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  • 1
    Electronic Resource
    Electronic Resource
    Conversion of biliary system to pancreatic tissue in Hes1 -deficient mice (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 83-87 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The biliary system, pancreas and liver all develop from the nearby foregut at almost the same time in mammals. The molecular mechanisms that determine the identity of each organ in this complex area are unknown. Hes1 encodes the basic helix-loop-helix protein Hes1 (ref. 1), which represses positive ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1273
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  • 2
    Electronic Resource
    Electronic Resource
    Differentiation of functional hepatocytes and biliary epithelial cells from immature hepatocytes of the fetal mouse in vitro (1993)
    Springer
    Anatomy and embryology 187 (1993), S. 221-229 
    Details
    ISSN: 1432-0568
    Keywords: Liver ; Biliary epithelial cells ; Hepatocytes ; Dexamethasone ; Matrigel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Differentiation of functional hepatocytes and biliary epithelial cells from immature hepatocytes was analysed in vitro. When fetal mouse liver fragments containing immature hepatocytes but no bile ducts were cultured organotypically, the immature hepatocytes differentiated into large hepatocytes. Some of these expressed bile duct markers such as cytokeratin and Dolichos biflorus agglutinin-binding sites, though only to a small extent, and typical intrahepatic bile duct cells failed to differentiate. Dexamethasone stimulated immature hepatocytes to differentiate into both mature hepatocyte and biliary epithelial cell lineages. Especially in the liver fragments cultured on Matrigel, dexamethasone stimulated the expression of bile duct markers (such as cytokeratin and binding sites for two types of lectin) in the immature hepatocytes. These results support the idea that immature hepatocytes can differentiate into both mature hepatocytes and biliary epithelial cells during normal development of the mouse liver, and suggest that glucocorticoids stimulate both these differentiation pathways. It also seems that basal laminar components may play a role in bile duct differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00195759
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  • 3
    Electronic Resource
    Electronic Resource
    Preferential differentiation of the bile ducts along the portal vein in the development of mouse liver (1992)
    Springer
    Anatomy and embryology 185 (1992), S. 17-24 
    Details
    ISSN: 1432-0568
    Keywords: Bile ducts ; Collagen ; Immunostaining ; Lectin binding sites ; Liver development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of bile ducts in the mouse liver was studied histochemically, with special reference to their preferential differentiation around the portal vein. Both portal vein and hepatic vein shared a common origin, the omphalomesenteric vein. In the early development of the liver, haematopoietic cells were predominant around both veins. With the progressive development of intrahepatic bile ducts, the following three steps were observed: cluster formation of type I hepatocytes around the portal vein, formation of primitive bile duct structures and basal lamina, then formation of ducts surrounded by connective tissue structures composed of type I and type III collagens and lectin-binding sites, which were predominant around the portal vein compared to the hepatic vein. These results suggest that the deposition of abundant connective tissue structures around the portal vein is a prerequisite for the cell differentiation and basal lamina formation in the bile duct precursors. A possible mechanism of the aggregation of type I hepatocytes around the portein vein is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213597
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  • 4
    Electronic Resource
    Electronic Resource
    Secondary joining of the bile ducts during the hepatogenesis of the mouse embryo (1987)
    Springer
    Anatomy and embryology 177 (1987), S. 153-163 
    Details
    ISSN: 1432-0568
    Keywords: Hepatogenesis ; Liver primordium ; Bile ducts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Development of the bile duct system of the mouse embryo was studied histologically and by an immunofluorescent technique. The hepatic primordium consisted of cranial and caudal portions. In the liver of young embryos, the hepatic cords were present in the presumptive cysticduct epithelium, and the histology of the presumptive cystic duct epithelium near the hilus was similar to that of the hilus epithelium. The results suggest that at least a part of the cystic duct epithelium develops from the cranial diverticulum of the hepatic primordium. Lumen structures were precursors of intrahepatic bile ducts and originated from type I (immature) hepatocytes. The lumina of the lumen structures appeared near the hilus area first, but most were discontinuous with those of the hepatic ducts. With the progress of development, the discontinuous lumen structures became distributed around the portal vein branches in the central part of the liver parenchyma, and gradually connected with each other and also with hepatic ducts. the discontinuous laminin immunofluorescence also appeared in the endodermal cells around the portal vein branches at the younger stages. Therefore, it is conceivable that the intrahepatic bile ducts originate from discrete cell populations of type I hepatocytes around the portal vein branches and subsequently become confluent, but not from the cells of hepatic ducts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572540
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  • 5
    Electronic Resource
    Electronic Resource
    Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytes (1994)
    Springer
    Cell & tissue research 278 (1994), S. 117-123 
    Details
    ISSN: 1432-0878
    Keywords: Cytokeratin ; Bile duct ; Differentiation ; Hepatocytes ; Basal lamina ; α-Fetoprotein ; Mouse (C3H/HeSlc)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The differentiation of hepatocytes and biliary epithelial cells has been histochemically analyzed with anti-calf cytokeratin antiserum in the fetal mouse liver. Almost all young fetal hepatocytes transiently express bile-duct-specific cytokeratin; subsequently, the strong staining of the cytokeratin is confined to progenitor cells of intrahepatic biliary epithelial cells around portal veins. These results suggest that all fetal hepatocytes are bi-potent in terms of the differentiation of mature hepatocytes and intrahepatic bile-duct cells, and that the microenvironment around portal veins plays an important role in bile-duct differentiation. Large periportal hepatocytes continue to stain weakly for cytokeratin until 2 weeks after birth, although the number of positive hepatocytes decreases with development. The differentiation of bile ducts from periportal hepatocytes may continue for 2 weeks after birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305783
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  • 6
    Electronic Resource
    Electronic Resource
    Transient expression of bile-duct-specific cytokeratin in fetal mouse hepatocytes (1994)
    Springer
    Cell & tissue research 278 (1994), S. 117-123 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Cytokeratin – Bile duct – Differentiation – Hepatocytes – Basal lamina –α-Fetoprotein – Mouse (C3H/HeSlc)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The differentiation of hepatocytes and biliary epithelial cells has been histochemically analyzed with anti-calf cytokeratin antiserum in the fetal mouse liver. Almost all young fetal hepatocytes transiently express bile-duct-specific cytokeratin; subsequently, the strong staining of the cytokeratin is confined to progenitor cells of intrahepatic biliary epithelial cells around portal veins. These results suggest that all fetal hepatocytes are bi-potent in terms of the differentiation of mature hepatocytes and intrahepatic bile-duct cells, and that the microenvironment around portal veins plays an important role in bile-duct differentiation. Large periportal hepatocytes continue to stain weakly for cytokeratin until 2 weeks after birth, although the number of positive hepatocytes decreases with development. The differentiation of bile ducts from periportal hepatocytes may continue for 2 weeks after birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305783
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