • 6
    Publication Date: 2022-02-18
    Description: The Paris Agreement introduces long-term strategies as an instrument to inform progressively more ambitious emission reduction objectives, while holding development goals paramount in the context of national circumstances. In the lead up to the twenty-first Conference of the Parties, the Deep Decarbonization Pathways Project developed mid-century low-emission pathways for 16 countries, based on an innovative pathway design framework. In this Perspective, we describe this framework and show how it can support the development of sectorally and technologically detailed, policy-relevant and country-driven strategies consistent with the Paris Agreement climate goal. We also discuss how this framework can be used to engage stakeholder input and buy-in; design implementation policy packages; reveal necessary technological, financial and institutional enabling conditions; and support global stocktaking and increasing of ambition.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: article , doc-type:article
    Format: application/pdf
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  • 7
    Publication Date: 2012-01-19
    Description: By a one-pot tandem Ugi multicomponent reaction (MCR)/click reaction sequence not requiring protecting groups, 1 H -1,2,3-triazole-modified Ugi -reaction products 6a – 6n ( Scheme 1 and Table 2 ), 7a – 7b ( Table 4 ), and 8 ( Scheme 2 ) were synthesized successfully. i.e. , terminal, side-chain, or both side-chain and terminal triazole-modified Ugi -reaction products as potential amino acid units for peptide syntheses. Different catalyst systems for the click reaction were examined to find the optimal reaction conditions ( Table 1, Scheme 1 ). Finally, an efficient Ugi MCR+ Ugi MCR/click reaction strategy was elaborated in which two Ugi -reaction products were coupled by a click reaction, thus incorporating the triazole fragment into the center of peptidomimetics ( Scheme 3 ). Thus, the Ugi MCR/click reaction sequence is a convenient and simple approach to different 1 H -1,2,3-triazole-modified amino acid derivatives and peptidomimetics.
    Print ISSN: 0018-019X
    Electronic ISSN: 1522-2675
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 8
    Publication Date: 2013-04-10
    Description: Analytical Chemistry DOI: 10.1021/ac303783j
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 9
    Publication Date: 2015-10-23
    Description: Analytical Chemistry DOI: 10.1021/acs.analchem.5b03142
    Print ISSN: 0003-2700
    Electronic ISSN: 1520-6882
    Topics: Chemistry and Pharmacology
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  • 10
    Publication Date: 2015-07-29
    Description: Background: Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one possible solution to overcome the heterogeneity challenge is a shift from gene-centric to pathway-centric therapies. Pathway-centric perspectives, which underscore the need to understand key pathways and their critical properties, could address the complexity of cancer heterogeneity better than gene-centric approaches to aid cancer drug discovery and therapy. Methods: We used large-scale pharmacogenomic profiling data provided by the Cancer Genome Project of the Wellcome Trust Sanger Institute and the Cancer Cell Line Encyclopedia. In a systematic in silico investigation of ERK signalling pathway components and topological structures determines their influences on pathway activity and targeted therapies. Mann–Whitney U test was used to identify gene alterations associated with drug sensitivity with p values and Benjamini–Hochberg correction for multiple hypotheses testing. Results: The analysis demonstrated that genetic alterations were crucial to activation of effector pathway and subsequent tumorigenesis, however drug sensitivity suffered from both drug effector and non-effector pathways, which were determined by not only underlying genomic alterations, but also interplay and topological relationship of components in pathway, suggesting that the combinatorial targets of key nodes in perturbed pathways may yield better treatment outcome. Furthermore, we proposed a model to provide a more comprehensive insight and understanding of pathway-centric cancer therapies. Conclusions: Our study provides a holistic view of factors influencing drug sensitivity and sheds light on pathway-centric cancer therapies.
    Electronic ISSN: 2001-1326
    Topics: Medicine
    Published by SpringerOpen
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