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  • 1
    Online Resource
    Online Resource
    Control of Gene Expression by Catecholamines and the Renin-Angiotensin System. (2000)
    New York, NY :Springer,
    Details
    Keywords: Genetic regulation. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (226 pages)
    Edition: 1st ed.
    ISBN: 9781461543510
    Series Statement: Developments in Molecular and Cellular Biochemistry Series ; v.33
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3069245
    DDC: 572.8/65
    Language: English
    Note: Intro -- Copyright -- CONTENTS VOLUME 212, Nos. 1 & -- 2, September 2000 -- Preface -- Index to Volume 212.
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  • 2
    Online Resource
    Online Resource
    Molecular and Cellular Effects of Nutrition on Disease Processes. (1998)
    New York, NY :Springer,
    Details
    Keywords: Nutritionally induced diseases-Molecular aspects-Congresses. ; Pathology, Molecular-Congresses. ; Functional foods-Congresses. ; Diet therapy-Congresses. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (227 pages)
    Edition: 1st ed.
    ISBN: 9781461557630
    Series Statement: Developments in Molecular and Cellular Biochemistry Series ; v.26
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6496546
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? (1998)
    Springer
    Molecular and cellular biochemistry 178 (1998), S. 353-366 
    Details
    ISSN: 1573-4919
    Keywords: stress ; heart ; dietary fatty acids ; blood pressure ; rats ; docosahexaenoic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Epidemiological studies suggest that n-3 polyunsaturated fatty acids (PUFA) are involved in the prevention of cardiovascular disease. Stress is known to increase the incidence of CVD and the present study was realised to evaluate some physiological and biochemical effects of dietary docosahexaenoic acid (DHA) in male Wistar rats subjected to a psycho social stress. Rats were fed for 8 weeks a semi-purified diet containing 10% of either sunflower seed oil or the same oil supplemented with DHA. This food supply represented 50% of their daily requirement. The remaining 50% were supplied as 45 mg food pellets designed to induce stress in rats by an intermittent-feeding schedule process. The control group (n = 12) was fed the equivalent food ration as a single daily feeding. The physiological cardiovascular parameters were recorded by telemetry through a transmitter introduced in the abdomen. At the end of the experimentation, the heart and adrenals were withdrawn and the fatty acid composition and the catecholamine store were determined. Dietary DHA induced a pronounced alteration of the fatty acid profile of cardiac phospholipids (PL). The level of all the n-6 PUFAs was reduced while 22:6 n-3 was increased. The stress induced a significant increase in heart rate which was not observed in DHA-fed group. The time evolution of the systolic blood pressure was not affected by the stress and was roughly similar in the stressed rats of either dietary group. Conversely, the systolic blood pressure decreased in the unstressed rats fed DHA. Similar data were obtained for the diastolic blood pressure. The beneficial effect of DHA was also observed on cardiac contractility, since the dP/dtmax increase was prevented in the DHA-fed rats. The stress-induced modifications were associated with an increase in cardiac noradrenaline level which was not observed in DHA-fed rats. The fatty acid composition of adrenals was significantly related to the fatty acid intake particularly the neutral lipid fraction (NL) which incorporated a large amount of DHA. Conversely, n-3 PUFAs were poorly incorporated in adrenal phospholipids. Moreover the NL/PL ratio was significantly increased in the DHA fed rats. The amount of adrenal catecholamines did not differ significantly between the groups. These results show that a supplementation of the diet with DHA induced cardiovascular alterations which could be detected in conscious animals within a few weeks. These alterations were elicited by a reduced heart rate and systolic and diastolic blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006813216815
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  • 4
    Electronic Resource
    Electronic Resource
    Preface (1998)
    Springer
    Molecular and cellular biochemistry 188 (1998), S. 1-1 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006807812593
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of different culture conditions on sarcoplasmic reticular calcium transport in isolated neonatal rat cardiomyocytes (1998)
    Springer
    Molecular and cellular biochemistry 188 (1998), S. 177-185 
    Details
    ISSN: 1573-4919
