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  • 1
    Online Resource
    Online Resource
    Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (2016)
    Tokyo : Springer Japan
    Details Availability
    Description / Table of Contents: Intro -- Preface -- Contents -- Contributors -- Part I: Instrument and Data Analysis -- Chapter 1: Advances in 4D Gated Cardiac PET Imaging for Image Quality Improvement and Cardiac Motion and Contractility Estimat... -- 1.1 Introduction -- 1.2 Materials and Methods -- 1.2.1 Data-Driven Respiratory Motion Detection and Gating Method -- 1.2.2 4D PET Image Reconstruction Methods with Attenuation, and Respiratory and Cardiac Motion Compensation -- 1.2.2.1 4D PET Image Reconstruction with Respiratory Motion and Attenuation Compensation -- 1.2.2.2 4D Image Reconstruction with Cardiac Motion Compensation -- 1.2.2.3 4D Image Reconstruction with Dual Respiratory and Cardiac Motion Compensation -- 1.2.3 Evaluation of the 4D PET Image Reconstruction with Respiratory and Attenuation Compensation -- 1.2.3.1 Evaluation Using Realistic Simulated PET Study with Small Lung Lesions -- 1.2.3.2 Evaluation Using Data from Clinical Gated Cardiac PET Studies -- 1.2.4 Evaluation of the 4D PET Image Reconstruction Method with Dual Respiratory and Cardiac Motion Compensation -- 1.3 Results and Discussion -- 1.3.1 Improvement of Small Lung Lesion Detection with Respiratory and Attenuation Compensation -- 1.3.2 Improvement of Gated Cardiac PET Images with Respiratory Motion and Attenuation Compensation -- 1.3.3 Improvement of Gated Cardiac PET Images with Dual Respiratory and Cardiac Motion Compensation -- 1.4 Conclusions -- References -- Chapter 2: The Need for Quantitative SPECT in Clinical Brain Examinations -- 2.1 Introduction -- 2.2 Requirements for Quantitative Reconstructions in SPECT -- 2.2.1 Scatter Correction -- 2.2.2 Septal Penetration in the Collimator -- 2.2.3 Attenuation Correction -- 2.2.4 Attenuation Coefficient Map -- 2.2.5 Implementation of the Collimator Aperture Model -- 2.2.6 SPECT Reconstruction.
    Type of Medium: Online Resource
    Pages: 1 online resource (328 pages)
    Edition: 1st ed.
    ISBN: 9784431558941
    URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=5592548
    DDC: 616.07575
    Language: English
    Note: Description based on publisher supplied metadata and other sources
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  • 2
    Electronic Resource
    Electronic Resource
    Positron Emission Tomography Reporter Gene Imaging in the Myocardium: For Monitoring of Angiogenic Gene Therapy in Ischemic Heart Disease (2005)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 20 (2005), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Cardiac angiogenic gene therapy has emerged as a novel treatment approach for patients with intractable ischemic heart disease, aiming at facilitating neovascularization to augment blood flow in the ischemic myocardium by introducing genes encoding for angiogenic factors. While several clinical trials for cardiac angiogenic gene therapy are currently in progress, there remains a discrepancy between impressive preclinical results and their limited clinical findings. On the other hand, positron emission tomography (PET) reporter gene imaging has been developed to monitor expression of transgenes in vivo. PET reporter genes encode for proteins that retain complementary positron-emitting tracers (PET reporter probes), and theoretically any therapeutic gene can be linked and coexpressed with an appropriate PET reporter gene. Consequently, PET reporter gene imaging with a PET reporter probe affords external determination of the location, magnitude, and duration of expression of therapeutic genes noninvasively. Since PET imaging can be performed in various species ranging from mice to humans, in vivo cardiac PET reporter gene imaging could play a critical role in identifying the “missing link” as a powerful translational research tool. In this article, we discuss the role of PET reporter gene imaging in basic and clinical research on cardiac angiogenic gene therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8191.2005.00152.x
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  • 3
    Electronic Resource
    Electronic Resource
    Laser to the heart in coronary artery disease (2000)
    Springer
    The international journal of cardiovascular imaging 16 (2000), S. 279-282 
    Details
    ISSN: 1573-0743
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026463200898
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  • 4
    Electronic Resource
    Electronic Resource
    Glucose metabolism in relation to perfusion in patients with ischaemic heart disease (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 292-296 
    Details
    ISSN: 1619-7089
    Keywords: Glucose metabolism ; Myocardial perfusion ; Positron emission tomography ; Myocardial viability ; Ischaemic heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to correlate myocardial perfusion and residual metabolism in patients with coronary artery disease, the regional metabolic rate of glucose (rMRGlu) was compared with regional perfusion under glucose loading state (GL) and fasting state (FA). Fluorine-18 deoxyglucose dynamic scan was obtained in ten patients after oral GL and in 16 patients under FA. rMRGlu in seven segments was calculated using Patlak graphic analysis for comparison with normalized percent uptake of nitrogen-13 ammonia at rest in each segment. When perfusion was less than 45%, no segment showed an increase in rMRGlu (≥0.3 pmol/min/g) under either FA (0/6 segments) or GL (0/8 segments), indicating a certain threshold of perfusion for maintenance of glucose metabolism. When perfusion exceeded 45%, rMRGlu was higher in GL (0.37±0.18 pmol/min/g) than FA (0.15±0.12 pmoVmin/g,P 〈 0.001) but there was very wide scatter of rMRGlu values under both states. Thus, both myocardium with preserved and myocardium with reduced glucose metabolism may exist when the perfusion exceeds 45%. In conclusion, a minimum threshold of perfusion for the maintenance of glucose metabolism may exist under both FA and GL. Below the threshold, irreversible damage may occur in the myocardium. Above the threshold, quantitative analysis of glucose metabolism should play an important role in differentiating reversibly injured myocardium from necrotic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00947963
