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  • 1
    Electronic Resource
    Electronic Resource
    Equilibrium in the System: Mercuric Iodide-Pyridine (1917)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 21 (1917), S. 269-274 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j150175a001
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Residues in Tissues of Fish Killed by Antimycin (1966)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 14 (1966), S. 403-407 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60146a020
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Echocardiographic Modeling of Cardiac Dyssynchrony Before and During Multisite Stimulation: A Prospective Study (2003)
    350 Main Street , Malden , MA 02148-5018 , USA . : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 26 (2003), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: CAZEAU, S., et al.: Echocardiographic Modeling of Cardiac Dyssynchrony Before and During Multisite Stimulation: A Prospective Study. Multisite biventricular pacing therapy offers significant clinical improvement in some stimulated patients with electrocardiographic criteria of cardiac dyssynchrony. However, observational data increasingly suggest that patients suffering from congestive heart failure in presence of modest QRS widening may also derive benefit from cardiac resynchronization therapy (CRT), and that some patients can be significantly improved clinically after system implantation despite no apparent change in QRS width. This pilot study explored the value of an echocardiographic model to identify cardiac electromechanical dyssynchrony parameters (EDP) in candidates for CRT, and their potential correction after implantation. The study included 66 consecutive CRT recipients of CRT in NYHA functional class III or IV who had one or more atrioventricular, interventricular or intraventricular dyssynchrony criteria. An immediate improvement was observed in 85% of the population with a partial or total correction of their EDP. However, the modifications in EDP differed considerably between recipients of de novo CRT systems and patients with previously implanted standard pacing systems upgraded with the implantation of a left ventricular lead. EDP measurements appear to identify potential candidates for CRT, and to confirm the success of system implantation. (PACE 2003; 26[Pt. II]:137–143)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.2003.00003.x
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  • 4
    Electronic Resource
    Electronic Resource
    Reduction in Energy Pacing Thresholds by Overlapping Biphasic Stimulation Versus Conventional Bipolar Pacing (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 21 (1998), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Overlapping biphasic (OLBI) stimulation is a new pacing waveform consisting of two simultaneous monophasic pulses of opposite polarities applied to a bipolar electrode. The goal of this prospective study was to compare, using conventional pacing leads, the acute energy pacing thresholds, measured at 0.5-ms pulse duration, associated with bipolar versus OLBI (mode 7 and mode 8) pulse delivery. Results: Thirty one leads were tested in 20 patients. Of these leads, 7 (23%) were implanted chronically, 12 (39%) were in atrial positions, and 19 (61%) in ventricular positions. Energy pacing thresholds were significantly lower (-25.6 ± 25.6 %, P = 0.005) in OLBI mode 8 (1.30 ± 3.96 μJ) compared to bipolar (1.55 ± 4.37 μJ) pacing, regardless of the pacing site or length of service of the leads. In contrast, OLBI mode 7, which has an anodal component, at the tip electrode was associated with higher energy pacing thresholds (3.65 ± 6.48 μJ; +358.3 ± 219.4%, P = 0.002). Conclusions: Mode 8 OLBI pacing is associated with lower acute energy pacing thresholds when used with bipolar leads in contact with the myocardium. OLBI pacing may increase pacemaker longevity by reducing long-term energy consumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.1998.tb01146.x
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of 3- and 4-monopivaloylepinephrine, degradation products in dipivefrin hydrochloride drug substance and ophthalmic formulations
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 10 (1992), S. 465-471 
    Details
    ISSN: 0731-7085
    Keywords: Dipivefrin hydrochloride ; HPLC ; degradation ; epinephrine ; mass spectrometry. ; stability
