Note: Front Cover -- Cell-Cell Signaling in Vertebrate Development -- Copyright Page -- Table of Contents -- Preface -- PART I: INTRODUCTION -- Chapter 1. Mechanisms of Gene Activation in Early Vertebrate Development -- Text -- References -- PART II: CELL-CELL CONTACTS AND INDUCTION -- Chapter 2. Control of Granule Cell Neurogenesis and Migration in Developing Cerebellar Cortex -- Introduction -- Granule Cell DNA Synthesis Stimulated by Contacts among Neuronal Precursor Cells -- Influence of Growth Factors on Granule Neuroblast DNA Synthesis -- Duration of Proliferation by Immature Granule Cells in Vitro -- Characterization of the Progeny of Granule Cell Neuroblasts in Vitro -- Initiation of Neuronal Differentiation: The Neurological Mutant Mouse Weaver -- Weaver EGL Cells Fail to Undergo Neuronal Differentiation in Vitro -- Weaver Cells Extend Neurites when Transplanted into Reaggregates of Wild-Type Cells -- Membranes from Wild-Type Cells Rescue the Weaver Defect in Neurite Outgrowth -- Weaver Cells Migrate along Glial Fascicles after Transplantation into Reaggregates of Wild-Type Cells -- Expression of TAG-1 and Astrotactin Increases when Weaver Cells Are Cocultured with Wild-Type Cells -- Features of Migrating Granule Neurons -- Molecular Components of Glia-Guided Neuronal Migration -- Spatiotemporal Pattern of Expression of Astrotactin -- Changing Patterns of Gene Expression Define Four Stages of Granule Neuron Differentiation -- Acknowledgments -- References -- Chapter 3. Mesoderm Induction and Pattern Formation in the Amphibian Embryo -- Mesoderm Induction and the Establishment of the Basic Body Plan in Xenopus -- Mesoderm Induction and the Formation of the Dorsoventral and Anteroposterior Axes -- Consequences of Mesoderm Induction: The Activation of Regulatory Genes -- The LIM Class of Homeobox Genes in Xenopus Development -- Conclusions. , References -- Chapter 4. Relationships between Mesoderm Induction and Formation of the Embryonic Axis in the Chick Embryo -- Germ Layers and Cell Movement Patterns during Primitive Streak Formation in the Chick Embryo -- Establishment of Cell Diversity: Expression of Cell-Type-Specific Markers during Primitive Streak Formation -- Nature of Macromolecules Carrying the L2/HNK-1 Epitope and Their Possible Involvement in Gastrulation -- Fate of HNK-1-Positive Cells -- Marginal Zone: Organizer of the Early Embryo -- Induction of the Primitive Streak: A Revised View -- Acknowledgment -- References -- PART III: CELL MIGRATION AND DIFFERENTIATION -- Chapter 5. Studies of Neural Cell Lineages Using Injectable Fluorescent Tracers -- Introduction -- Fluorescent Dextran and Retroviral Vectors as Lineage Tracers -- Cell Lineages in the Frog Eyebud -- Cell Lineages in the Spinal Cord and Hindbrain of the Chick -- Concluding Remarks -- Acknowledgments -- References -- Chapter 6. Axon Guidance in the Mammalian Spinal Cord -- Introduction -- Orientation of Commissural Axons in Response to a Floor Plate-Derived Chemoattractant -- Patterning of Axons by Contact-Mediated Cues at the Floor Plate -- Summary -- Acknowledgments -- References -- Chapter 7. Axon Patterning in the Visual System: Divergence of Retinal Axons to Each Side of the Brain at the Midline of the Optic Chiasm -- Dye-Labeling Studies in Fixed Brain: Axon Trajectory and Growth Cone Morphology Reflect the Pattern of Divergence -- Growth Cone Form as an Indicator of Behavior and Cell-Cell Interactions -- Real Time Studies -- Midline of the Optic Chiasm: A First Cue for Divergence -- Fiber-Fiber Interactions Also Contribute to Axon Divergence -- Concluding Remarks -- Acknowledgments -- References. , Chapter 8. Cellular Interactions Regulating the Formation of Terminal Arbors by Primary Motoneurons in the Zebrafish -- Identified Primary Motoneurons of the Zebrafish -- Pathfinding by the Primary Motoneurons -- Formation of Terminal Arbors -- Extension and Retraction of Projections -- Regulation of Branch Extension and Retraction -- Summary -- Acknowledgments -- References -- PART IV: GRADIENTS AND DIFFUSIBLE SIGNALS -- Chapter 9. The DVR Gene Family in Embryonic Development -- Introduction -- Results and Discussion -- References -- Chapter 10. Control of Neural Cell Identity and Pattern by Notochord and Floor Plate Signals -- Introduction -- Induction of the Floor Plate by the Notochord -- Signals from the Floor Plate and Notochord Control Cell Pattern in the Ventral Half of the Neural Tube -- Influence of the Notochord and Floor Plate on Cell Differentiation in the Dorsal Neural Tube -- Possible Mechanisms for the Control of Neural Cell Pattern by the Notochord and Floor Plate -- Acknowledgments -- References -- Chapter 11. Retinoids and Pattern Formation in Vertebrate Embryos -- Biochemistry of Retinoids -- Retinoids Induce a Homeobox Gene during Early Development of the Chick Embryo -- Retinolc Acid Induces Somite-like Structures in Cranial Mesoderm -- Retinoid Metabolism in Early Chick Embryos -- Acknowledgments -- References -- PART V: PATTERN FORMATION -- Chapter 12. The Relationship between Krox-20 Gene Expression and the Segmentation of the Vertebrate Hindbrain -- Introduction -- Conserved Expression Pattern of Krox-20 -- Establishment of Krox-20 Expression in the Neural Epithelium -- Implications for Krox-20 Function -- Relationship between Krox-20 Expression and Lineage Restriction -- References -- Chapter 13. The Effect of Retinoids on Amphibian Limb Regeneration -- Introduction -- Events of Limb Regeneration. , Effects of Retinoids on Limb Regeneration -- Conclusions -- References -- PART VI: TRANSCRIPTION FACTORS -- Chapter 14. Role of Transcription Factor GATA-1 in the Differentiation of Hemopoietic Cells -- Introduction -- Results -- Discussion and Conclusions -- Acknowledgments -- References -- Chapter 15. Expression of Hox-2 Genes and Their Relationship to Regional Diversity in the Vertebrate Head -- Introduction -- Conservation and Properties of the Hox Network -- Hox Expression in the Branchial Arches: A Hox Code for the Head -- Role of Mesoderm in Neural Plate Regionalization -- Temporal Onset of Expression -- Transmission of Spatial Specification to Other Parts of the Head -- Areas of Reduced Crest Emigration -- Mechanism of Head Segmentation -- Differences in Extent of Specification in Cranial Crest -- Experimental Support for the Hox Code -- Conclusions -- References -- Chapter 16. Murine Paired Box Containing Genes -- Introduction -- Murine Pax Gene Family -- Conclusions -- Acknowledgments -- References -- Chapter 17. Gene Regulation during Nerve Growth Factor-Induced Differentiation -- Expression of Immediate Early Genes -- Expression of Delayed Early Genes -- Expression of Late Genes -- Proto-oncogenes and Neural Development and Function -- Summary -- Acknowledgments -- References -- Index.