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  • 1
    Electronic Resource
    Electronic Resource
    Infliximab and the bone in Crohn's disease (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02400.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Podium presentations (1993)
    Springer
    Diseases of the colon & rectum 36 (1993), S. P1 
    Details
    ISSN: 1530-0358
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02053958
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Parametric four-wave mixing in the 3d and 4d Rydberg states of NO (1998)
    Springer
    Applied physics 67 (1998), S. 253-256 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 42.65; 33.20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: 2 Σ+,H′ 2Π±(v′=2), and 4dσ,πO2Σ+,O′ 2Π±(v′=0) Rydberg states of NO molecules are described. The analyses of the two-photon excitation functions and infrared emission spectra revealed that only the 2Π- component was involved in PFWM. This is in good accordance with the absence of amplified spontaneous emission (ASE) in the 2Σ+ and 2Π+ components due to their predissociative character. Results provide some support for the mechanism that the generation of the vacuum ultraviolet radiation was brought by PFWM in which ASE served as a third driving wave.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400050502
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  • 4
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    Eltrombopag inhibition of acute myeloid leukemia cell survival does not depend on c-Mpl expression (2013)
    Nature Publishing Group (NPG)
    In: Leukemia
    Details
    Publication Date: 2013-05-09
    Description: Eltrombopag inhibition of acute myeloid leukemia cell survival does not depend on c-Mpl expression Leukemia 27, 1207 (April 2013). doi:10.1038/leu.2012.310 Authors: M Sugita, A Kalota, A M Gewirtz & M Carroll
    Print ISSN: 0887-6924
    Electronic ISSN: 1476-5551
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 5
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    Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation (2016)
    Oxford University Press
    Details
    Publication Date: 2016-07-30
    Description: The C-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit contains tandem repeats of the heptapeptide, Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. The CTD is subject to dynamic phosphorylation during transcription, mainly at serine residues (Ser2, Ser5 and Ser7). Regulation of CTD phosphorylation by specific kinases and phosphatases is crucial for coordinating transcription with RNA processing and histone modification. Human small CTD phosphatase 4 (SCP4), also called CTDSPL2 or HSPC129, is a putative CTD phosphatase belonging to the FCP/SCP family and implicated in control of - and -globin gene expression. Here, we report the biochemical and functional characterization of SCP4. SCP4 exhibited Ser5-preferential CTD phosphatase activity in vitro , while small interfering RNA-mediated SCP4 knockdown in HeLa cells increased phosphorylation levels of Pol II at Ser5 and Ser7, but not at Ser2. Furthermore, cell fractionation, chromatin immunoprecipitation and immunofluorescence assays revealed an exclusive localization for SCP4 in the chromatin, particularly at transcriptionally silenced chromosomal regions. Interestingly, SCP4 was gradually released from the chromatin fraction during hemin-induced erythroid differentiation of K562 cells, with concomitant cytoplasmic accumulation. Therefore, SCP4 is a unique chromatin-associated, Ser5-preferential CTD phosphatase that preferentially distributes to transcriptionally silenced gene regions and may participate in gene regulation during erythroid differentiation.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
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  • 6
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    Does subjective sleep quality improve by a walking intervention? A real-world study in a Japanese workplace (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2016-10-26
    Description: Objectives The purpose of this study was to evaluate the impact of a 4-week walking intervention on subjective sleep quality. Design A prospective open-label study. Participants A total of 490 healthy workers were included in the study. The 490 participants were divided into a group of 214 participants with exercise habits (exercising group, EG) and a group of 276 participants without exercise habits (non-EG). Interventions A walking intervention with a target of walking 10 000 steps daily for 4 weeks. Outcome measures The Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered twice (before the start and after the end of the study). Results Overall, the walking intervention improved the participants’ PSQI global score, sleep latency (minutes), sleep duration (hours), perceived sleep quality factor and daily disturbance factor. Among the EG participants, the walking intervention significantly improved the PSQI global score and perceived sleep quality. Among the non-EG participants, the walking intervention significantly improved the PSQI global score, sleep latency, sleep duration and perceived sleep quality. Conclusions A walking intervention might reduce the sleep latency and increase total sleep duration in working persons without exercise habits.
