GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Reaktivität und Toxizität cyclischer Schwefelsäur eester (1975)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 317 (1975), S. 943-952 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Zur Einschätzung des Alkylierungsvermögens der cyclischen Schwefelsäureester 1,2-Äthylensulfat 1, 1,3-Propylensulfat 2 und 1,3-Butylensulfat 3 wurden die Geschwindigkeiten ihrer Umsetzungen mit 4-(4-Nitrobenzyl)-pyridin (NPB) in Acetophenon bei 20-50°C gemessen und analog ermittelten Parametern des Dimethylsulfats 4, Diäthylsulfats 5, 1,3-Propansultons 6, 1,4-Butansultons 7 und p-Toluolsulfonsäuremethylesters 8 gegenübergestellt. Die resultierende Reaktivitätsabstufung unterscheidet sich z. T. von der, die man bei der Hydrolyse in Wasser erhält, doch erweist sich in beiden Fällen 1,2-Äthylensulfat 1 als jeweils reaktivstes Agens. Aus LD50-Bestimmungen (Maus, i. p.) geht hervor, daß 1,2-Äthylensulfat auch die höchste akute Toxizität der untersuchten Verbindungen besitzt.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19753170610
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Reaktivität und Toxizität cyclischer Schwefelsäureester (1976)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 318 (1976), S. 701-701 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19763180421
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Reaktivität und Toxizität homologer Brom- und Dibromalkane (1978)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 320 (1978), S. 133-139 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reactivity and Toxicity of Homologous Bromo- and DibromoalkanesThe rate constants of the reactions of 4-(4-nitrobenzyl)-pyridine (NBP) with ω,ω′-dibromoalkanes Br—(CH2)n—Br (n = 2-4), alkyl bromides CnH2+n1Br (N = 2-4) and allyl bromide in acetophenone were measured and compared with the LD50-values of these compounds estimated on mice. The tested dibromoalkanes show a contrary graduation of reactivity and acute toxicity.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19783200117
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Vinyloge Acylverbindungen. XX. Reaktivität und Toxizität arylsubstituierter β-Chlorvinylketone, β-Chlorvinylaldehyde und β-Chlorvinylmethyleniminiumsalze (1983)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 325 (1983), S. 55-65 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Vinylogous Acyl Compounds. XX. Reactivity and Toxicity of Aryl-substituted β-Chlorovinyl Ketones, β-Chlorovinyl Aldehydes, and β-Chlorovinyl Methyleniminium SaltsBased on kinetic measurements, the nucleophilic replaceability of the chlorine in aromatic β-chlorovinyl ketones ArCO-CH = CH-Cl (1), isomeric β-chlorovinyl aldehydes OCH—CH=C(Cl)Ar(2), and corresponding β-chlorovinyl methyleniminium salts Me2N⊕;=CH—CH=C(Cl)Ar X⊖ (3) is compared and related to toxicological findings. The chemical reactivity of these important synthetic building blocks increases in the order 2〈1〈3, the acute toxicity (24 h LD50 i. p. in the mouse) shows the graduation 2〈3〈1. Compounds of type 1 prove to be relatively toxic (LD50 24-42 mg/kg) and display a marked necrotic action after percutaneous absorption, whereas the aldehydes 2 have not only a minor acute toxicity (LD50 158-298 mg/kg) but also a somewhat less marked skin damaging activity. In addition, the LD50 values of selected β-chlorovinyl carbonyl compounds are compared with those of corresponding halogen-free compounds as well as of vinylogous carbonamidium salts ArCO—CH=CH—N⊕R3X⊖. The latter, which can be used as synthetic equivalents of 1, differ in both the reduced acute toxicity and missing skin damaging properties.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19833250108
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...