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  • 1
    Electronic Resource
    Electronic Resource
    Be incorporation and surface morphologies in homoepitaxial InP films (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 67 (1995), S. 1122-1124 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have studied the mechanism of Be incorporation in InP homoepitaxial films grown by metalorganic molecular beam epitaxy. The actual Be concentration in the films reaches 1–2×1019 cm−3 while the hole concentration saturates at a lower value (large-closed-square)∼2×1018 cm−3 in our case). The measured lattice mismatch between film and substrate depends both on growth temperature and Be flux. The resulting changes in morphology suggest that the excess Be forms microclusters in the films grown at higher temperatures—due to the higher surface mobility, leading to the growth of oval defects. Be rejection to the surface is also observed. The surfaces of samples with no cap layer present a granulation which may be related to the formation of a new phase like Be3P2. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.114981
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  • 2
    Electronic Resource
    Electronic Resource
    Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole (2002)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC0–2 h. Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01262.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL-4, IL-5 and IL-10 on Peripheral Blood Mononuclear Cell Responses (1997)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 46 (1997), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chronic intestinal (INT) patients to SEA and SWAP is increased by the blockage of IL-10 with specific monoclonal antibodies (MAb). The effects of these antibodies were readily reversed by the addition of recombinant IL-10. In contrast, no effect was observed on the PBMC response of acute and hepatosplenic patients (HS) in the presence of anti-IL-10. Anti-IL-4 antibodies decreased the PBMC response of the intestinal (INT) and HS individuals to SEA and SWAP, and the PBMC response of acute patients to SEA but not to SWAP. Addition of anti-IL-5 MAb did not decrease the PBMC response of acute patients to SEA or SWAP. These results suggested that IL-10 has an important role in the modulation of the immune response in chronic asymptomatic patients and that this cytokine may be an important factor in controlling morbidity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.1997.d01-136.x
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic diversity in tropical maize inbred lines: heterotic group assignment and hybrid performance determined by RFLP markers (2000)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 119 (2000), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Tropical maize inbred lines, eight derived from a Thai synthetic population (BR-105) and 10 from a Brazilian composite population (BR-106), were assayed for restriction fragment length polymorphisms with 185 clone-enzyme combinations. The aim of this study was to investigate genetic distances among tropical maize material and their relationship to heterotic group allocation and hybrid performance. Genetic distances (GDs) were on average greater for BR-105×BR-106 lines (0.77) than for BR-106×BR-106 (0.71) and for BR-105×BR-105 (0.69) lines. Cluster analysis resulted in a clear separation of BR-105 and BR-106 populations and was according to pedigree information. Correlations of parental GDs with single crosses and their heterosis for grain yield were high for line crosses from the same heterotic group and low for line combinations from different heterotic groups. Our results suggest that RFLP-based GDs are efficient and reliable to assess and allocate genotypes from tropical maize populations into heterotic groups. However, RFLP-based GDs are not suitable for predicting the performance of line crosses from genetically different heterotic groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2000.00539.x
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  • 5
    Electronic Resource
    Electronic Resource
    Selection of mouse cells with amplified metallothionein genes retaining their glucocorticoid inducibility
    Amsterdam : Elsevier
    FEBS Letters 310 (1992), S. 75-78 
    Details
    ISSN: 0014-5793
    Keywords: Cadmium ; Gene amplification ; Glucocorticoid ; Heavy metal ; Metallothionein
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)81150-K
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  • 6
    Electronic Resource
    Electronic Resource
    Late effects of chronic graft-vs.-host disease in minor salivary glands (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of oral pathology & medicine 34 (2005), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The established pathologic criteria for minor salivary gland (MSG) involvement in chronic graft-vs.-host disease (cGVHD) could play a role in monitoring response to therapy.Methods:  We evaluated MSG sequential biopsies during cGVHD therapy in 14 allogeneic bone marrow transplantation (BMT) patients. Nine patients that did not develop GVHD after BMT entered the control group. Biopsies were examined using hematoxylin-eosin, Periodic acid-Schiff (PAS) and leukocyte common antigen staining.Results:  A significant loss of PAS+ acinar volume was observed at the diagnosis of cGVHD as much as at the end of treatment when compared with the control group. In the second evaluation, the inflammatory infiltrate was still greater than control group.Conclusions:  The results suggest that persistent xerostomia after cGVHD treatment is because of maintenance of lymphocytic infiltrate and consequent absence of MSG secretory unit recovery. This data may be useful to provide improved insight into the histopathology of this organ involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.2005.00347.x
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  • 7
    Electronic Resource
    Electronic Resource
    Induction of xylanase in Aspergillus tamarii by methyl β-d-xyloside (1997)
