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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of Steroid 5α-Reductase Activity by Aliphatic Fatty Acids (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 768 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb12127.x
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  • 2
    Electronic Resource
    Electronic Resource
    Vaginaler oder abdominaler Verschluß von Blasenscheidenfisteln? (1981)
    Springer
    Archives of gynecology and obstetrics 232 (1981), S. 694-695 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02429769
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  • 3
    Electronic Resource
    Electronic Resource
    Therapie des invasiven Blasenkarzinoms (1997)
    Springer
    Der Onkologe 3 (1997), S. 248-253 
    Details
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Bei Erstdiagnose eines Blasenkarzinoms findet sich in 75–85% ein oberflächlicher, auf die Schleimhaut bzw. Submukosa begrenzter Tumor (Ta, Tis, T1), der durch lokale Maßnahmen wie transurethrale Resektion und/oder topische Chemotherapie kontrollierbar ist [32]. In 15–25% findet sich dagegen bei der Erstdiagnose ein bereits fortgeschrittenes, muskelinvasives Karzinom (≥T2). Neben der als Standardtherapie muskelinvasiver Tumoren geltenden radikalen Zystektomie umfaßt das Spektrum der Therapiemodalitäten des invasiven Blasenkarzinoms eine ganze Palette von Möglichkeiten, die individuell als Mono- oder Kombinationstherapie nach den unterschiedlichen Gegebenheiten und Präferenzen zur Anwendung kommen können. Die Entscheidung zur Wahl der definitiven Therapieform bei invasivem Blasenkarzinoms ist dabei von multiplen Faktoren wie Alter, Allgemeinzustand, Tumorstadium, Begleiterkrankungen, soziales Umfeld, Intelligenz, manuelle Geschicklichkeit des Patienten, aber auch von den persönlichen Erfahrungen und Präferenzen des behandelnden Arztes abhängig. Zunehmend finden auch Aspekte der Lebensqualität und einer steigenden Lebenserwartung Berücksichtigung für die Therapieplanung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007610050119
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  • 4
    Electronic Resource
    Electronic Resource
    Extracorporeal shock wave lithotripsy in children (1997)
    Springer
    Der Urologe 36 (1997), S. 200-208 
    Details
    ISSN: 1433-0563
    Keywords: Key words ESWL in children • Stone-free rate • Recurrence rate • Blood pressure • Renal function ; Schlüsselwörter ESWL im Kindesalter • Steinfreiheitsrate • Rezidivrate • Blutdruck • Nierenfunktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Steintherapie im Kindesalter unterscheidet sich prinzipiell nicht von der Steintherapie im Erwachsenenalter. So stellt auch im Kindesalter die extrakorporale Stoßwellenlithotripsie (ESWL) bei konservativ nicht beeinflußbarer Urolithiasis die Therapie der 1. Wahl dar. Indikationen bestehen bei Kelch- und Nierenbeckensteinen bis 2 cm im Durchmesser sowie nicht abgangsfähigen Uretersteinen, die endoskopisch retromanipuliert werden oder im proximalen und distalen Ureterdrittel in situ behandelt werden. Auch im Kindesalter hat sich die ESWL als sicheres und effektives Verfahren bewährt. Die Erfolgsraten nach 3 Monaten liegen zwischen 57 und 97 % bei fast unveränderten Erfolgsraten im Langzeitverlauf zwischen 57 und 92 %. Eine Limitierung der Stoßwellenzahl und Energie wird wegen potentieller Schädigung des vulnerablen kindlichen Nierengewebes einheitlich empfohlen. Langzeitschäden durch die ESWL sind bisher nicht bekannt. Insbesondere sind bislang weder die Induktion eines Hypertonus noch eine Verschlechterung der Nierenfunktion beobachtet worden.
