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  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The relation between the availability of newly synthesized protein and lipid and the axonal transport of optically detectable organelles was examined in peripheral nerve preparations of amphibia (Rana catesbeiana and Xenopus laevis) in which intracellular traffic from the endo-plasmic reticulum to the Golgi complex was inhibited with brefeldin A (BFA). Accumulation of fast-transported radio-labeled protein or phospholipid proximal to a sciatic nerve ligature was monitored in vitro in preparations of dorsal root ganglia and sciatic nerve. Organelle transport was examined by computer-enhanced video microscopy of single myelinated axons. BFA reduced the amount of radiolabeled protein and lipid entering the fast-transport system of the axon without affecting either the synthesis or the transport rate of these molecules. The time course of the effect of BFA on axonal transport is consistent with an action at an early step in the intrasomal pathway, and with its action being related to the observed rapid (〈1 h) disassembly of the Golgi complex. At a concentration of BFA that reduced fast-transported protein by 〉95%, no effect was observed on the flux or velocity of anterograde or retrograde organelle transport in axons for at least 20 h. Bidirectional axonal transport of organelles was similarly unaffected following suppression of protein synthesis by 〉99%. The findings suggest that the anterograde flux of transport organelles is not critically dependent on a supply of newly synthesized membrane precursors. The possibilities are considered that anterograde organelles normally arise from membrane components supplied from a post-Golgi storage pool, as well as from recycled retrograde organelles.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    PO Box 1354, 9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Publishing Ltd
    Geophysical prospecting 51 (2003), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The nth-order moments of the electromagnetic impulse response are useful for interpreting electromagnetic data. We have derived an analytic expression for the half-order moment of a conductive half-space. By inverting this expression, the measured half-order moment can be used to estimate an apparent conductivity of the ground. The first-order moment can also be used to estimate the half-space conductivity. A sensitivity analysis indicates that for an airborne EM configuration, the half-order moment will be most sensitive to material in the top 26–48 m, while the first-order moment will be sensitive to deeper material (down to depths between 66 and 127 m).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    Geophysical prospecting 46 (1998), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Interpretation of an anomalous magnetic response involves determining the parameters that characterize the source of the anomaly. The depth to the top of the structure is a parameter that is commonly sought, and the Source Parameter ImagingTM (SPITM) method is one way of determining this depth estimate. One advantage of the SPI method is that the depths can be displayed on an image. Typically there can be one image for an assumed contact (fault) model and another image for an assumed dipping thin sheet (dike) model. The depth estimate obtained will depend on the model assumed. An improvement to the source parameter imaging method extends the method to horizontal cylinders and at the same time allows the most appropriate model to be determined automatically. This model can be displayed on an image and the correct depth estimate for each anomaly can also be determined. The depth estimates can therefore be summarized on one map independent of an assumed model. The images generated from synthetic and field data show that the improved SPI method makes the task of interpreting magnetic data significantly easier.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    PO Box 1354, 9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Science Ltd
    Geophysical prospecting 53 (2005), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: We have developed a method for imaging magnetic data collected for mineral exploration to yield the following structural information: depth, model type (structural index) and susceptibility. The active nature of mineral exploration data requires we derive the structural information from a robust quantity: we propose that the first- or second-order analytic-signal amplitude is suitably stable. The procedure is to normalize the analytic-signal amplitude by the peak value and then use non-linear inversion to estimate the depth and the structural index for each anomaly. In our field example, different results are obtained depending on whether we inverted for the first- or second-order analytic-signal amplitude. This is probably because the two-dimensional contact, thin sheet or horizontal cylinder models we have assumed are not appropriate. In cases such as these, when our model assumptions are not correct, the results should not be interpreted quantitatively, but they might be useful for giving a qualitative indication of how the structure might vary.With a priori information, it is possible to assume a model type (i.e. set the structural index) and generate estimates of the depth and susceptibility. These data can then be gridded and imaged. If a contact is assumed, the susceptibility contrast is estimated; for the dike model, the susceptibility-thickness is estimated; for the horizontal cylinder, the susceptibility-area is estimated. To emphasize that the results are dependent on our assumed model, we advocate prefixing any derived quantity by the term ‘apparent’.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 57 (1990), S. 1087-1089 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report the homodyne detection of phase modulation sidebands induced on a laser beam by a coherently bunched electron beam. This provides a sensitive and nonperturbing measurement of complex Fourier time series components of the electron density. A proof-of-principle measurement of the microwave frequency component of electron density in a crossed-field device, which agrees well with a calculation of the same quantity, is reported.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 355-358 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A Michelson interferometer using a 5-mW He–Ne laser can either be used in a photodiode detector mode to resolve transient fringe shifts (approximately-less-than)10−4 fringe or in a streak mode to obtain entire nanosecond resolved density profiles in a single shot. Extreme sensitivity is achieved by avoiding most noise sources. The effects of plasma light and of ray deflection due to density gradients are compensated for by the use of a lens, stop, and filter combination. Vibration induced signals are nearly eliminated by the use of feedback stabilization. A differential light detector system which subtracts signals at opposite sides of a fringe protects against laser noise and other spurious signals while doubling the sensitivity. In the streak mode a cylindrical lens beam expander allows utilization of nearly all of the laser light.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Pigmentary glaucoma is a significant cause of human blindness. Abnormally liberated iris pigment and cell debris enter the ocular drainage structures, leading to increased intraocular pressure (IOP) and glaucoma. DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment ...
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  • 8
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Glaucomas are a major cause of blindness. Visual loss typically involves retinal ganglion cell death and optic nerve atrophy subsequent to a pathologic elevation of intraocular pressure (IOP). Some human glaucomas are associated with anterior segment abnormalities such as pigment dispersion ...
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 390 (1982), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurocytology 7 (1978), S. 611-621 
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light microscopic examination of living giant axons from the walking legs ofHemigrapsus nudus revealed intra-axonal inclusions which were usually several tens of micrometers long and about 5 μm wide. The inclusions were filled with small light-scattering particles. The inclusions were shown, by thin section electron microscopy, to be composed largely (68% by volume) of mitochondria. Each inclusion was surrounded by membrane bounded spaces which are presumed to represent a part of the smooth endoplasmic reticulum. Similar inclusions were not found in the leg axons of a variety of other decapod crustaceans.
    Type of Medium: Electronic Resource
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