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0731-7085(92)80066-V
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  • 6
    Electronic Resource
    Electronic Resource
    Cardiovascular responses to thermal stress in conscious goats
    Amsterdam : Elsevier
    Journal of Thermal Biology 8 (1983), S. 241-246 
    Details
    ISSN: 0306-4565
    Keywords: Capra sp ; Temperature regulation ; cardiovascular system ; goat ; thermal stress
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4565(83)90002-5
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  • 7
    Electronic Resource
    Electronic Resource
    A comparative study of immuno-blotting techniques for the detection of Gc-subtypes after isoelectric focusing on agarose and polyacrylamide gels (1987)
    Springer
    International journal of legal medicine 98 (1987), S. 175-180 
    Details
    ISSN: 1437-1596
    Keywords: Gc-subtyping ; comparative study ; Gc-Subtypen, Methodenvergleich ; Semi-dry-Electroblot ; Enzymgekoppelte Antigen-Antikörperreaktion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung In der vorliegenden Studie werden Methoden zum Nachweis und zur Darstellung der Gc-Subtypen verglichen. Die isoelektrische Fokussierung findet im Agarosegel pH 4–6 und im Polyacrylamidgel pH 4,5–5,4 Anwendung. Die Nachweismethoden der direkten Immunfixation mit Anti-Gc, der Immunfixation mit anschließendem Enzym-Antikörperkomplex, des passiven Blot und des Semi-dry-Electroblot hinsichtlich ihrer Empfindlichkeit und Nachweisgrenzen werden überprüft. Erste Untersuchungen an auf Baumwollstoff angelegten Blutspuren unterschiedlichen Alters schließen sich an. Die Auftrennung des Gc-Proteins im Polyacrylamidgel erweist sich als Methode der Wahl, insbesondere wegen guter Bandenschärfe und genügend großem Korridor zwischen den 1S- und 1F-Banden. Innerhalb der Darstellungstechniken ist eindeutig dem Semi-dry-Electroblot mit anschließender enzymgekoppelter Antigen-Antikörperreaktion der Vorzug zu geben. Hier erfolgt durch eine vertikale Elektrophorese ein annähernd 100%iger Transfer des aufgetrennten Gc-Proteins in eine Nitrozellulosemembran, welche im nachfolgenden 2-Schrittverfahren (Antigen-Antikörperreaktion und gekoppelte Enzym-Substratreaktion) zur Darstellung desselben eingesetzt wird. Durch Kombination dieser Techniken können maximale Serumverdünnungen von über 1/500 bestimmt werden; ferner lassen sich nach ersten Versuchen Blutspuren bis zu einem Mindestalter von 20 Wochen bei Raumtemperaturlagerung eindeutig typisieren.
    Notes: Summary A comparison of separation and detection techniques has been carried out to determine the most suitable combination for use in Gc-subtyping. The best results (i.e., high sensitivity, distinct bands, especially with reference to the 1S and 1F separation) were achieved using isoelectric focusing in polyacrylamide gel (pH 4.5–5.4) followed by transfer to nitrocellulose membrane by electroblotting and finally detection with enzyme-linked antibody complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200340
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  • 8
    Electronic Resource
    Electronic Resource
    Tritium environmental transport studies at TFTR (1993)
    Springer
    Journal of fusion energy 12 (1993), S. 145-148 
    Details
    ISSN: 1572-9591
    Keywords: tritium ; transport ; monitoring ; environment ; model ; validation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Environmental tritium concentrations will be measured near the Tokamak Fusion Test Reactor (TFTR) to help validate dynamic models of tritium transport in the environment. For model validation the database must contain sequential measurements of tritium concentrations in key environmental compartments. Since complete containment of tritium is an operational goal, the supplementary monitoring program should be able to glean useful data from an unscheduled acute release. Portable air samplers will be used to take samples automatically every 4 hours for a week after an acute release, thus obtaining the time resolution needed for code validation. Samples of soil, vegetation, and foodstuffs will be gathered daily at the same locations as the active air monitors. The database may help validate the plant/soil/air part of tritium transport models and enhance environmental tritium transport understanding for the International Thermonuclear Experimental Reactor (ITER).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01059370