    Keywords: neonatal rat cardiomyocyte culture ; sarcoplasmic reticulum ; phospholamban ; calcium ATPase ; calcium transport ; thyroid hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract This study investigates sarcoplasmic reticulum (SR) calcium-(Ca2+) transport ATPase (SERCA2a) and phospholamban (PLB) in cultured spontaneously contracting neonatal rat cardiomyocytes (CM) to ascertain the function of both SR proteins under various culture conditions. The two major SR proteins were readily detectable in cultured CM by immunofluorescent microscopy using specific anti-SERCA2 and anti-PLB antibodies. Double labeling technique revealed that PLB-positive CM also labeled with anti-SERCA2. Coexpression of SERCA2 and PLB in CM was supported by measurement of cell homogenate oxalate-supported Ca2+ uptake which was completely inhibited by thapsigargin and stimulated by protein kinase A-catalyzed phosphorylation. Under serum-free conditions, incubation of CM with the SERCA2a expression modulator 3,3′,5-triiodo-L-thyronine (100 nM, 72 h) resulted in elevated Ca2+ uptake of +33%. Specific Ca2+ uptake activity was not altered if insulin was omitted from the serum-free culture medium but total SR Ca2+ transport activity was reduced under this culture condition. The results indicate that primary culture of spontaneously contracting neonatal rat CM can be employed as a useful model system for investigating both short- and long-term mechanisms determining the Ca2+ re-uptake function of the SR under defined culture conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006850724830
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  • 6
    Electronic Resource
    Electronic Resource
    Preface (2000)
    Springer
    Molecular and cellular biochemistry 212 (2000), S. 1-1 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007192214046
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of adrenolutin as an oxidation product of catecholamines in plasma (1989)
    Springer
    Molecular and cellular biochemistry 87 (1989), S. 85-92 
    Details
    ISSN: 1573-4919
    Keywords: plasma adrenolutin ; adrenochrome ; catecholamines ; oxidation of catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Using the reverse phase high-performance liquid chromatography (HPLC) with mobile phases composed of simple acids, we have developed an assay technique for the measurement of adrenolutin, one of the oxidation products of catecholamines, in rat plasma. Ion-pairing chromatography permits the separation and quantitation of plasma adrenolutin (μM) in a linear manner. Sample preparation involved the precipitation of plasma proteins with perchloric acid and it is easier to handle a large number of samples at a time. However, we were unable to demonstrate the presence of adrenochrome, another oxidation product of catecholamines, in plasma since adrenochrome was rapidly destroyed in acid as well as in blood and was quickly changed, into adrenolutin. Adrenolutin peak in HPLC was confirmed by 1) the retention time; 2) co-injection of adrenolutin and; 3) the appearance of 3H-adrenolutin after injection of 3H-norepinephrine. Administration of different catecholamines as well as adrenochrome and adrenolutin in rats also increased the level of adrenolutin in plasma. Adrenolutin was found to be present in plasma in other species including dog, rabbit and pig. High level of adrenolutin, which may represent total concentration of aminolutin in plasma, suggests the presence of an efficient mechanism for the oxidation of catecholamines under in vivo conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421086
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  • 8
    Electronic Resource
    Electronic Resource
    Paradoxical role of lipid metabolism in heart function and dysfunction (1992)
    Springer
    Molecular and cellular biochemistry 116 (1992), S. 3-9 
    Details
    ISSN: 1573-4919
    Keywords: fatty acid metabolism ; membrane phospholipids ; heart membranes ; myocardial ischemia ; diabetic heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The heart utilizes fatty acids as a substrate in preference to glucose for the production of energy. The rate of fatty acid uptake and oxidation by heart muscle is controlled by the availability of exogenous fatty acids, the rate of acyl translocation across the mitochondrial membrane and the rate of acetyl-CoA oxidation by the citric acid cycle. Carnitine acyl-CoA tranferase appears to have an important function in coupling the fatty acid activation and acyl transfer to the oxidative phosphorylation. Activated fatty acids are also utilized for the synthesis of triglycerides and membrane phospholipids in the myocardium. The inhibition of long chain acyl-carnitine transferase I reduces the oxidation of fatty acids and promotes the synthesis of lipids in the myocardium. Accumulation of fatty acids and their metabolites such as long chain acyl-CoA and long chain acyl-carnitine has been associated with cardiac dysfunction and cell damage in both ischemic and diabetic hearts. Alterations in the composition of membrane phospholipids are also considered to change the activities of various membrane bound enzymes and subsequently heart function under different pathophysiological conditions. Chronic diabetes was found to be associated with increased plasma lipids, subcellular defects and cardiac dysfunction. Lowering the plasma lipids or reducing the oxidation of fatty acids by agents such as etomoxir, an inhibitor of palmitoylcarnitine transferase I was found to promote glucose utilization and remodel the subcellular membranous organelles in the heart. The crucial role of fatty acids in membrane phospholipids for the maintenance of structural integrity and production of energy for cardiac contractile activity as well as the toxic effects of fatty acids and their long chain acyl-derivatives support the concept of `lipid paradox' in the myocardium. (Mol Cell Biochem116: 3–9, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01270562