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  • 5
    Electronic Resource
    Electronic Resource
    Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 272-279 
    Details
    ISSN: 1619-7089
    Keywords: Single-photon emission tomography ; Myocardial infarction ; Prognosis ; Iodine-123 fatty acid ; Thallium-201
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was undertaken to evaluate the prognostic value of iodine-123 labelled 15-iodophenyl3-R,S-methyl pentadecanoic acid (BMIPP) imaging in patients with myocardial infarction. BMIPP is an iodinated methyl branched fatty acid analogue which is trapped in the myocardium with little washout, thereby reflecting fatty acid utilization in the myocardium. We previously reported that in patients with myocardial infarction, regions are often observed where reduced BMIPP uptake is seen relative to thallium-201 perfusion at rest. However, the clinical significance of such discordant BMIPP uptake remains unknown. Fifty consecutive patients with chronic myocardial infarction referred for stress thallium scan and coronary arteriography underwent BMIPP imaging at rest. Each patient was in a stable condition at the time of the radionuclide study. Follow-up was performed at a mean interval of 23 months to investigate the prognostic implications of the radionuclide studies. Nine patients had cardiac events during the follow-up period. Univariate analysis showed that the number of discordant BMIPP versus201TL uptake segments was the best predictor of future cardiac events (P=0.0245), followed by the presence of discordant BMIPP uptake (P=0.0388) and the number of201TL redistribution segments (P=0.0444). When all the clinical and radionuclide variables were analysed by Cox regression analysis, the presence of discordant BMIPP uptake was the best, and an independent, predictor of future cardiac events (χ2=8.5) followed by the number of coronary stenoses on angiography (χ2=3.9). These preliminary data suggest that decreased BMIPP uptake relative to201TL is a valuable predictor of future cardiac events in patients with myocardial infarction. Areas with such discordant BMIPP uptake may contain jeopardized myocardium where fatty acid utilization has been severely suppressed relative to myocardial perfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00837625
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  • 6
    Electronic Resource
    Electronic Resource
    Myocardial positron computed tomography with 13N-ammonia at rest and during exercise (1985)
    Springer
    European journal of nuclear medicine 11 (1985), S. 246-251 
    Details
    ISSN: 1619-7089
    Keywords: Positron computed tomography ; 13N-Ammonia ; Ischemia ; Coronary-artery disease ; Myocardial-perfusion imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the value of myocardial-perfusion positron computed tomography (PCT) for the evaluation of coronary artery disease (CAD), 13N-ammonia PCT using a whole-body multislice PCT device was performed at rest and during exercise in 6 normal subjects and 19 patients with angiographically documented CAD. The 13N-ammonia distribution in the myocardium was assessed both qualitatively and quantitatively. At rest and during exercise, the tracer distribution was homogeneous in the 6 normal cases. In the 19 patients with CAD, regional hypoperfusion was observed in 14 cases (74%) at rest and in 18 cases (95%) during exercise. Additional perfusion abnormalities were detecting during exercise in 12 cases. Segmental analysis of the myocardial perfusion identified 30 out of 34 stenosed vessels (88%) during exercise, with only one false-positive finding of diseased vessels (specificity, 98%). For the quantitative analysis of myocardial perfusion by PCT, the percentage of change in the tracer concentration in the same region between the rest and stress images was calculated. The concentration was slightly increased in normal myocardial segments (14.4%±5.8%; P〈0.001), whereas in CAD, it was significantly decreased in segments with stenosed vesels (-18.0%±18.3%; P〈0.02). We conclude that 13N-ammonia PCT at rest and during exercise provides highquality images, and is a sensitive and effective technique for detecting CAD and identifying individual stenosed vessels. Furthermore, this technique makes possible quantitative assessment of the coronary reserve function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279078
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  • 7
    Electronic Resource
    Electronic Resource
    A new method of three dimensional analysis of left ventricular wall motion (1988)
    Springer
    European journal of nuclear medicine 14 (1988), S. 113-119 
    Details
    ISSN: 1619-7089