    Notes: Summary In general, the criteria for treatment of urolithiasis in children are the same as those for adults. Today, extracorporeal shock wave lithotripsy (ESWL) is the method of choice for treatment of most pediatric urinary stones. Stone-free rates between 57 % and 97 % at short-term follow-up and 57 %–92 % at long-term follow-up have proven the efficacy of ESWL treatment in children. So far, there is no evidence of negative side effects of ESWL treatment in children in the longterm, confirming the safety of ESWL treatment seen in the short-term results. In particular, neither induction of hypertension nor deterioration of renal function have been detected in children when limitation of shock wave energy and shock wave numbers have been carefully observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050090
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  • 5
    Electronic Resource
    Electronic Resource
    Sakrale Neuromodulation der Harnblase (2000)
    Springer
    Der Urologe 39 (2000), S. 55-63 
    Details
    ISSN: 1433-0563
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050011
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  • 6
    Electronic Resource
    Electronic Resource
    Surgical Treatment of Interstitial Cystitis in Women (2000)
    Springer
    International urogynecology journal 11 (2000), S. 113-119 
    Details
    ISSN: 1433-3023
    Keywords: Key words:Bladder augmentation – Interstitial cystitis – Orthotopic bladder substitution – S3 neurectomy – Surgical treatment – Urinary diversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Interstitial cystitis is a clinical entity that has been known for a century, but its pathophysiology remains largely unknown and the optimal treatment is a matter of ongoing discussion. A successful strategy for treatment relies on precise appraisal of symptoms, clinical findings and histology, as well as on the patient’s individual personality. The least invasive treatment possible should be chosen, and only after conservative options have been exhausted should a surgical solution be considered. In this respect, anatomical bladder capacity plays an important role. A large capacity indicates the potential for conservative treatment and may be regarded as a negative predictor for the outcome of orthotopic bladder substitution. In contrast, a small anatomical capacity is unlikely to respond to conservative therapy, but is associated with a high probability of successful orthotopic bladder substitution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001920050080
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  • 7
    Electronic Resource
    Electronic Resource
    The use of operative ultrasonography for the localization of renal calculi (1987)
    Springer
    World journal of surgery 11 (1987), S. 586-592 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La technique de la néphrotomie guidée par l'échographie pour localiser les calculs rénaux et par la sonographie-Doppler pour identifier les zones avasculaires du parenchyme rénal permet l'ablation transparenchymateuse des calculs sans avoir recours au clampage de l'artère rénale et au refroidissement rénal. Au cours de 175 opérations de ce type la perte moyenne de sang a été de 1,350 ml et le taux des échecs nécessitant une intervention secondaire a été de 2.8%. Malgré l'avènement de nouvelles modalités thérapeutiques non-invasives, cette méthode de traitement est encore employée dans 23% des cas de calculs coralliformes.
    Abstract: Resumen La técnica de nefrotomía guíada por ultrasonografía utilizando la escanografía de modo B para définir la localización de los cálculos y la sonografía de Doppler para identificar áreas avasculares del parenquima para la realización de las nefrotomías, permite la remoción tránsparenquimatosa de cálculos sin necesidad de oclusión de la arteria renal ni hipotermia del riñón. En 175 procedimientos realizados la pérdida promedio de sangre fue de 1,350 ml y la tasa de cálculos residuales que requirieron una intervención secundaria fue de 2.8%. A pesar del advenimiento de modalidades terapéuticas no invasivas, esta técnica todavía se aplica en 23% de los pacientes con cálculos coraliformes.
