GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 68 (1997), S. 1-10 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Computertomographie (CT) ; Magnetresonanztomographie (MRT) ; ICD-10 ; Psychiatrische Diagnostik ; Key words Computed tomography (CT) ; Magnetic resonance imaging (MRI) ; ICD-10 ; Psychiatric diagnoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This paper evaluates the role of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of psychiatric disorders according to the “International Classification of Diseases” (ICD-10). Indications for CT/MRI can be derived from ICD-10 for the identification or exclusion of defined cerebral lesions resp. for the etiology in organic disorders. Due to the lack of specific morphological findings, CT/MRI do not contribute to the classification of all other diagnoses. CT/MRI can only exclude causal organic factors. However, ICD-10 provides only few guidelines for ruling out cerebal pathology (e. g. tumors in bulimic anorexia). Therefore, recommendations for routine CT/MRI-investigations for the exclusion of organic disorders are required and might be developed by the quality assurance. Application of CT or MRI: CT plays an important role in diagnostic imaging in routine as well as in emergency situations (haemorraghe, hamatoma, infaction, head injury, tumour, vascular malformation). MRI on the other hand, is more sensitive in the diagnosis of inflammatory diseases, skull base lesions, degenerative changes of the white matter and in the imaging of hydrocephalus and epilepsy.
    Notes: Zusammenfassung In dieser Arbeit wird der Stellenwert der Computertomographie (CT) und Magnetresonanztomographie (MRT) für die psychiatrische Diagnostik unter Berücksichtigung der „Internationalen Klassifikation psychischer Störungen“ (ICD-10) dargestellt. Indikationen für CT/MRT-Untersuchungen lassen sich nach der ICD-10 in erster Linie für den Nachweis oder Ausschluß spezifischer zerebraler Läsionen bzw. die ätiologische Klärung bei Verdacht auf organisch bedingte Störungen herleiten. Für die Klassifikation aller anderen Störungen tragen CT/MRT nicht bei, da keine spezifischen morphologischen Befunde zu erwarten sind. Allenfalls kann die Diagnosesicherheit durch den Ausschluß zerebaler Prozesse erhöht werden. Allerdings bietet die ICD-10 nur in Ausnahmefällen an Hand der aufgeführten organischen Differentialdiagnostik (z. B. Hirntumor bei bulimischer Anorexie) Hinweise für die Indikationen von CT/MRT. Empfehlungen für den Einsatz beider Schnittbildtechniken für die somatische Ausschlußdiagnostik im Rahmen der psychiatrischen Qualitätssicherung wären daher erforderlich. Die Anwendung von CT oder MRT: die CT kommt v. a. in der Notfall- und Routinediagnostik (Blutung, Hämatom, Infarkt, Schädel-Hirn-Trauma, Tumor, vaskuläre Malformation) zum Einsatz, während die MRT sensitiver für den Nachweis von entzündlichen Prozessen, basisnahen Läsionen, Marklagerdegenerationen und in der Hydrozephalus- und Epilepsiediagnostik ist.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-2072
    Keywords: Key words EMD 57445 ; Sigma receptor ; Antipsychotic ; Dopamine receptor ; Iodobenzamide ; Single photon emission computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: EMD 57445 (panamesine) is a high affinity sigma ligand with the profile of an atypical antipsychotic in animal studies. It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D2 and D3 dopamine (DA) receptors. Objectives: The aim of this study was to test, using single photon emission computed tomography (SPECT) and [123I]iodobenzamide (IBZM) as the radiotracer, whether EMD 59983 would pass the blood-brain barrier and to what extent it would contribute to the effects of EMD 57445 in schizophrenia. Methods: Two IBZM SPECT-scans were performed in five neuroleptic-free schizophrenic patients (DSM IV), one before and one after treatment with 60 mg panamesine daily for a treatment duration of 12–26 days. Results: A high occupancy of striatal D2-like DA receptors similar to that induced by typical neuroleptics was observed in all patients treated with EMD 57445. Conclusions: Our results suggest that a possible antipsychotic activity of EMD 57445 in schizophrenia is not necessarily attributable to its affinity for sigma receptors, but could be simply due to the potent antidopaminergic effects of EMD 59983, its main metabolite.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...