Note: Front Cover -- The Endocrine Function of the Human Testis -- Copyright Page -- Table of Contents -- PREFACE -- Chapter 1. Determination of Androgens in Human Plasma -- Acknowledgement -- References -- CHAPTER 2. METHODOLOGIC CONSIDERATIONS ON THE MEASUREMENT OF PLASMA ANDROGENS BY COMPETITIVE PROTEIN BINDING METHODS AND RADIO-ASSAYS -- Abstract -- Symbols -- Introduction -- Reliability Criteria of Competitive Binding Analysis -- Methodologie Problems of Competitive Binding Methods for the Measurement of Androgens -- Extraction of androgens from plasma and elimination of nonspecific interference -- Acknowledgments -- References -- Chapter 3. Problems Connected with Steroid Radioimmunoassay -- 1. Steroid antisera -- 2. Assay optimization -- 3. Extraction and purification procedures -- 4. 125 I labelled steroid-TME derivatives as tracers in steroid -- References -- Chapter 4. Mathematical Analysis of the Results of Competitive Binding Methods -- Abstract -- Symbols -- Introduction -- Choice of model -- Arcsin transformation -- Orthogonal polynomials -- Logit-log transformation -- Analysis of transformations -- The modified logit-log model -- Experimental examination of the models -- Conclusions -- Acknowledgments -- References -- CHAPTER 5. DETERMINATION OF ANDROGENS IN PLASMA -- Abstract -- Introduction -- 1. Gas Chromatographie determination of plasma testosterone. -- II. Testosterone determination by competitive protein binding -- III. Determination of plasma testosterone by radioimmunoassay -- Summary -- References -- CHAPTER 6. DETERMINATION OF TESTOSTERONE IN PERIPHERAL AND SPERMATIC VENOUS PLASMA BY A COMPETITIVE PROTEIN BINDING METHOD -- Abstract -- Symbols -- Introduction -- Materials and Reagents -- Method -- Results -- Discussion -- Acknowledgments -- References -- CHAPTER 7. GAS CHROMATOGRAPHIC DETERMINATION OF PLASMA TESTOSTERONE. , Introduction -- General Considerations -- III. Validation of the Procedure -- IV. SUMMARY AND CONCLUSIONS -- APPENDIX 1. DESCRIPTION OF THE PROCEDURE -- APPENDIX 2. MATERIALS -- Acknowledgements -- References -- CHAPTER 8. ELEMENTS OF A FORWARD APPROACH TO THE MECHANISM OF ANDROGEN ACTION -- Abstract -- General metabolism -- Transport -- Testosterone metabolism in target organs and mode of action -- Androgen receptors in target cells -- Testosterone : a connecting molecule -- References -- CHAPTER 9. THE PHYSICAL STATE OF TESTOSTERONE IN PLASMA -- Abstract -- Introduction -- Four plasma proteins are known to bind testosterone -- Reproducibility -- Comments -- References -- Chapter 10. Mathematical Models for Study of Androgen Metabolism -- Summary -- References -- CHAPTER 11. THE METABOLIC CLEARANCE RATE AND THE METABOLISM OF TESTOSTERONE -- Abstract -- Introduction -- 1. The hepatic bloodflow -- 2. The hepatic extraction -- 3. The extrahepatic clearance -- Summary -- References -- Chapter 12. Recent Data on the Chemistry of Human Gonadotropins -- References -- Chapter 13. Immunochemical and Biological Nature of Gonadotrophin Subunits -- Acknowledgements -- References -- Chapter 14. Aspects of the Mechanism of Action of Gonadotrophins -- Introduction -- Experimental design -- Ovarian Carbohydrate Metabolism -- Amino acid transport and protein synthesis -- Concluding remarks -- Acknowledgements -- References -- Chapter 15. Radioimmunoassay of Gonadotropins -- Summary -- I. The first problem: the hormone preparation for labeling -- II. The second problem: specificity of antiserum against FSH or LH -- III. Third problem: Choice of a reference preparation -- IV. Methods of Separating Free from Antibody-Bound Gonadotrophins -- V. Application of FSH and LH radioimmunoassay to urines -- VI. Application of gonadotrophin radioimmunoassay -- References. , Chapter 16. Characteristics of a Solid Phase Method for FSH and LH -- Summary -- Introduction -- II - Binding of the antibody to the plastic surface -- Ill - Reaction between bound antibodies and the antigen -- IV - Preparation of radioiodated hormones -- Conclusion -- Acknowledgements -- References -- Chapter 17. Sexual Differentiation of the Hypothalamic "Prolactin Inhibiting Factor Center" and Other Brain Areas -- Introduction -- I. Sexual differentiation of gonadotrophic secretion and sexualbehaviour -- II. Sexual differentiation of prolactin secretion -- III. Sexual differentiation of non-reproductive behavioural patterns -- Acknowledgement -- References -- Chapter 18. Organizing Effects of "Early" Testosterone Secretion on Steroid Metabolism and Binding -- A. Testosterone Secretion During Fetal and Neonatal Life -- B. General Survey of the Changes Induced by Pre- or Neonatal Testosterone Secretion -- C. Steroidal and other Biochemical Changes Programmed by Pre- or Neonatal Testosterone -- D. Clustering of the Testosterone Induced Changes: An Attemptto Relate the Steroidal Changes to Morphological and Behavioral Differentiation -- E. A Search for the Teleonomy of the Changes in Steroid Metabolism Induced by Pre- or Neonatal Testosterone -- F. Possible Role of Steroid Binding in Regression of Facilitation Induced by "Early" Testosterone Secretion -- G. Effect of Estrogens on the Differentiation Induced by Fetal and Neonatal Testosterone -- H. Conclusion -- References -- Chapter 19. Mechanisms Which Control Puberty in Males -- Introduction -- II. Results -- III. Discussion -- Acknowledgment -- References -- Chapter 20 The Hypothalamic Gonadotrophin Releasing Factors -- Summary -- References -- Chapter 21. In Vitro Methods for the Study of Releasing Hormones -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion. , Acknowledgements -- References -- Chapter 22. Synthetic Gonadotropin Releasing Hormone: A Powerful Tool for the Clinician -- Abstract -- References -- Chapter 23. Feedback Activity of Testosterone and of its 5a-Reduced Metabolites -- Introduction -- II. Results -- III. Conclusions -- Acknowledgment -- References -- Chapter 24. Human Gonadotropin Secretion in Male Subjects -- Summary -- A. Influence of Testosterone -- B. Factors controlling FSH secretion -- C. Influence of Clomiphene -- D. Influence of Releasing-Factor -- E. Gonadotropin function in various disease states in men -- References -- Chapter 25. Regulation of the Production of Testicular Steroids -- Introduction -- Acknowledgement -- References -- CHAPTER 26. ANDROGEN DEPENDENCY OF SPERMATOGENESIS AND THE PHYSIOLOGICAL SIGNIFICANCE OF STEROID METABOLISM IN VITRO BY THE SEMINIFEROUS TUBULES -- Summary -- Introduction -- Androgen Dependency of Spermatogenesis -- Physiological significance of steroid metabolism in vitro by the seminiferous tubules -- Separation of the tubules and interstitium and the possibility of cross-contamination -- Metabolism of cholesterol by the seminiferous tubules -- Relative abilities of the interstitium and seminiferoustubules of the rat testis to metabolise progesterone to testosterone in vitro -- Correlation between events occurring in vivo and changesin steroid metabolism by the seminiferous tubules in vitro -- The Sertoli cells as the site of androgen production:biochemical and morphological studies -- Steroid metabolism by the seminiferous tubules of the human testis in vitro -- Endogenous production of testosterone by the interstitium and tubules in vitro and the roles of LH and FSH -- General Discussion and Conclusions -- Acknowledgements -- References. , Chapter 27. Biochemical Functions of Isolated Interstitial Tissue and Seminiferous Tubules from Rat Testis -- Introduction -- References -- Chapter 28. Evaluation of Male Infertility by Dynamic Tests -- Summary -- Introduction -- Acknowledgments -- References -- SUBJECT INDEX.

