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  • 1
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: In a study of the biochemical mechanisms of renal toxicity of acetaminophen, quantitative studies of the nonspecific kidney esterases were carried out in New Zealand white female rabbits. After the administration of a sublethal dose of 2.5 g/kg acetaminophen, four animals each plus four controls were sacrificed at 24 and 48 h. subsequent isoelectric focusing of kidney homogenate supernatants over a pH range of 3.5-8.0 showed marked changes in each of the groups. Zymograms of the nonspecific esterases in each group showed a characteristic pattern which deviated greatly from control animals. A morphological and histochemical examination of kidney sections from all animals showed no pathological changes in any of the kidneys. This would indicate that abnormal biochemical changes are being manifested in the kidney long before any morphological deviations. It would seem that this group of enzymes could provide a valuable market for early toxicological changes.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2014-12-13
    Description: One–dimensional analytical heat transport equations based on temperature time series data have become popular tools to quantify groundwater–surface water interactions. The influence of non–ideal field conditions on the use of these equations has been assessed for non–sinusoidal stream temperature signals, uncertainty in thermal parameters, sensor accuracy and multidimensional flow. Given that streambeds are often highly heterogeneous, the influence of streambed heterogeneity on flux estimates from temperature time series requires further investigation. Synthetic streambed temperatures were generated using two–dimensional numerical models with heterogeneous hydraulic conductivity distributions. Streambed temperatures were used to calculate fluxes using methods based on amplitude ratios ( A r ), phase shifts (Δ Φ ) and both ( A r Δ Φ ). Calculated fluxes were compared to known fluxes from the numerical models for flow fields analogous to losing streams. The influence of streambed structure, degree of heterogeneity, depth of the sensor pair, and location along a flow path were assessed. Errors in calculated fluxes increased with sensor pair depth, position along a flow path, and with the degree of heterogeneity. These errors were larger for streambeds with isotropic structures compared with anisotropic structures, and of the three methods tested; the Δ Φ method produced the largest errors. The simultaneous estimation of strong fluxes using Δ Φ , and an inability to obtain a flux estimate from A r can suggest the presence of low hydraulic conductivity zones. Given the large errors and inability to determine flow direction from the Δ Φ method, the A r and A r Δ Φ methods are recommended for downwelling fluxes. This article is protected by copyright. All rights reserved.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
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