Publication Date:
2018-05-22
Description:
Computational redesign of enzymes for regio- and enantioselective hydroamination Computational redesign of enzymes for regio- and enantioselective hydroamination, Published online: 21 May 2018; doi:10.1038/s41589-018-0053-0 Computational protein design, without subsequent directed evolution, rapidly provides a set of aspartase variants capable of biocatalytic asymmetric addition of ammonia to substituted acrylates, producing various enantiopure β-amino acids.
Print ISSN:
1552-4450
Electronic ISSN:
1552-4469
Topics:
Biology
,
Chemistry and Pharmacology
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