Note: Front Cover -- The Endocrine Function of the Human Testis -- Copyright Page -- Table of Contents -- PREFACE -- Chapter 1. Steroid Secretion by the Testis in Man -- Introduction -- Measurement -- Testosterone Secretion -- Dihydrotestosterone -- Estrogens -- 17 - hydroxyprogesterone -- Δ5 -3β-hydroxysteroids -- References -- Chapter 2. Temporal Variations of Testosterone and Gonadotrophins in Man -- Acknowledgements -- References -- Chapter 3. Steroid Regulation of Gonadotropin Secretion -- Introduction -- References -- Chapter 4. Gonadotrophins and Plasma Testosterone in Senescence -- Materials and Methods -- Results -- Discussion -- References -- Chapter 5. Genetic Lesions of the Leydig Tissue -- 1. Tardive anorchia (the vanishing testes). -- 2. Turner's syndrome with male phenotype -- 3. Monoorchitic dysgenesis (mixed gonadal dysgenesis with testis). -- 4. Orchitic hermaphroditism. -- 5. The Royer syndrome (male subjects with uterus). -- 6. The Reifenstein syndrome -- 7. Ordinary male pseudohermaphroditism -- 8. The YY Syndrome -- 9. The XX males -- 10. The Klinefelter syndrome -- 11. Hypogonadotropic hypogonadism -- References -- Chapter 6. Androgen Secretion in Male Hypogonadism -- Introduction -- Androgens and the Assessment of Androgen Secretion -- Radioimmunoassay of plasma T -- Androgens In Male Hypogonadism -- References -- Chapter 7. Testosterone Metabolism and Action in Testicular Feminization Syndrome -- Introduction -- The 5α-Reduction of Testosterone in Testicular Feminization Syndrome -- The Intracellular Androgen Binding Protein in Testicular Feminization Syndrome -- The Extracellular Binding of Testosterone to TeBG in the Testicular Feminization Syndrome -- An Attemptedlnterpretation of the Different Abnormalities Observed in Testicular Feminization Syndrome -- References -- Chapter 8. Male Sexual Precocity The Clinician's View. , References -- Chapter 9. Leydig Cell Secretion in (Pre) Pubertal Boys and in Delayed Puberty -- Delayed puberty -- Agonadal boys -- References -- Chapter 10. The "Fertile Eunuch" Syndrome : Primary or Hypogonadotrophic Dissociated Hypogonadism? -- Summary -- Results -- Discussion -- References -- Chapter 11. Testicular Germinal Dysgenesis Associated with Idiopathic Hypothyroidism and Renal Tubular Acidosis -- Discussion -- Conclusions -- References -- Chapter 12. Gonadal Morphology and Non-Responsiveness to Androgens in the Testicular Feminization Syndrome -- Summary -- Clinical and histological studies -- Discussion -- References -- Chapter 13. Human Chorionic Gonadotrophin as Stimulator for Androgen Secretion -- References -- Chapter 14. Gonadotrophin Levels in Infertile Patients -- 1. Method of Investigation of Gonadotrophin Secretion -- II. Aetiological Diagnosis of Infertility Associated with Hypogonadism -- III. Relationship between FSH and LH levels and Spermatogenesis -- Summary -- References -- Chapter 15. Management and Treatment of Male Pseudohermaphrodites -- Syndrome of androgen non-responsiveness -- Patients with female external genitals -- Patients with ambiguous external genitals -- References -- Chapter 16. Hormonal Control of Spermatogenesis -- Materials and Methods -- Results -- Discussion -- Acknowledgement -- References -- SUBJECT INDEX.