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  • 9
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    Left ventricular endocardial or triventricular pacing to optimize cardiac resynchronization therapy in a chronic canine model of ischemic heart failure (2012)
    The American Physiological Society (APS)
    Details
    Publication Date: 2012-07-16
    Description: Cardiac resynchronization therapy (CRT) is a proven treatment for heart failure but ~30% of patients appear to not benefit from the therapy. Left ventricular (LV) endocardial and multisite epicardial [triventricular (TriV)] pacing have been proposed as alternatives to traditional LV transvenous epicardial pacing, but no study has directly compared the hemodynamic effects of these approaches. Left bundle branch block ablation and repeated microembolizations were performed in dogs to induce electrical dysynchrony and to reduce LV ejection fraction to 〈35%. LVdP/d t max and other hemodynamic indexes were measured with a conductance catheter during LV epicardial, LV endocardial, biventricular (BiV) epicardial, BiV endocardial, and TriV pacing performed at three atrioventricular delays. LV endocardial pacing was obtained with a clinically available pacing system. The optimal site was defined as the site that increased dP/d t max by the largest percentage. Implantation of the endocardial lead was feasible in all canines ( n = 8) without increased mitral regurgitation seen with transesophageal echocardiography and with full access to the different LV endocardial pacing sites. BiV endocardial pacing increased dP/d t max more than BiV epicardial and TriV pacing on average ( P 〈 0.01) and at the optimal site ( P 〈 0.01). There were no significant differences between BiV epicardial and TriV pacing. BiV endocardial pacing was superior to BiV epicardial and to TriV pacing in terms of acute hemodynamic response. Further investigation is needed to confirm the chronic benefit of this approach in humans.
    Print ISSN: 0363-6135
    Electronic ISSN: 1522-1539
    Topics: Medicine
    Published by The American Physiological Society (APS)
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    PAPER CURRENT
  • 10
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    Association between frequent cardiac resynchronization therapy optimization and long-term clinical response: a post hoc analysis of the Clinical Evaluation on Advanced Resynchronization (CLEAR) pilot study (2013)
    Oxford University Press
    In: Europace
    Details
    Publication Date: 2013-07-23
    Description: Aims The long-term clinical value of the optimization of atrioventricular (AVD) and interventricular (VVD) delays in cardiac resynchronization therapy (CRT) remains controversial. We studied retrospectively the association between the frequency of AVD and VVD optimization and 1-year clinical outcomes in the 199 CRT patients who completed the Clinical Evaluation on Advanced Resynchronization study. Methods and results From the 199 patients assigned to CRT-pacemaker (CRT-P) (New York Heart Association, NYHA, class III/IV, left ventricular ejection fraction 〈35%), two groups were retrospectively composed a posteriori on the basis of the frequency of their AVD and VVD optimization: Group 1 ( n = 66) was composed of patients ‘systematically’ optimized at implant, at 3 and 6 months; Group 2 ( n = 133) was composed of all other patients optimized ‘non-systematically’ (less than three times) during the 1 year study. The primary endpoint was a composite of all-cause mortality, heart failure-related hospitalization, NYHA functional class, and Quality of Life score, at 1 year. Systematic CRT optimization was associated with a higher percentage of improved patients based on the composite endpoint (85% in Group 1 vs . 61% in Group 2, P 〈 0.001), with fewer deaths (3% in Group 1 vs. 14% in Group 2, P = 0.014) and fewer hospitalizations (8% in Group 1 vs. 23% in Group 2, P = 0.007), at 1 year. Conclusion These results further suggest that AVD and VVD frequent optimization (at implant, at 3 and 6 months) is associated with improved long-term clinical response in CRT-P patients.
    Print ISSN: 1099-5129
    Electronic ISSN: 1532-2092
    Topics: Medicine
    Published by Oxford University Press
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    PAPER CURRENT
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