    Springer
    Applied microbiology and biotechnology 47 (1997), S. 267-271 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Aspergillus tamarii produced extracellular xylanase and intracellular β-xylosidase inductively in washed glucose-grown mycelia incubated with xylan and methyl β-d-xyloside, a synthetic glycoside. Methyl β-d-xyloside was a more effective inducer than xylan at the same concentration for both enzymes. Glucose and cycloheximide were found to inhibit xylanase production by methyl β-d-xyloside. Methyl β-d-xyloside was hydrolyzed to xylose by mycelial extract in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050925
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  • 8
    Electronic Resource
    Electronic Resource
    A New Approach to Linearly Perturbed Riccati Equations Arising in Stochastic Control (1998)
    Springer
    Applied mathematics & optimization 37 (1998), S. 99-126 
    Details
    ISSN: 1432-0606
    Keywords: Key words. Linearly perturbed Riccati equation, Strong solution, Mean square stabilizability, Nonobservable systems, Stochastic control. AMS Classification. 93E20, 93C60.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract. In this paper a linearly perturbed version of the well-known matrix Riccati equations which arise in certain stochastic optimal control problems is studied. Via the concepts of mean square stabilizability and mean square detectability we improve previous results on both the convergence properties of the linearly perturbed Riccati differential equation and the solutions of the linearly perturbed algebraic Riccati equation. Furthermore, our approach unifies, in some way, the study for this class of Riccati equations with the one for classical theory, by eliminating a certain inconvenient assumption used in previous works (e.g., [10] and [26]). The results are derived under relatively weaker assumptions and include, inter alia, the following: (a) An extension of Theorem 4.1 of [26] to handle systems not necessarily observable. (b) The existence of a strong solution, subject only to the mean square stabilizability assumption. (c) Conditions for the existence and uniqueness of stabilizing solutions for systems not necessarily detectable. (d) Conditions for the existence and uniqueness of mean square stabilizing solutions instead of just stabilizing. (e) Relaxing the assumptions for convergence of the solution of the linearly perturbed Riccati differential equation and deriving new convergence results for systems not necessarily observable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002459900070
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of d-fenfluramine on human experimental anxiety (1996)
    Springer
    Psychopharmacology 127 (1996), S. 276-282 
    Details
    ISSN: 1432-2072
    Keywords: Key wordsd-Fenfluramine ; Simulated public speaking ; Skin electrical conductance ; Aversive conditioning ; 5-Hydroxytryptamine ; Anxiety ; Panic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the role of 5-HT in human anxiety, the 5-HT releaser and uptake blocker d-fenfluramine (FEN) was administered to healthy volunteers under two models of experimental anxiety. The first was a simulated public speaking (SPS) test consisting of talking in front of a video camera, anxiety being evaluated mainly by self-rating scales. The second was a conditioned fear test, in which the changes in skin electrical conductance caused by a tone associated once with an aversive white noise were measured. The doses of 15 and 30 mg FEN, PO, decreased anxiety induced by SPS in a dose-dependent way, as indicated by the anxiety factor of Norris Visual Analogue Mood Scale. In the conditioned fear test, however, the amplitude and level of skin conductance responses to the conditioned aversive stimulus were not significantly changed by FEN. The differential effects of FEN in these human experimental models of anxiety, together with similar results reported in rats, support the view that 5-HT exerts a dual action on brain mechanisms regulating anxiety, facilitating conditioned while inhibiting unconditioned fear. The presumed reduction in unconditioned fear caused by FEN may have implications for the treatment of panic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050086
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  • 10
    Electronic Resource
    Electronic Resource
    Effect ofd-fenfluramine on human experimental anxiety (1996)
    Springer
    Psychopharmacology 127 (1996), S. 276-282 
    Details
    ISSN: 1432-2072
    Keywords: d-Fenfluramine ; Simulated public speaking ; Skin electrical conductance ; Aversive conditioning ; 5-Hydroxytryptamine ; Anxiety ; Panic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the role of 5-HT in human anxiety, the 5-HT releaser and uptake blockerd-fenfluramine (FEN) was administered to healthy volunteers under two models of experimental anxiety. The first was a simulated public speaking (SPS) test consisting of talking in front of a video camera, anxiety being evaluated mainly by self-rating scales. The second was a conditioned fear test, in which the changes in skin electrical conductance caused by a tone associated once with an aversive white noise were measured. The doses of 15 and 30 mg FEN, PO, decreased anxiety induced by SPS in a dose-dependent way, as indicated by the anxiety factor of Norris Visual Analogue Mood Scale. In the conditioned fear test, however, the amplitude and level of skin conductance responses to the conditioned aversive stimulus were not significantly changed by FEN. The differential effects of FEN in these human experimental models of anxiety, together with similar results reported in rats, support the view that 5-HT exerts a dual action on brain mechanisms regulating anxiety, facilitating conditioned while inhibiting unconditioned fear. The presumed reduction in unconditioned fear caused by FEN may have implications for the treatment of panic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246136
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