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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Cidofovir [(S)-1-(3-hydroxy-2-phosphonyl-methoxypropyl) cytosine] is a commercially available nucleotide analogue that has antiviral activity against a broad range of DNA viruses and is effective against human cytomegalovirus infection. Objectives We aimed to study the effect of cidofovir on growth of the highly aggressive melanoma tumour arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. Methods Mice were treated daily with systemic cidofovir at several doses. In treated and control groups, tumour growth was measured using a calliper, and histological studies were performed. Results In untreated mice, massive invasive melanoma tumours were observed on day 5 after tumour cell grafting. Cidofovir treatment gave a dose-dependent reduction in tumour size. Tumour growth was inhibited by 62% at a dose of 37·5 mg kg−1 three times weekly, as compared with control mice treated with saline alone. At 67 mg kg−1 three times weekly, tumour growth was inhibited by 90%. Increasing the cidofovir dose to 50 or 100 mg kg−1 daily resulted in a gradual increase in the antitumoral effect of the compound. In one experiment, cidofovir was administered at 100 mg kg−1 five times weekly from the eighth day after the injection of tumour cells, when the tumour already had a volume of approximately 100 mm3. In the treatment group, on the 14th day the tumour volume was approximately 200 mm3, while in the control group it had increased to 750 mm3. Conclusions Although the mechanism is unknown, an antitumoral or antiangiogenic effect may be the reason for the activity of cidofovir in this model. In view of our findings, use of cidofovir should be further explored in the treatment of neoplastic diseases.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Keratosis lichenoides chronica (KLC) is a rare chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhea-like dermatitis on the face. We report a 2-year-old girl diagnosed with KLC whose lesions, arranged in symmetrical linear fashion, improved after sunlight exposure during the summer.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background The Fas/Fas ligand (FasL) system plays a key part in maintaining tissue homeostasis via the induction of apoptosis. Functional impairment of the Fas/FasL system is associated with the development and progression of malignancies. Malignant melanoma cells and tissues have been shown to express Fas and FasL to variable extents. Objectives To demonstrate the expression and the presence of soluble circulating levels of Fas and FasL in cutaneous malignant melanoma. Methods Biopsy specimens of 42 patients with primary melanoma and nine patients with cutaneous metastatic melanoma were obtained for immunohistochemistry studies. All patients were followed for at least 5 years. In another 46 patients with melanoma (15 stage I and II; 11 stage III; and 20 stage IV) and in 10 healthy volunteer control subjects circulating levels of Fas and FasL were analysed with commercial ELISA tests. Results FasL was strongly positive in 38 (90%) of 42 primary melanomas; two of nine metastases did not express FasL. In the primary melanomas Fas was strongly or intensely positive in 17 (40%), moderately or weakly positive in 10 (24%) and negative in 15 (36%) of 42 melanomas. Soluble Fas plasma levels in patients with metastatic malignant melanoma were significantly elevated over those in the control group (P = 0·01). Conclusions The absence of Fas in most of the thick melanomas that did not metastasize, and in insitu melanomas, might be taken as a theoretical factor for a good prognosis. Soluble Fas is increased in patients with metastatic melanoma and might be associated with poor prognosis.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2021-05-19
    Description: The present paper defines the methodological path used in the project “Vertical Reference Hydrographic Network for the main Colombian maritime ports”, during the generation of reference vertical frame called “Vertical Reference Hydrographic Surface (SHRV2016)” for Buenaventura and Malaga bays in the Colombian Pacific, based on three main components: the mathematical determination of vertical datums associated with historical records of the water level, the establishment of first order geodetic points network, and the measurement of sea surface heights with reference to the WGS84 ellipsoid (World Geodetic System), using GNSS (Global Navigation Satellite System) receivers in differential mode RTK (Real Time Kinematic). The ground reference points were used to have precision vertical control to the datums in the water, and also for the installation of GNSS reference receivers, that were in charge of sending real time differential corrections during the measurement of sea surface heights. These measurements in connection to the calculated vertical datums densification for the area, formed the necessary basis for development the SHRV2016, a model with a spatial resolution of 500 meters, where all water level vertical datums refers to the WGS84 ellipsoid. In addition to standardize measurements made by different users in jurisdictional waters relative to a vertical datum; allowing to take advantage of the benefits of GNSS technology to perform the water level measurement and correction in real-time with the lesser degree of uncertainty during the execution of hydrographic surveying, optimizing time, quality and resources, particularly in places such as Buenaventura and Malaga bays, where the tidal regime makes complex the activity of correction due to the variability in range and phase of the sector, by which makes necessary install multiple tide stations, perform tasks of Surveying and Geodesy in difficult access places, and will wait for include tide gauge records in the final correction of the depths, only until the hydrographic survey will finish. In a medium term, the SHRV will allow the generation of a total tide datums reference model relative to the ellipsoid, covering completely the coastal and island regions of the country, up to the limits of the Territorial Sea, thanks to the combination with satellite altimetry data and observational offshore tools as GPS buoys, which allow the correct fusion with the local models generated in each one of the bays and harbors.
    Description: The present paper defines the methodological path used in the project “Vertical Reference Hydrographic Network for the main Colombian maritime ports”, during the generation of reference vertical frame called “Vertical Reference Hydrographic Surface (SHRV2016)” for Buenaventura and Malaga bays in the Colombian Pacific, based on three main components: the mathematical determination of vertical datums associated with historical records of the water level, the establishment of first order geodetic points network, and the measurement of sea surface heights with reference to the WGS84 ellipsoid (World Geodetic System), using GNSS (Global Navigation Satellite System) receivers in differential mode RTK (Real Time Kinematic). The ground reference points were used to have precision vertical control to the datums in the water, and also for the installation of GNSS reference receivers, that were in charge of sending real time differential corrections during the measurement of sea surface heights. These measurements in connection to the calculated vertical datums densification for the area, formed the necessary basis for development the SHRV2016, a model with a spatial resolution of 500 meters, where all water level vertical datums refers to the WGS84 ellipsoid. In addition to standardize measurements made by different users in jurisdictional waters relative to a vertical datum; allowing to take advantage of the benefits of GNSS technology to perform the water level measurement and correction in real-time with the lesser degree of uncertainty during the execution of hydrographic surveying, optimizing time, quality and resources, particularly in places such as Buenaventura and Malaga bays, where the tidal regime makes complex the activity of correction due to the variability in range and phase of the sector, by which makes necessary install multiple tide stations, perform tasks of Surveying and Geodesy in difficult access places, and will wait for include tide gauge records in the final correction of the depths, only until the hydrographic survey will finish. In a medium term, the SHRV will allow the generation of a total tide datums reference model relative to the ellipsoid, covering completely the coastal and island regions of the country, up to the limits of the Territorial Sea, thanks to the combination with satellite altimetry data and observational offshore tools as GPS buoys, which allow the correct fusion with the local models generated in each one of the bays and harbors.
    Description: Published
    Keywords: Referencia vertical ; superficie hidrográfica ; Bahía Málaga ; bahía de Buenaventura ; Nivel medio del mar ; Pleamar media de sicigia ; Bajamar media de sicigia ; Marea astronómica más alta ; ASFA_2015::G::Geophysics ; ASFA_2015::M::Mean sea level ; ASFA_2015::H::Hydrographic data
    Repository Name: AquaDocs
    Type: Journal Contribution , Not Known
    Format: pp.53-69
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