    Notes: Abstract The ultrasonically guided nephrotomy technique using B-scanning to identify the localization of stones and Doppler sonography to identify avascular parenchymal areas for nephrotomies allows for transparenchymal stone removal without the need for renal artery clamping and renal cooling. In 175 procedures the average blood loss was 1,350 ml and the rate of residual stones requiring a secondary intervention was 2.8%. Despite the advent of new noninvasive treatment modalities, this technique is still applied in 23% of staghorn stones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01655832
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  • 8
    Electronic Resource
    Electronic Resource
    Long-term metabolic effects in patients with urinary diversion (1998)
    Springer
    World journal of urology 16 (1998), S. 292-297 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The use of intestinal segments in genitourinary reconstruction could influence vitamin metabolism and affect the skeletal bone and its mineral content in the long term. In 137 patients, serum levels of the vitamins A, B1, B2, B6, B12, D, and E and of folic acid, bile acid, and ammonia as well as levels of intracorpuscular vitamin B12 and folic acid were examined and a red blood cell count was performed. The patients were divided into three groups (≤2 years, 〉2 to ≤4 years, and 〉4 years after surgery) as well as into children and adults. In addition, bone mineral density (dual-photon absorptiometry) was measured in 25 patients. Of these, 16 patients were ≈16.8 years s/p rectal reservoir, 6 were ≈20.5 years s/p colonic conduit, two were 6 and 8 years s/p ileocecal pouch, and one adolescent was 5 years s/p ileal bladder augmentation. In all patients the levels of vitamins A, B1, B2, B6, D, and E and of folic acid, bile acid, and ammonia as well as the red blood cell count were within normal ranges. In children (n= 51) there was no significant drop in vitamin B12 levels after the operation. In adults (n= 86), serum vitamin B12 levels dropped significantly from 402 ± 182 ng/l during the first 2 years after the operation to 292 ± 204 ng/l after the 4th year (normal range 240–1,100 ng/l). No significant increase in the intracorpuscular vitamin B12 level was observed during the same period. The bone mineral density was normal in all 25 patients with different types of urinary diversion. In addition to regular examination (sonography, creatinine levels, and base excess), vitamin B12 levels should be determined at 4 years after urinary diversion. It remains unclear whether substitution is necessary. However, substitution is easy to achieve and cheaper than the regular determination of vitamin B12. No decrease in bone mineral content was seen in the long-term follow-up with early correction of the base excess (below −2.5).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003450050069
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  • 9
    Electronic Resource
    Electronic Resource
    Refinements in buccal mucosal graft urethroplasty for hypospadias repair (1998)
    Springer
    World journal of urology 16 (1998), S. 192-194 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated our experience with buccal mucosa in urethral reconstruction for complex hypospadias repair in a total of 62 children operated on at our institution since 1990 at a mean follow-up of 23␣months. After the graft had been taken from the lower lip, with possible extension to the inner cheek, complete thinning of the graft was performed. The graft was then sutured in an onlay fashion to the urethral plate, and suprapubic urinary diversion was carried out for 3␣weeks. The overall complication rate in this rather complex series of patients, including 26 “hypospadias cripples,” was 13%; the complications involved 4 fistulas, 3 cases of graft necrosis, and only 1 meatal stenosis during the follow-up period. These favorable results prompted us to use buccal mucosa onlays as our current method of choice for urethral reconstruction with avoidance of tubularized repairs. The definite value of this technique, however, will become evident only after a longer follow-up period and confirmation of these favorable results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003450050051
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  • 10
    Electronic Resource
    Electronic Resource
    Parenchyma-sparing surgery for renal tumors (1991)
    Springer
    World journal of urology 9 (1991), S. 178-183 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Between 1969 und 1989 conservative surgery for kidney tumors was performed in 123 patients. In 49 patients there was an imperative indication for a parenchyma-sparing operation because nephrectomy would have made dialysis obligatory. Thirty-five of these 49 patients show no signs of tumor progression after a mean follow-up of 4.5 years. Known metastases were present in 3 of 6 patients who died as a result of their tumors. In two patients there was a recurrence after 1 and 5 years, respectively, requiring a second organ-preserving operation. In one further patient we suspect that multiple small tumor lesions may be present 2 years after the first operation. In 74 patients with a healthy contralateral kidney the tumor was enucleated by choice (elective indication). Sixty-eight of these 74 patients show no signs of tumor progression after a mean follow-up period of 3.3 years. One patient died from tumor metastases. Two patients had tumor recurrence, requiring nephrectomy and enucleation, respectively. Fifty-seven enucleated tumors were available for image analysis DNA cytometry. Only the two patients with a hypertriploid tumor died from their cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182837
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