    Keywords: Open access, Mental health, Occupational and environmental medicine, Sports and exercise medicine
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 7
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    Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through Fc{gamma}R-mediated CD14 macrophage activation (2013)
    BMJ Publishing Group
    In: Gut
    Details
    Publication Date: 2013-11-08
    Description: Background Chronic inflammation characterised by IgG-producing plasma cell infiltration of colonic mucosa is a histological hallmark of ulcerative colitis (UC); however, whether its function is pathogenic or protective remains unclear. Objective To explore the contribution of intestinal IgG plasma cells to UC pathogenesis. Methods We isolated lamina propria mononuclear cells (LPMCs) from intestinal mucosa of UC patients and analysed the characteristics of intestinal plasma cells (expression profiles of differentiation molecules and chemokine receptors). We investigated the involvement of IgG-immune complex (IC)-Fc gamma receptor (FcR) signalling in intestinal inflammation by examining the cytokine production by LPMCs in response to IgG-IC stimulation. Results IgG plasma cells that were markedly increased in number in the inflamed mucosa of UC patients showed a distinct expression profile (CD19 + CD27 low , CCR10 low CXCR4 high ) compared with IgA plasma cells (CD19 +/– CD27 high , CCR10 high CXCR4 –/low ). In vitro IgG-IC stimulation activated intestinal CD14 macrophages that were increased in number in the inflamed mucosa of UC patients via FcRI and FcRII, and induced the extensive production of pro-inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin-1β (IL-1β), comparable to the effect of commensal bacteria stimulation. Co-stimulation with IgG-IC and commensal bacteria increased TNF and IL-1β production more than stimulation with the latter alone. Furthermore, IgG-IC notably up-regulated the expression of TL1A, whereas commensal bacteria specifically induced IL-23. Conclusions Collectively, these results demonstrate a novel aspect of UC pathogenesis in which unique IgG plasma cells infiltrate the inflamed mucosa via CXCR4, and critically influence UC pathogenesis by exacerbating mucosal inflammation through the activation of ‘pathogenic’ intestinal CD14 macrophages via IgG-IC-FcR signalling.
    Keywords: Ulcerative colitis
    Print ISSN: 0017-5749
    Electronic ISSN: 1468-3288
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 8
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    Visual assessment of Ki67 using a 5-grade scale (Eye-5) is easy and practical to classify breast cancer subtypes with high reproducibility (2015)
    BMJ Publishing Group
    Details
    Publication Date: 2015-04-17
    Description: Aims Personalised breast cancer therapy requires pathological characterisation of tumours. The proliferative index, based on Ki67, is pivotal, but a standard method has not been established. Here we look for an easy and practical way to evaluate Ki67. Methods Immunohistochemical staining of estrogen receptors, progesterone receptors, HER2 and Ki67 (MIB-1) was performed on resected specimens from 406 primary invasive ductal carcinomas. Ki67 labelling index (LI) from manual counting was compared with visual assessment using a 5-grade scale (Eye-5). Next, 10 pathologists evaluated 100 samples with marked hot spots by using Eye-5. Another 100 samples without marking were also assessed by eight pathologists. One year later, two pathologists reviewed 222 cases with Eye-5. Prognosis was analysed among estrogen receptor-positive cases with postoperative endocrine therapy. Results Eye-5 showed good correlation to LI. All 136 cases of score 4–5 had LI 〉20% and all 56 cases of score 1 had LI〈20%, which means that manual counting was not necessary for about half of the cases. Interobserver and intraobserver variability was low even when a hot spot was not fixed. Eye-5 also correlated with histological grade and lymph node metastasis. Combining Eye-5 and histological grade created a new algorism to predict LI, which allows 80% of all cases (74% of luminal cases) without manual counting. Cases of Eye-5 score 1–2 had significantly better survival than score 3–5. Conclusions Visual assessment of Ki67 by a 5-grade scale (Eye-5) is fast, easy, and reliable with acceptably low interobserver and intraobserver variability. Eye-5 can replace LI in many luminal tumours, and is a strong candidate as a standard method of evaluating Ki67.
    Keywords: Immunology (including allergy), Breast cancer
    Print ISSN: 0021-9746
    Electronic ISSN: 1472-4146
    Topics: Medicine
    Published by BMJ Publishing Group
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