    Keywords: Radionuclide ventriculography ; Emission computed tomography ; Heart ; Wall motion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The three dimensional (3D) shape of left ventricles (LV) was reconstructed from gated blood pool emission computed tomography (GECT) to assess regional LV wall motion. The 3D LV shape was created using LV boundaries detected by a threshold method. Based on the length from each LV boundary to the end diastolic LV center of mass, regional percent shortening and phase of the first harmonic by Fourier analysis were calculated to create 3D functional images. These images clearly demonstrated the 3D extent of wall motion abnormality. In addition, the same 3D analysis was applied to biplane X-ray left ventriculography (LVG) by assuming that LV short axis sections were elliptic. Results of planar imaging, 3D analysis of GECT, 3D analysis of LVG and conventional LVG findings correlated well with each other. The 3D analysis of GECT is useful for non invasive quantitative analysis of LV wall motion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293533
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  • 8
    Electronic Resource
    Electronic Resource
    Oxidative metabolism in the myocardium in normal subjects during dobutamine infusion (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 231-237 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; Carbon-11 acetate ; Myocardial metabolism ; Dobutamine ; Oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the biventricular response of the clearance rate of carbon-11 acetate as an index of myocardial oxidative metabolism to increase in work-load, dynamic positron emission tomography was performed at rest and during dobutamine infusion in 14 normal subjects. The clearance rate constant (Kmono) of the left ventricular (LV) myocardium increased during dobutamine infusion (0.112±0.020 min−1 vs 0.065±0.015 min−1 at rest) (P〈0.001) in proportion to the increase in the pressure-rate product. Kmono in the right ventricular (RV) myocardium also increased (0.080±0.018 min−1 vs 0.034±0.013 min−1 at rest) (P〈0.001), with an excellent correlation with the LV Kmono (r=0.920). The fact that the increase in RV Kmono during dobutamine infusion was greater (158%±81%) than that in LV Kmono (79%±39%) (P 〈 0.005) indicates a greater increase in oxidative metabolism in the RV in response to inotropic stimulation in normal subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170004
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  • 9
    Electronic Resource
    Electronic Resource
    Glucose metabolism in relation to perfusion in patients with ischaemic heart disease (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 292-296 
    Details
    ISSN: 1619-7089
    Keywords: Glucose metabolism ; Myocardial perfusion ; Positron emission tomography ; Myocardial viability ; Ischaemic heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to correlate myocardial perfusion and residual metabolism in patients with coronary artery disease, the regional metabolic rate of glucose (rMRGlu) was compared with regional perfusion under glucose loading state (GL) and fasting state (FA). Fluorine-18 deoxyglucose dynamic scan was obtained in ten patients after oral GL and in 16 patients under FA. rMRGlu in seven segments was calculated using Patlak graphic analysis for comparison with normalized percent uptake of nitrogen-13 ammonia at rest in each segment. When perfusion was less than 45%, no segment showed an increase in rMRGlu (≥0.3 pmol/min/g) under either FA (0/6 segments) or GL (0/8 segments), indicating a certain threshold of perfusion for maintenance of glucose metabolism. When perfusion exceeded 45%, rMRGlu was higher in GL (0.37±0.18 pmol/min/g) than FA (0.15±0.12 pmoVmin/g, P 〈 0.001) but there was very wide scatter of rMRGlu values under both states. Thus, both myocardium with preserved and myocardium with reduced glucose metabolism may exist when the perfusion exceeds 45%. In conclusion, a minimum threshold of perfusion for the maintenance of glucose metabolism may exist under both FA and GL. Below the threshold, irreversible damage may occur in the myocardium. Above the threshold, quantitative analysis of glucose metabolism should play an important role in differentiating reversibly injured myocardium from necrotic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176567
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  • 10
    Electronic Resource
    Electronic Resource
    Changes in cerebral blood flow induced by balloon test occlusion of the internal carotid artery under hypotension (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 1268-1273 
    Details
    ISSN: 1619-7089
    Keywords: Balloon occlusion ; Cerebral blood flow ; Hypotension ; Single-photon emission tomography ; Ischaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Balloon test occlusion (BTO) of the internal carotid artery (ICA) combined with cerebral blood flow (CBF) study has proved to be a sensitive test for prediction of the outcome of permanent vessel occlusion. In this study, we evaluated the acute changes in regional CBF during BTO under hypotension in order to examine the possible risk of cerebral ischaemia after surgical treatment. Eleven patients in whom surgical carotid sacrifice was planned underwent BTO combined with CBF studies using technetium-99m hexamethyl-propylene amine oxime single-photon emission tomography under hypotension by decreasing the systemic blood pressure by about 50 mm Hg using a ganglion blocking agent. All patients showed a mild to severe decrease in CBF in the ipsilateral ICA territory relative to the contralateral side. A decrease in CBF of greater than 20% was observed in nine patients (82%), and two of them showed a decrease exceeding 40%. However, no ischaemic symptoms were demonstrated during scanning with hypotensive BTO. Our results suggest that in many patients with negative normotensive BTO, a considerable reduction in CBF would occur during hypotension. This procedure may predict a possible risk of hypotensive accident during and/or after surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801611
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