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  • 1
    Digitale Medien
    Digitale Medien
    Exogenous Sources of Urinary Phenol and Indole Acids (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 797-798 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Two healthy adults were placed on a high-protein diet from which materials of plant origin were excluded in order to minimize the excretion of exogenous phenol and indole acids. Control urines were collected for 6 hr. on the second and third days. One subject then ingested 4 bananas (480 gm.) and ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/182797a0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of Atmospheric Contaminants on Paper Chromatography of Urinary Indole and Phenol Acids (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 664-664 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The occurrence of chromatographic difficulties appeared to coincide with an increased level of atmospheric contaminants. The eye-irritating haze known as smog , develops frequently in the Los Angeles area where topography and meteorological conditions favour the formation of a large stagnant air ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/182664a0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet (1982)
    Springer
    Journal of inherited metabolic disease 5 (1982), S. 95-99 
    Details
    ISSN: 1573-2665
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A brother and sister aged 11 and 17 years have been reported previously to have hyperargininaemia and arginase deficiency: they were treated with a semi-synthetic diet consisting of fat, carbohydrate, minerals, vitamins and essential amino acids in amounts equivalent to 0.55–0.65 g protein kg−1 day−1 for 2 years. Plasma arginine levels fell from 0.50–0.90 µmol/l to 0.13–0.30 µmol/l (normal range 0.02–0.15). Increased concentrations of arginine in the cerebrospinal fluid (CSF) fell from 0.069–0.098 µmol/l to 0.040–0.056 µmol/l (normal mean ± SD=0.020±0.006). Dibasic aminoaciduria returned to normal within 1 week. Substitution of the keto-acid analogues of five essential amino acids in the formula lowered arginine concentrations further, but proved to be unpalatable. Urinary concentrations of orotic acid, uridine and uracil fell toward normal but remained increased, even when the plasma ammonia concentration was measured as normal. Both patients showed a stable clinical improvement.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01800000
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Immune functions in methylmalonicaciduria (1984)
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 12-14 
    Details
    ISSN: 1573-2665
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A variety of phagocytic cell and lymphocyte assays were employed to evaluate the immune status of four patients with methylmalonicaciduria. One patient had a depressed absolute granulocyte count and two patients had depressed neutrophil and monocyte chemotactic responses. All subjects had normal neutrophil phagocytic and bactericidal activities. One patient had a decreased T-cell number; blastogenic responses to phytohaemagglutinin and pokeweed mitogen were normal in all subjects. B lymphocyte measurements were variably abnormal; two children had decreased B-cell numbers; two had marginally decreased IgG levels; a third had an undetectable rubella titre; and two had elevated serum IgE concentrations.In vitro exposure of normal cells to methylmalonic acid concentrations up to 50mg/100 ml did not affect chemotactic or lymphoproliferative responses. In conclusion, although B-cell function may be affected, no consistent abnormality of lymphocyte or phagocytic cell functions could be attributed to the metabolic disorder.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01805612
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Neonatal pyruvate carboxylase deficiency with renal tubular acidosis and cystinuria (1983)
    Springer
    Journal of inherited metabolic disease 6 (1983), S. 89-94 
    Details
    ISSN: 1573-2665
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This report concerns a patient with severe congenital lacticacidosis associated with proximal renal tubular acidosis and cystinuria. Enzyme studies with cultured skin fibroblasts obtained from the patient revealed zero pyruvate carboxylase activity, but propionyl-CoA carboxylase activity was normal. Administration of various vitamins in large amounts did not improve the clinical condition. In contrast, the patient began to thrive when her diet was supplemented with aspartic acid, asparagine, glutamic acid, and glutamine. The particular dietary treatment used and the biochemical findings merit consideration for management of future cases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01800731
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Hepatic metabolites and uric acid excretion in fructose-1,6-diphosphatase deficiency (1988)
    Springer
    Journal of inherited metabolic disease 11 (1988), S. 303-304 
    Details
    ISSN: 1573-2665
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01800375
    Standort Signatur Einschränkungen Verfügbarkeit
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