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  • 1
    Publication Date: 2012-12-01
    Description: Feasibility studies on simulating seismic-wave propagation in media for a suboceanic earthquake, including both land and ocean-bottom topographies and a seawater layer, are scarce. Some of the conventional staggered-grid finite-difference method (FDM) simulations use a simplified structure model without a seawater layer and with a flat ocean-bottom topography. In this study, we apply our heterogeneity, oceanic layer, and topography scheme (HOT)-FDM and a 3D structure model including land and ocean-bottom topographies, a seawater layer, and a fluid–solid boundary condition to an aftershock ( M w  5.8) of the 2009 Suruga Bay earthquake. We attempt to reproduce observations at seismic stations near the coast and then simulate waveforms in the ocean-bottom stations. Our results show that a large difference between the cases with and without topographies can be seen in the coda part after the S  wave in the simulated waveforms in terms of amplitudes and elongations. The synthetic waveforms in the model with topographies are in agreement with the observed waveforms. Our results also show that a significant difference in the amplification of the coda part between the cases with and without the seawater layer can be found at the ocean-bottom stations. This coda part is the S - and Rayleigh-wave propagation associated with the ocean and the underlying sediment layers. Our results show that a realistic model with topographies and a seawater layer is needed in FDM simulations in order to precisely reproduce observed waveforms or predict seismic motion for a suboceanic earthquake.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 2
    Publication Date: 2013-09-05
    Description: Evaluating the association between histological manifestations of cord colitis syndrome with GVHD Bone Marrow Transplantation 48, 1249 (September 2013). doi:10.1038/bmt.2013.44 Authors: S Shimoji, K Kato, Y Eriguchi, K Takenaka, H Iwasaki, T Miyamoto, Y Oda, K Akashi & T Teshima
    Keywords: GVHDcord blood transplantationcolitis
    Print ISSN: 0268-3369
    Electronic ISSN: 1476-5365
    Topics: Medicine
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  • 3
    Publication Date: 2012-08-09
    Description: Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians Bone Marrow Transplantation 47, 1075 (August 2012). doi:10.1038/bmt.2011.229 Authors: Y Mori, T Teshima, K Kamezaki, K Kato, K Takenaka, H Iwasaki, T Miyamoto, K Nagafuji, T Eto & K Akashi
    Keywords: PAM scorehematopoietic SCTprognosisJapanese
    Print ISSN: 0268-3369
    Electronic ISSN: 1476-5365
    Topics: Medicine
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  • 4
    Publication Date: 2013-02-15
    Description: The whole-Moon model was recently proposed by re-analyzing of lunar seismic data, which presumes efficient propagation of seismic waves within the Moon. However, common seismic body-wave or surface-wave phases observed for earthquake are absent or very weak in lunar seismic signals characterized by strong reverberations and coda. Hence, the process of seismic wave propagation in the Moon's interior is not well understood from limited lunar seismic data. We present numerical simulations of seismic body wave propagation in the whole Moon based on recently published whole-Moon model. Seismic wave equations are solved in a 2-D cross-section of spherical Moon with a staggered grid pseudospectral and finite difference hybrid method. Our simulation results provide the processes of seismic body wave propagation in the whole Moon for both deep and shallow moonquakes with sequential wavefield snapshots and synthetic waveforms. Effects of lateral heterogeneity on seismic wave propagation were investigated by simulations for a Moon tomographic model. Comparisons with the observed Apollo seismograms show that simulations predicted the arrivals of direct P and S waves and reproduced the reverberating nature of both direct and secondary waves. However, modelling with only the 1-D or tomographic model does not seem to be enough to produce the slow decay of energy in observations if other possible factors, such as scattering, are not considered in the model. Comparisons between different focal mechanisms suggest that great differences can be seen for the direct waves, but the structure model contributes significantly to the overall characteristics of synthetic seismograms. Numerical simulations demonstrated efficient propagation and interactions with various interfaces of seismic body waves within the whole Moon. Seismic energy propagating in the near surface low-velocity layer formed trapped waves, which propagate along the surface and appear as reverberations in the waveforms. Strength of the reverberations increases with dominant frequency and decreasing focal depth. Detectability of lunar seismic body-wave phases should be enhanced with deployment of very broad band seismometer network in the future lunar seismic experiment, which will further improve our knowledge of the Moon's interior.