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  • 9
    Electronic Resource
    Electronic Resource
    Modification of myosin isozymes and SR Ca2+-pump ATPase of the diabetic rat heart by lipid-lowering interventions (1994)
    Springer
    Molecular and cellular biochemistry 132 (1994), S. 69-80 
    Details
    ISSN: 1573-4919
    Keywords: diabetic heart ; myosin isozymes ; sarcoplasmic reticulum Ca2+-stimulated ATPase ; blood lipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract To define metabolic influences on cardiac myosin expression and sarcoplasmic reticulum (SR) Ca2+-stimulated ATPase streptozotocin-diabetic rats were treated for 9–10 wk with etomoxir, an inhibitor of carnitine palmitoyl transferase I (CPT-1) and fatty acid synthesis, or an antilipolytic drug, acipimox. Etomoxir reduced myosin V3 of diabetic rats but did not normalize it. However, the high serum triglyceride, free-fatty acid and cholesterol concentrations in diabetic animals were greatly reduced. After bypassing the CPT-1 inhibition with a medium-chain fatty acid (miglyol) diet, the V3 contents and serum lipids were still reduced in the etomoxir-treated diabetic rats; V3 was also reduced in diabetic rats fed miglyol or treated with acipimox. Since low serum insulin or triiodothyronine concentrations in diabetic rats were not improved by these interventions but changes in V3 were correlated with those in triglyceride, free-fatty acid and cholesterol concentrations, it is likely that myosin may be influenced by some metabolic factors. To assess the role of adrenergic influences, diabetic rats (7–8 wk) were treated with an antisympathotonic drug, moxonidine, a β-adrenoceptor blocking drug, propranolol, and a bradycardic drug, tedisamil. Myosin V3 was not reduced significantly in moxonidine-treated or propranolol-treated rats in comparison to untreated diabetic rats. Serum thyroid hormones and insulin were not altered, whereas triglycerides were reduced but not significantly by these antiadrenergic agents. Lowering serum lipids in diabetic rats by treatment with etomoxir, miglyol and acipimox increased the depressed SR Ca2+-stimulated ATPase activity. On the other hand, in diabetic rats treated with moxonidine, propranolol or tedisamil, the ATPase activity was not increased significantly. These results suggest that normalization of blood lipids is important for improving subcellular organelle function in diabetic hearts with impaired glucose utilization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00925676
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  • 10
    Electronic Resource
    Electronic Resource
    Dietary linolenic acid-mediated increase in vascular prostacyclin formation (1996)
    Springer
    Molecular and cellular biochemistry 162 (1996), S. 59-64 
    Details
    ISSN: 1573-4919
    Keywords: fatty acid ; dietary treatment ; prostanoids ; linseed oil ; radio telemetry ; spontaneously hypertensive rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract To define vascular effects of an enhanced dietary α-linolenic acid intake, 28 spontaneously hypertensive rats were fed a 3% sunflowerseed oil (44% linoleic acid) diet; in 3 groups (7 rats each), the diet was supplemented with 1, 2.5 or 5% linseed oil containing 62% α-linolenic acid. α-Linolenic acid was incorporated up to 12% in the aorta of the 5% linseed oil group. The eicosapentaenoic acid content was not significantly increased. The content of arachidonic acid and docosatetraenoic acid was moderately reduced in rats fed 5% linseed oil. The generation of 6-keto-PGF1α (degradation product of prostacyclin) assessed by HPLC/electrochemical detection was, however, markedly increased (p 〈 0.05) in rats fed 2.5 and 5% linseed oil. The minor prostanoids TXB2, PGE2 and PGF2α were not significantly altered. The high systolic and diastolic blood pressure of SHR monitored by radio telemetry was more effectively reduced (p 〈 0.05) in the light, i.e. sleep, cycle. An increased prostacyclin formation and lowered vascular arachidonic acid content associated with enhanced dietary α-linolenic acid intake would thus be expected to prove beneficial in the prevention of vascular disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00250996
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