Note: Front Cover -- Molecular Control of Proliferation and Differentiation -- Copyright Page -- Table of Contents -- List of Contributors -- Foreword -- Part I: Introduction -- Chapter 1. Cell Communication in Embryological Development: The Role of Distal and Proximal Signals -- I. INTRODUCTION -- II. EVOLUTION OF CELL COMMUNICATION -- III. DISTAL AND PROXIMAL REGULATION IN EMBRYO LOGICAL DEVELOPMENT -- IV. STRATEGIES OF REGULATION OF DIFFERENTIATION -- REFERENCES -- Part II: Growth Factors -- Chapter 2. Biological and Molecular Studies of the Mitogenic Effects of Human Epidermal Growth Factor -- I. INTRODUCTION -- II. ISOLATION AND CHEMICAL PROPERTIES OF HUMAN EGF -- III. BIOLOGICAL PROPERTIES OF hEGF -- IV. INTERACTION OF 125 LABELED hEGF WITH HUMAN FIBROBLASTS -- V. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3. Cellular Specificities of Fibroblast Growth Factor and Epidermal Growth Factor -- I. INTRODUCTION -- II. RESULTS -- III. DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4. Growth Control by Serum Factors and Hormones in Mammalian Cells in Culture -- I. INTRODUCTION -- II. SERUM FACTORS REQUIRED BY 3T3 AND SV3T3 CELLS -- III. SERUM FACTOR REQUIREMENTS OF OTHER CELL TYPES -- IV. GROWTH CONTROL BY SERUM FACTORS, HORMONES AND CELL ANCHORAGE -- V. CELLULAR RESPONSES AFTER STIMULATION OF G1 -ARRESTED CELLS WITH SERUM FACTORS -- ACKNOWLEDGMENTS -- REFERENCES -- Part III: Factors Affecting Nerve Cell Differentiation and Function -- Chapter 5. Nerve Growth Factor: Studies on the Localization, Regulation and Mechanism of Its Biosynthesis -- I. INTRODUCTION -- II. MEASUREMENT OF βNGF BIOSYNTHESIS -- III. THE SITES OF βNGF BIOSYNTHESIS -- IV. HORMONAL REGULATION OF βNGF BIOSYNTHESIS -- V. THE NATURE OF THE INITIAL BIOSYNTHETIC PRODUCT -- VI. CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES. , Chapter 6. Nerve Growth Factor as a Mediator of Information Between Effector Organs and Innervating Neurons -- I. INTRODUCTION -- II. EVIDENCE FOR RETROGRADE AXONAL TRANSPORT OF NGF IN ADRENERGIC NEURONS -- III. SPECIFICITY OF THE RETROGRADE AXONAL TRANSPORT OF NGF IN ADRENERGIC NEURONS -- IV. RESTRICTION OF RETROGRADE AXONAL TRANSPORT OF NGF TO ADRENERGIC AND SENSORY NEURONS -- V. FUNCTIONAL SIGNIFICANCE OF THE MOIETY OF NGF REACHING THE PERIKARYON BY RETROGRADE AXONAL TRANSPORT -- VI. EVIDENCE FOR THE FUNCTIONAL IMPORTANCE OF RETROGRADELY TRANSPORTED NGF DURING ONTOGENETIC DEVELOPMENT -- VII. PRODUCTION OF NGF IN ADRENERGICALLY INNERVATED EFFECTOR ORGANS -- VIII. SITE AND MECHANISM OF ACTION OF NGF -- IX. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7. Peptides as Central Nervous System Neurotransmitters -- I. INTRODUCTION -- II. ENKEPHALIN: THE BRAIN'S MORPHINE-LIKE PEPTIDE -- OTHER PEPTIDES -- REFERENCES -- Part IV: Cell Interactions in Blood Cell Development -- Chapter 8. Factors Affecting the Differentiation of Blood Cells -- I. INTRODUCTION -- II. CELL BIOLOGY OF EARLY HEMOPOIESIS -- III. THE MEMBRANE BIOLOGY OF EARLY HEMOPOIESIS -- IV. IMPLICATIONS FOR HUMAN MYELOGENOUS LEUKEMIA -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9. Factors Controlling the Proliferation of Haemopoietic Stem Cells In Vitro -- I. INTRODUCTION -- II. MATERIALS AND METHODS -- III. RESULTS -- IV. DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 10. Aspects of Erythroid Differentiation and Proliferation -- I. INTRODUCTION -- II. ERYTHROPOIETIN AND ITS ACTION -- III. CELLS RESPONDING TO ERYTHROPOIETIN -- IV. MODULATORS OF ERYTHROPOIESIS -- ACKNOWLEDEMENTS -- REFERENCES -- Chapter 11. The Role of Factors in Differentiation of Non-Erythroid Cells -- I. INTRODUCTION -- II. SOURCES OF CSF -- III. BIOCHEMICAL CHARACTERIZATION OF CSF. , IV. REGULATION OF CSF PRODUCTION -- V. THE ROLE OF PROSTAGLANDINS IN MODULATION OF HEMOPOIESIS -- ACKNOWLEDGMENTS -- REFERENCES -- Part V: Cell Interactions in the Immune System -- Chapter 12. Cell Interactions in Cell Mediated Immunity -- I. STIMULATOR CELL-LYMPHOCYTE INTERACTIONS -- II. MACROPHAGE-LYMPHOCYTE INTERACTIONS -- III. CELL INTERACTIONS OF T-LYMPHOCYTES -- IV. EFFECTOR-TARGET CELL INTERACTIONS -- REFERENCES -- Chapter 13. Lymphocyte Differentiations Induced by Thymopoietin, Bursopoietin and Ubiquitin -- I. INTRODUCTION -- II. THE T CELL INDUCTION ASSAY -- III. THE DUAL INDUCTION ASSAY -- IV. THYMOPOIETIN -- V. UBIQUITIN -- VI. APPROACH TO DETECTING SPECIFIC INDUCING AGENTS IN TISSUE EXTRACTS -- VII. BURSOPOIETIN -- ACKNOWLEDGMENTS -- REFERENCES -- Part VI. Cell Interactions in Organogenesis -- Chapter 14. An Analysis of Pancreatic Development: Role of Mesenchymal Factor and Other Extracellular Factors -- I. INTRODUCTION -- II. THE DEVELOPING PANCREAS CONTAINS THE INFORMATION REQUIRED FOR MORPHOGENESIS AND CYTODIFFERENTIATION -- III. ORIGIN OF THE ENDOCRINE PANCREAS -- IV. DIFFERENTIATION OF THE A CELL: GLUCAGON AND DEVELOPMENT -- V. MORPHOGENESIS AND CYTODIFFERENTIATION -- VI. MESENCHYMAL FACTOR CONTROLS NORMAL PANCREATIC DEVELOPMENT -- VII. THE MODULATION OF DEVELOPMENT BY HORMONES AND OTHER EXTRINSIC FACTORS -- VIII. EMBRYOLOGICAL PRECURSORS TO PANCREAS CELLS: A PLURIPOTENTIAL STEM CELL? -- IX. STEM CELLS AND THE MECHANISM OF ACTION OF THE MESENCHYMAL FACTOR -- ACKNOWLEDGMENTS -- REFERENCES -- Part VII: Factors Effecting Differentiation in Lower Eukaryotes -- Chapter 15. Action of a Morphogenetic Substance from Hydra -- I. INTRODUCTION -- II. EFFECTS OF THE HEAD ACTIVATOR AS A MORPHOGEN CONTROLLING HEAD FORMATION IN HYDRA -- III. ACTION OF THE HEAD ACTIVATOR AT THE CELLULAR LEVEL -- CONCLUSION -- REFERENCES. , Chapter 16. Mating-Type Specific Pheromones as Mediators of Sexual Conjugation in Yeast -- I. INTRODUCTION -- II. PHYSIOLOGICAL LANDMARKS LEADING TO CONJUGATION -- III. PROPERTIES OF MATING FACTORS -- IV. INVOLVEMENT OF THE MATING FACTORS IN CONJUGATION -- V. SUMMARY -- REFERENCES -- Subject Index.

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