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 142 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report the clinical and histopathological features of a keratosis that developed in association with syringocystadenoma papilliferum. This tumour shows a pinkish, pedunculated, spherical nodule with a cerebriform surface and visible keratinous plugs. In addition to the typical features of syringocystadenoma papilliferum, the tumour shows many hyperkeratotic columns surrounded by acanthotic epidermis with the characteristics of trichilemmal keratinization and keratohyalin granules. This keratosis seems to be derived from the middle to lower portion of the apocrine acrosyringium, based on the distribution of keratohyalin granules and the direct connection with the apocrine acrosyringium in an early lesion. Accordingly, we propose to identify this rare keratosis as apocrine acrosyringeal keratosis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apoptosis and the expression of p53 protein, an apoptosis-related protein, in the process of healing of a full-thickness burn wound in guinea-pig skin were studied with the terminal deoxynucleotide transferase nick-end labelling method, electron microscopy, and immunohistochemistry, respectively. Apoptosis was detected in the peripheral zone of heat-injured skin from 12 h until day 10 after the burn, with the peak occurring on day 2. The peripheral zone of heat-injured skin showed p53 protein from 12 h through day 2, with the peak occurring on day 2. Apoptosis was also detected in tissues regenerated for covering skin defects. The peak of apoptosis in the regenerated epidermis occurred at days 7–10, when the epidermis was most acanthotic. p53 protein reactivity was also detected in the acanthotic regenerated epidermis, with a peak on day 7. The peak of apoptosis in the granulation and scar tissue took place from day 10 to 14, when the granulation tissue started diminishing, but p53 protein reactivity was not detected there. These findings suggest that apoptosis plays an important part in the elimination of dying and/or dead cells resulting from heat stress, the terminal differentiation of the regenerated epidermis, and the decrease in cellularity during remodelling. The apoptotic process during remodelling may be mediated by some p53-independent pathway.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 139 (1998), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 59-year-old woman who exhibited a recurrent malignant proliferating trichilemmal tumour on the scalp for 15 years. The tumour was recalcitrant to conventional treatments such as chemotherapy, radiation or hyperthermia and we performed intratumoral ethanol injection as an alternative means of reducing tumour mass and obtaining haemostasis. Biopsy specimens obtained after the ethanol injection revealed oedema, haemorrhage in the dermis and degeneration of the tumour cells, showing vacuolization with pyknotic nuclei. For cases of recurrent skin tumours and for patients in poor clinical condition, intratumoral ethanol injection is likely to be a therapeutic alternative to surgery or other conventional treatments.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 105 (1991), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Laterally varying interfaces cause coupling between wavenumbers so that seismograms in two-dimensionally layered media can be synthesized by means of ‘supermatrices’, which include the coupled contributions of all the wavenumbers. We introduce reflection and transmission ‘supermatrices’ in order to eliminate numerical problems arising from loss of precision for evanescent waves in the seismogram synthesis. An interface is assumed to be such that the reflected and transmitted wavefields; on its two sides can be represented as purely upgoing and downgoing waves, i.e. the Rayleigh ansatz is imposed. The computational demands of this method can be kept to a minimum by exploiting propagation invariants in the coupled wavenumber domain.The superior performance of this ‘invariant embedding’ approach when compared to propagator or finite difference schemes is illustrated by application to the response of sedimentary basins to excitation by an incident plane wave or a line force. The results are in good general agreement with the other methods, but show greater numerical stability and computational efficiency. In the case of a single interface the ‘invariant embedding’ procedure for P-SV-waves takes 45 per cent less computation time and 29 per cent less memory than the propagator method of Koketsu (1987a, b). The gains are reduced in a multilayer case because of the level of computation required to calculate the addition rules for the large reflection and transmission supermatrices.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Basic fibroblast growth factor (bFGF) stimulates the mitogenesis of various cells and plays a key part in wound healing. Objectives To determine the spatial and temporal expression of bFGF protein during wound healing after burning of rat skin. Methods Immunohistochemical methods were used. Results The immunostaining for bFGF in the normal epidermis was faint and sporadic in the basal cell layer. However, significant staining for bFGF was found in four locations: regenerated epidermis, a band-like zone near the regenerated epidermis, renewed capillaries, and cells infiltrating into the granulation tissue at the inflammatory to proliferative stages after the burn. The intensity of immunostaining of regenerated epidermis, the band-like zone and renewed capillaries was maximal during the proliferative stage and decreased to normal levels or disappeared simultaneously with wound closure. Immunopositive macrophage-like cell numbers in the granulation tissue increased during the proliferative stage and promptly decreased after wound closure, but such cells were only poorly visible in the scar tissue until 42 days postburn. Conclusions bFGF may affect the proliferation, differentiation and migration of regenerated keratinocytes and the recruitment of inflammatory cells, as well as neovascularization in granulation tissue during wound healing. Macrophages may play a pivotal role in cutaneous wound repair by producing bFGF not only during the inflammatory or proliferative stages but also during the remodelling stage.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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