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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Mycophenolate mofetil (MMF) is an immunosuppressive agent that has been shown to be effective in transplant patients. Some case reports and pilot studies have suggested efficacy against systemic lupus erythematosus (LE), particularly in the case of lupus nephritis. Reports on MMF treatment of skin manifestations of LE are still anecdotal. We report two cases with extensive skin lesions owing to subacute cutaneous LE (SCLE). Both patients had been treated with azathioprine and antimalarials without effect. Finally both patients were given highly dosed glucocorticosteroids, which were also ineffective but led to vertebral fractures because of long-term steroid treatment in one patient and steroid-induced psychosis in the other. MMF 2 g daily caused the skin manifestations to disappear within a few weeks in both patients. One patient was followed up for more than 24 months, and showed good toleration of MMF treatment. The skin remained stable over this period when at least 1 g MMF per day was administered. In conclusion, MMF appears to be an attractive treatment option in skin manifestations of SCLE, and seems to be beneficial for patients with steroid-refractory lesions that are also resistant to treatment with immunosuppressants or antimalarials. The observations suggest that further evaluation of this route in randomized controlled trials is warranted.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 313 (1992), S. 71-74 
    ISSN: 0014-5793
    Keywords: Pinus sylvestris ; heterologous expression ; pinosylvin synthase ; stilbene synthase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2016-04-29
    Description: Measurements of channel bed and bank incision into bedrock coupled with mapping and radiocarbon dating of strath terraces in the West Fork Teanaway River, Washington, provide insight into rates and mechanisms of river incision and strath terrace formation in a forested landscape. The West Fork drains 102 km 2 of the slowly exhuming southeastern North Cascade Range, and it is rapidly eroding its bed and creating strath terraces in its lower reach. Minimum vertical incision, measured annually relative to nails embedded in the streambed, was greater in the seasonally exposed, weathering-dominated, high-flow channel (mean = 10.9 mm yr –1 ) than in the perennially wet, abrasion-dominated, low-flow channel (3.8 mm yr –1 ), documenting unsteady lowering of the channel margin. Ages of radiocarbon-dated materials from alluvium on strath terraces, 0.1 m to 5.4 m above the water surface, suggest three episodes of strath abandonment at maximum ages of ca. A.D. 830, A.D. 1560, and A.D. 1890, and average incision rates of 1.3 mm yr –1 , 1.4 mm yr –1 , and 7.4 mm yr –1 for the oldest to youngest surfaces, respectively. Weathering-promoted vertical incision in the high-flow channel provides a mechanism for "top-down" rapid lateral strath planation in which scour of alluvium on incipient strath terraces incorporates the surface into the high-flow channel, allowing rapid removal of bedrock weathered during wetting and drying cycles. Relationships among channel width, channel confinement by bedrock terrace risers, modeled bankfull shear stress, and alluvial bed cover suggest that rapid channel widening could also internally limit vertical incision by slowing incision as shear stresses decline and more alluvium is retained on the bed. The timing of the most recent (ca. A.D. 1890) strath abandonment corresponds with historical anthropogenic removal of fluvial wood, suggesting that the relative abundance of fluvial wood may influence episodes of vertical bedrock incision by affecting the retention of alluvium on streambeds.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 7
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    The American Association for Cancer Research (AACR)
    Publication Date: 2016-11-02
    Description: Purpose: Intensity-modulated radiotherapy (IMRT) enables the delivery of high doses to target volume while sparing surrounding nontargeted tissues. IMRT treatment, however, substantially increases the normal tissue volume receiving low-dose irradiation, but the biologic consequences are unclear. Experimental Design: Using mouse strains that varied in genetic DNA repair capacity, we investigated the DNA damage response of cortical neurons during daily low-dose irradiation (0.1 Gy). Using light and electron microscopic approaches, we enumerated and characterized DNA damage foci as marker for double-strand breaks (DSBs). Results: During repeated low-dose irradiation, cortical neurons in brain tissues of all mouse strains had a significant increase of persisting foci with cumulative doses, with the most pronounced accumulation of large-sized foci in repair-deficient mice. Electron microscopic analysis revealed that persisting foci in repair-proficient neurons reflect chromatin alterations in heterochromatin, but not persistently unrepaired DSBs. Repair-deficient SCID neurons, by contrast, showed high numbers of unrepaired DSBs in eu- and heterochromatin, emphasizing the fundamental role of DNA-PKcs in DSB rejoining, independent of chromatin status. In repair-deficient ATM –/– neurons, large persisting damage foci reflect multiple unrepaired DSBs concentrated at the boundary of heterochromatin due to disturbed KAP1 phosphorylation. Conclusion: Repeated low-dose irradiation leads to the accumulation of persisting DNA damage foci in cortical neurons and thus may adversely affect brain tissue and increase the risk of carcinogenesis. Multiple unrepaired DSBs account for large-sized foci in repair-deficient neurons, thus quantifying foci alone may underestimate extent and complexity of persistent DNA damage. Clin Cancer Res; 22(21); 5300–11. ©2016 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
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