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  • 1
    Online Resource
    Online Resource
    Forschungsvorhaben 1: "Innovative medizinische Systeme und Implantate im Blutkontakt: Regenerative und adaptive Konzepte als Grundlage für eine optimierte Patientenversorgung" : Schlussbericht : Förderzeitraum: 1.11.2016-31.10.2019 (2019)
    Rostock : Universitätsmedizin Rostock
    Details Availability
    Keywords: Forschungsbericht ; Drug-eluting Stent ; Kunststoff ; Beschichten ; Biokompatibilität ; Blutgefäß
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (231 Seiten, 9,48 MB) , Illustrationen, Diagramme
    URL: https://doi.org/10.2314/KXP:1747858250
    DOI: 10.2314/KXP:1747858250
    Language: German
    Note: Förderkennzeichen BMBF 03ZZ0906A+C+E-J , Verbundnummer 01168933 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Sonstige Körperschaften, die mit dem Werk in Verbindung stehen und Teilvorhaben teilweise dem Förderkatalog entnommen , Teilvorhaben "Innovative medizinische Systeme und Implantate im Blutkontakt - Konzepte für regenerative Polymerstents, Wirkstoffbeschichtungen und Biokompatibilität" , Teilvorhaben TP3: „Ionische Flüssigkeiten für Stentbeschichtungen“ , Teilvorhaben 5: Molekular-dynamische Prozesse an Grenzflächen zwischen Biomaterialien und humanen Zellen : hier zusammengefasst die AP 1.8 und 1.9 da diese thematisch zusammenhängen , Teilvorhaben „Innovative medizinische Systeme und Implantate im Blutkontakt (TP6), Kardio EMAU“ , TP7: Bioresponsive Hydrogel-Beschichtung für Gefäßstents , Teilvorhaben „Innovative medizinische Systeme und Implantate im Blutkontakt: Prüfung des Einsatzes von additiven Fertigungsverfahren zur Herstellung von neuartigen, geometrisch komplexen, abbaubaren Gefäßstützen“ , Teilprojekt am Institut für ImplantatTechnologie und Biomaterialien e.V. „In vitro Prüfungen und Abbau von Implementierungshürden“ , Teilvorhaben „Entwicklung bioabbaubarer Drug-Eluting-Scaffolds“
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  • 2
    Electronic Resource
    Electronic Resource
    Correlation of endothelial vimentin content with hemodynamic parameters (1998)
    Springer
    Histochemistry and cell biology 110 (1998), S. 161-167 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  In mammalian species, vimentin is the sole intermediate filament protein of endothelial cells lining the chambers of the heart and the inner surface of large blood vessels. Obvious quantitative differences in the vimentin-like immunoreactivity of endothelial cells observed in different vascular segments led us to undertake a systematic survey on the endothelial content of vimentin throughout the heart chambers, the vena cava, the pulmonary trunk, and the aorta of the pig. Immunostaining and immunoblotting showed that vimentin in endothelial cells of cardiovascular segments exposed to high shear stress and blood pressure (pulmonary trunk, aorta, left ventricle) is approximately 2- to -3-fold higher than in endothelial cells exposed to lower levels of hemodynamic stress (vena cava, left and right atria, right ventricle). Throughout the aorta, an approximately 1.5-fold increase in the vimentin contents was observed in a proximal to distal direction. The total endothelial amount of vimentin was determined to be 1.2% (inferior vena cava) and 2–3.5% (aorta) of total cellular protein. These data support the notion that the endothelial vimentin cytoskeleton can adapt to different hemodynamic loads, indicating that vimentin might help endothelial cells to withstand the mechanical forces exerted by blood flow and blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180050277
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Structural and functional aspects of intercellular junctions in vascular endothelium (1998)
    Springer
    Basic research in cardiology 93 (1998), S. s030 
    Details
    ISSN: 1435-1803
    Keywords: Key words VE-cadherin – catenins shear stress – permeability actin filaments – cytoskeleton
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cell-to-cell-junctions of endothelial cells are specialized and differentiated areas of the plasma membrane. The main functions include the separation of the intravascular and extravascular compartments, the mechanical connection of the cells, and the maintenance of the cell polarity. Although a wide heterogeneity of endothelial cell-to-cell junctions exists in situ, they should be considered in general as adherens type junctions in which gap and tight junctions are morphologically inserted. Under certain pathological conditions, such as wound healing, angiogenesis and many types of inflammation, the interendothelial junctions have to be dissociated and reorganized in which proteins of the junctions are crucially involved. These important mechanisms predict a sophisticated regulation of junctional proteins. The present paper describes the organization and functional aspects of the occludin/ZO-1 complex typically found in tight junctions, the cadherin/catenin complex of the adherens junctions and the connection of these protein complexes to the dense peripheral band via actin filaments. In addition, special attention has been drawn on the function of junction-associated proteins with respect to their role under fluid shear stress and interendothelial gap formation during inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003950050205
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  • 4
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    Endothelial Alpha-Parvin Controls Integrity of Developing Vasculature and Is Required for Maintenance of Cell-Cell Junctions [Cellular Biology] (2015)
    American Heart Association (AHA)
    Details
    Publication Date: 2015-06-19
    Description: Rationale: Angiogenesis and vessel integrity depend on the adhesion of endothelial cells (ECs) to the extracellular matrix and to adjacent ECs. The focal adhesion protein α-parvin (α-pv) is essential for vascular development. However, the role of α-pv in ECs in vivo is not known. Objective: To determine the function of α-pv in ECs during vascular development in vivo and the underlying mechanisms. Methods and Results: We deleted the α-pv gene specifically in ECs of mice to study its role in angiogenesis and vascular development. Here, we show that endothelial-specific deletion of α-pv in mice results in late embryonic lethality associated with hemorrhages and reduced vascular density. Postnatal-induced EC-specific deletion of α-pv leads to retinal hypovascularization because of reduced vessel sprouting and excessive vessel regression. In the absence of α-pv, blood vessels display impaired VE-cadherin junction morphology. In vitro, α-pv–deficient ECs show reduced stable adherens junctions, decreased monolayer formation, and impaired motility, associated with reduced formation of integrin-mediated cell–extracellular matrix adhesion structures and an altered actin cytoskeleton. Conclusions: Endothelial α-pv is essential for vessel sprouting and for vessel stability.
    Keywords: Angiogenesis, Developmental biology
    Print ISSN: 0009-7330
    Electronic ISSN: 1524-4571
    Topics: Medicine
    Published by American Heart Association (AHA)
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